Abstract:
INTRODUCTION:Nosocomial pneumonia (NP) and ventilator associated pneumonia (VAP) occur most frequently in intensive care units (ICU). This study seeks to determine the etiological agents of NP and VAP along with their antibacterial susceptibility patterns, and to evaluate the factors contributing to patient mortality. The impact of appropriate therapy in terms of three parameters (body temperature, PaO2/FiO2 ratio and leukocyte count) was also assessed. METHODOLOGY:This study involved 836 adult patients admitted to ICUs at the Nemazee Hospital, Shiraz, Iran, over nine months during 2008 and 2009. The inclusion criterion was the commencement of infection at least 48 hours following hospital admission. Clinical parameters including core temperature, leukocyte count. and PaO2/FiO2 ratio were evaluated. Antibiotic sensitivities of the isolated bacteria to a panel of antibiotics were determined using E-test. RESULTS:Of 836 cases, only 58 (6.9 %) cases of NP were diagnosed, of which 42 (72 %) were VAP. A. baumannii, MRSA, P. aeruginosa and MSSA were the most prevalent bacteria. Significant correlations between previous antibiotic therapy (p = 0.04), use of corticosteroids (p = 0.02) and attributable mortality were found. A strong correlation between fever abatement and the ratio of PaO2/FiO2 with responses to treatment and outcomes was also evident. CONCLUSIONS:Combined treatment with meropenem/imipenem, ciprofloxacin and vancomycin seems to be appropriate and could cover all possible infective agents. To reduce mortality rate, reasonable prescription of antibiotics and corticosteroids could be effective. Furthermore, adopting a strategy to reduce body temperature and PaO2/FiO2 ratio could be beneficial in patients' outcomes.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Japoni A,Vazin A,Davarpanah MA,Afkhami Ardakani M,Alborzi A,Japoni S,Rafaatpour Ndoi
10.3855/jidc.1212subject
Has Abstractpub_date
2011-04-26 00:00:00pages
286-93issue
4eissn
2036-6590issn
1972-2680journal_volume
5pub_type
杂志文章abstract:INTRODUCTION:Due to the shortcomings in the 1997-World Health Organisation (WHO) dengue case classification (DCC), a revised classification was proposed in 2009. This study was aimed to assess the clinical usefulness of the two classifications during a large dengue epidemic. METHODOLOGY:Clinical data of dengue patient...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12468
更新日期:2020-07-31 00:00:00
abstract:INTRODUCTION:Association between Ascaris lumbricoides infection and asthma is a controversial subject that has been studied by several authors based on the hygiene theory. This work contributes to better understanding this issue. METHODOLOGY:This was a cross-sectional study involving 1,004 children from a neighborhood...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3585
更新日期:2014-07-14 00:00:00
abstract:INTRODUCTION:Despite tremendous progress made toward elimination, measles continues to pose a great threat to the health of children in developing countries. The objective of this study was to summarize and analyze the clinical characteristics and treatment experience of serious complications of measles pneumonia in ch...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6534
更新日期:2015-10-29 00:00:00
abstract::We present the case of a 42-year-old male patient who applied to the emergency department of our hospital with clinical nephritis, orchitis, acute renal failure without endocarditis, and a low-grade fever. Brucella agglutinin titers were 1:160, Rose Bengal test was positive and Brucella melitensis was isolated from ur...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1442
更新日期:2011-12-13 00:00:00
abstract:BACKGROUND:Non-typhoidal Salmonella are frequently food-borne zoonotic pathogens that may cause invasive disease in HIV-positive individuals. METHODOLOGY:Invasive isolates (n = 652) of Salmonella Typhimurium from human patients in Gauteng Province of South Africa were investigated for the years 2006 and 2007. Bacteria...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.549
更新日期:2009-09-15 00:00:00
abstract:BACKGROUND:In the year 2005, an epidemic of Japanese encephalitis (JE) occurred in the northern states of India. The present study was planned to reconfirm the circulation of JE in the area and to assess the trend of the disease to slow down the burden of JE. METHODOLOGY:Surveillance was conducted to identify patients...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.470
更新日期:2009-08-30 00:00:00
abstract:INTRODUCTION:Intestinal and extraintestinal infections by Aeromonas spp., remain controversial, due to the existence of healthy carriers of Aeromonas spp. In children under five years old, the diarrhea of infectious origin constitutes the second cause of mortality and remains a major concern for public health. The aim ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12966
更新日期:2020-10-31 00:00:00
abstract:INTRODUCTION:Anti-hepatitis B core antibody (Anti-HBc) alone is defined as the presence of anti-HBc in the absence of HBsAg and anti-HBs. The significance of this serological pattern as a predicting factor for occult hepatitis B virus (HBV) infection remains largely unknown. This study aimed to assess the significance ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.728
更新日期:2010-10-28 00:00:00
abstract:INTRODUCTION:Acinetobacter baumannii, a multidrug-resistant Gram-negative opportunist has been known among the cause of nosocomial infection. Risk factors of infection related to A. baumannii have been reported elsewhere. This study aimed to find the association of A. baumannii positive culture and invasive procedures ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12525
更新日期:2020-12-31 00:00:00
abstract:INTRODUCTION:A one of the step towards achieving TB related targets is to ensure early and quality diagnosis of TB in national laboratories. WHO recommends that all national reference laboratories in TB burden countries strive to reach accreditation by 2025, based on ISO15189:2012 quality management system standard. To...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10935
更新日期:2019-05-16 00:00:00
abstract::Pegylated interferon (PEG-IFN) alpha and ribavirin therapy has become the standard treatment in chronic hepatitis C virus (HCH)-infected patients. While thrombocytopenia associated with IFN use is frequently observed among these patients, autoimmune thrombocytopenia is one of the rarely observed adverse effects. In th...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.559
更新日期:2009-09-15 00:00:00
abstract::Ochrobactrum and Brucella are genetically related genera of the family Brucellaceae, sharing 98.8% rRNA similarity. Because of their phenotypic similarity, Ochrobactrum can be miscoded as Brucella by automated identification systems. The misidentification on blood cultures (BCs) of B. suis as O. anthropi by the VITEK ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7532
更新日期:2016-04-28 00:00:00
abstract:INTRODUCTION:When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms of bacterial pericarditi...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6027
更新日期:2015-07-30 00:00:00
abstract:INTRODUCTION:Following the recommendation of the Global Leprosy Strategy, Ethiopia targeted to reduce the incidence of new leprosy cases, and the proportion with severe disability (grade 2) from 13.6% in 2016 to < 1% in 2020. This study assessed the clinical profile of new leprosy cases and the sequelae of previously t...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11706
更新日期:2020-06-29 00:00:00
abstract::Dengue is the most important tropical mosquito-borne infectious disease caused by an arbovirus, the dengue virus. It should be noted that there are still other unusual modes of transmission of dengue infection. This paper summarizes those non vector-borne transmissions of dengue including vertical transmission, transf...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.145
更新日期:2009-11-30 00:00:00
abstract::Although malaria is endemic in India, neonatal disease is considered rare. We report a case of neonatal malaria in a 26-day-old neonate with fever and splenomegaly who was diagnosed after a long and unsuccessful battery of tests for splenomegaly. Routine screening for malaria is essential for all neonates with fever i...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1623
更新日期:2011-07-04 00:00:00
abstract:INTRODUCTION:Use of herbal remedies among HIV-infected individuals in Africa increased in the past decade, mainly due to traditional beliefs and at times inconsistent access to antiretroviral drugs. In Zimbabwe, accessibility and availability of antiretroviral drugs has increased in recent years; however, the use of he...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1415
更新日期:2011-02-01 00:00:00
abstract::Tuberculosis (TB) remains a serious public health problem, worsened by an increased frequency of multidrug-resistant (MDR) Mycobacterium tuberculosis strains. The World Health Organization (WHO) and the International Union Against Tuberculosis and Lung Disease (IUATLD) launched the Global Project on Anti-Tuberculosis ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.31
更新日期:2009-04-30 00:00:00
abstract:INTRODUCTION:The widespread use of tigecycline raises the question of increasing infection rates of Pseudomonas aeruginosa (PA) in ICUs which are not affected by this antibiotic. OBJECTIVE:The aim of this study was to determine if treatment with tigecycline is a risk factor for PA infection in ICU patients. METHODOLO...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4700
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:This work demonstrates successful propagation of HCV in HepG2 and human blood cells as well as viral shedding into their culture media. The influence of Schistosoma mansoni crude soluble egg antigens (SEA) on the rate of viral propagation in both mammalian cells was also monitored. METHODOLOGY:HepG2 cells w...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.522
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. METHODOLOGY:Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and phylogenetic analyses of completely sequenced genes were performed to com...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6546
更新日期:2015-11-30 00:00:00
abstract:INTRODUCTION:We investigated the frequency of H274Y-positive swine-origin 2009 A (H1N1) influenza virus outbreak in Thailand during May-August 2009. METHODOLOGY:This study sought to find Oseltamivir resistance mutation H274Y by using pyrosequencing. RESULTS:From 8,710 real-time RT-PCR swine-origin 2009 A(H1N1) influ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1197
更新日期:2011-05-28 00:00:00
abstract:INTRODUCTION:Plasmid-mediated quinolone resistance, which complicates treatment, has been increasingly identified in Escherichia coli isolates worldwide. The purpose of this study was to identify the plasmid-mediated qnrA and qnrB genes among the quinolone-resistant Escherichia coli isolated from urinary tract infectio...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3746
更新日期:2014-07-14 00:00:00
abstract:INTRODUCTION:Currently available tests have limitations for the identification of Brucella species and strains, and their genetic lineage. The genome sequence of the rpoB gene encoding the β-subunit of DNA-dependent RNA polymerase was investigated for its use in genotyping Brucella melitensis. METHODOLOGY:Complete rpo...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7598
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:This study sought to identify the association of antibiotic prescribing and the risk of antibiotic-associated diarrhoea (AAD) in Korle Bu Teaching Hospital (KBTH) in Ghana. METHODOLOGY:Patients from the Male Urology Ward and Treatment Room of the Surgical Department of KBTH were followed up over three mon...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11259
更新日期:2020-08-31 00:00:00
abstract:INTRODUCTION:Assays based on DNA amplification can provide information that contributes to the initial management of patients with leptospirosis. However, these have not been adopted in Uruguay. Our aim was to evaluate the performance of the lipL32 real-time PCR (qPCR) for diagnosis of leptospirosis. METHODOLOGY:We an...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4110
更新日期:2013-12-15 00:00:00
abstract:INTRODUCTION:Sexually transmitted infections (STI) are a major public health, social, and economic problem leading to morbidity, mortality, and stigma. This study was conducted to determine the prevalence of STIs, investigate behavioral risk factors and the relationship between the STIs/HIV and demographic factors. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5964
更新日期:2015-04-15 00:00:00
abstract::Lebanon yearly witnesses a high flux of expatriates and workers from Dengue virus (DENV) endemic regions. Multiple cases of Dengue fever have been documented at the American University of Beirut Medical Center (AUBMC) in travellers to endemic regions. Given the presence of the Aedes aegypti mosquito in Lebanon, introd...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9954
更新日期:2018-04-30 00:00:00
abstract:INTRODUCTION:Salmonella enterica is recognised worldwide as one of the major agents of human gastrointestinal infections. The aim of the present work is to ascertain the antimicrobial susceptibilities of 150 Salmonella enterica serovar Enteritidis isolates from humans in Morocco during the period from 2000 to 2008. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.806
更新日期:2010-12-23 00:00:00
abstract:BACKGROUND:Salmonella spp. are recognized as some of the most common causes of enteritis worldwide. This study aimed to identify clinically isolated S. Typhimurium in western Kenya and to assess antimicrobial resistance profiles and strain inter-relatedness. METHODS:The study was performed in rural Maseno, Nyanza prov...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.610
更新日期:2009-10-26 00:00:00