Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease.

Abstract:

:Inter-individual variability has been a major hurdle to optimize disease management. Precision medicine holds promise for improving health and healthcare via tailor-made therapeutic strategies. Herein, we outline the paradigm of "pharmacometabolomics-aided pharmacogenomics" in autoimmune diseases. We envisage merging pharmacometabolomic and pharmacogenomic data (to address the interplay of genomic and environmental influences) with information technologies to facilitate data analysis as well as sense- and decision-making on the basis of synergy between artificial and human intelligence. Humans can detect patterns, which computer algorithms may fail to do so, whereas data-intensive and cognitively complex settings and processes limit human ability. We propose that better-informed, rapid and cost-effective omics studies need the implementation of holistic and multidisciplinary approaches.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Katsila T,Konstantinou E,Lavda I,Malakis H,Papantoni I,Skondra L,Patrinos GP

doi

10.1016/j.ebiom.2016.02.001

subject

Has Abstract

pub_date

2016-02-02 00:00:00

pages

40-5

issn

2352-3964

pii

S2352-3964(16)30032-9

journal_volume

5

pub_type

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