Abstract:
INTRODUCTION:Bacille Calmette-Guerin (BCG) vaccination remains a routine immunization in primary care in tuberculosis (TB)-endemic areas, though several studies found that its efficacy was inconclusive. Natural resistance-asociated machrophage protein 1 (NRAMP1) polymorphism has been shown to result in higher susceptibility to TB. Information on genetic susceptibility in populations will be useful in planning the application of the BCG vaccine. The present study explored BCG efficacy in a rural Timor population with specific NRAMP1 polymorphism in a TB-endemic region of eastern Indonesia. METHODOLOGY:A case-control study with 64 newly diagnosed pulmonary TB patients and 65 healthy controls was performed. BCG scars were examined by a physician. NRAMP1 polymorphism was evaluated using molecular methods. RESULTS:Half of the subjects (65; 50.4%) had a clear presenting BCG scar on the upper arm, suggesting a successful BCG vaccination. Among the subjects, D543N NRAMP1 polymorphism, history of contact with TB patients, and not having a clear BCG scar on the upper arm tended to be significantly association with active TB. The significant differences were more profound when subjects were divided based on presenting BCG scar. Subjects without clear BCG scars had significant association with developing TB disease (p = 0.014). In multivariate analysis, history of previous contact with TB patients and unclear presenting BCG scar were associated with active TB (OR 9.2; 2.0-43.8 95% CI, OR 4.8; 2.1-11.0 95% CI, respectively). CONCLUSIONS:BCG vaccination in our population was effective for TB protection, especially in highly endemic areas of TB, regardless genetic susceptibility.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Putera I,Pakasi TA,Syahmar I,Bramantyo AA,Karyadi E,Melani A,Sahiratmadja Edoi
10.3855/jidc.5047subject
Has Abstractpub_date
2015-01-15 00:00:00pages
42-7issue
1eissn
2036-6590issn
1972-2680journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Tungiasis, caused by the sand flea Tunga penetrans, is highly prevalent in many resource-poor communities in sub-Saharan Africa, Latin America and the Caribbean. Studies on knowledge and treatment practices related to tungiasis in affected populations are virtually nonexistent. To fill this gap, we performed...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.418
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:We investigated the frequency of H274Y-positive swine-origin 2009 A (H1N1) influenza virus outbreak in Thailand during May-August 2009. METHODOLOGY:This study sought to find Oseltamivir resistance mutation H274Y by using pyrosequencing. RESULTS:From 8,710 real-time RT-PCR swine-origin 2009 A(H1N1) influ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1197
更新日期:2011-05-28 00:00:00
abstract:UNLABELLED:We describe the first two cases of invasive disease caused by Haemophilus influenzae serotype A in Saudi Arabia. This is the first known reported invasive Haemophilus influenzae serotype A from Saudi Arabia. CASE PRESENTATION:A ten-month-old and three-month-old male not known to have any past history of any...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6687
更新日期:2016-05-31 00:00:00
abstract:INTRODUCTION:Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) is currently problematic. Although the population analysis profile with area under the curve (PAP-AUC) is the gold standard for detecting hVISA strains, this method is time consuming. This study aimed to induce vancomycin non-...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5059
更新日期:2015-02-19 00:00:00
abstract:INTRODUCTION:Extended-Spectrum Beta-Lactamases (ESBL) are a common mechanism of bacterial resistance in Enterobacteriaceae. The purpose of this study is to characterize the ESBL genes produced by community-acquired uropathogenic Escherichia coli strains in the Nouna District, in the West-African country, Burkina Faso. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11737
更新日期:2020-11-30 00:00:00
abstract:INTRODUCTION:Epidemiological studies have shown the association between risk of developing cervical cancer and the persistence of high-risk papillomavirus types in addition to some co-factors. However, little is known about co-factors associated with human papillomavirus (HPV) infection, especially in developing countr...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1675
更新日期:2012-07-23 00:00:00
abstract:BACKGROUND:Research on the effects of corticosteroids in bacterial meningitis (BM) yielded conflicting results. While some studies reveal that corticosteroids improve the outcomes in BM treatments, others provide strong evidence that patients do not profit from this treatment. We investigated the factors that may impac...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.51
更新日期:2009-12-14 00:00:00
abstract::Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can late...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.1487
更新日期:2011-08-12 00:00:00
abstract:BACKGROUND:Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs affecting their mobi...
journal_title:Journal of infection in developing countries
pub_type: 临床试验,杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract:INTRODUCTION:Argentina has been a preferential target for Bolivian immigrants for decades. The relatively recent migratory flux includes Germany, France, the United States, Australia, Japan, and some Latin American countries. The aim of this cross-sectional study was to describe the prevalence of Chagas disease in preg...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7118
更新日期:2016-09-30 00:00:00
abstract:BACKGROUND:Melioidosis is an important public health problem causing community acquired sepsis in the northeastern part of Malaysia. METHODOLOGY:From January 2001 to December 2005, we reviewed case reports of all bacteraemic melioidosis admitted to a tertiary teaching hospital, Hospital Universiti Sains Malaysia. RES...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.491
更新日期:2010-08-04 00:00:00
abstract:INTRODUCTION:Brucellosis is a multisystemic infectious disease, which can manifest as endocarditis. Diagnosis can be challenging. CASE PRESENTATION:An 80-year-old male patient presented with fever 38.5 °C, cough and progressive shortness of breath of 14 days. History of Brucellosis 18 months earlier inadequately treat...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10186
更新日期:2018-02-22 00:00:00
abstract:INTRODUCTION:Giardiasis is a human health concern worldwide, especially among schoolchildren. Giardia duodenalis genotypes A and B are infective to humans, but their zoonotic potential remains controversial. In Mexico, the most prevalent genotype is A, but B was also detected in southeastern Mexico. In Sinaloa state, n...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8223
更新日期:2017-02-28 00:00:00
abstract::The increasing prevalence of foodborne diseases observed in developing countries has been linked to a rise in the consumption of raw foods. However, unlike the classical pathogens that are commonly implicated in foodborne illnesses, members of the genus Acinetobacter are rarely associated with diarrheal disease, proba...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.8418
更新日期:2017-02-28 00:00:00
abstract:INTRODUCTION:Although tuberculosis (TB) is frequently seen in Turkey, there are limited studies on childhood TB. We aimed to describe clinical and laboratory findings, including drug resistance, of children with TB in Istanbul, Turkey. METHODOLOGY:The study included all children aged 0-14 years who were registered in ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3950
更新日期:2014-03-13 00:00:00
abstract:INTRODUCTION:Staphylococcal colonization is a risk factor for healthcare-associated infections, which are frequent in Neonatal Intensive Care Units (NICU). This study analyzed microbiology, epidemiology and clinical aspects of Staphylococcus spp. colonizing neonates. METHODOLOGY:Nasal or periumbilical swabs were evalu...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11241
更新日期:2019-09-30 00:00:00
abstract:INTRODUCTION:The efficacy of non-adjuvanted seasonal influenza vaccine in young children is considered to be suboptimal. This study compared the safety and immunogenicity profiles of MF59-adjuvanted, trivalent, influenza vaccine (ATIV) and non-adjuvanted, trivalent, influenza vaccine (TIV) in Guatemalan children (N = 3...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3855/jidc.4594
更新日期:2014-09-12 00:00:00
abstract:INTRODUCTION:The correlation of Chlamydia pneumoniae to coronary artery disease (CAD) in Jordan was investigated in this study. METHODOLOGY:Totals of 361 atherosclerotic patients and 392 apparently healthy controls of both sexes were enrolled. C. pneumoniae-specific IgG antibodies were measured by the microimmunofluor...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7363
更新日期:2016-05-31 00:00:00
abstract:INTRODUCTION:The sputum smear or the culture are the definitive diagnosis of pulmonary tuberculosis. Only a fraction of clinical patients are culture-confirmed. METHODOLOGY:A total of 24 clinical cases (40 ± 14 years old) with positive smear and negative co-morbidity were studied. Cases were selected from 600 patients...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10583
更新日期:2019-01-31 00:00:00
abstract:INTRODUCTION:The severity of urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) is due to the expression of a wide spectrum of virulence genes. E. coli strains were divided into four phylogenetic groups (A, B1, B2 and D) based on their virulence genes. The present study aimed to assess the ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7903
更新日期:2017-01-30 00:00:00
abstract:INTRODUCTION:Dogs may act as potential sources of zoonotic parasites, e.g. intestinal helminths like Toxocara spp., Ancylostoma spp., Echinococcus spp. In particular circumstances, the environment contaminated by parasitic elements represents a source of infection for people and animals. The present study has evaluated...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9865
更新日期:2018-08-31 00:00:00
abstract:INTRODUCTION:Plasmid-mediated quinolone resistance, which complicates treatment, has been increasingly identified in Escherichia coli isolates worldwide. The purpose of this study was to identify the plasmid-mediated qnrA and qnrB genes among the quinolone-resistant Escherichia coli isolated from urinary tract infectio...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3746
更新日期:2014-07-14 00:00:00
abstract:INTRODUCTION:This study aims at defining through a retrospective evaluation, the clinical parameters affecting the clinical course and consequently the management of patients presenting with cervicofacial abscesses. METHODOLOGY:A total of 394 patients diagnosed with abscess at the University of Sassari Otorhinolaryngo...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12191
更新日期:2020-05-31 00:00:00
abstract::Lebanon yearly witnesses a high flux of expatriates and workers from Dengue virus (DENV) endemic regions. Multiple cases of Dengue fever have been documented at the American University of Beirut Medical Center (AUBMC) in travellers to endemic regions. Given the presence of the Aedes aegypti mosquito in Lebanon, introd...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9954
更新日期:2018-04-30 00:00:00
abstract:INTRODUCTION:The emergence and rapid spread of blaIMP and blaVIM metallo-beta-lactamase (MBL) producing Gram-negative bacteria causing nosocomial infections are of concern worldwide due to limited treatment options. METHODOLOGY:A total of 179 nonreplicate, consecutive, carbapenem resistant Pseudomonas aeruginosa (61),...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2268
更新日期:2012-11-26 00:00:00
abstract:INTRODUCTION:Men who have sex with men (MSM) are one of the key populations driving HIV/AIDS epidemic globally. To date, MSM is the only population in Ukraine where the prevalence and incidence of HIV is increasing. As HIV-positive MSM might feel uncomfortable to report homosexual intercourses as a possible mode of tra...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11967
更新日期:2020-11-16 00:00:00
abstract:INTRODUCTION:HIV causes progressive impairment of the cellular immune system leading to increased susceptibility to infectious agents. Parasitic infestations are common in HIV-infected patients and usually lead to diarrhoea. Few studies have addressed the issue of intestinal parasites among HIV-infected persons in Came...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2757
更新日期:2013-02-15 00:00:00
abstract::Although malaria is endemic in India, neonatal disease is considered rare. We report a case of neonatal malaria in a 26-day-old neonate with fever and splenomegaly who was diagnosed after a long and unsuccessful battery of tests for splenomegaly. Routine screening for malaria is essential for all neonates with fever i...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1623
更新日期:2011-07-04 00:00:00
abstract:INTRODUCTION:The impact of mutations in the reverse transcriptase region of HBV on serum HBsAg titer and its correlation with HBV DNA is largely unknown. METHODOLOGY:A total of 644 patients, with a history of lamivudine or adefovir dipivoxil resistance who underwent genotypic resistance tests, were enrolled in this st...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11447
更新日期:2019-11-30 00:00:00
abstract:INTRODUCTION:Multidrug resistance tuberculosis (MDR-TB) is a continuing threat because the treatment is rather toxic. One of the causes of poor treatment outcome is due to the adverse events, especially the occurrence of psychiatric adverse events. METHODOLOGY:The two cases presented in this paper are MDR-TB patients ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10352
更新日期:2018-07-31 00:00:00