当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

Abstract：

BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibrosis is poorly understood. METHODS:miR-4739 levels were detected by miRNA array and real-time PCR. Real-time PCR, western blotting and immunofluorescence were used to identify the expression profile of indicators related to fibrosis. Target gene of miR-4739 and promoter activity assay was measured by using dual-luciferase reporter assay system. In vivo, pleural fibrosis was evaluated by Masson staining and miR-4739 level was detected by In situ hybridization histochemistry. FINDINGS:We found that bleomycin induced up-regulation of miR-4739 in pleural mesothelial cells (PMCs). Over-regulated miR-4739 mediated mesothelial-mesenchymal transition and increased collagen-I synthesis in PMCs. Investigation on the clinical specimens revealed that high levels of miR-4739 and low levels of bone morphogenetic protein 7 (BMP-7) associated with pleural fibrosis in patients. Then we next identified that miR-4739 targeted and down-regulated BMP-7 which further resulted in unbalance between Smad1/5/9 and Smad2/3 signaling. Lastly, in vivo studies revealed that miR-4739 over-expression induced pleural fibrosis, and exogenous BMP-7 prevented pleural fibrosis in mice. INTERPRETATION:Our data indicated that miR-4739 targets BMP-7 which mediates pleural fibrosis. The miR-4739/BMP-7 axis is a promising therapeutic target for the disease. FUND: The National Natural Science Foundation of China.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

doi

10.1016/j.ebiom.2019.02.057

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

670-682

issn

2352-3964

pii

S2352-3964(19)30136-7

journal_volume

41

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Gut microbiota from colorectal cancer patients enhances the progression of intestinal adenoma in Apcmin/+ mice.

    abstract：BACKGROUND:Accumulating evidence points to a close relationship between gut dysbiosis and colorectal cancer (CRC). As >90% of CRC develop from adenoma, we aimed to investigate the crucial role of imbalanced gut microbiota on the progression of intestinal adenoma. METHODS:The Apcmin/+ mice gavage with phosphate-buffere...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.021

    authors： Li L,Li X,Zhong W,Yang M,Xu M,Sun Y,Ma J,Liu T,Song X,Dong W,Liu X,Chen Y,Liu Y,Abla Z,Liu W,Wang B,Jiang K,Cao H

    更新日期：2019-10-01 00:00:00

  • A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants.

    abstract：BACKGROUND:The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with advanced disease that is treatment resistant. Familial pancreatic cancer (FPC) is a rare disorder that is defined as a family with at least two affected fi...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102675

    authors： Earl J,Galindo-Pumariño C,Encinas J,Barreto E,Castillo ME,Pachón V,Ferreiro R,Rodríguez-Garrote M,González-Martínez S,Ramon Y Cajal T,Diaz LR,Chirivella-Gonzalez I,Rodriguez M,de Castro EM,García-Seisdedos D,Muñoz G,Rosa

    更新日期：2020-03-01 00:00:00

  • Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction.

    abstract：:Cerebral microinfarcts have significant effects on the development of geriatric neurological disorders, including vascular dementia and Alzheimer's disease. However, little is known about the pathophysiological mechanisms involved in the evolution of microinfarcts and potential treatment and prevention against these m...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.028

    authors： Luo C,Ren H,Yao X,Shi Z,Liang F,Kang JX,Wan JB,Pei Z,Su KP,Su H

    更新日期：2018-06-01 00:00:00

  • The Population Level Cascade of Care for Hepatitis C in British Columbia, Canada: The BC Hepatitis Testers Cohort (BC-HTC).

    abstract：BACKGROUND:Population-level monitoring of hepatitis C virus (HCV) infected people across the cascade of care identifies gaps in access and engagement in care and treatment. We characterized a population-level cascade of care for HCV in British Columbia (BC), Canada and identified factors associated with leakage at each...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.08.035

    authors： Janjua NZ,Kuo M,Yu A,Alvarez M,Wong S,Cook D,Wong J,Grebely J,Butt ZA,Samji H,Ramji A,Tyndall M,Krajden M

    更新日期：2016-10-01 00:00:00

  • Climate Change and Aedes Vectors: 21st Century Projections for Dengue Transmission in Europe.

    abstract：:Warming temperatures may increase the geographic spread of vector-borne diseases into temperate areas. Although a tropical mosquito-borne viral disease, a dengue outbreak occurred in Madeira, Portugal, in 2012; the first in Europe since 1920s. This outbreak emphasizes the potential for dengue re-emergence in Europe gi...

    journal_title：EBioMedicine

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.ebiom.2016.03.046

    authors： Liu-Helmersson J,Quam M,Wilder-Smith A,Stenlund H,Ebi K,Massad E,Rocklöv J

    更新日期：2016-05-01 00:00:00

  • Impact of the host environment on the antitubercular action of pyrazinamide.

    abstract：:Pyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the m...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2019.10.014

    authors： Lamont EA,Baughn AD

    更新日期：2019-11-01 00:00:00

  • Transcriptional and clonal characterization of B cell plasmablast diversity following primary and secondary natural DENV infection.

    abstract：:Antibody-mediated humoral immunity is thought to play a central role in mediating the immunopathogenesis of acute DENV infection, but limited data are available on the diversity, specificity, and functionality of the antibody response at the molecular level elicited by primary or secondary DENV infection. In order to ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102733

    authors： Waickman AT,Gromowski GD,Rutvisuttinunt W,Li T,Siegfried H,Victor K,Kuklis C,Gomootsukavadee M,McCracken MK,Gabriel B,Mathew A,Grinyo I Escuer A,Fouch ME,Liang J,Fernandez S,Davidson E,Doranz BJ,Srikiatkhachorn A,Endy

    更新日期：2020-04-01 00:00:00

  • Intratumor Heterogeneity in Primary Kidney Cancer Revealed by Metabolic Profiling of Multiple Spatially Separated Samples within Tumors.

    abstract：:Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. However, intratumor metabolic heterogeneity has not been investigated. Here...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.04.009

    authors： Okegawa T,Morimoto M,Nishizawa S,Kitazawa S,Honda K,Araki H,Tamura T,Ando A,Satomi Y,Nutahara K,Hara T

    更新日期：2017-05-01 00:00:00

  • Image-guided surgery of head and neck carcinoma in rabbit models by intra-operatively defining tumour-infiltrated margins and metastatic lymph nodes.

    abstract：BACKGROUND:The infiltrative nature and lymphatic metastasis of head and neck squamous cell carcinoma (HNSCC) are the main reasons leading to its poor prognosis. METHODS:A multimodal surface-enhanced resonance Raman spectroscopy (SERRS) and magnetic resonance (MR) nanoprobe, in which paramagnetic chelators and heptamet...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.055

    authors： Sun P,Zhang Y,Li K,Wang C,Zeng F,Zhu J,Wu Y,Tao X

    更新日期：2019-12-01 00:00:00

  • Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling.

    abstract：BACKGROUND:Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it is unknown whether and how Scribble is involve...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.08.057

    authors： Wang N,Song L,Xu Y,Zhang L,Wu Y,Guo J,Ji W,Li L,Zhao J,Zhang X,Zhan L

    更新日期：2019-09-01 00:00:00

  • Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection.

    abstract：BACKGROUND:Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103129

    authors： Novelli S,Lécuroux C,Goujard C,Reynes J,Villemant A,Blum L,Essat A,Avettand-Fenoël V,Launay O,Molina JM,Bourgeois C,Meyer L

    更新日期：2020-12-01 00:00:00

  • Beyond multidrug resistance: Leveraging rare variants with machine and statistical learning models in Mycobacterium tuberculosis resistance prediction.

    abstract：BACKGROUND:The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.016

    authors： Chen ML,Doddi A,Royer J,Freschi L,Schito M,Ezewudo M,Kohane IS,Beam A,Farhat M

    更新日期：2019-05-01 00:00:00

  • Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis.

    abstract：BACKGROUND:Hepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less is known about the hepatocyte-specific anti-apoptotic molecular events and it lacks effective approach to combat hepatocyte apoptosis. We investigated ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.10.028

    authors： Wang H,Ge C,Zhou J,Guo Y,Cui S,Huang N,Yan T,Cao L,Che Y,Zheng Q,Zheng X,Gonzalez FJ,Wang G,Hao H

    更新日期：2018-11-01 00:00:00

  • Implementation and use of whole exome sequencing for metastatic solid cancer.

    abstract：BACKGROUND:Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients. METHODS:Exoma trial (NCT02840604) i...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ebiom.2019.102624

    authors： Réda M,Richard C,Bertaut A,Niogret J,Collot T,Fumet JD,Blanc J,Truntzer C,Desmoulins I,Ladoire S,Hennequin A,Favier L,Bengrine L,Vincent J,Hervieu A,Dusserre JG,Lepage C,Foucher P,Borg C,Albuisson J,Arnould L,Na

    更新日期：2020-01-01 00:00:00

  • Mitochondria in acute myocardial infarction and cardioprotection.

    abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2020.102884

    authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

    更新日期：2020-07-01 00:00:00

  • Erythroid Adhesion Molecules in Sickle Cell Anaemia Infants: Insights Into Early Pathophysiology.

    abstract：:Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ebiom.2014.12.006

    authors： Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

    更新日期：2014-12-18 00:00:00

  • Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

    abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.017

    authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

    更新日期：2019-12-01 00:00:00

  • TP63 isoform expression is linked with distinct clinical outcomes in cancer.

    abstract：BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.022

    authors： Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

    更新日期：2020-01-01 00:00:00

  • Sphingomyelin synthase 1 enhances BCR signaling to promote lupus-like autoimmune response.

    abstract：BACKGROUND:Sphingomyelin synthase 1 (SMS1) has been reported to participate in hepatitis and atherosclerosis. However, its role in autoimmune response is not clear. This study investigates the possible involvement of SMS1 in B-cell activation and lupus-like autoimmunity. METHODS:SMS1 knockout lupus-like animal model a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.038

    authors： Wang C,Ming B,Wu X,Wu T,Cai S,Hu P,Tang J,Tan Z,Liu C,Zhong J,Zheng F,Dong L

    更新日期：2019-07-01 00:00:00

  • AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

    abstract：:Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated protein kinase (AMPK) is viewed as a pathogenic factor in the development of fatty liver its role has not been directly demonstrated. Une...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.01.008

    authors： Boudaba N,Marion A,Huet C,Pierre R,Viollet B,Foretz M

    更新日期：2018-02-01 00:00:00

  • Nutritional Psychiatry: Where to Next?

    abstract：:The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depressi...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2017.02.020

    authors： Jacka FN

    更新日期：2017-03-01 00:00:00

  • OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.

    abstract：BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.051

    authors： Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

    更新日期：2019-03-01 00:00:00

  • Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks.

    abstract：:Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.ebiom.2016.11.020

    authors： Mallikarjun V,Swift J

    更新日期：2016-12-01 00:00:00

  • Liver Dysfunction during Pregnancy and Its Association of With Preterm Birth in China: A Prospective Cohort Study.

    abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.014

    authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

    更新日期：2017-12-01 00:00:00

  • RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate Cancer.

    abstract：:Prostate cancer (PCa) is the most commonly diagnosed cancer in males in the Western world. Although prostate-specific antigen (PSA) has been widely used as a biomarker for PCa diagnosis, its results can be controversial. Therefore, new biomarkers are needed to enhance the clinical management of PCa. From publicly avai...

    journal_title：EBioMedicine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.ebiom.2018.05.010

    authors： Hou Q,Bing ZT,Hu C,Li MY,Yang KH,Mo Z,Xie XW,Liao JL,Lu Y,Horie S,Lou MW

    更新日期：2018-06-01 00:00:00

  • Long non-coding RNA CDKN2B-AS1 contributes to atherosclerotic plaque formation by forming RNA-DNA triplex in the CDKN2B promoter.

    abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102694

    authors： Ou M,Li X,Zhao S,Cui S,Tu J

    更新日期：2020-05-01 00:00:00

  • Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signalling.

    abstract：BACKGROUND:Dachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 in intestinal cell stemness and colorectal tumorigenesis remain largely undefined. METHODS:We used immunohistochemistry, western blotting and quantitative real-time PCR to ana...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102800

    authors： Hu X,Zhang L,Li Y,Ma X,Dai W,Gao X,Rao X,Fu G,Wang R,Pan M,Guo Q,Xu X,Zhou Y,Gao J,Zhang Z,Cai S,Peng J,Hua G

    更新日期：2020-06-01 00:00:00

  • Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1.

    abstract：BACKGROUND:A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and present therapeutic challenges. The underlying resistance mechanisms are not fully investigated. We repo...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.04.061

    authors： Islam SS,Uddin M,Noman ASM,Akter H,Dity NJ,Basiruzzman M,Uddin F,Ahsan J,Annoor S,Alaiya AA,Al-Alwan M,Yeger H,Farhat WA

    更新日期：2019-05-01 00:00:00

  • Three kinds of corneal host cells contribute differently to corneal neovascularization.

    abstract：BACKGROUND:Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of cor...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.05.026

    authors： Yu H,Sun L,Cui J,Li Y,Yan Y,Wei X,Wang C,Song F,Jiang W,Liu Y,Ge H,Qian H,Li X,Tang X,Liu P

    更新日期：2019-06-01 00:00:00

  • Dissociation between urate and blood pressure in mice and in people with early Parkinson's disease.

    abstract：BACKGROUND:Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also be neuroprotective, and urate-elevating treatment with its precurs...

    journal_title：EBioMedicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2018.10.039

    authors： Chen X,Umeh CC,Tainsh RE,Feng DD,Maguire M,Zuo F,Rahimian M,Logan R,Wang X,Ascherio A,Macklin EA,Buys ES,Schwarzschild MA,Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators.

    更新日期：2018-11-01 00:00:00