Abstract:
INTRODUCTION:Clostridium difficile is the leading cause of hospital-acquired diarrhoea. There is no defined protocol for treating severe Clostridium difficile infection (CDI) refractory to vancomycin or vancomycin and metronidazole combination therapy. The aim of this study was to evaluate the rate of clinical cure, time to resolution of diarrhoea and recurrence rate in patients with severe refractory CDI treated with oral teicoplanin. METHODOLOGY:A one-year prospective study was carried out in the Clinic for Infectious and Tropical Diseases, Clinical Center Serbia. Patients with severe and complicated CDI who failed to respond to oral vancomycin and intravenous metronidazole combination therapy were enrolled. They were given oral teicoplanin 100 mg bi-daily. Patients were followed for recurrence for eight weeks. RESULTS:Nine patients with a mean age of 70.8±9.4 years were analyzed. All patients had pseudomembranous colitis, and five had complicated disease. In four patients intracolonic delivery of vancomycin was also performed in addition to oral vancomycin and intravenous metronidazole prior to initiating teicoplanin, but without improvement. After teicoplanin initiation all patients achieved clinical cure. The mean time to resolution of diarrhoea after teicoplanin introduction was 6.3±4.5 days. There was no statistically significant difference in time to resolution of diarrhoea according to initial leucocyte count, age over 65 years, the presence of ileus, complicated disease and the use of concomitant antibiotic therapy (p = 0.652, 0,652, 0.374, 0.374, and 0,548, respectively). None of the patients experienced recurrence. CONCLUSIONS:Oral teicoplanin might be a potential treatment for severe and complicated refractory CDI, but further studies are required.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Popovic N,Korac M,Nesic Z,Milosevic B,Urosevic A,Jevtovic D,Pelemis M,Delic D,Prostran M,Milosevic Idoi
10.3855/jidc.6335subject
Has Abstractpub_date
2015-10-29 00:00:00pages
1062-7issue
10eissn
2036-6590issn
1972-2680journal_volume
9pub_type
杂志文章abstract::The incidence of invasive salmonellosis has increased among children and HIV-infected adults in Malawi. This has been associated with the emergence of drug resistance in the non-typhoidal Salmonella serovars Enteritidis and Typhimurium. In contrast, S. Typhi isolates have remained fully sensitive to commonly used anti...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.158
更新日期:2008-12-01 00:00:00
abstract:INTRODUCTION:Hepatitis B infection is a serious global public health problem. The aim of the study was to assess the seroprevalance of hepatitis B surface antigen (HBsAg), as well as the risk factors associated with hepatitis B virus (HBV) infection among pregnant women attending antenatal care clinics of the Universit...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10018
更新日期:2018-10-31 00:00:00
abstract:INTRODUCTION:Malaria remains an important public health problem despite recent scientific breakthroughs regarding knowledge about malaria and treatment strategies. The objective of this study was to analyze malaria patients' knowledge about the disease, its treatment and prevention, linking it to drug treatment adheren...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7129
更新日期:2016-11-24 00:00:00
abstract:INTRODUCTION:There is limited knowledge about the associations of Helicobacter pylori (H. pylori) infections in developing countries. This study aimed to determine the current prevalence and associations of H. pylori infection with breastfeeding practices, nutritional status, and recurrent abdominal pain (RAP) in a gro...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3196
更新日期:2014-04-15 00:00:00
abstract:INTRODUCTION:This study was aimed to determine the relationship between vitamin D and soluble vitamin D receptor (VDR) levels and brucellosis, a common infection in Turkey, in which the cellular immune system is important in the course of the disease. METHODOLOGY:Patients who had been followed up in the Department of ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5675
更新日期:2016-02-28 00:00:00
abstract:INTRODUCTION:Ice can be contaminated by pathogenic bacteria. This study aimed to identify critical points in iced beverage production and distribution lines to examine the presence of pathogenic bacteria in a beverage and its processing environment, as well as when water and ice used as main ingredients. METHODOLOGY:T...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8934
更新日期:2017-06-30 00:00:00
abstract:BACKGROUND:Brucella is a facultative, intracellular pathogen that causes severe disease in animals and humans. Immunity against Brucella involves both humoral and cellular responses. To investigate the characteristics of immune response in acute brucellosis in Sprague-Dawley (SD) rats, IgG and its subclass specific imm...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.248
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Livestock are nowadays considered potent reservoirs of multi drug resistance. Enteric resistant organisms in animals can be transmitted to humans and be causative agents of infections with therapeutic challenges. The aim of this study is to determine the prevalence of multi drug resistant organisms in Leba...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10024
更新日期:2018-02-22 00:00:00
abstract:INTRODUCTION:Sexually transmitted infections (STI) are a major public health, social, and economic problem leading to morbidity, mortality, and stigma. This study was conducted to determine the prevalence of STIs, investigate behavioral risk factors and the relationship between the STIs/HIV and demographic factors. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5964
更新日期:2015-04-15 00:00:00
abstract:INTRODUCTION:Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. METHODOLOGY:Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and phylogenetic analyses of completely sequenced genes were performed to com...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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更新日期:2015-11-30 00:00:00
abstract:INTRODUCTION:Sepsis is a major cause of childhood death worldwide. In developing countries, epidemiological data about sepsis is scarce. This study describes and compares the frequency of etiological agents and initial sites of infection in children with or without sepsis, identifying risk factors and assessing outcome...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9257
更新日期:2017-09-05 00:00:00
abstract:INTRODUCTION:Education and adequate training regarding the appropriate use of antibiotics for health care professionals is essential in developing countries. Educational strategies can also influence appropriate antibiotic use in the community. The aim of this study was to assess and compare knowledge of antibiotics an...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10388
更新日期:2018-09-30 00:00:00
abstract::Madura foot is a deep mycosis commonly seen in tropical and subtropical countries such as India. Its incidence is likely to rise in temperate regions as well, due to the increase in worldwide travel. The cases presented here are all agricultural workers from a rural part of northern India who had induration, fibrosis ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2387
更新日期:2012-09-17 00:00:00
abstract:BACKGROUND:Many maternity hospitals in developing country settings deliver women who are of unknown HIV status. The main objectives of this study were to evaluate the acceptability of post-partum infant cord blood HIV testing and the subsequent uptake of interventions to prevent mother-to-child transmission of HIV. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Anti-hepatitis B core antibody (Anti-HBc) alone is defined as the presence of anti-HBc in the absence of HBsAg and anti-HBs. The significance of this serological pattern as a predicting factor for occult hepatitis B virus (HBV) infection remains largely unknown. This study aimed to assess the significance ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.728
更新日期:2010-10-28 00:00:00
abstract:INTRODUCTION:Antimicrobial substances (AMS) produced by bacteria may reduce or prevent the growth of pathogenic and spoilage microorganisms in food. In this study, 16 isolates of Acinetobacter baumannii/calcoaceticus (ABC) complex, previously obtained from reconstituted infant milk formula (IMF) samples and the prepara...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9894
更新日期:2018-05-31 00:00:00
abstract:INTRODUCTION:Nosocomial pneumonia remains an important cause of mortality and morbidity worldwide. Surveillance programs play an important role in the identification of common etiologic agents and local patterns of antimicrobial resistance. METHODOLOGY:In this study we determined the frequency and antimicrobial suscep...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2604
更新日期:2013-04-17 00:00:00
abstract:INTRODUCTION:The severity of urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) is due to the expression of a wide spectrum of virulence genes. E. coli strains were divided into four phylogenetic groups (A, B1, B2 and D) based on their virulence genes. The present study aimed to assess the ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7903
更新日期:2017-01-30 00:00:00
abstract:INTRODUCTION:Tuberculosis (TB) continues to be a public health problem globally. The burden is further exacerbated in developing countries like Nigeria, by poor diagnosis, management and treatment, as well as rapid emergence of drug-resistant TB. This study was conducted to evaluate the prevalence of drug-resistant TB,...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12736
更新日期:2020-09-30 00:00:00
abstract:INTRODUCTION:Intestinal and extraintestinal infections by Aeromonas spp., remain controversial, due to the existence of healthy carriers of Aeromonas spp. In children under five years old, the diarrhea of infectious origin constitutes the second cause of mortality and remains a major concern for public health. The aim ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.12966
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND:Non-typhoidal Salmonella are frequently food-borne zoonotic pathogens that may cause invasive disease in HIV-positive individuals. METHODOLOGY:Invasive isolates (n = 652) of Salmonella Typhimurium from human patients in Gauteng Province of South Africa were investigated for the years 2006 and 2007. Bacteria...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.549
更新日期:2009-09-15 00:00:00
abstract:INTRODUCTION:Uropathogenic Escherichia coli (UPEC) are the main etiological agent of urinary tract infections (UTIs). Association between different serotypes and UTIs is known, however, some strains are incapable to be serotyped. The aim of this work was to study bthe phenotypical and genotypical characteristics of 113...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11098
更新日期:2019-06-30 00:00:00
abstract:INTRODUCTION:Use of herbal remedies among HIV-infected individuals in Africa increased in the past decade, mainly due to traditional beliefs and at times inconsistent access to antiretroviral drugs. In Zimbabwe, accessibility and availability of antiretroviral drugs has increased in recent years; however, the use of he...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1415
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Pancreatitis is a rare complication of hemorrhagic fever with renal syndrome (HFRS). The causative agents of HFRS are hantaviruses, which belong to the genus Hantavirus, family Bunyaviridae. The purpose of this study was to evaluate cases of acute pancreatitis (AP) in patients with HFRS at the Service of I...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9567
更新日期:2017-12-10 00:00:00
abstract:INTRODUCTION:Although omphalitis (umbilical infections) among newborns is common and a major cause of neonatal deaths in developing countries, information on its burden and etiology from community settings is lacking. This study aimed to determine the incidence and etiology of omphalitis in newborns in high neonatal mo...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.1229
更新日期:2011-12-13 00:00:00
abstract::Brucellosis is an endemic disease in developing countries. The most commonly observed complications include bone-joint involvement, particularly sacroiliitis and spondylitis. Epidural abscesses caused by brucellosis are a rare complication. We describe the case of a 33-year-old man presenting with high fever, back pai...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1470
更新日期:2011-05-28 00:00:00
abstract:UNLABELLED:We describe the first two cases of invasive disease caused by Haemophilus influenzae serotype A in Saudi Arabia. This is the first known reported invasive Haemophilus influenzae serotype A from Saudi Arabia. CASE PRESENTATION:A ten-month-old and three-month-old male not known to have any past history of any...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6687
更新日期:2016-05-31 00:00:00
abstract:INTRODUCTION:The present study aimed to assess the antibiotic resistance profiles and detect the presence of the sul2 gene in sulfamethoxazole-susceptible and resistant isolates of Escherichia coli obtained from outpatients and inpatients with urinary tract infections. METHODOLOGY:The resistance profiles of 739 strain...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3380
更新日期:2014-01-15 00:00:00
abstract:INTRODUCTION:The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2942
更新日期:2013-03-14 00:00:00
abstract:INTRODUCTION:Dogs may act as potential sources of zoonotic parasites, e.g. intestinal helminths like Toxocara spp., Ancylostoma spp., Echinococcus spp. In particular circumstances, the environment contaminated by parasitic elements represents a source of infection for people and animals. The present study has evaluated...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9865
更新日期:2018-08-31 00:00:00