当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.

Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.

Abstract：

BACKGROUND:Sphingomyelin synthase 1 (SMS1) has been reported to participate in hepatitis and atherosclerosis. However, its role in autoimmune response is not clear. This study investigates the possible involvement of SMS1 in B-cell activation and lupus-like autoimmunity. METHODS:SMS1 knockout lupus-like animal model and SLE patient samples were utilized. B-cell activation and associated signal transduction were detected by flow cytometry, confocal analysis and western blotting. The SMS1 expression in B cells was measured by real-time qPCR. FINDINGS:SMS1 deficiency suppressed B-cell activation in culture, which was restored by exogenous SM supplementation. The BCR-mediated early signal transduction including the colocalization of BCR with F-actin or pY/pBtk, and the phosphorylation of intracellular Fyn and Syk were impaired in SMS1 knockout B cells. Furthermore, SMS1 knockout mice showed reduced production and deposition of autoantibodies, accompanied by less severe kidney pathological changes after pristane induction. SMS1 deficiency also displayed lower autoantibody titers and 24 h urine protein excretion in bm12-induced lupus, which were associated with reduced B-cell activation. Adoptively transferred wide-type B cells partially recovered B-cell activation and autoantibody production in SMS1 deficient bm12-induced lupus mice. Moreover, the SMS1 mRNA level in B cells of SLE patients was increased and positively correlated with the serum anti-dsDNA level, IgG and globulin titers. INTERPRETATION:These data suggest that SMS1 is involved in lupus-like autoimmunity via regulating BCR signal transduction and B cell activation. (Word count for the abstract: 230).

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Wang C,Ming B,Wu X,Wu T,Cai S,Hu P,Tang J,Tan Z,Liu C,Zhong J,Zheng F,Dong L

doi

10.1016/j.ebiom.2019.06.038

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

578-587

issn

2352-3964

pii

S2352-3964(19)30419-0

journal_volume

45

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • FoxO3a inhibiting expression of EPS8 to prevent progression of NSCLC: A new negative loop of EGFR signaling.

    abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.053

    authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

    更新日期：2019-02-01 00:00:00

  • Absence of a Socioeconomic Gradient in Older Adults' Survival with Multiple Chronic Conditions.

    abstract：BACKGROUND:Individuals of low socioeconomic status experience a disproportionate burden of chronic conditions; however it is unclear whether chronic condition burden affects survival differently across socioeconomic strata. METHODS:This retrospective cohort study used health administrative data from all residents of O...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.11.018

    authors： Lane NE,Maxwell CJ,Gruneir A,Bronskill SE,Wodchis WP

    更新日期：2015-11-18 00:00:00

  • Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness.

    abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ebiom.2019.02.028

    authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

    更新日期：2019-03-01 00:00:00

  • Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.

    abstract：BACKGROUND:The contribution of hepcidin as a regulator of iron metabolism & erythropoiesis on the severity of anemia in sickle cell disease (SCD) remains poorly characterized, especially in Sub-Saharan African populations. The aims of the study were to determine if hepcidin is associated with severity of steady-state a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.07.024

    authors： Lee N,Makani J,Tluway F,Makubi A,Armitage AE,Pasricha SR,Drakesmith H,Prentice AM,Cox SE

    更新日期：2018-08-01 00:00:00

  • Genetic Variation in the Dopamine System Influences Intervention Outcome in Children with Cerebral Palsy.

    abstract：BACKGROUND:There is large variation in treatment responses in children with cerebral palsy. Experimental and clinical results suggest that dopamine neurotransmission and brain-derived neurotrophic factor (BDNF) signalling are involved in motor learning and plasticity, which are key factors in modern habilitation succes...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2017.12.028

    authors： Diaz Heijtz R,Almeida R,Eliasson AC,Forssberg H

    更新日期：2018-02-01 00:00:00

  • Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease.

    abstract：:Inter-individual variability has been a major hurdle to optimize disease management. Precision medicine holds promise for improving health and healthcare via tailor-made therapeutic strategies. Herein, we outline the paradigm of "pharmacometabolomics-aided pharmacogenomics" in autoimmune diseases. We envisage merging ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.02.001

    authors： Katsila T,Konstantinou E,Lavda I,Malakis H,Papantoni I,Skondra L,Patrinos GP

    更新日期：2016-02-02 00:00:00

  • Surgery, neuroinflammation and cognitive impairment.

    abstract：:Trauma experienced during surgery can contribute to the development of a systemic inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis. Vari...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2018.10.021

    authors： Alam A,Hana Z,Jin Z,Suen KC,Ma D

    更新日期：2018-11-01 00:00:00

  • Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment.

    abstract：BACKGROUND:Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS:Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.064

    authors： Tejero R,Huang Y,Katsyv I,Kluge M,Lin JY,Tome-Garcia J,Daviaud N,Wang Y,Zhang B,Tsankova NM,Friedel CC,Zou H,Friedel RH

    更新日期：2019-04-01 00:00:00

  • The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.

    abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102970

    authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

    更新日期：2020-09-01 00:00:00

  • Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.

    abstract：:Cholangiocarcinoma (CCA) is the primary cancer of the bile duct system. The role of bile duct tissue microbiomes in CCA tumorigenesis is unestablished. To address this, sixty primary CCA tumors and matched normals, from both liver fluke (Opisthorchis viverrini) associated (OVa, n=28) and non-O. viverrini associated (n...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.034

    authors： Chng KR,Chan SH,Ng AHQ,Li C,Jusakul A,Bertrand D,Wilm A,Choo SP,Tan DMY,Lim KH,Soetinko R,Ong CK,Duda DG,Dima S,Popescu I,Wongkham C,Feng Z,Yeoh KG,Teh BT,Yongvanit P,Wongkham S,Bhudhisawasdi V,Khuntikeo N,T

    更新日期：2016-06-01 00:00:00

  • Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1.

    abstract：BACKGROUND:A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and present therapeutic challenges. The underlying resistance mechanisms are not fully investigated. We repo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.061

    authors： Islam SS,Uddin M,Noman ASM,Akter H,Dity NJ,Basiruzzman M,Uddin F,Ahsan J,Annoor S,Alaiya AA,Al-Alwan M,Yeger H,Farhat WA

    更新日期：2019-05-01 00:00:00

  • PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.

    abstract：:Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyro...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.09.007

    authors： Lopez-Campistrous A,Adewuyi EE,Benesch MGK,Ko YM,Lai R,Thiesen A,Dewald J,Wang P,Chu K,Ghosh S,Williams DC,Vos LJ,Brindley DN,McMullen TPW

    更新日期：2016-10-01 00:00:00

  • TP63 isoform expression is linked with distinct clinical outcomes in cancer.

    abstract：BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.022

    authors： Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

    更新日期：2020-01-01 00:00:00

  • Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A.

    abstract：BACKGROUND:The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC). Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor prom...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.07.004

    authors： Burgermeister E,Battaglin F,Eladly F,Wu W,Herweck F,Schulte N,Betge J,Härtel N,Kather JN,Weis CA,Gaiser T,Marx A,Weiss C,Hofheinz R,Miller IS,Loupakis F,Lenz HJ,Byrne AT,Ebert MP

    更新日期：2019-07-01 00:00:00

  • An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.

    abstract：BACKGROUND:Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeated exposure can also ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2014.10.003

    authors： Pena OM,Hancock DG,Lyle NH,Linder A,Russell JA,Xia J,Fjell CD,Boyd JH,Hancock RE

    更新日期：2014-11-01 00:00:00

  • Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

    abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.005

    authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

    更新日期：2019-03-01 00:00:00

  • Cardiac Function Improvement and Bone Marrow Response -: Outcome Analysis of the Randomized PERFECT Phase III Clinical Trial of Intramyocardial CD133+ Application After Myocardial Infarction.

    abstract：OBJECTIVE:The phase III clinical trial PERFECT was designed to assess clinical safety and efficacy of intramyocardial CD133+ bone marrow stem cell treatment combined with CABG for induction of cardiac repair. DESIGN:Multicentre, double-blinded, randomised placebo controlled trial. SETTING:The study was conducted acro...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ebiom.2017.07.022

    authors： Steinhoff G,Nesteruk J,Wolfien M,Kundt G,PERFECT Trial Investigators Group.,Börgermann J,David R,Garbade J,Große J,Haverich A,Hennig H,Kaminski A,Lotz J,Mohr FW,Müller P,Oostendorp R,Ruch U,Sarikouch S,Skorska A,Sta

    更新日期：2017-08-01 00:00:00

  • Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial.

    abstract：BACKGROUND:There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt signaling, in patients with HCV cirrhosis. METHODS:In this single-center...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.08.016

    authors： Kimura K,Ikoma A,Shibakawa M,Shimoda S,Harada K,Saio M,Imamura J,Osawa Y,Kimura M,Nishikawa K,Okusaka T,Morita S,Inoue K,Kanto T,Todaka K,Nakanishi Y,Kohara M,Mizokami M

    更新日期：2017-09-01 00:00:00

  • Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.

    abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.06.026

    authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

    更新日期：2017-07-01 00:00:00

  • Identification of Associations Between Prescribed Medications and Cancer: A Nationwide Screening Study.

    abstract：PURPOSE:We present a systematic screening for identifying associations between prescribed drugs and cancer risk using the high quality Danish nationwide health registries. METHODS:We identified all patients (cases) with incident cancer in Denmark during 2000-2012 (n=278,485) and matched each case to 10 controls. Compl...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.03.018

    authors： Pottegård A,Friis S,Christensen Rd,Habel LA,Gagne JJ,Hallas J

    更新日期：2016-05-01 00:00:00

  • A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease.

    abstract：BACKGROUND:Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. METHODS:Circulating PDGFRβ levels were analysed in a cohort of patients wi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.036

    authors： Lambrecht J,Verhulst S,Mannaerts I,Sowa JP,Best J,Canbay A,Reynaert H,van Grunsven LA

    更新日期：2019-05-01 00:00:00

  • Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease.

    abstract：BACKGROUND:Some interstitial lung disease (ILD) patients develop a progressive fibrosing-ILD phenotype (PF-ILD), with similar persistent lung function decline suggesting common molecular pathways involved. Nintedanib, a tyrosine kinase inhibitor targeting the PDGF, FGF, VEGF and M-CSF pathways, has shown comparable eff...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.050

    authors： Hoffmann-Vold AM,Weigt SS,Saggar R,Palchevskiy V,Volkmann ER,Liang LL,Ross D,Ardehali A,Lynch JP 3rd,Belperio JA

    更新日期：2019-12-01 00:00:00

  • Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by emphysema and/or obstructive bronchiolitis. Deficiency in vitamin D3 (VD3), which regulates gene expression through binding to vitamin D receptor (VDR), is associated with high risks of COPD susceptibility. Alveolar macrophages (AM), which are ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.039

    authors： Hu G,Dong T,Wang S,Jing H,Chen J

    更新日期：2019-07-01 00:00:00

  • Skeletal muscle as potential central link between sarcopenia and immune senescence.

    abstract：:As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Ske...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.034

    authors： Nelke C,Dziewas R,Minnerup J,Meuth SG,Ruck T

    更新日期：2019-11-01 00:00:00

  • Nutritional Psychiatry: Where to Next?

    abstract：:The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depressi...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2017.02.020

    authors： Jacka FN

    更新日期：2017-03-01 00:00:00

  • Bifidobacterium longum counters the effects of obesity: Partial successful translation from rodent to human.

    abstract：BACKGROUND:The human gut microbiota has emerged as a key factor in the development of obesity. Certain probiotic strains have shown anti-obesity effects. The objective of this study was to investigate whether Bifidobacterium longum APC1472 has anti-obesity effects in high-fat diet (HFD)-induced obese mice and whether B...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103176

    authors： Schellekens H,Torres-Fuentes C,van de Wouw M,Long-Smith CM,Mitchell A,Strain C,Berding K,Bastiaanssen TFS,Rea K,Golubeva AV,Arboleya S,Verpaalen M,Pusceddu MM,Murphy A,Fouhy F,Murphy K,Ross P,Roy BL,Stanton C,Dinan

    更新日期：2021-01-01 00:00:00

  • Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

    abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.017

    authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

    更新日期：2019-12-01 00:00:00

  • Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.

    abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic aci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.036

    authors： Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

    更新日期：2019-01-01 00:00:00

  • Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

    abstract：:Dendritic cells (DCs) play an important role in controlling T cell-mediated adaptive immunity in atherogenesis. However, the role of the basic leucine zipper transcription factor, ATF-like 3 (Batf3)-dependent CD8α+ DC subset in atherogenesis remains unclear. Here we show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, e...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.04.008

    authors： Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

    更新日期：2017-04-01 00:00:00

  • A panel of five plasma proteins for the early diagnosis of hepatitis B virus-related hepatocellular carcinoma in individuals at risk.

    abstract：BACKGROUND:To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomarkers is reported to distinguish individuals with early-stage HCC from at-risk individuals. METHODS:Participants in this study were recruited from six hospitals in China. ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ebiom.2020.102638

    authors： Cheng K,Shi J,Liu Z,Jia Y,Qin Q,Zhang H,Wan S,Niu Z,Lu L,Sun J,Xue J,Lu C,Wei X,Guo L,Zhang F,Zhou D,Tang Y,Hu Y,Huang Y,Chen Y,Lau WY,Cheng S,Liu S

    更新日期：2020-02-01 00:00:00