A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis.

abstract：:Antiretroviral therapy (ART) has led to dramatic improvements in the lives of HIV-infected persons. However, residual immune activation, which persists despite ART, is associated with increased risk of non-AIDS morbidities. Accumulating evidence shows that disruption of the gut mucosal epithelium during SIV/HIV infect...

journal_title：EBioMedicine

authors： Ponte R,Mehraj V,Ghali P,Couëdel-Courteille A,Cheynier R,Routy JP

更新日期：2016-01-26 00:00:00

abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

journal_title：EBioMedicine

authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

更新日期：2019-02-01 00:00:00

abstract：:Histone deacetylases (HDACs) are enzymes that regulate protein functions by catalyzing the removal of acetyl and acyl groups from lysine residues. They play pivotal roles in governing cell behaviors and are indispensable in numerous biological processes. HDAC11, the last identified and sole member of class IV HDACs, w...

journal_title：EBioMedicine

authors： Sun L,Marin de Evsikova C,Bian K,Achille A,Telles E,Pei H,Seto E

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

journal_title：EBioMedicine

authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) is highly prevalent in atrial fibrillation (AF) patients and associated with an increased risk of adverse outcomes. Our objectives were to study clinical features associated with CKD in AF patients and the impact of CKD on anticoagulation control, as reflected by time in therapeu...

journal_title：EBioMedicine

authors： Proietti M,Lane DA,Lip GYH

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Half of muscle-invasive bladder cancer patients will relapse with metastatic disease and molecular tests to predict relapse are needed. TP63 has been proposed as a prognostic biomarker in bladder cancer, but reports associating it with clinical outcomes are conflicting. Since TP63 is expressed as multiple is...

journal_title：EBioMedicine

authors： Bankhead A 3rd,McMaster T,Wang Y,Boonstra PS,Palmbos PL

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The composition of the bile acid (BA) pool is closely associated with obesity and is modified by gut microbiota. Perturbations of gut microbiota shape the BA composition, which, in turn, may alter important BA signaling and affect host metabolism. METHODS:We investigated BA composition of high BMI subjects ...

journal_title：EBioMedicine

authors： Wei M,Huang F,Zhao L,Zhang Y,Yang W,Wang S,Li M,Han X,Ge K,Qu C,Rajani C,Xie G,Zheng X,Zhao A,Bian Z,Jia W

更新日期：2020-05-01 00:00:00

abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

journal_title：EBioMedicine

authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

更新日期：2019-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest th...

journal_title：EBioMedicine

authors： Lu H,Sun J,Hamblin MH,Chen YE,Fan Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Atherosclerosis involves a slow process of plaque formation on the walls of arteries, and comprises a leading cause of cardiovascular disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of atherosclerosis. In this study, we aim to explore the possible involvement of lncRNA 'cycli...

journal_title：EBioMedicine

authors： Ou M,Li X,Zhao S,Cui S,Tu J

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:An estimated 100,000 cases of congenital rubella syndrome (CRS) occur worldwide each year. The reported mortality rate for infants with CRS is up to 33%. The cellular mechanisms responsible for the multiple congenital defects in CRS are presently unknown. Here we identify cell types positive for rubella viru...

journal_title：EBioMedicine

authors： Lazar M,Perelygina L,Martines R,Greer P,Paddock CD,Peltecu G,Lupulescu E,Icenogle J,Zaki SR

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The mechanisms driving its epithelial salient features remain largely elusive. We aimed to evaluate the activation and the role of the canonica...

journal_title：EBioMedicine

authors： Carlier FM,Dupasquier S,Ambroise J,Detry B,Lecocq M,Biétry-Claudet C,Boukala Y,Gala JL,Bouzin C,Verleden SE,Hoton D,Gohy S,Bearzatto B,Pilette C

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tumour budding and poorly differentiated clusters (PDC) represent forms of tumour invasion. We hypothesised that T-cell densities (reflecting adaptive anti-tumour immunity) might be inversely associated with tumour budding and PDC in colorectal carcinoma. METHODS:Utilising 915 colon and rectal carcinomas in...

journal_title：EBioMedicine

authors： Fujiyoshi K,Väyrynen JP,Borowsky J,Papke DJ Jr,Arima K,Haruki K,Kishikawa J,Akimoto N,Ugai T,Lau MC,Gu S,Shi S,Zhao M,Da Silva AFL,Twombly TS,Nan H,Meyerhardt JA,Song M,Zhang X,Wu K,Chan AT,Fuchs CS,Lennerz JK

更新日期：2020-07-01 00:00:00

abstract：:Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...

journal_title：EBioMedicine

authors： Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:Liver dysfunction is common in pregnancy but its association with adverse pregnancy outcomes such as preterm birth (PTB) remains unclear. METHODS:A prospective cohort of HBV-infected or uninfected pregnant women attending antenatal care was recruited at Nantong Maternal and Child Health Hospital between Jan...

journal_title：EBioMedicine

authors： Zhuang X,Cui AM,Wang Q,Cheng XY,Shen Y,Cai WH,Li HB,Zhang S,Qin G

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The rapid spread of SARS-CoV-2, the causative agent of Coronavirus disease 2019 (COVID-19), has been accompanied by the emergence of distinct viral clades, though their clinical significance remains unclear. Here, we aimed to investigate the phylogenetic characteristics of SARS-CoV-2 infections in Chicago, I...

journal_title：EBioMedicine

authors： Lorenzo-Redondo R,Nam HH,Roberts SC,Simons LM,Jennings LJ,Qi C,Achenbach CJ,Hauser AR,Ison MG,Hultquist JF,Ozer EA

更新日期：2020-12-01 00:00:00

abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

journal_title：EBioMedicine

authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

更新日期：2018-04-01 00:00:00

abstract：:We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Pat...

journal_title：EBioMedicine

authors： Malone M,Johani K,Jensen SO,Gosbell IB,Dickson HG,Hu H,Vickery K

更新日期：2017-07-01 00:00:00

abstract：:Angiogenesis is the formation of new capillaries from pre-existing blood vessels and participates in proper vasculature development. In pathological conditions such as cancer, abnormal angiogenesis takes place. Angiogenesis is primarily carried out by endothelial cells, the innermost layer of blood vessels. The vascul...

journal_title：EBioMedicine

authors： Pauty J,Usuba R,Cheng IG,Hespel L,Takahashi H,Kato K,Kobayashi M,Nakajima H,Lee E,Yger F,Soncin F,Matsunaga YT

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeated exposure can also ...

journal_title：EBioMedicine

authors： Pena OM,Hancock DG,Lyle NH,Linder A,Russell JA,Xia J,Fjell CD,Boyd JH,Hancock RE

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown. METHODS:We recruited 86 Chinese children born to OHSS women and 172 c...

journal_title：EBioMedicine

authors： Xu GF,Zhou CL,Xiong YM,Li JY,Yu TT,Tian S,Lin XH,Liao Y,Lv Y,Zhang FH,Liu ZW,Shi YY,Shen Y,Sha J,Zhang D,Zhu YM,Sheng JZ,Huang HF

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Visual function and brain function decline concurrently with aging. Notably, cataract patients often present with accelerated age-related decreases in brain function, but the underlying mechanisms are still unclear. Optical structures of the anterior segment of the eyes, such as the lens and cornea, can be r...

journal_title：EBioMedicine

authors： Lin H,Zhang L,Lin D,Chen W,Zhu Y,Chen C,Chan KC,Liu Y,Chen W

更新日期：2018-04-01 00:00:00

abstract：:Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacterial signaling molec...

journal_title：EBioMedicine

authors： Knecht LD,O'Connor G,Mittal R,Liu XZ,Daftarian P,Deo SK,Daunert S

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomarkers is reported to distinguish individuals with early-stage HCC from at-risk individuals. METHODS:Participants in this study were recruited from six hospitals in China. ...

journal_title：EBioMedicine

authors： Cheng K,Shi J,Liu Z,Jia Y,Qin Q,Zhang H,Wan S,Niu Z,Lu L,Sun J,Xue J,Lu C,Wei X,Guo L,Zhang F,Zhou D,Tang Y,Hu Y,Huang Y,Chen Y,Lau WY,Cheng S,Liu S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...

journal_title：EBioMedicine

authors： Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:There is currently no anti-fibrotic drug therapy available to treat hepatitis C virus (HCV) cirrhosis. The aim of this study was to assess the safety, tolerability, and anti-fibrotic effect of PRI-724, a small-molecule modulator of Wnt signaling, in patients with HCV cirrhosis. METHODS:In this single-center...

journal_title：EBioMedicine

authors： Kimura K,Ikoma A,Shibakawa M,Shimoda S,Harada K,Saio M,Imamura J,Osawa Y,Kimura M,Nishikawa K,Okusaka T,Morita S,Inoue K,Kanto T,Todaka K,Nakanishi Y,Kohara M,Mizokami M

更新日期：2017-09-01 00:00:00

abstract：:Acute myocardial infarction (AMI) and the heart failure (HF) that often follows are among the leading causes of death and disability worldwide. As such, new treatments are needed to protect the myocardium against the damaging effects of the acute ischaemia and reperfusion injury (IRI) that occurs in AMI, in order to r...

journal_title：EBioMedicine

authors： Ramachandra CJA,Hernandez-Resendiz S,Crespo-Avilan GE,Lin YH,Hausenloy DJ

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease severity remain unclear. METHODS:Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 patients and examined for lymphocyt...

journal_title：EBioMedicine

authors： Liu J,Li S,Liu J,Liang B,Wang X,Wang H,Li W,Tong Q,Yi J,Zhao L,Xiong L,Guo C,Tian J,Luo J,Yao J,Pang R,Shen H,Peng C,Liu T,Zhang Q,Wu J,Xu L,Lu S,Wang B,Weng Z,Han C,Zhu H,Zhou R,Zhou H,Chen X,

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer where a primary site of origin cannot be found despite a standard diagnostic workup. Because knowledge of a patient's primary cancer remains fundamental to their treatment, CUP patients are s...

journal_title：EBioMedicine

authors： Zhao Y,Pan Z,Namburi S,Pattison A,Posner A,Balachander S,Paisie CA,Reddi HV,Rueter J,Gill AJ,Fox S,Raghav KPS,Flynn WF,Tothill RW,Li S,Karuturi RKM,George J

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

journal_title：EBioMedicine

authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

更新日期：2019-02-01 00:00:00