Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers.

abstract：:Objective: A number of studies have reported that aldehyde dehydrogenase-2 (ALDH2) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH...

journal_title：Frontiers in neurology

authors： Chen J,Huang W,Cheng CH,Zhou L,Jiang GB,Hu YY

更新日期：2019-03-28 00:00:00

abstract：:Objective: Myotonia congenita (MC) is a rare muscle disease characterized by sarcolemma over-excitability inducing skeletal muscle stiffness. It can be inherited either as an autosomal dominant (Thomsen's disease) or an autosomal recessive (Becker's disease) trait. Both types are caused by loss-of-function mutations i...

journal_title：Frontiers in neurology

authors： Altamura C,Ivanova EA,Imbrici P,Conte E,Camerino GM,Dadali EL,Polyakov AV,Kurbatov SA,Girolamo F,Carratù MR,Desaphy JF

更新日期：2020-09-04 00:00:00

abstract：:Background: Prolonged static whole-body roll-tilt has been shown to bias estimates of the direction of gravity when assessed by static paradigms such as the subjective visual vertical and the subjective haptic vertical. Objective: We hypothesized that these shifts are paradigm-independent and thus predicted a post-til...

journal_title：Frontiers in neurology

authors： Wedtgrube A,Bockisch CJ,Straumann D,Tarnutzer AA

更新日期：2020-10-15 00:00:00

abstract：:This review article provides a general perspective of the experimental and clinical work surrounding the role of type-I, type-II, and type-III interferons (IFNs) in the pathophysiology of brain and spinal cord injury. Since IFNs are themselves well-known therapeutic targets (as well as pharmacological agents), and ant...

journal_title：Frontiers in neurology

authors： Roselli F,Chandrasekar A,Morganti-Kossmann MC

更新日期：2018-06-19 00:00:00

abstract：:With respect to photoreceptor function, it is well known that electroretinogram (ERG) amplitudes decrease with age, but to our knowledge, studies describing age-related changes in the pupil light response (PLR) of mice are lacking. This study recorded the PLR and ERG in C57BL/6 and Sv129S6 wild-type mice at three diff...

journal_title：Frontiers in neurology

authors： Kircher N,Crippa SV,Martin C,Kawasaki A,Kostic C

更新日期：2019-02-04 00:00:00

abstract：OBJECTIVES:Use of oral contraceptive pills (OCP) increases the risk of cerebral venous sinus thrombosis (CVST). Whether this risk varies by type, duration, and other forms of hormonal contraceptives is largely unknown. This systematic review and meta-analysis update the current state of knowledge. METHODS:We performed...

journal_title：Frontiers in neurology

authors： Amoozegar F,Ronksley PE,Sauve R,Menon BK

更新日期：2015-02-02 00:00:00

abstract：:Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and the following overshooting inflammatory host response damage the vulnerable sensory cells of the inner ear, resulting in loss of hair cells and spiral gang...

journal_title：Frontiers in neurology

authors： Erni ST,Fernandes G,Buri M,Perny M,Rutten RJ,van Noort JM,Senn P,Grandgirard D,Roccio M,Leib SL

更新日期：2019-06-10 00:00:00

abstract：:Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship bet...

journal_title：Frontiers in neurology

authors： Terrazzino S,Cargnin S,Viana M,Sances G,Tassorelli C

更新日期：2017-05-01 00:00:00

abstract：:When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. The...

journal_title：Frontiers in neurology

authors： Farrugia ME,Goodfellow JA

更新日期：2020-07-07 00:00:00

abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...

journal_title：Frontiers in neurology

authors： Xu JH,He XW,Li Q,Liu JR,Zhuang MT,Huang FF,Bao GS

更新日期：2019-11-13 00:00:00

abstract：:The aim of the present study was to evaluate the correlation between the end of an Oxford sleep resistance (OSLER) test session and a neurophysiological marker of sleep onset in Parkinson's disease (PD) patients. Single center study was conducted in PD patients with excessive daytime sleepiness [Epworth sleepiness sca...

journal_title：Frontiers in neurology

authors： Neutel D,Peralta R,Pires J,Bentes C,Ferreira JJ

更新日期：2015-09-24 00:00:00

abstract：:The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid-vertebrobasilar anastomosis, with an incidence of 0.027-0.26%. PPHAs change the hemodynamics of the carotid and vertebrobasilar system and may be associated with intracranial vascular anomalies, but basilar bifurcation aneu...

journal_title：Frontiers in neurology

authors： Wang M,Gu J,Lan P,Wan S,Zhou Y,Zheng X,Zhan R

更新日期：2017-04-26 00:00:00

abstract：:Glycogenosis VII (GSD VII) is a rare autosomal recessive glycogen storage disorder caused by mutations in the PFKM gene encoding the phosphofructokinase (PFK) enzyme. A classical form with exercise intolerance, contractures, and myoglobinuria, a severe multisystem infantile form, an hemolytic variant and a late-onset ...

journal_title：Frontiers in neurology

authors： Filosto M,Cotti Piccinelli S,Pichiecchio A,Musumeci O,Galvagni A,Caria F,Gallo Cassarino S,Baldelli E,Vitale R,Padovani A,Toscano A

更新日期：2019-02-07 00:00:00

abstract：:New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign ...

journal_title：Frontiers in neurology

authors： Meletti S,Giovannini G,d'Orsi G,Toran L,Monti G,Guha R,Kiryttopoulos A,Pascarella MG,Martino T,Alexopoulos H,Spilioti M,Slonkova J

更新日期：2017-03-27 00:00:00

abstract：:Acute ischemic stroke is a devastating disease that is often complicated by hemorrhagic transformation. While significant advances have been made over the past two decades with regard to emergent treatment of AIS, many of the therapeutic options are limited by an increased risk of hemorrhage. Here, we sought to review...

journal_title：Frontiers in neurology

authors： Sussman ES,Connolly ES Jr

更新日期：2013-06-10 00:00:00

abstract：:The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA t...

journal_title：Frontiers in neurology

authors： Cenci MA

更新日期：2014-12-15 00:00:00

abstract：:Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...

journal_title：Frontiers in neurology

authors： Rostami E,Engquist H,Johnson U,Howells T,Ronne-Engström E,Nilsson P,Hillered L,Lewén A,Enblad P

更新日期：2014-06-02 00:00:00

abstract：:Background/Objective: Stroke is a leading global cause of adult disability. As the population ages as well as suffers co-morbidities, it is expected that the stroke burden will increase further. There are no established safe and effective restorative treatments to facilitate a good functional outcome in stroke patient...

journal_title：Frontiers in neurology

authors： Mu J,Bakreen A,Juntunen M,Korhonen P,Oinonen E,Cui L,Myllyniemi M,Zhao S,Miettinen S,Jolkkonen J

更新日期：2019-03-26 00:00:00

abstract：:Formulaic expressions naturally convey affective content. The unique formal and functional characteristics of idioms, slang, expletives, proverbs, conversational speech formulas, and the many other conventional expressions in this repertory have been well-described: these include unitary form, conventionalized and non...

journal_title：Frontiers in neurology

authors： Sidtis DVL,Sidtis JJ

更新日期：2018-07-24 00:00:00

abstract：:Background and Purpose: Recent findings suggested that non-stenosing atherosclerosis (NSA) may play an important pathogenic role, especially in cryptogenic strokes. Furthermore, arterial stiffness has been suggested to be a useful tool in identifying patients with embolic stroke of undetermined source (ESUS) with poor...

journal_title：Frontiers in neurology

authors： Acampa M,Lazzerini PE,Manfredi C,Guideri F,Tassi R,Domenichelli C,Cartocci A,Martini G

更新日期：2020-07-24 00:00:00

abstract：:Previous studies have suggested that the corticoreticular tract (CRT) has an important role in motor function almost next to the corticospinal tract (CST) in the human brain. Herein, the CRT is reviewed with regard to its anatomy, function, and recovery mechanisms after injury, with particular focus on previous diffus...

journal_title：Frontiers in neurology

authors： Jang SH,Lee SJ

更新日期：2019-11-12 00:00:00

abstract：:The therapy of focal epilepsy remains unsatisfactory for as many as 25% of patients. The photolysis of caged-γ-aminobutyric acid (caged-GABA) represents a novel and alternative option for the treatment of intractable epilepsy. Our previous experimental results have demonstrated that the use of blue light produced by l...

journal_title：Frontiers in neurology

authors： Wang D,Yu Z,Yan J,Xue F,Ren G,Jiang C,Wang W,Piao Y,Yang X

更新日期：2017-05-18 00:00:00

abstract：:Narcolepsy with cataplexy is a rare, but important differential diagnosis for daytime sleepiness and atonic paroxysms in an adolescent. A recent increase in incidence in the pediatric age group probably linked to the use of the Pandemrix influenza vaccine in 2009, has increased awareness that different environmental f...

journal_title：Frontiers in neurology

authors： Rosch RE,Farquhar M,Gringras P,Pal DK

更新日期：2016-08-10 00:00:00

abstract：:Objectives: This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke. Background: While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review whic...

journal_title：Frontiers in neurology

authors： Sheng Z,Liu Y,Li H,Zheng W,Xia B,Zhang X,Yong VW,Xue M

更新日期：2018-12-20 00:00:00

abstract：:Cognitive impairment is prevalent and disabling in multiple sclerosis (MS) and is severely impacting quality of life (QoL). Aside its routine assessment in clinical care, it should more often be implemented as endpoint/outcome measure in clinical trials. However, a fundamental aspect-often neglected in clinical practi...

journal_title：Frontiers in neurology

authors： Beste C,Ziemssen T

更新日期：2020-08-28 00:00:00

abstract：:Paraneoplastic autoimmune neurological disorders reflect tumor-initiated immune responses against onconeural antigens. Symptoms and signs can affect the central and/or peripheral nervous systems, neuromuscular junction or muscle, and typically evolve subacutely before an underlying neoplasm is discovered. We describe ...

journal_title：Frontiers in neurology

authors： Zhu M,Ma Y,Zekeridou A,Lennon VA

更新日期：2020-12-10 00:00:00

abstract：BACKGROUND AND PURPOSE:The presence of aortic atherosclerosis is an independent risk factor for secondary stroke. The present study was designed to have an initial exploration of the correlation between the load and extent of aortic atheroma (AA) and initial stroke severity or clinical outcome 3 months after stroke. M...

journal_title：Frontiers in neurology

authors： Lazzaro MA,Zaidat OO,Issa MA,Gilkeson RC,Sunshine JL,Tarr RW,Husain S,Suarez JI

更新日期：2011-03-21 00:00:00

abstract：:Introduction: This study quantified stroke-related changes in the following: (1) the averaged discharge rate of motor units (individually tracked and untracked) identified from high-density electromyography (HD-EMG) recordings, (2) global muscle EMG properties of the dorsiflexors during a fatiguing contraction, and th...

journal_title：Frontiers in neurology

authors： Negro F,Bathon KE,Nguyen JN,Bannon CG,Orizio C,Hunter SK,Hyngstrom AS

更新日期：2020-10-29 00:00:00

abstract：:Introduction: It remains unclear if tau imaging may assist diagnosis of chronic traumatic encephalopathy (CTE). Flortaucipir PET has shown superior frontal with medial temporal tau binding consistent with the provisional neuropathological criteria for mid-stage CTE in group-level analyses of retired symptomatic NFL pl...

journal_title：Frontiers in neurology

authors： Krishnadas N,Doré V,Lamb F,Groot C,McCrory P,Guzman R,Mulligan R,Huang K,O'Donnell M,Ponsford J,Hopwood M,Villemagne VL,Rowe CC

更新日期：2020-12-22 00:00:00

abstract：:Non-linear relations of brain amyloid beta (Aβ) with task- based functional connectivity (tbFC) measured with functional magnetic resonance imaging (fMRI) have been reported in late middle age. Our objective was to examine the association between brain Aβ and resting-state functional connectivity (rsFC) in late middle...

journal_title：Frontiers in neurology

authors： Tahmi M,Rippon B,Palta P,Soto L,Ceballos F,Pardo M,Sherwood G,Hernandez G,Arevalo R,He H,Sedaghat A,Arabshahi S,Teresi J,Moreno H,Brickman AM,Razlighi QR,Luchsinger JA

更新日期：2020-10-06 00:00:00