Abstract:
INTRODUCTION:Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. METHODOLOGY:Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and phylogenetic analyses of completely sequenced genes were performed to compare with other viral HA and NA gene sequences available in the public databases. RESULTS:Molecular characterization of the H5N1 viruses revealed two genetically distinct clades, 2.2.2 and 2.3.1, of H5N1 viruses circulating in the area. Amino acid sequence analysis of the HA gene indicated that the virus from 2.2.2 contained the sequence SPQGERRRK-R/G at the cleavage site, while the virus from 2.3.1 contained the sequence SPQRERRRK-R/G. Additionally, a few mutations with amino acid substitutions such as M226I at N-link glycosylation site were identified in two of these isolates. Amino acid sequence of the NA gene showed a 20-amino-acid deletion in the NA stalk region, required for enhanced virulence of influenza viruses and its adaptation from wild birds to domestic chickens. As close contact between humans and birds is unavoidable, there is a need for a thorough understanding of the virus epidemiology, factors affecting the spread of the virus, and molecular characterization such as phylogeny and substitution rates of H5N1 viruses circulating in the region. CONCLUSION:Two genetically distinct clades were found to be circulating in the country, which could likely result in recombination and emergence of more virulent viral strains. These findings could be helpful for the authorities devising control measures against these viruses.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Al-Qahtani AA,Mubin M,Almajhdi FN,Alarifi S,Dela Cruz DM,Rehman MS,Ismail MM,Ahmed N,Al-Blowi MH,Khalak H,Al-Ahdal MNdoi
10.3855/jidc.6546subject
Has Abstractpub_date
2015-11-30 00:00:00pages
1210-9issue
11eissn
2036-6590issn
1972-2680journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Research on the effects of corticosteroids in bacterial meningitis (BM) yielded conflicting results. While some studies reveal that corticosteroids improve the outcomes in BM treatments, others provide strong evidence that patients do not profit from this treatment. We investigated the factors that may impac...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.51
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abstract:BACKGROUND:Brucella is a facultative, intracellular pathogen that causes severe disease in animals and humans. Immunity against Brucella involves both humoral and cellular responses. To investigate the characteristics of immune response in acute brucellosis in Sprague-Dawley (SD) rats, IgG and its subclass specific imm...
journal_title:Journal of infection in developing countries
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abstract:BACKGROUND:Melioidosis is an important public health problem causing community acquired sepsis in the northeastern part of Malaysia. METHODOLOGY:From January 2001 to December 2005, we reviewed case reports of all bacteraemic melioidosis admitted to a tertiary teaching hospital, Hospital Universiti Sains Malaysia. RES...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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abstract:INTRODUCTION:Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) is currently problematic. Although the population analysis profile with area under the curve (PAP-AUC) is the gold standard for detecting hVISA strains, this method is time consuming. This study aimed to induce vancomycin non-...
journal_title:Journal of infection in developing countries
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abstract:BACKGROUND:Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs affecting their mobi...
journal_title:Journal of infection in developing countries
pub_type: 临床试验,杂志文章
doi:
更新日期:2008-04-01 00:00:00
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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abstract:BACKGROUND:Salmonella spp. are recognized as some of the most common causes of enteritis worldwide. This study aimed to identify clinically isolated S. Typhimurium in western Kenya and to assess antimicrobial resistance profiles and strain inter-relatedness. METHODS:The study was performed in rural Maseno, Nyanza prov...
journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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abstract:INTRODUCTION:Methicillin resistant Staphylococcus aureus (MRSA) causes illness to people and can be picked up from both healthcare facilities and the environment leading to high morbidity and mortality. The study was aimed at identifying phenotypic characteristics of Methicillin-Resistant Staphylococcus aureus and dete...
journal_title:Journal of infection in developing countries
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abstract::Increasing antimicrobial resistance to key antibiotics in Helicobacter pylori has become a main cause of treatment failures in many countries, including Vietnam. For this reason it is advisable to perform antimicrobial sensitivity tests to provide more focused regimens for H. pylori eradication. However, this approach...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Human papillomavirus (HPV) infection is typically critical in the oncogenesis of cervical cancer. However, available HPV detection kits differ in their ability and sensitivity to detect various types of HPV, and this variability has led to inconsistencies in the reporting of the geographic prevalence of HP...
journal_title:Journal of infection in developing countries
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abstract:INTRODUCTION:Following the recommendation of the Global Leprosy Strategy, Ethiopia targeted to reduce the incidence of new leprosy cases, and the proportion with severe disability (grade 2) from 13.6% in 2016 to < 1% in 2020. This study assessed the clinical profile of new leprosy cases and the sequelae of previously t...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9956
更新日期:2018-02-22 00:00:00
abstract:BACKGROUND:The treatment of methicillin-resistant staphylococcal infections has been a growing problem both in and out of hospitals for the past 30 years. Therefore, there is a need for other antibiotics as an alternative to glycopeptides in the treatment of methicillin-resistant staphylococcal infections. This study i...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3867
更新日期:2013-11-15 00:00:00
abstract:INTRODUCTION:Although tuberculosis (TB) is frequently seen in Turkey, there are limited studies on childhood TB. We aimed to describe clinical and laboratory findings, including drug resistance, of children with TB in Istanbul, Turkey. METHODOLOGY:The study included all children aged 0-14 years who were registered in ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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abstract:INTRODUCTION:Extended-Spectrum Beta-Lactamases (ESBL) are a common mechanism of bacterial resistance in Enterobacteriaceae. The purpose of this study is to characterize the ESBL genes produced by community-acquired uropathogenic Escherichia coli strains in the Nouna District, in the West-African country, Burkina Faso. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
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journal_title:Journal of infection in developing countries
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abstract:INTRODUCTION:Acinetobacter baumannii, a multidrug-resistant Gram-negative opportunist has been known among the cause of nosocomial infection. Risk factors of infection related to A. baumannii have been reported elsewhere. This study aimed to find the association of A. baumannii positive culture and invasive procedures ...
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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