当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.

Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma.

Abstract：

:Cholangiocarcinoma (CCA) is the primary cancer of the bile duct system. The role of bile duct tissue microbiomes in CCA tumorigenesis is unestablished. To address this, sixty primary CCA tumors and matched normals, from both liver fluke (Opisthorchis viverrini) associated (OVa, n=28) and non-O. viverrini associated (non-OVa, n=32) cancers, were profiled using high-throughput 16S rRNA sequencing. A distinct, tissue-specific microbiome dominated by the bacterial families Dietziaceae, Pseudomonadaceae and Oxalobacteraceae was observed in bile duct tissues. Systemic perturbation of the microbiome was noted in tumor and paired normal samples (vs non-cancer normals) for several bacterial families with a significant increase in Stenotrophomonas species distinguishing tumors vs paired normals. Comparison of parasite associated (OVa) vs non-associated (non-OVa) groups identified enrichment for specific enteric bacteria (Bifidobacteriaceae, Enterobacteriaceae and Enterococcaceae). One of the enriched families, Bifidobacteriaceae, was found to be dominant in the O. viverrini microbiome, providing a mechanistic link to the parasite. Functional analysis and comparison of CCA microbiomes revealed higher potential for producing bile acids and ammonia in OVa tissues, linking the altered microbiota to carcinogenesis. These results define how the unique microbial communities resident in the bile duct, parasitic infections and the tissue microenvironment can influence each other, and contribute to cancer.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Chng KR,Chan SH,Ng AHQ,Li C,Jusakul A,Bertrand D,Wilm A,Choo SP,Tan DMY,Lim KH,Soetinko R,Ong CK,Duda DG,Dima S,Popescu I,Wongkham C,Feng Z,Yeoh KG,Teh BT,Yongvanit P,Wongkham S,Bhudhisawasdi V,Khuntikeo N,T

doi

10.1016/j.ebiom.2016.04.034

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

195-202

issn

2352-3964

pii

S2352-3964(16)30177-3

journal_volume

8

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.

    abstract：:Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission of ATP. FLX increased ATP ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.036

    authors： Kinoshita M,Hirayama Y,Fujishita K,Shibata K,Shinozaki Y,Shigetomi E,Takeda A,Le HPN,Hayashi H,Hiasa M,Moriyama Y,Ikenaka K,Tanaka KF,Koizumi S

    更新日期：2018-06-01 00:00:00

  • d-Ribose as a Contributor to Glycated Haemoglobin.

    abstract：:Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.10.001

    authors： Chen X,Su T,Chen Y,He Y,Liu Y,Xu Y,Wei Y,Li J,He R

    更新日期：2017-11-01 00:00:00

  • Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

    abstract：BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102777

    authors： Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

    更新日期：2020-06-01 00:00:00

  • Cardiac Function Improvement and Bone Marrow Response -: Outcome Analysis of the Randomized PERFECT Phase III Clinical Trial of Intramyocardial CD133+ Application After Myocardial Infarction.

    abstract：OBJECTIVE:The phase III clinical trial PERFECT was designed to assess clinical safety and efficacy of intramyocardial CD133+ bone marrow stem cell treatment combined with CABG for induction of cardiac repair. DESIGN:Multicentre, double-blinded, randomised placebo controlled trial. SETTING:The study was conducted acro...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ebiom.2017.07.022

    authors： Steinhoff G,Nesteruk J,Wolfien M,Kundt G,PERFECT Trial Investigators Group.,Börgermann J,David R,Garbade J,Große J,Haverich A,Hennig H,Kaminski A,Lotz J,Mohr FW,Müller P,Oostendorp R,Ruch U,Sarikouch S,Skorska A,Sta

    更新日期：2017-08-01 00:00:00

  • Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease.

    abstract：:Inter-individual variability has been a major hurdle to optimize disease management. Precision medicine holds promise for improving health and healthcare via tailor-made therapeutic strategies. Herein, we outline the paradigm of "pharmacometabolomics-aided pharmacogenomics" in autoimmune diseases. We envisage merging ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.02.001

    authors： Katsila T,Konstantinou E,Lavda I,Malakis H,Papantoni I,Skondra L,Patrinos GP

    更新日期：2016-02-02 00:00:00

  • OLA-Simple: A software-guided HIV-1 drug resistance test for low-resource laboratories.

    abstract：BACKGROUND:HIV drug resistance (HIVDR) testing can assist clinicians in selecting treatments. However, high complexity and cost of genotyping assays limit routine testing in settings where HIVDR prevalence has reached high levels. METHODS:The oligonucleotide ligation assay (OLA)-Simple kit was developed for detection ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.002

    authors： Panpradist N,Beck IA,Vrana J,Higa N,McIntyre D,Ruth PS,So I,Kline EC,Kanthula R,Wong-On-Wing A,Lim J,Ko D,Milne R,Rossouw T,Feucht UD,Chung M,Jourdain G,Ngo-Giang-Huong N,Laomanit L,Soria J,Lai J,Klavins ED,Fr

    更新日期：2019-12-01 00:00:00

  • Nutritional Psychiatry: Where to Next?

    abstract：:The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depressi...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2017.02.020

    authors： Jacka FN

    更新日期：2017-03-01 00:00:00

  • Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

    abstract：:Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.10.008

    authors： Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

    更新日期：2016-11-01 00:00:00

  • Transcription factor EB regulates cardiovascular homeostasis.

    abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.103207

    authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

    更新日期：2021-01-01 00:00:00

  • Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancer.

    abstract：BACKGROUND:Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology. Owing to the rapid development of phosphoproteomics, we can now measure thousands of phosphoproteins in human cancer tissues. However, limited studie...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.039

    authors： Tong M,Yu C,Zhan D,Zhang M,Zhen B,Zhu W,Wang Y,Wu C,He F,Qin J,Li T

    更新日期：2019-02-01 00:00:00

  • A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

    abstract：:Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking both DNA replication and repair by inhibiting the bifunctional DNA2 could be a ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.02.043

    authors： Liu W,Zhou M,Li Z,Li H,Polaczek P,Dai H,Wu Q,Liu C,Karanja KK,Popuri V,Shan SO,Schlacher K,Zheng L,Campbell JL,Shen B

    更新日期：2016-04-01 00:00:00

  • Three kinds of corneal host cells contribute differently to corneal neovascularization.

    abstract：BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of cor...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.026

    authors： Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu P

    更新日期：2019-06-01 00:00:00

  • Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.

    abstract：:Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2014.12.006

    authors： Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

    更新日期：2014-12-18 00:00:00

  • Heterologous Two-Dose Vaccination with Simian Adenovirus and Poxvirus Vectors Elicits Long-Lasting Cellular Immunity to Influenza Virus A in Healthy Adults.

    abstract：BACKGROUND:T-cell responses against highly conserved influenza antigens have been previously associated with protection. However, these immune responses are poorly maintained following recovery from influenza infection and are not boosted by inactivated influenza vaccines. We have previously demonstrated the safety and...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.02.011

    authors： Coughlan L,Sridhar S,Payne R,Edmans M,Milicic A,Venkatraman N,Lugonja B,Clifton L,Qi C,Folegatti PM,Lawrie AM,Roberts R,de Graaf H,Sukhtankar P,Faust SN,Lewis DJM,Lambe T,Hill A,Gilbert SC

    更新日期：2018-03-01 00:00:00

  • Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice.

    abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.021

    authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

    更新日期：2019-10-01 00:00:00

  • Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.

    abstract：BACKGROUND:Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit stroke injury have ye...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103161

    authors： Barzegar M,Wang Y,Eshaq RS,Yun JW,Boyer CJ,Cananzi SG,White LA,Chernyshev O,Kelley RE,Minagar A,Stokes KY,Lu XH,Alexander JS

    更新日期：2021-01-01 00:00:00

  • Liver Dysfunction during Pregnancy and Its Association of With Preterm Birth in China: A Prospective Cohort Study.

    abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.014

    authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

    更新日期：2017-12-01 00:00:00

  • Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks.

    abstract：:Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.11.020

    authors： Mallikarjun V,Swift J

    更新日期：2016-12-01 00:00:00

  • Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury.

    abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ebiom.2016.07.015

    authors： Orešič M,Posti JP,Kamstrup-Nielsen MH,Takala RSK,Lingsma HF,Mattila I,Jäntti S,Katila AJ,Carpenter KLH,Ala-Seppälä H,Kyllönen A,Maanpää HR,Tallus J,Coles JP,Heino I,Frantzén J,Hutchinson PJ,Menon DK,Tenovuo O,Hyötyl

    更新日期：2016-10-01 00:00:00

  • Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation.

    abstract：:Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.030

    authors： Li X,Liu L,Yang J,Yu Y,Chai J,Wang L,Ma L,Yin H

    更新日期：2016-06-01 00:00:00

  • A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility.

    abstract：BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102766

    authors： Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

    更新日期：2020-05-01 00:00:00

  • Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection.

    abstract：:Antibody-mediated humoral immunity is thought to play a central role in mediating the immunopathogenesis of acute DENV infection, but limited data are available on the diversity, specificity, and functionality of the antibody response at the molecular level elicited by primary or secondary DENV infection. In order to ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102733

    authors： Waickman AT,Gromowski GD,Rutvisuttinunt W,Li T,Siegfried H,Victor K,Kuklis C,Gomootsukavadee M,McCracken MK,Gabriel B,Mathew A,Grinyo I Escuer A,Fouch ME,Liang J,Fernandez S,Davidson E,Doranz BJ,Srikiatkhachorn A,Endy

    更新日期：2020-04-01 00:00:00

  • Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression.

    abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.01.045

    authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

    更新日期：2019-02-01 00:00:00

  • HIV Transmission Networks in the San Diego-Tijuana Border Region.

    abstract：BACKGROUND:HIV sequence data can be used to reconstruct local transmission networks. Along international borders, like the San Diego-Tijuana region, understanding the dynamics of HIV transmission across reported risks, racial/ethnic groups, and geography can help direct effective prevention efforts on both sides of the...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.07.024

    authors： Mehta SR,Wertheim JO,Brouwer KC,Wagner KD,Chaillon A,Strathdee S,Patterson TL,Rangel MG,Vargas M,Murrell B,Garfein R,Little SJ,Smith DM

    更新日期：2015-07-18 00:00:00

  • Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

    abstract：BACKGROUND:The Early Cancer Detection Consortium is developing a blood-test to screen the general population for early identification of cancer, and has therefore conducted a systematic mapping review to identify blood-based biomarkers that could be used for early identification of cancer. METHODS:A mapping review wit...

    journal_title：EBioMedicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ebiom.2016.07.004

    authors： Uttley L,Whiteman BL,Woods HB,Harnan S,Philips ST,Cree IA,Early Cancer Detection Consortium.

    更新日期：2016-08-01 00:00:00

  • Developed and validated a prognostic nomogram for recurrence-free survival after complete surgical resection of local primary gastrointestinal stromal tumors based on deep learning.

    abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.028

    authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

    更新日期：2019-01-01 00:00:00

  • Chronic Kidney Disease, Time in Therapeutic Range and Adverse Clinical Outcomes in Anticoagulated Patients with Non-valvular Atrial Fibrillation: Observations from the SPORTIF Trials.

    abstract：BACKGROUND:Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study clinical features associated with CKD in AF patients and the impact of CKD on anticoagulation control, as reflected by time in therapeu...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.013

    authors： Proietti M,Lane DA,Lip GYH

    更新日期：2016-06-01 00:00:00

  • Two years of treatment with the recombinant grass pollen allergy vaccine BM32 induces a continuously increasing allergen-specific IgG4 response.

    abstract：BACKGROUND:BM32, a grass pollen allergy vaccine containing four recombinant fusion proteins consisting of hepatitis B-derived PreS and hypoallergenic peptides from the major timothy grass pollen allergens adsorbed on aluminium hydroxide has been shown to be safe and to improve clinical symptoms of grass pollen allergy ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.006

    authors： Eckl-Dorna J,Weber M,Stanek V,Linhart B,Ristl R,Waltl EE,Villazala-Merino S,Hummel A,Focke-Tejkl M,Froeschel R,Neubauer A,Henning R,Perkmann T,Valenta R,Niederberger V

    更新日期：2019-12-01 00:00:00

  • Anthropogenic Carbon Nanotubes Found in the Airways of Parisian Children.

    abstract：:Compelling evidence shows that fine particulate matters (PMs) from air pollution penetrate lower airways and are associated with adverse health effects even within concentrations below those recommended by the WHO. A paper reported a dose-dependent link between carbon content in alveolar macrophages (assessed only by ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.10.012

    authors： Kolosnjaj-Tabi J,Just J,Hartman KB,Laoudi Y,Boudjemaa S,Alloyeau D,Szwarc H,Wilson LJ,Moussa F

    更新日期：2015-10-09 00:00:00

  • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort.

    abstract：BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative A...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2015.04.008

    authors： Hou L,Joyce BT,Gao T,Liu L,Zheng Y,Penedo FJ,Liu S,Zhang W,Bergan R,Dai Q,Vokonas P,Hoxha M,Schwartz J,Baccarelli A

    更新日期：2015-04-13 00:00:00