Duodenal ulcer promoting gene (DupA), plasticity region genes and sigma factors in H. pyloristrains from Nigeria.

Abstract:

INTRODUCTION:Helicobacter pylori is a principal cause of gastric cancer. The aim of this study was to determine the prevalence and contribution of duodenal ulcer promoting gene A (dupA), the plasticity region genes and sigma factors in relation to their pathological expression of H. pylori infections in the Nigerian population. METHODOLOGY:Polymerase Chain Reaction was used to analyze a total of forty-nine H. pylori strains isolated from patients attending various endoscopic units in tertiary hospitals in Nigeria for complete dupA (G27 variant), jhp0917, jhp0918, other plasticity region genes jhp 914/917, jhp0914, jhp0940 and sigma factors. RESULTS:PCR results indicated that the prevalence of complete dupA (G27 variants), jhp0917, jhp0918 and other plasticity region genes jhp0914, jhp0914/0917 and jhp0940 in the H. pylori strains were 4%, 53%, 88%, 73%, 12% and 0% respectively. The prevalence values of the sigma factors were 96%, 92%, 80% for rpoN,  fliA and rpoD respectively. However, the endoscopic findings showed that erosion, normal mucosal, ulcer, hyperaemic stomach, mucosal atrophy and oedematous stomach in the patients where the H. pylori strains were isolated were 40.8%, 32.7%, 10.2%, 8.2%, 2.0% and 6.1% respectively. There was significant association between jhp0917, jhp914/917 and G27 variant and the endoscopic findings, while other plasticity genes showed no association with the endoscopic findings. CONCLUSION:These results suggest that the presence of jhp0917, jhp0914/917 and G27 variant could be used as marker to predict the pathological effect of severity in Nigeria patients with H. pylori infection.

journal_name

J Infect Dev Ctries

authors

Jolaiya TF,Fowora MA,Onyekwere C,Ugiagbe R,Agbo II,Lesi O,Ndububa DA,Adekanle O,Njom HA,Idowu A,Adeleye IA,Bamidele M,Ngoka FN,Palamides PF,Smith SI

doi

10.3855/jidc.11746

subject

Has Abstract

pub_date

2020-02-29 00:00:00

pages

162-168

issue

2

eissn

2036-6590

issn

1972-2680

journal_volume

14

pub_type

杂志文章
  • Misdiagnosis of an imported case of malaria caused by Plasmodium falciparum.

    abstract::An unusual case of malaria presented with gastroenteritis and bloody diarrhoea in a 46-year-old male. The patient was a non-Saudi resident of Makkah, Saudi Arabia. Fever was not the presenting complaint, and the patient had not experienced any chills or sweating. He gave history of recent travel to Pakistan. Initial l...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.58

    authors: Hussain WM,Bukhari SZ,Fatani MI,Karima TM,Madani TA,Badreddine S

    更新日期:2009-03-01 00:00:00

  • Antimicrobial stewardship approach: Prevalence of antimicrobial resistant bacteria at a regional hospital in South Africa.

    abstract:INTRODUCTION:Antimicrobial stewardship practices are crucial for the regular surveillance to change the antimicrobial policy. This study was conducted to decide the prevalence of common bacteria and their antibiogram regarding antimicrobial stewardship program within one year, at the regional and district, Stanger hosp...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.10685

    authors: Han KS,Gustavo L,Rajkumar VC,Swe Swe-Han K

    更新日期:2019-08-31 00:00:00

  • Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil.

    abstract:INTRODUCTION:Coronary heart disease and its risk factors depend on genetic characteristics, behaviors, and habits, all of which vary in different regions. The use of antiretroviral therapy (ARV) has increased the survival of people living with HIV/AIDS (PLWHA), who begin to present mortality indicators similar to the g...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.5867

    authors: Ximenes RA,Lacerda HR,Miranda-Filho DB,Albuquerque Mde F,Montarroyos UR,Turchi MD,Nery MW,Martelli CM,Alencastro PR,Ikeda ML,Wolff FH,Brandao AB,Barcellos NT,Fuchs SC

    更新日期:2015-09-27 00:00:00

  • Antimicrobial susceptibility of microorganisms causing Urinary Tract Infections in Saudi Arabia.

    abstract:INTRODUCTION:Urinary Tract Infections (UTIs) is one of the most common infections worldwide. UTIs remain a challenge to the healthcare system because of the emergence of antimicrobial resistance. The aim of this study is to report the most common UTI-causative organisms associated with the emergence of antimicrobial re...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.9517

    authors: Balkhi B,Mansy W,AlGhadeer S,Alnuaim A,Alshehri A,Somily A

    更新日期:2018-04-30 00:00:00

  • High hepatitis B seroprevalence and risk factors for infection in pregnant women on the Thailand-Myanmar Border.

    abstract:INTRODUCTION:Infection from Hepatitis B primarily results from peri-partum vertical transmission and the risk increases in the presence of hepatitis B e antigen. We aimed to evaluate a new screening program for hepatitis B in pregnant women as a component of antenatal services in a marginalized population. METHODOLOGY...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.7422

    authors: Banks T,Kang J,Watts I,Tyrosvoutis ME,Min AM,Tun NW,Keereecharoen L,Simmawong W,Wanyatip S,Hanboonkunupakarn B,Nosten F,McGready R

    更新日期:2016-04-28 00:00:00

  • Antimicrobial susceptibility and serovars of Salmonella from chickens and humans in Ibadan, Nigeria.

    abstract:BACKGROUND:This study determines the prevalence and antibiotic resistance of Salmonella serovars from humans and chickens in Ibadan, Nigeria, in 2004-2007. METHODOLOGY:A total of 991 blood samples were collected from patients in 2004 to 2005 and 641 fecal samples were collected from poultry farms in 2007. All Salmonel...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.909

    authors: Fashae K,Ogunsola F,Aarestrup FM,Hendriksen RS

    更新日期:2010-09-03 00:00:00

  • Distribution and antifungal susceptibility patterns of Candida species at a university hospital in Northern Turkey.

    abstract:INTRODUCTION:The aim of this study was to establish local resistance profiles of Candida species isolated from various clinical specimens by identifying isolates and determining their susceptibilities to commonly used antifungal agents. METHODOLOGY:All isolates were identified to species level and amphotericin B, fluc...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.9698

    authors: Calgin MK,Cetinkol Y

    更新日期:2018-02-28 00:00:00

  • Evaluation of two methods of preoperative hair removal and their relationship to postoperative wound infection.

    abstract:INTRODUCTION:When a surgical operation is to be conducted through a hair bearing part of the body, hair removal is often performed. This study aimed to evaluate the relationship of two methods of preoperative hair removal to postoperative wound infection in a developing country where razor shaving is very popular. MET...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章,随机对照试验

    doi:10.3855/jidc.1527

    authors: Adisa AO,Lawal OO,Adejuyigbe O

    更新日期:2011-10-13 00:00:00

  • RSV infection in Istanbul: risk factors and frequency.

    abstract:INTRODUCTION:Respiratory syncytial virus (RSV) is one of the most common causes of acute respiratory infections in all age groups especially under two years. The aim of this study was to investigate the frequency and clinical features of RSV in hospitalized children under two years of age with the diagnosis of lower re...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.8871

    authors: İzci Güllü E,Akın Y,Karaaslan A,Vayvada ER,Atabek AA,Kaya Narter F

    更新日期:2017-09-30 00:00:00

  • Secondary infections after cytotoxic chemotherapy in patient with hematological malignancies.

    abstract:INTRODUCTION:This study was initiated to investigate the risk factors of secondary infections in febrile neutropenic patients following chemotherapy, and to evaluate the clinical, microbiological, and mortality outcomes of these infections. METHODOLOGY:An evaluation was done on all patients with hematological malignan...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.8530

    authors: Büyüktuna SA,Saba R,Gözel MG,Turhan Ö,İnan D,Aşık Z,Köse A

    更新日期:2017-07-31 00:00:00

  • Salmonella enterica Serovars Typhi and Paratyphi A are avirulent in newborn and infant mice even when expressing virulence plasmid genes of Salmonella Typhimurium.

    abstract:BACKGROUND:Salmonella enterica serovars Typhi and Paratyphi A are human host-restricted pathogens. Therefore, there is no small susceptible animal host that can be used to assess the virulence and safety of vaccine strains derived from these Salmonella serovars.  However, infant mice have been used to evaluate virulenc...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1218

    authors: Santander J,Curtiss R 3rd

    更新日期:2010-11-24 00:00:00

  • Pediatric invasive disease due to Haemophilus influenzae serogroup A in Riyadh, Saudi Arabia: case series.

    abstract:UNLABELLED:We describe the first two cases of invasive disease caused by Haemophilus influenzae serotype A in Saudi Arabia. This is the first known reported invasive Haemophilus influenzae serotype A from Saudi Arabia. CASE PRESENTATION:A ten-month-old and three-month-old male not known to have any past history of any...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6687

    authors: Roaa Z,Abdulsalam A,Shahid G,Kamaldeen B,Tariq AF

    更新日期:2016-05-31 00:00:00

  • The rarity of gonococcal arthritis in association with HIV infection.

    abstract::Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Neisseria gonorrhoeae was cultured from the ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.4450

    authors: Maharaj R,Mody GM

    更新日期:2014-09-12 00:00:00

  • Detection of virulence genes, phylogenetic group and antibiotic resistance of uropathogenic Escherichia coli in Mongolia.

    abstract:INTRODUCTION:The severity of urinary tract infection (UTI) produced by uropathogenic Escherichia coli (UPEC) is due to the expression of a wide spectrum of virulence genes. E. coli strains were divided into four phylogenetic groups (A, B1, B2 and D) based on their virulence genes. The present study aimed to assess the ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.7903

    authors: Munkhdelger Y,Gunregjav N,Dorjpurev A,Juniichiro N,Sarantuya J

    更新日期:2017-01-30 00:00:00

  • Sero-epidemiology of human immunodeficiency virus (HIV) in Plateau State, Nigeria.

    abstract:INTRODUCTION:Previous sentinel surveys of HIV in Nigeria studied pregnant women attending antenatal care, thereby omitting other important high-risk groups. We therefore investigated the prevalence of HIV/AIDS in low- and high-risk populations in the state of Plateau, Nigeria. METHODOLOGY:Blood samples were collected ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.1872

    authors: Gomwalk NE,Nimzing L,Mawak JD,Ladep NG,Dapiap SB,Damshak D,Kim E,Barau C,Jinung JK,Rumtong BM,Agabi YA

    更新日期:2012-12-15 00:00:00

  • Characteristics of the immune response during acute brucellosis in Sprague-Dawley rats.

    abstract:BACKGROUND:Brucella is a facultative, intracellular pathogen that causes severe disease in animals and humans. Immunity against Brucella involves both humoral and cellular responses. To investigate the characteristics of immune response in acute brucellosis in Sprague-Dawley (SD) rats, IgG and its subclass specific imm...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.248

    authors: Khatun MM,Islam MA,Baek BK,Lee SI

    更新日期:2009-06-01 00:00:00

  • Acinetobacter: an underrated foodborne pathogen?

    abstract::The increasing prevalence of foodborne diseases observed in developing countries has been linked to a rise in the consumption of raw foods. However, unlike the classical pathogens that are commonly implicated in foodborne illnesses, members of the genus Acinetobacter are rarely associated with diarrheal disease, proba...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章,评审

    doi:10.3855/jidc.8418

    authors: Amorim AM,Nascimento JD

    更新日期:2017-02-28 00:00:00

  • A pilot study on the usefulness of information and education campaign materials in enhancing the knowledge, attitude and practice on rabies in rural Sri Lanka.

    abstract:BACKGROUND:Rabies remains endemic in Sri Lanka despite a strong government patronized anti-rabies campaign. Personal, cultural or religious beliefs have been thought to influence health practices that could render rabies prevalent in the country. METHODOLOGY:The knowledge, attitudes, and beliefs of 580 household heads...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.106

    authors: Matibag GC,Ohbayashi Y,Kanda K,Yamashina H,Kumara WR,Perera IN,De Silva DD,De S Gunawardena GS,Jayasinghe A,Ditangco RA,Tamashiro H

    更新日期:2009-02-28 00:00:00

  • Prevalence of zoonotic helminths in Italian house dogs.

    abstract:INTRODUCTION:Dogs may act as potential sources of zoonotic parasites, e.g. intestinal helminths like Toxocara spp., Ancylostoma spp., Echinococcus spp. In particular circumstances, the environment contaminated by parasitic elements represents a source of infection for people and animals. The present study has evaluated...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.9865

    authors: La Torre F,Di Cesare A,Simonato G,Cassini R,Traversa D,Frangipane di Regalbono A

    更新日期:2018-08-31 00:00:00

  • Susceptibility of clinical methicillin-resistant Staphylococci isolates to new antibiotics.

    abstract:BACKGROUND:The treatment of methicillin-resistant staphylococcal infections has been a growing problem both in and out of hospitals for the past 30 years. Therefore, there is a need for other antibiotics as an alternative to glycopeptides in the treatment of methicillin-resistant staphylococcal infections. This study i...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.3867

    authors: Oksuz L,Gurler N

    更新日期:2013-11-15 00:00:00

  • Knowledge, attitudes, and practices about tuberculosis and choice of communication channels in Thailand.

    abstract:INTRODUCTION:The aim of this study was to assess tuberculosis (TB) knowledge, attitudes, and practices in both the general population and risk groups in Thailand. METHODOLOGY:In a cross-sectional survey, a general population (n = 3,074) and family members of a TB patient (n = 559) were randomly selected, using stratif...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6963

    authors: Pengpid S,Peltzer K,Puckpinyo A,Tiraphat S,Viripiromgool S,Apidechkul T,Sathirapanya C,Leethongdee S,Chompikul J,Mongkolchati A

    更新日期:2016-08-02 00:00:00

  • Microbial contamination of raw meat and its environment in retail shops in Karachi, Pakistan.

    abstract:BACKGROUND:This study was conducted to examine the frequency of contamination in retail meat available in Karachi, Pakistan. METHODOLOGY:Raw meat samples (250) and surface swabs (90) from meat processing equipment and the surrounding environment were analyzed for microbiological contamination. RESULTS:Out of 340 samp...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:

    authors: Hassan Ali N,Farooqui A,Khan A,Khan AY,Kazmi SU

    更新日期:2010-06-30 00:00:00

  • Pharyngeal and peritonsillar abscess due to Leclercia adecarboxylata in an immunocompetant patient.

    abstract::Leclercia adecarboxylata was isolated in pure culture from a peritonsillar and lateral pharyngeal abscess in an immunocompetent host. To our knowledge, this is the first case of infection caused by this microorganism being found in an odontogenic area of the head and neck. ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.2651

    authors: Bali R,Sharma P,Gupta K,Nagrath S

    更新日期:2013-01-15 00:00:00

  • Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients.

    abstract:INTRODUCTION:The distribution of both malaria and schistosomiasis exhibits a large geographical overlap in tropical environments, particularly in sub-Saharan Africa. This part of the world currently harbours more than 85% of the estimated global burden of these diseases. Studies showed that artemisinin derivatives used...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.2658

    authors: Abay SM,Tilahun M,Fikrie N,Habtewold A

    更新日期:2013-06-15 00:00:00

  • Treatment of pediatric diarrhea: a simulated client study at private pharmacies of Ujjain, Madhya Pradesh, India.

    abstract:INTRODUCTION:In low- and middle-income countries such as India, private pharmacies play an important role in medical treatments, offering advice for common illnesses such as diarrhea and respiratory tract infections. There is a need to explore the details of the dispensing practices at the private pharmacies in low- an...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.5694

    authors: Diwan V,Sabde YD,Byström E,De Costa A

    更新日期:2015-05-18 00:00:00

  • Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan.

    abstract:INTRODUCTION:The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.2942

    authors: Khan A,Farooqui A,Raza Y,Rasheed F,Manzoor H,Akhtar SS,Quraishy MS,Rubino S,Kazmi SU,Paglietti B

    更新日期:2013-03-14 00:00:00

  • Brucella suis bacteremia misidentified as Ochrobactrum anthropi by the VITEK 2 system.

    abstract::Ochrobactrum and Brucella are genetically related genera of the family Brucellaceae, sharing 98.8% rRNA similarity. Because of their phenotypic similarity, Ochrobactrum can be miscoded as Brucella by automated identification systems. The misidentification on blood cultures (BCs) of B. suis as O. anthropi by the VITEK ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.7532

    authors: Vila A,Pagella H,Vera Bello G,Vicente A

    更新日期:2016-04-28 00:00:00

  • Availability and prescription practice of anti-malaria drugs in the private health sector in Yemen.

    abstract:INTRODUCTION:Although the government of Yemen changed the national policy for treating malaria in November 2005 from chloroquine to combination drugs in the form of artesunate + sulphadoxine-pyrimethamine (SP) as first line and lumefantrine + artemether as second line treatment for uncomplicated malaria, clinicians in ...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.2528

    authors: Bin Ghouth AS

    更新日期:2013-05-13 00:00:00

  • Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak perceptions of risk and stress evaluation in nurses.

    abstract:INTRODUCTION:Saudi Arabia was affected by an outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV). We aimed to determine the perception of risk and level of stress among nurses. METHODOLOGY:A questionnaire survey was administered to determine the perceptions of risk of MERS-CoV infection. RESULTS:The m...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.6925

    authors: Bukhari EE,Temsah MH,Aleyadhy AA,Alrabiaa AA,Alhboob AA,Jamal AA,Binsaeed AA

    更新日期:2016-08-31 00:00:00

  • High prevalence of noroviruses among hospitalized diarrheal patients in Bangladesh, 2011.

    abstract:INTRODUCTION:Norovirus is not usually investigated in diarrheal patients in Bangladesh which may account for the many cases where no pathogens are identified. METHODOLOGY:Stool specimens collected from diarrheal patients from three hospitals in Bangladesh during 2011 were investigated for norovirus RNA using real-time...

    journal_title:Journal of infection in developing countries

    pub_type: 杂志文章

    doi:10.3855/jidc.2944

    authors: Nahar S,Afrad MH,Begum N,Al-Mamun F,Sarker AK,Das SK,Faruque AS,Pourkarim MR,Choudhuri MS,Azim T,Rahman M

    更新日期:2013-11-15 00:00:00