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Vitamin K Dependent Protection of Renal Function in Multi-ethnic Population Studies.

Abstract：

BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (eGFR [CKD-EPI formula]) and stage of chronic kidney disease (CKD [KDOQI stages 2-3]) with inactive desphospho-uncarboxylated MGP (dp-ucMGP), using multivariable linear and logistic regression. RESULTS:Among Flemish and white and black Africans, between-group differences in eGFR (90, 100 and 122 mL/min/1.73 m(2)), dp-ucMGP (3.7, 6.5 and 3.2 μg/L), and CKD prevalence (53.5, 28.7 and 10.5%) were significant, but associations of eGFR with dp-ucMGP did not differ among ethnicities (P ≥ 0.075). For a doubling of dp-ucMGP, eGFR decreased by 1.5 (P = 0.023), 1.0 (P = 0.56), 2.8 (P = 0.0012) and 2.1 (P < 0.0001) mL/min/1.73 m(2) in Flemish, white Africans, black Africans and all participants combined; the odds ratios for moving up one CKD stage were 1.17 (P = 0.033), 1.03 (P = 0.87), 1.29 (P = 0.12) and 1.17 (P = 0.011), respectively. INTERPRETATION:In the general population, eGFR decreases and CKD risk increases with higher dp-ucMGP, a marker of VK deficiency. These findings highlight the possibility that VK supplementation might promote renal health.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

doi

10.1016/j.ebiom.2016.01.011

subject

Has Abstract

pub_date

2016-01-13 00:00:00

pages

162-9

issn

2352-3964

pii

S2352-3964(16)30009-3

journal_volume

4

pub_type

杂志文章

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