Abstract:
INTRODUCTION:The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different clinical outcomes among dyspeptic patients in Pakistan over a period of four years. METHODOLOGY:Gastric biopsy samples from a total of 450 dyspeptic individualswere subjected to PCR, genotypingand histology. RESULTS:A total of 201 (45%) cases were found positive for H. pylori. The detection rate was high in GU (91%), DU (86%) and GC (83%) cases compared with those cases who had intact gastric mucosa (18%). Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC). Prevalent genotypic combinations were s1am1/cagA- in gastritis and s1am1/cagA+ in DU, GU, and GC. CONCLUSIONS:Our study indicates the predominant circulation of Western type cagA and vacAs1am1 type H. pylori strains in Pakistan.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Khan A,Farooqui A,Raza Y,Rasheed F,Manzoor H,Akhtar SS,Quraishy MS,Rubino S,Kazmi SU,Paglietti Bdoi
10.3855/jidc.2942subject
Has Abstractpub_date
2013-03-14 00:00:00pages
220-8issue
3eissn
2036-6590issn
1972-2680journal_volume
7pub_type
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