Abstract：
INTRODUCTION:There is a high prevalence of cytomegalovirus (CMV) seropositivity in developing countries. An apparent risk of CMV reactivation increases following hematopoeitic stem cell transplantation. With effective surveillance and timely treatment using anti-viral therapy, morbidity and mortality associated with CMV reactivation can be reduced. OBJECTIVES:To evaluate the incidence and morbidity associated with CMV reactivation following hematopoeitic stem cell transplantation. METHODOLOGY:We retrospectively analysed 136 hematopoeitic stem cell transplant recipients at our centre for CMV reactivation and their complications. Quantification of CMV-DNA was done by PCR. CMV disease was confirmed histologically via CMV inclusion bodies or immunostaining of biopsy of the affected organ, mainly the gastrointestinal tract. RESULTS:A total of 13 out of 136 patients (9.56%) had CMV reactivation. 6 out of 13 patients had CMV disease, 3 of which died (23.1% of patients with CMV reactivation). CMV reactivation occurred at a median duration of 52.5 days post transplantation (range 35-178 days). The gastrointestinal tract was the organ most commonly affected by CMV. The median follow-up was 14 months (range 6 - 64 months). CONCLUSION:Through a higher rate of sero-prevalance in developing countries, the incidence of CMV infection following hematopoeitic stem cell transplantation is comparable to that reported in Western literature. Oral valganciclovir was an effective pre-emptive therapy for CMV disease.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Sharma SK,Kumar S,Agrawal N,Singh L,Mukherjee A,Seth T,Mishra P,Mathur S,Dar L,Mahapatra Mdoi
10.3855/jidc.2947subject
Has Abstractpub_date
2013-12-15 00:00:00pages
1003-7issue
12eissn
2036-6590issn
1972-2680journal_volume
7pub_type
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