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Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.

Abstract：

:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Patients≥18years presenting with a new Diabetic Foot Infection (DFI) who had not received topical or oral antimicrobials in the two weeks prior to presentation, were eligible for enrolment. Tissue punch biopsies were obtained from infected DFUs for analysis. Demographics, clinical and laboratory data were collected and correlated against microbiota data. Thirty-nine patients with infected DFUs were recruited over twelve-months. Shorter duration DFUs (

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

doi

10.1016/j.ebiom.2017.06.026

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

142-149

issn

2352-3964

pii

S2352-3964(17)30261-X

journal_volume

21

pub_type

杂志文章

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