Abstract:
INTRODUCTION:The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The study was conducted to examine the distribution of aminoglycosides, tetracycline, and sulfonamide-resistant determinants among CRAB isolates that carry the blaOXA-23 gene. METHODOLOGY:For a total of 160 CRAB strains isolated at tertiary care hospitals of Pakistan that mainly carried blaOXA-23 gene were included in the study to evaluate the assortment of antibiotic resistance genes. RESULTS:The susceptibility rates of CRAB for other than beta-lactam drugs were 2.5% for both ciprofloxacin and aminoglycosides and 18% and 25% for sulfonamides and tetracyclines, respectively. Polymyxin B (MIC90, 1 g/mL) Colistin (MIC90, 1 g/mL) and Tigecycline (MIC90, 2 g/mL) were most active against these extensively drug-resistant CRAB isolates. The isolates were found to possess various genes mainly the tetB and sul2 for tetracycline and sulfonamide but the genes conferring resistance to aminoglycosides were varied with various combinations. CONCLUSION:Despite the CRAB clones containing blaOXA-23 have been previously reported in Pakistani hospitals, the screening of genetic determinants responsible for other antimicrobial agents is crucial for developing an effective surveillance and mitigation system for infection management.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Khurshid M,Rasool MH,Siddique MH,Azeem F,Naeem M,Sohail M,Sarfraz M,Saqalein M,Taj Z,Nisar MA,Qamar MU,Shahzad Adoi
10.3855/jidc.11410subject
Has Abstractpub_date
2019-10-31 00:00:00pages
899-905issue
10eissn
2036-6590issn
1972-2680journal_volume
13pub_type
杂志文章abstract:INTRODUCTION:Shigellosis is a major public health concern worldwide. This study intended to assess the baseline genotyping data among local Shigella sonnei strains spanning over five years. METHODOLOGY:Fifty non-repeat clinical strains of S. sonnei isolated from stools of patients in different hospitals in Nanjing, Ch...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4933
更新日期:2014-12-15 00:00:00
abstract:INTRODUCTION:Norovirus is not usually investigated in diarrheal patients in Bangladesh which may account for the many cases where no pathogens are identified. METHODOLOGY:Stool specimens collected from diarrheal patients from three hospitals in Bangladesh during 2011 were investigated for norovirus RNA using real-time...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2944
更新日期:2013-11-15 00:00:00
abstract:INTRODUCTION:Gallbladder stones are a very frequently occurring condition. Despite bile bactericidal activity, many bacteria have been detected inside the gallbladder, and gallstones facilitate their presence. Between 3% and 5% of the patients with Salmonella spp. infection develop the carrier stage, with the bacteria ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8258
更新日期:2017-03-31 00:00:00
abstract:INTRODUCTION:The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2942
更新日期:2013-03-14 00:00:00
abstract:INTRODUCTION:The impact of mutations in the reverse transcriptase region of HBV on serum HBsAg titer and its correlation with HBV DNA is largely unknown. METHODOLOGY:A total of 644 patients, with a history of lamivudine or adefovir dipivoxil resistance who underwent genotypic resistance tests, were enrolled in this st...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11447
更新日期:2019-11-30 00:00:00
abstract:INTRODUCTION:Although the government of Yemen changed the national policy for treating malaria in November 2005 from chloroquine to combination drugs in the form of artesunate + sulphadoxine-pyrimethamine (SP) as first line and lumefantrine + artemether as second line treatment for uncomplicated malaria, clinicians in ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2528
更新日期:2013-05-13 00:00:00
abstract:INTRODUCTION:Antimicrobial stewardship practices are crucial for the regular surveillance to change the antimicrobial policy. This study was conducted to decide the prevalence of common bacteria and their antibiogram regarding antimicrobial stewardship program within one year, at the regional and district, Stanger hosp...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10685
更新日期:2019-08-31 00:00:00
abstract:INTRODUCTION:Acute respiratory infections (ARIs) are major causes of morbidity in early childhood. They are mainly caused by viruses, including influenza (INF) and respiratory syncytial viruses (RSV). We aimed to investigate the role of RSV and INF in children hospitalized for ARIs and to show the impact of RSV/INF rap...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11386
更新日期:2019-05-16 00:00:00
abstract:INTRODUCTION:Infections caused by multidrug-resistant bacteria are increasingly common and represent a serious problem for public health. Staphylococcus aureus is one of the major agents of infections, and methicillin-resistant S. aureus (MRSA) has spread worldwide. The aim of this study was to phenotypically and genot...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7887
更新日期:2016-12-30 00:00:00
abstract:INTRODUCTION:Acquisition of sexually transmitted infections (STIs) is an epidemiological marker of high-risk sexual behavior in HIV-infected patients. We assessed the prevalence of STIs among patients attending an HIV care and support centre. METHODOLOGY:From January to August 2009, we assessed socio-demographic varia...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1754
更新日期:2012-03-12 00:00:00
abstract:INTRODUCTION:Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. METHODOLOGY:in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris-red thyme geraniol w...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10988
更新日期:2018-11-30 00:00:00
abstract::Madura foot is a deep mycosis commonly seen in tropical and subtropical countries such as India. Its incidence is likely to rise in temperate regions as well, due to the increase in worldwide travel. The cases presented here are all agricultural workers from a rural part of northern India who had induration, fibrosis ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2387
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:The prevalence of multi-infections with helminthes, protozoans and Campylobacter spp. in Guatemalan children is a reflection of differences in the risk factors related to pathogen transmission. METHODOLOGY:Two hundred and eighty-nine fecal samples were collected from children of the Guatemalan highlands and...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.41
更新日期:2009-04-30 00:00:00
abstract:INTRODUCTION:Surgical wound infection is a serious problem, especially with metallo-beta lactamases (MBLs)- producing gram-negative bacteria as Pseudomonas aeruginosa. The main objective of this work was to evaluate for the first time in Minia- Upper Egypt, the incidence of imipenem-resistant Pseudomonas aeruginosa inf...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9936
更新日期:2018-07-31 00:00:00
abstract::Leukocyte adhesion deficiency type 1 (LAD-1) is a rare, inherited immunodeficiency that affects one per million people yearly and usually presents with recurrent, indolent bacterial infections of the skin, mouth, and respiratory tract and impaired pus formation and wound healing. A 13-year-old girl diagnosed LAD-I at ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.387
更新日期:2010-03-29 00:00:00
abstract:INTRODUCTION:Mastitis is one of the most frequent and costly disease in cattle. We studied milk samples from cattle with mastitis from farms in Kosovo to identify mastitis-causing pathogens and possible effective antibiotics. Our ultimate goal is to help implement adequate antibiotic management and treatment practices ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7912
更新日期:2016-10-31 00:00:00
abstract:BACKGROUND:This work demonstrates successful propagation of HCV in HepG2 and human blood cells as well as viral shedding into their culture media. The influence of Schistosoma mansoni crude soluble egg antigens (SEA) on the rate of viral propagation in both mammalian cells was also monitored. METHODOLOGY:HepG2 cells w...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.522
更新日期:2010-05-01 00:00:00
abstract::Although malaria is endemic in India, neonatal disease is considered rare. We report a case of neonatal malaria in a 26-day-old neonate with fever and splenomegaly who was diagnosed after a long and unsuccessful battery of tests for splenomegaly. Routine screening for malaria is essential for all neonates with fever i...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1623
更新日期:2011-07-04 00:00:00
abstract:INTRODUCTION:Melioidosis can have multiple organ involvement which can then mimic other infections. The aim of this study was to determine if there are any factors significantly associated with melioidosis which can inform diagnostic evaluations before receiving the results of confirming laboratory testing. METHODOLOG...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10727
更新日期:2019-02-28 00:00:00
abstract:INTRODUCTION:Staphylococcus aureus-induced bloodstream infections (BSIs) remain a prevalent clinical challenge and the underlying pathogenesis is still poorly understood. The aim of this study was to investigate the inflammatory responses and histopathological changes in BSIs in mice. METHODOLOGY:Male C57BL/6 mice wer...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7800
更新日期:2017-04-30 00:00:00
abstract::We present the case of a 42-year-old male patient who applied to the emergency department of our hospital with clinical nephritis, orchitis, acute renal failure without endocarditis, and a low-grade fever. Brucella agglutinin titers were 1:160, Rose Bengal test was positive and Brucella melitensis was isolated from ur...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1442
更新日期:2011-12-13 00:00:00
abstract:INTRODUCTION:Vaccine strategies represent an essential component for the future control of schistosomiasis. This work aimed to evaluate the role of detergents for potentiating the effect of Schistosoma mansoni tegumental antigens (TA) against challenge infection. METHODOLOGY:Two detergents; Triton X-100 (TX-100) and s...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1199
更新日期:2011-03-21 00:00:00
abstract:BACKGROUND:The diagnosis of extra-pulmonary tuberculosis (EPTB) by conventional methods such as culture and microscopy has low sensitivity and requires an invasive procedure. A simple rapid serological test would be of great value. METHODS:Six antigens (ESAT-6, Ag85A, TB10.4, Rv3881c, lipoarabinomannan (LAM) and Ara6-...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.116
更新日期:2010-03-08 00:00:00
abstract:INTRODUCTION:Schistosomiasis is one of the Neglected Tropical Diseases in Ethiopia. Since 2015, yearly school-based mass drug administration (MDA) using praziquantel has become the major control strategy. This study aimed to assess trends of Schistosoma mansoni infection in a high-endemic area in Northwest Ethiopia. M...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11727
更新日期:2020-06-29 00:00:00
abstract:INTRODUCTION:The sputum smear or the culture are the definitive diagnosis of pulmonary tuberculosis. Only a fraction of clinical patients are culture-confirmed. METHODOLOGY:A total of 24 clinical cases (40 ± 14 years old) with positive smear and negative co-morbidity were studied. Cases were selected from 600 patients...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10583
更新日期:2019-01-31 00:00:00
abstract:INTRODUCTION:Surgical site infections (SSI) continue to be a major problem for thoracic surgery patients. We aimed to determine incidence rate (IR) and risk factors for SSI in patients with thoracic surgical procedures. METHODOLOGY:During 12 years of hospital surveillance of patients with thoracic surgical procedures,...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11240
更新日期:2019-03-31 00:00:00
abstract:INTRODUCTION:Although tuberculosis (TB) is frequently seen in Turkey, there are limited studies on childhood TB. We aimed to describe clinical and laboratory findings, including drug resistance, of children with TB in Istanbul, Turkey. METHODOLOGY:The study included all children aged 0-14 years who were registered in ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3950
更新日期:2014-03-13 00:00:00
abstract::Dengue is the most important tropical mosquito-borne infectious disease caused by an arbovirus, the dengue virus. It should be noted that there are still other unusual modes of transmission of dengue infection. This paper summarizes those non vector-borne transmissions of dengue including vertical transmission, transf...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.145
更新日期:2009-11-30 00:00:00
abstract:INTRODUCTION:Anti-hepatitis B core antibody (Anti-HBc) alone is defined as the presence of anti-HBc in the absence of HBsAg and anti-HBs. The significance of this serological pattern as a predicting factor for occult hepatitis B virus (HBV) infection remains largely unknown. This study aimed to assess the significance ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.728
更新日期:2010-10-28 00:00:00
abstract:BACKGROUND:Infection with Herpes Simplex Virus Type-2 (HSV-2) is the primary cause of genital herpes and the most common cause of genital ulcer disease (GUD) worldwide. There is little information on the prevalence of HSV-2 in Nigeria. METHODOLOGY:Specimens were collected from 162 volunteers attending Jos University ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.567
更新日期:2010-10-04 00:00:00