Abstract:
INTRODUCTION:Staphylococcus aureus-induced bloodstream infections (BSIs) remain a prevalent clinical challenge and the underlying pathogenesis is still poorly understood. The aim of this study was to investigate the inflammatory responses and histopathological changes in BSIs in mice. METHODOLOGY:Male C57BL/6 mice were inoculated with S. aureus intravenously to induce BSIs. The survival rate, weight loss, and murine sepsis scores (MSS) were monitored in BSI and phosphate-buffered saline (PBS) control mice. Blood samples and tissue homogenates were plated on agar plates to determine the bacterial burden. Inflammatory proteins and cytokines were determined by enzyme-linked immunosorbent assay (ELISA) kits. Histopathologic changes were assessed by pathological inflammation score (PIS) and macroscopic and microscopic examinations. RESULTS:BSI mice induced by 4.5 × 108 CFU/mL S. aureus showed ~70% survival rate, higher sepsis scores, significantly decreased body weight, elevated levels of white blood cell (WBC) counts, C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α. Prominent correlations were found between elevated CRP and PCT levels as well as among IL-1β, IL-6, and TNF-α. Pathological changes and higher PIS were also observed in BSI mice. CONCLUSIONS:Our results demonstrate that inflammatory proteins (PCT and CRP) and cytokines (IL-6, IL-1β and TNF-α) play an important role in the inflammatory responses and histopathological changes in S. aureus-induced BSIs.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Wu D,Zhou S,Hu S,Liu Bdoi
10.3855/jidc.7800subject
Has Abstractpub_date
2017-04-30 00:00:00pages
294-305issue
4eissn
2036-6590issn
1972-2680journal_volume
11pub_type
杂志文章abstract::Leclercia adecarboxylata was isolated in pure culture from a peritonsillar and lateral pharyngeal abscess in an immunocompetent host. To our knowledge, this is the first case of infection caused by this microorganism being found in an odontogenic area of the head and neck. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2651
更新日期:2013-01-15 00:00:00
abstract:INTRODUCTION:Infants represent an important risk group for influenza associated hospitalizations and mortality. This study evaluated the clinical presentations, hospitalization course and outcome of infants hospitalized with the pandemic influenza A H1N1 [Influenza A(H1N1)pdm09] in relation to their previous health sta...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2339
更新日期:2012-08-21 00:00:00
abstract:INTRODUCTION:The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The study was conducted to examine the distribution of aminoglycosides, tetrac...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11410
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.728
更新日期:2010-10-28 00:00:00
abstract:INTRODUCTION:Ice can be contaminated by pathogenic bacteria. This study aimed to identify critical points in iced beverage production and distribution lines to examine the presence of pathogenic bacteria in a beverage and its processing environment, as well as when water and ice used as main ingredients. METHODOLOGY:T...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8934
更新日期:2017-06-30 00:00:00
abstract:INTRODUCTION:Inadequate hand-washing facilities have been reported as a barrier to hand washing. This study aimed to evaluate the availability and accessibility of hand-washing facilities and supplies of hand-washing agents in the outpatient department (OPD) complex of a tertiary care teaching hospital. METHODOLOGY:A ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1003
更新日期:2011-03-02 00:00:00
abstract:BACKGROUND:Tungiasis, caused by the sand flea Tunga penetrans, is highly prevalent in many resource-poor communities in sub-Saharan Africa, Latin America and the Caribbean. Studies on knowledge and treatment practices related to tungiasis in affected populations are virtually nonexistent. To fill this gap, we performed...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.418
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2942
更新日期:2013-03-14 00:00:00
abstract:INTRODUCTION:Nosocomial pneumonia (NP) and ventilator associated pneumonia (VAP) occur most frequently in intensive care units (ICU). This study seeks to determine the etiological agents of NP and VAP along with their antibacterial susceptibility patterns, and to evaluate the factors contributing to patient mortality. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1212
更新日期:2011-04-26 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.116
更新日期:2010-03-08 00:00:00
abstract:INTRODUCTION:Rotavirus (RV) is the leading cause of severe diarrhea-associated morbidity and mortality among children worldwide. Limited data exist on the epidemiology and burden of rotavirus gastroenteritis in Armenia. The purpose of this study is to estimate the economic losses and describe the epidemiological charac...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10883
更新日期:2019-04-30 00:00:00
abstract:INTRODUCTION:Inappropriate use of antibiotics is recognised as a leading cause of antibiotic resistance. Little is known about antibiotic prescribing practices at public health facilities in low- and middle-income countries. We examined patterns of antibiotic prescribing in public health facilities in Nepal and explore...
journal_title:Journal of infection in developing countries
pub_type: 社论,多中心研究
doi:10.3855/jidc.11817
更新日期:2020-01-31 00:00:00
abstract:INTRODUCTION:Multidrug resistance tuberculosis (MDR-TB) is a continuing threat because the treatment is rather toxic. One of the causes of poor treatment outcome is due to the adverse events, especially the occurrence of psychiatric adverse events. METHODOLOGY:The two cases presented in this paper are MDR-TB patients ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10352
更新日期:2018-07-31 00:00:00
abstract::Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can late...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.1487
更新日期:2011-08-12 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2635
更新日期:2012-10-19 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6422
更新日期:2015-12-30 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3589
更新日期:2014-03-13 00:00:00
abstract::Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4450
更新日期:2014-09-12 00:00:00
abstract:INTRODUCTION:The emergence and rapid spread of blaIMP and blaVIM metallo-beta-lactamase (MBL) producing Gram-negative bacteria causing nosocomial infections are of concern worldwide due to limited treatment options. METHODOLOGY:A total of 179 nonreplicate, consecutive, carbapenem resistant Pseudomonas aeruginosa (61),...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2268
更新日期:2012-11-26 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.491
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.387
更新日期:2010-03-29 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1525
更新日期:2012-02-13 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1836
更新日期:2011-07-27 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11769
更新日期:2020-01-31 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11706
更新日期:2020-06-29 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess tuberculosis (TB) knowledge, attitudes, and practices in both the general population and risk groups in Thailand. METHODOLOGY:In a cross-sectional survey, a general population (n = 3,074) and family members of a TB patient (n = 559) were randomly selected, using stratif...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6963
更新日期:2016-08-02 00:00:00
abstract:INTRODUCTION:Intestinal and extraintestinal infections by Aeromonas spp., remain controversial, due to the existence of healthy carriers of Aeromonas spp. In children under five years old, the diarrhea of infectious origin constitutes the second cause of mortality and remains a major concern for public health. The aim ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12966
更新日期:2020-10-31 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9894
更新日期:2018-05-31 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1675
更新日期:2012-07-23 00:00:00
abstract::The case of a Hickman catheter-related bacteremia caused by Gordonia sputi in a patient with breast cancer is presented. Blood cultures grew a Gram-positive rod, susceptible to several antimicrobials, subsequently identified by 16S rRNA gene sequencing as Gordonia sputi. The infection resolved after successful treatme...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1770
更新日期:2012-02-13 00:00:00