Secondary infections after cytotoxic chemotherapy in patient with hematological malignancies.

Abstract:

INTRODUCTION:This study was initiated to investigate the risk factors of secondary infections in febrile neutropenic patients following chemotherapy, and to evaluate the clinical, microbiological, and mortality outcomes of these infections. METHODOLOGY:An evaluation was done on all patients with hematological malignancy who developed a febrile neutropenic episode (FNE) after cytotoxic chemotherapy in the Department of Hematology, Akdeniz University Faculty of Medicine, between January 2007 and December 2008. RESULTS:A total of 294 primary FNEs that responded to the initial empirical or targeted treatment were included in the study, and secondary infections developed after 72 (24.5%) of 294 primary FNEs. Risk factors for secondary infections were determined as acute leukemia as the underlying disease, salvage chemotherapy for refractory/relapse diseases, prolonged neutropenia (10 days and over), Multinational Association of Supportive Care in Cancer (MASSC) score < 21, and fungal infection during the primary episode. The mortality rate of patients who developed secondary infections was significantly higher compared to patients without secondary infections (27.8% and 5.4%, respectively; p = 0.001). CONCLUSIONS:The development of secondary infections in patients with hematological malignancy was not very rare. Greater concern should be shown for these infections to increase patient survival rates.

journal_name

J Infect Dev Ctries

authors

Büyüktuna SA,Saba R,Gözel MG,Turhan Ö,İnan D,Aşık Z,Köse A

doi

10.3855/jidc.8530

subject

Has Abstract

pub_date

2017-07-31 00:00:00

pages

521-526

issue

7

eissn

2036-6590

issn

1972-2680

journal_volume

11

pub_type

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