当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Therapeutic Targeting of Autophagy.

Therapeutic Targeting of Autophagy.

Abstract：

:Autophagy is a catabolic process that facilitates nutrient recycling via degradation of damaged organelles and proteins through lysosomal mediated degradation. Alterations in this complex, and tightly regulated process, lead to disease. Autophagy is widely accepted as cytoprotective against neurodegenerative diseases and a variety of clinical interventions are moving forward to increase autophagy as a therapeutic intervention. Autophagy has both positive and negative roles in cancer and this has led to controversy over whether or how autophagy manipulation should be attempted in cancer therapy. Nevertheless, cancer is the disease where most current activity in trying to manipulate autophagy for therapy is taking place and dozens of clinical trials are using autophagy inhibition with Chloroquine or Hydroxychloroquine in combination with other drugs for the treatment of multiple neoplasms. Here, we review recent literature implicating autophagy in neurodegenerative diseases and cancer and highlight some of the opportunities, controversies and potential pitfalls of therapeutically targeting autophagy.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Towers CG,Thorburn A

doi

10.1016/j.ebiom.2016.10.034

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

15-23

issn

2352-3964

pii

S2352-3964(16)30495-9

journal_volume

14

pub_type

杂志文章,评审

相关文献

EBioMedicine文献大全
  • A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.

    abstract：BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102766

    authors： Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

    更新日期：2020-05-01 00:00:00

  • A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

    abstract：BACKGROUND:Tumor necrosis factor-like weak inducer of apoptosis (Tnfsf12; TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Tnfrsf12a; Fn14) participate in the inflammatory response associated with vascular remodeling. However, the functional effect of TWEAK on vascular smooth muscle cells (VSMCs) is not c...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.072

    authors： Méndez-Barbero N,Gutierrez-Muñoz C,Madrigal-Matute J,Mínguez P,Egido J,Michel JB,Martín-Ventura JL,Esteban V,Blanco-Colio LM

    更新日期：2019-08-01 00:00:00

  • Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial.

    abstract：BACKGROUND:The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalisssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-r...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ebiom.2016.10.036

    authors： Stenman LK,Lehtinen MJ,Meland N,Christensen JE,Yeung N,Saarinen MT,Courtney M,Burcelin R,Lähdeaho ML,Linros J,Apter D,Scheinin M,Kloster Smerud H,Rissanen A,Lahtinen S

    更新日期：2016-11-01 00:00:00

  • Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis.

    abstract：:Pericardial tuberculosis (TB) is associated with high therapy failure and high mortality rates. Antibiotics have to penetrate to site of infection at sufficient non-protein bound concentrations, and then enter bacteria to inhibit intracellular biochemical processes. The antibiotic concentrations achieved in pericardia...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.09.025

    authors： Shenje J,Ifeoma Adimora-Nweke F,Ross IL,Ntsekhe M,Wiesner L,Deffur A,McIlleron HM,Pasipanodya J,Gumbo T,Mayosi BM

    更新日期：2015-09-16 00:00:00

  • Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia.

    abstract：:To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) t...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.02.021

    authors： Jiang WJ,Song HX,Li SY,Guo B,Wu JF,Li GP,Guo DD,Shi L,Bi HS,Jonas JB

    更新日期：2017-03-01 00:00:00

  • Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

    abstract：BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (e...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.01.011

    authors： Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

    更新日期：2016-01-13 00:00:00

  • Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

    abstract：BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102777

    authors： Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

    更新日期：2020-06-01 00:00:00

  • Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.

    abstract：BACKGROUND:Neurodegenerative diseases are incurable disorders caused by progressive neuronal cell death. Retinitis pigmentosa (RP) is a blinding neurodegenerative disease that results in photoreceptor death and progresses to the loss of the entire retinal network. We previously found that proteomic analysis of the adja...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102636

    authors： Wert KJ,Velez G,Kanchustambham VL,Shankar V,Evans LP,Sengillo JD,Zare RN,Bassuk AG,Tsang SH,Mahajan VB

    更新日期：2020-02-01 00:00:00

  • Artificial intelligence-assisted prediction of preeclampsia: Development and external validation of a nationwide health insurance dataset of the BPJS Kesehatan in Indonesia.

    abstract：BACKGROUND:We developed and validated an artificial intelligence (AI)-assisted prediction of preeclampsia applied to a nationwide health insurance dataset in Indonesia. METHODS:The BPJS Kesehatan dataset have been preprocessed using a nested case-control design into preeclampsia/eclampsia (n = 3318) and normotensive p...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102710

    authors： Sufriyana H,Wu YW,Su EC

    更新日期：2020-04-01 00:00:00

  • Endothelial FAM3A positively regulates post-ischaemic angiogenesis.

    abstract：BACKGROUND:Angiogenesis improves reperfusion to the ischaemic tissue after vascular obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not clear. FAM3A belongs to the family with sequence similarity 3 (FAM3) genes, but its biological function in endothelial cells in regards to vascular ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.038

    authors： Xu W,Liang M,Zhang Y,Huang K,Wang C

    更新日期：2019-05-01 00:00:00

  • Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The mechanisms driving its epithelial salient features remain largely elusive. We aimed to evaluate the activation and the role of the canonica...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103034

    authors： Carlier FM,Dupasquier S,Ambroise J,Detry B,Lecocq M,Biétry-Claudet C,Boukala Y,Gala JL,Bouzin C,Verleden SE,Hoton D,Gohy S,Bearzatto B,Pilette C

    更新日期：2020-11-01 00:00:00

  • Fatty Acid Metabolism is Associated With Disease Severity After H7N9 Infection.

    abstract：BACKGROUND:Human infections with the H7N9 virus could lead to lung damage and even multiple organ failure, which is closely associated with a high mortality rate. However, the metabolic basis of such systemic alterations remains unknown. METHODS:This study included hospitalized patients (n = 4) with laboratory-confirm...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.06.019

    authors： Sun X,Song L,Feng S,Li L,Yu H,Wang Q,Wang X,Hou Z,Li X,Li Y,Zhang Q,Li K,Cui C,Wu J,Qin Z,Wu Q,Chen H

    更新日期：2018-07-01 00:00:00

  • Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

    abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.03.014

    authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

    更新日期：2018-04-01 00:00:00

  • Cell-Mediated Immune Predictors of Vaccine Effect on Viral Load and CD4 Count in a Phase 2 Therapeutic HIV-1 Vaccine Clinical Trial.

    abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.09.028

    authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

    更新日期：2017-10-01 00:00:00

  • Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

    abstract：BACKGROUND:In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. METHODS:To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Ca...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102971

    authors： George SL,Lorenzi F,King D,Hartlieb S,Campbell J,Pemberton H,Toprak UH,Barker K,Tall J,da Costa BM,van den Boogaard ML,Dolman MEM,Molenaar JJ,Bryant HE,Westermann F,Lord CJ,Chesler L

    更新日期：2020-09-01 00:00:00

  • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study.

    abstract：PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.03.018

    authors： Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

    更新日期：2016-05-01 00:00:00

  • miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

    abstract：BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.057

    authors： Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

    更新日期：2019-03-01 00:00:00

  • Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

    abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.005

    authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

    更新日期：2019-03-01 00:00:00

  • Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility.

    abstract：:Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a compr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.06.018

    authors： Zhu J,Jia W,Wu C,Fu W,Xia H,Liu G,He J

    更新日期：2018-07-01 00:00:00

  • Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.

    abstract：BACKGROUND:Sphingomyelin synthase 1 (SMS1) has been reported to participate in hepatitis and atherosclerosis. However, its role in autoimmune response is not clear. This study investigates the possible involvement of SMS1 in B-cell activation and lupus-like autoimmunity. METHODS:SMS1 knockout lupus-like animal model a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.038

    authors： Wang C,Ming B,Wu X,Wu T,Cai S,Hu P,Tang J,Tan Z,Liu C,Zhong J,Zheng F,Dong L

    更新日期：2019-07-01 00:00:00

  • Mitochondria in acute myocardial infarction and cardioprotection.

    abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.102884

    authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

    更新日期：2020-07-01 00:00:00

  • Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children.

    abstract：:Compelling evidence shows that fine particulate matters (PMs) from air pollution penetrate lower airways and are associated with adverse health effects even within concentrations below those recommended by the WHO. A paper reported a dose-dependent link between carbon content in alveolar macrophages (assessed only by ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.10.012

    authors： Kolosnjaj-Tabi J,Just J,Hartman KB,Laoudi Y,Boudjemaa S,Alloyeau D,Szwarc H,Wilson LJ,Moussa F

    更新日期：2015-10-09 00:00:00

  • Incidentalome from Genomic Sequencing: A Barrier to Personalized Medicine?

    abstract：BACKGROUND:In Western cohorts, the prevalence of incidental findings (IFs) or incidentalome, referring to variants in genes that are unrelated to the patient's primary condition, is between 0.86% and 8.8%. However, data on prevalence and type of IFs in Asian population is lacking. METHODS:In 2 cohorts of individuals w...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.01.030

    authors： Jamuar SS,Kuan JL,Brett M,Tiang Z,Tan WL,Lim JY,Liew WK,Javed A,Liew WK,Law HY,Tan ES,Lai A,Ng I,Teo YY,Venkatesh B,Reversade B,Tan EC,Foo R

    更新日期：2016-02-04 00:00:00

  • Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.

    abstract：:Therapeutic approaches to fight Alzheimer's disease include anti-Amyloidβ (Aβ) antibodies and secretase inhibitors. However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB permeable. The Brain Shuttle (BS) technology is capable of shuttling lar...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.09.004

    authors： Ruderisch N,Schlatter D,Kuglstatter A,Guba W,Huber S,Cusulin C,Benz J,Rufer AC,Hoernschemeyer J,Schweitzer C,Bülau T,Gärtner A,Hoffmann E,Niewoehner J,Patsch C,Baumann K,Loetscher H,Kitas E,Freskgård PO

    更新日期：2017-10-01 00:00:00

  • MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.

    abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.032

    authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

    更新日期：2019-02-01 00:00:00

  • CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.

    abstract：BACKGROUND:Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and extracellular matrix...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102679

    authors： Xiang Q,Kang L,Wang J,Liao Z,Song Y,Zhao K,Wang K,Yang C,Zhang Y

    更新日期：2020-03-01 00:00:00

  • Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury.

    abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ebiom.2016.07.015

    authors： Orešič M,Posti JP,Kamstrup-Nielsen MH,Takala RSK,Lingsma HF,Mattila I,Jäntti S,Katila AJ,Carpenter KLH,Ala-Seppälä H,Kyllönen A,Maanpää HR,Tallus J,Coles JP,Heino I,Frantzén J,Hutchinson PJ,Menon DK,Tenovuo O,Hyötyl

    更新日期：2016-10-01 00:00:00

  • Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.

    abstract：BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102800

    authors： Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

    更新日期：2020-06-01 00:00:00

  • Epidemiologic and genomic insights on mcr-1-harbouring Salmonella from diarrhoeal outpatients in Shanghai, China, 2006-2016.

    abstract：BACKGROUND:Colistin resistance mediated by mcr-1-harbouring plasmids is an emerging threat in Enterobacteriaceae, like Salmonella. Based on its major contribution to the diarrhoea burden, the epidemic state and threat of mcr-1-harbouring Salmonella in community-acquired infections should be estimated. METHODS:This ret...

    journal_title：EBioMedicine

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.ebiom.2019.03.006

    authors： Lu X,Zeng M,Xu J,Zhou H,Gu B,Li Z,Jin H,Wang X,Zhang W,Hu Y,Xiao W,Zhu B,Xu X,Kan B

    更新日期：2019-04-01 00:00:00

  • Chronic Kidney Disease, Time in Therapeutic Range and Adverse Clinical Outcomes in Anticoagulated Patients with Non-valvular Atrial Fibrillation: Observations from the SPORTIF Trials.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study clinical features associated with CKD in AF patients and the impact of CKD on anticoagulation control, as reflected by time in therapeu...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.013

    authors： Proietti M,Lane DA,Lip GYH

    更新日期：2016-06-01 00:00:00