Genotypic and demographic characterization of invasive isolates of Salmonella Typhimurium in HIV co-infected patients in South Africa.

Abstract:

BACKGROUND:Non-typhoidal Salmonella are frequently food-borne zoonotic pathogens that may cause invasive disease in HIV-positive individuals. METHODOLOGY:Invasive isolates (n = 652) of Salmonella Typhimurium from human patients in Gauteng Province of South Africa were investigated for the years 2006 and 2007. Bacteria were identified using standard microbiological techniques and serotyping was performed using commercially available antisera. Susceptibility testing to antimicrobial agents was determined by the E-test. Genotypic relatedness of isolates was investigated by pulsed-field gel electrophoresis analysis of digested genomic DNA. RESULTS:Forty-five clusters of isolates were identified, of which four (clusters 3, 5, 6 and 11) were major clusters. Most isolates originated from hospital H2 and most were isolated from patients in the age range of 15 to 64 years. Ninety-three percent (213/230) of patients with a known HIV status were HIV-positive. Most isolates showed resistance to multiple antibiotics. The most commonly expressed antibiotic resistance profiles were ACSSuNa (14%; 75/555) and ACSSuTNa (13%; 72/555). Some evidence was found for nosocomial acquisition of isolates. Of the isolates from the major clusters 3, 5, 6, and 11, 33% (8/24), 6% (7/117), 4% (1/26) and 6% (3/52) were of nosocomial origin, respectively. CONCLUSIONS:In South Africa, Salmonella Typhimurium remains a major opportunistic infection of predominantly HIV-positive patients. Clonally diverse strains that are resistant to multiple antibiotics may circulate in patients aged between 15 and 64 years over prolonged periods within the hospital environment, adding to the health care burden.

journal_name

J Infect Dev Ctries

authors

Keddy KH,Dwarika S,Crowther P,Perovic O,Wadula J,Hoosen A,Sooka A,Crewe-Brown HH,Smith AM

doi

10.3855/jidc.549

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

585-92

issue

8

eissn

2036-6590

issn

1972-2680

journal_volume

3

pub_type

杂志文章
  • Molecular typing of Shigella sonnei isolates circulating in Nanjing, China, 2007-2011.

    abstract:INTRODUCTION:Shigellosis is a major public health concern worldwide. This study intended to assess the baseline genotyping data among local Shigella sonnei strains spanning over five years. METHODOLOGY:Fifty non-repeat clinical strains of S. sonnei isolated from stools of patients in different hospitals in Nanjing, Ch...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.4933

    authors: Cheng T,Shi X,Yong W,Wang J,Xie G,Ding J

    更新日期:2014-12-15 00:00:00

  • Salmonella enterica Serovars Typhi and Paratyphi A are avirulent in newborn and infant mice even when expressing virulence plasmid genes of Salmonella Typhimurium.

    abstract:BACKGROUND:Salmonella enterica serovars Typhi and Paratyphi A are human host-restricted pathogens. Therefore, there is no small susceptible animal host that can be used to assess the virulence and safety of vaccine strains derived from these Salmonella serovars.  However, infant mice have been used to evaluate virulenc...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1218

    authors: Santander J,Curtiss R 3rd

    更新日期:2010-11-24 00:00:00

  • On the spread of the novel influenza A (H1N1) virus in Mexico.

    abstract::A novel influenza A H1N1 virus of swine origin is responsible for the influenza epidemic affecting Mexico, the United States of America (USA), and 39 other countries. While the origin of this emerging pathogen remains uncertain, an increase in the reported incidence of respiratory diseases was noted during March 2009 ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章,评审

    doi:10.3855/jidc.238

    authors: López-Cervantes M,Venado A,Moreno A,Pacheco-Domínguez RL,Ortega-Pierres G

    更新日期:2009-06-01 00:00:00

  • Comparative analysis of antibodies and lymphocytes in pulmonary tuberculosis patients with negative and positive cultures.

    abstract:INTRODUCTION:The sputum smear or the culture are the definitive diagnosis of pulmonary tuberculosis. Only a fraction of clinical patients are culture-confirmed. METHODOLOGY:A total of 24 clinical cases (40 ± 14 years old) with positive smear and negative co-morbidity were studied. Cases were selected from 600 patients...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.10583

    authors: Cázares-Sosa FR,Hernández-Solís A,Andrés-Dionicio AE,González-González H,Ibáñez-Hernández M,Cicero-Sabido R,Huerta H,Tapia-Romero R,De-la-Rosa-Arana JL

    更新日期:2019-01-31 00:00:00

  • Ribavirin therapy for Chikungunya arthritis.

    abstract:BACKGROUND:Chikungunya is an acute viral infection presenting with a febrile episode and severe arthralgia, swelling of soft tissues, especially around the ankles. Many patients recover with nonspecific treatment of analgesics. Some patients continue to have subacute crippling arthritis in the legs affecting their mobi...

    journal_title:Journal of infection in developing countries

    pub_type: 临床试验,杂志文章

    doi:

    authors: Ravichandran R,Manian M

    更新日期:2008-04-01 00:00:00

  • Risk mapping of bovine hypodermosis using geographical information system (GIS) in cattle of subtropical region, Pakistan.

    abstract:INTRODUCTION:Hypodermosis is an ectoparasitic disease of cattle caused by Hypoderma lineatum and Hypoderma bovis. It is an important health problem of cattle, leading to considerable economic losses. There are various factors that are involved in the spread of this disease such as herd size, location, temperature, humi...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.5387

    authors: Khan MR,Ahmed H,Panadero-Fontan R,Lopez-Sandez C,Khan MA,Asif S,Mustafa I,Ali MI,Raza H,Qayyum M

    更新日期:2015-08-29 00:00:00

  • Identification of Entamoeba histolytica and E. dispar infection in Maceió, Alagoas State, northeast Brazil.

    abstract:INTRODUCTION:A cross-sectional study was carried out to assess the prevalence of E. histolytica and E. dispar by examining stool samples obtained from 1,003 students of public schools in Maceió, Alagoas, Brazil. METHODOLOGY:All stool samples were processed using the spontaneous sedimentation technique and examined mic...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6781

    authors: Santos RV,Fontes G,Duarte IA,Santos-Júnior JA,Rocha EM

    更新日期:2016-10-31 00:00:00

  • Clinical characteristics of imported malaria: An 11-year experience in a Serbian referral center.

    abstract:INTRODUCTION:Due to intercontinental traffic, population migration trends, natural disasters, and climate change, imported malaria remains important to consider in a febrile returning traveler. This study aims to raise awareness about malaria and help European clinicians maintain a working knowledge of this disease by ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6799

    authors: Poluga J,Milosevic I,Jordovic J,Dakic Z,Lavadinovic L,Stevanovic G,Milosevic B,Jevtovic D,Pavlovic M

    更新日期:2016-08-02 00:00:00

  • Clinical report of serious complications associated with measles pneumonia in children hospitalized at Shengjing hospital, China.

    abstract:INTRODUCTION:Despite tremendous progress made toward elimination, measles continues to pose a great threat to the health of children in developing countries. The objective of this study was to summarize and analyze the clinical characteristics and treatment experience of serious complications of measles pneumonia in ch...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6534

    authors: Li J,Zhao Y,Liu Z,Zhang T,Liu C,Liu X

    更新日期:2015-10-29 00:00:00

  • Feasibility of infant cord blood HIV testing for anti-retroviral post-exposure prophylaxis.

    abstract:BACKGROUND:Many maternity hospitals in developing country settings deliver women who are of unknown HIV status. The main objectives of this study were to evaluate the acceptability of post-partum infant cord blood HIV testing and the subsequent uptake of interventions to prevent mother-to-child transmission of HIV. ME...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:

    authors: Inwani IW,Nduati RW,Musoke RM

    更新日期:2007-12-01 00:00:00

  • The Human papillomavirus among women living with Human Immunodeficiency Virus in Morocco: A prospective cross-sectional study.

    abstract:INTRODUCTION:Women infected with human immunodeficiency virus (HIV) have a higher risk of contracting human papillomavirus (HPV) infections and are more prone to develop cervical cancer. The objective of this study was to determine the prevalence of HPV and its association with risk factors among Moroccan women living ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.9711

    authors: Ouladlahsen A,Fayssel N,Bensghir R,Baba H,Lamdini H,Sodqi M,Marih L,Essebbani M,Nadifi S,Benjelloun S,Himmich H,Chakib A,Wakrim L,Marhoum El Filali K,Ezzikouri S

    更新日期:2018-06-30 00:00:00

  • Application of a point-of-care test for the serodiagnosis of typhoid fever in Nigeria and the need for improved diagnostics.

    abstract:INTRODUCTION:There is an urgent need for affordable point-of-care diagnostics for the differentiation of febrile illnesses and the confirmation of typhoid in endemic countries. METHODOLOGY:Blood samples were collected from febrile patients with clinical suspicion of typhoid and screened for typhoid fever using the Wid...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1836

    authors: Smith SI,Bamidele M,Fowora M,Goodluck HT,Omonigbehin EA,Akinsinde KA,Fesobi T,Pastoor R,Abdoel TH,Smits HL

    更新日期:2011-07-27 00:00:00

  • Emergence of an SGI1-bearing Salmonella enterica serotype Kentucky isolated from septic poultry in Nigeria.

    abstract:INTRODUCTION:Salmonella enterica serotype Kentucky was isolated from septic poultry in Nigeria. The objective of this study was to characterize this isolate by screening for SGI1 and hyper-virulence. METHODOLOGY:The strain was characterized by identification of Salmonella genomic island 1 (SGI1) through a PCR assay an...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1988

    authors: Ogunleye AO,Carlson SA

    更新日期:2012-06-15 00:00:00

  • Fasciolopsis buski infection in a Vietnamese pregnant woman with systemic lupus erythematosus.

    abstract::A clinical case of infection caused by Fasciolopsis buski in a 24 weeks pregnant woman from Vietnam affected by systemic lupus erythematosus (SLE) is reported here. On 22 February 2012 the patient was admitted to Hue Hospital in Hue, Vietnam, with a diagnosis of general illness and suspected acute anaemia. Laboratory ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.7017

    authors: Fiamma M,Longoni SS,Ngo TM,Le Phan MT,Santona A,Ton Nu PA,Paglietti B

    更新日期:2015-07-04 00:00:00

  • First report of Chikungunya virus infection in Nepal.

    abstract::Chikungunya virus is an emerging arboviral disease that has been spreading rapidly across south Asia in recent years. Until recently, no chikungunya cases have been reported in Nepal. For the first time, we report three cases of chikungunya virus infection in Nepal. ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.3701

    authors: Pun SB,Bastola A,Shah R

    更新日期:2014-06-11 00:00:00

  • Analysis of patterns of antibiotic prescribing in public health facilities in Nepal.

    abstract:INTRODUCTION:Inappropriate use of antibiotics is recognised as a leading cause of antibiotic resistance. Little is known about antibiotic prescribing practices at public health facilities in low- and middle-income countries. We examined patterns of antibiotic prescribing in public health facilities in Nepal and explore...

    journal_title:Journal of infection in developing countries

    pub_type: 社论,多中心研究

    doi:10.3855/jidc.11817

    authors: Nepal A,Hendrie D,Robinson S,Selvey LA

    更新日期:2020-01-31 00:00:00

  • Giardia duodenalis genotypes among schoolchildren and their families and pets in urban and rural areas of Sinaloa, Mexico.

    abstract:INTRODUCTION:Giardiasis is a human health concern worldwide, especially among schoolchildren. Giardia duodenalis genotypes A and B are infective to humans, but their zoonotic potential remains controversial. In Mexico, the most prevalent genotype is A, but B was also detected in southeastern Mexico. In Sinaloa state, n...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.8223

    authors: García-Cervantes PC,Báez-Flores ME,Delgado-Vargas F,Ponce-Macotela M,Nawa Y,De-la-Cruz-Otero MD,Martínez-Gordillo MN,Díaz-Camacho SP

    更新日期:2017-02-28 00:00:00

  • Comparing the 2009 and 1997 World Health Organization dengue case classifications in a large cohort of South Asian patients.

    abstract:INTRODUCTION:Due to the shortcomings in the 1997-World Health Organisation (WHO) dengue case classification (DCC), a revised classification was proposed in 2009. This study was aimed to assess the clinical usefulness of the two classifications during a large dengue epidemic. METHODOLOGY:Clinical data of dengue patient...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.12468

    authors: Jayarajah U,Dissanayake U,Abeysuriya V,De Silva PK,Jayawardena P,Kulatunga A,Fernando H,Madarasinghe M,Hapugoda D,Perera L,Kannangara V,Udayangani C,Peiris R,Faizer S,Yasawardene P,De Mel S,De Zoysa I,Seneviratne SL

    更新日期:2020-07-31 00:00:00

  • Treatment of pediatric diarrhea: a simulated client study at private pharmacies of Ujjain, Madhya Pradesh, India.

    abstract:INTRODUCTION:In low- and middle-income countries such as India, private pharmacies play an important role in medical treatments, offering advice for common illnesses such as diarrhea and respiratory tract infections. There is a need to explore the details of the dispensing practices at the private pharmacies in low- an...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.5694

    authors: Diwan V,Sabde YD,Byström E,De Costa A

    更新日期:2015-05-18 00:00:00

  • Surgical site infection incidence and risk factors in thoracic surgical procedures: A 12-year prospective cohort study.

    abstract:INTRODUCTION:Surgical site infections (SSI) continue to be a major problem for thoracic surgery patients. We aimed to determine incidence rate (IR) and risk factors for SSI in patients with thoracic surgical procedures. METHODOLOGY:During 12 years of hospital surveillance of patients with thoracic surgical procedures,...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.11240

    authors: Cvijanovic VS,Ristanović AS,Maric NT,Vesovic NV,Kostovski VV,Djenic LV,Stojkovic DV,Nikolic AS,Djordevic DM,Suljagic VD

    更新日期:2019-03-31 00:00:00

  • Assessment of Brazilian pharmacists' knowledge about antimicrobial resistance.

    abstract:INTRODUCTION:Antimicrobial resistance (AR) is a multifaceted problem of global significance. In addition to developing new drugs and using antimicrobial guidelines, it is essential that health professionals understand all aspects of the problem and the most effective ways to handle it. This study evaluated pharmacists'...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.4853

    authors: Del Fiol Fde S,Barberato-Filho S,Lopes LC,Bergamaschi Cda C,Boscariol R

    更新日期:2015-03-15 00:00:00

  • The rarity of gonococcal arthritis in association with HIV infection.

    abstract::Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.4450

    authors: Maharaj R,Mody GM

    更新日期:2014-09-12 00:00:00

  • Secondary infections after cytotoxic chemotherapy in patient with hematological malignancies.

    abstract:INTRODUCTION:This study was initiated to investigate the risk factors of secondary infections in febrile neutropenic patients following chemotherapy, and to evaluate the clinical, microbiological, and mortality outcomes of these infections. METHODOLOGY:An evaluation was done on all patients with hematological malignan...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.8530

    authors: Büyüktuna SA,Saba R,Gözel MG,Turhan Ö,İnan D,Aşık Z,Köse A

    更新日期:2017-07-31 00:00:00

  • Zika virus outbreak in Brazil.

    abstract::Zika virus (ZIKV) infection is spreading rapidly within the Americas after originating from an outbreak in Brazil. We describe the current ZIKV infection epidemic in Brazil and the neurological symptoms arising. First cases of an acute exanthematic disease were reported in Brazil's Northeast region at the end of 2014....

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.8217

    authors: Heukelbach J,Alencar CH,Kelvin AA,de Oliveira WK,Pamplona de Góes Cavalcanti L

    更新日期:2016-02-28 00:00:00

  • Misdiagnosis of an imported case of malaria caused by Plasmodium falciparum.

    abstract::An unusual case of malaria presented with gastroenteritis and bloody diarrhoea in a 46-year-old male. The patient was a non-Saudi resident of Makkah, Saudi Arabia. Fever was not the presenting complaint, and the patient had not experienced any chills or sweating. He gave history of recent travel to Pakistan. Initial l...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.58

    authors: Hussain WM,Bukhari SZ,Fatani MI,Karima TM,Madani TA,Badreddine S

    更新日期:2009-03-01 00:00:00

  • Potency of detergents in enhancing Schistosoma mansoni tegumental antigens.

    abstract:INTRODUCTION:Vaccine strategies represent an essential component for the future control of schistosomiasis. This work aimed to evaluate the role of detergents for potentiating the effect of Schistosoma mansoni tegumental antigens (TA) against challenge infection. METHODOLOGY:Two detergents; Triton X-100 (TX-100) and s...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1199

    authors: Hamed MA

    更新日期:2011-03-21 00:00:00

  • Ventilator-associated pneumonia in Iranian intensive care units.

    abstract:INTRODUCTION:Nosocomial pneumonia (NP) and ventilator associated pneumonia (VAP) occur most frequently in intensive care units (ICU). This study seeks to determine the etiological agents of NP and VAP along with their antibacterial susceptibility patterns, and to evaluate the factors contributing to patient mortality. ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1212

    authors: Japoni A,Vazin A,Davarpanah MA,Afkhami Ardakani M,Alborzi A,Japoni S,Rafaatpour N

    更新日期:2011-04-26 00:00:00

  • Biocide susceptibilities and biofilm-forming capacities of Acinetobacter baumannii clinical isolates from Malaysia.

    abstract:INTRODUCTION:Acinetobacter baumannii is a Gram-negative nosocomial pathogen that has the capacity to develop resistance to all classes of antimicrobial compounds. However, very little is known regarding its susceptibility to biocides (antiseptics and disinfectants) and capacity to form biofilms, particularly for Malays...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.11455

    authors: Nor A'shimi MH,Alattraqchi AG,Mohd Rani F,A Rahman NI,Ismail S,Abdullah FH,Othman N,Cleary DW,Clarke SC,Yeo CC

    更新日期:2019-07-31 00:00:00

  • Recognizing true H5N1 infections in humans during confirmed outbreaks.

    abstract:INTRODUCTION:The goal of this study was to evaluate whether any characteristics that are evident at presentation for urgent medical attention could be used to differentiate cases of H5N1 in the absence of viral testing. METHODOLOGY:Information about exposure to poultry, clinical signs and symptoms, treatments, and out...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.3329

    authors: Zaman M,Gasimov V,Oner AF,Dogan N,Adisasmito W,Coker R,Bamgboye EL,Chan PK,Hanshaoworakul W,Lee N,Phommasack B,Touch S,Tsang O,Swenson A,Toovey S,Dreyer NA

    更新日期:2014-02-13 00:00:00

  • Epidemiology of multi drug resistant organisms in pigs in Lebanon.

    abstract:INTRODUCTION:Livestock are nowadays considered potent reservoirs of multi drug resistance. Enteric resistant organisms in animals can be transmitted to humans and be causative agents of infections with therapeutic challenges. The aim of this study is to determine the prevalence of multi drug resistant organisms in Leba...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.10024

    authors: Dandachi I,Fayad E,El-Bazzal B,Sleiman A,Rolain JM,Daoud Z

    更新日期:2018-02-22 00:00:00