Abstract:
:Coronavirus disease 2019 (COVID-19) represents a severe global public health threat. Caused by SARS-Cov-2, COVID-19 is characterized by high transmission rate that correlates with high viral load. The full clinical spectrum of the illness, the prevalence rates of mild symptomatic and asymptomatic cases, and the case fatality rates are still poorly understood, highlighting the importance of early preventive measures. Unfortunately, appropriate vaccination against SARS-Cov-2 is not yet available. Unless a target vaccine is developed, COVID-19 impacts will be devastating. "Trained immunity" (TI), which could be induced by live attenuated vaccines (LAVs), is a potential public health preventive approach to boost the host immune system. Trained innate immune cells demonstrated phenotypical and functional changes leading them to acquire immunological memory and amplify their responses against subsequent infections. This phenomenon could have important public health preventive implications by harnessing the early immune responses against COVID-19, restricting its progression, and suppressing its infectivity. Some LAVs have induced a broad, nonspecific, protection against unrelated pathogens and decreased mortality from conditions other than the targeted infectious diseases. This review summarizes the relevant literature and 1) emphasizes the role of available LAVs as potential stimulants for TI and 2) proposes this phenomenon as a potential preventive approach against COVID-19 that needs thoughtful consideration and further investigation. Clinical trials in this field are then urgently needed in line of vaccine and treatment unavailability. This is specifically true when considering two evolving scenarios; the virus spread may not diminish with warm weather, and that it will erupt a second-hit severe outbreak next winter.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Alsulaiman JW,Khasawneh AI,Kheirallah KAdoi
10.3855/jidc.12805subject
Has Abstractpub_date
2020-09-30 00:00:00pages
957-962issue
9eissn
2036-6590issn
1972-2680journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:The prevalence of multi-infections with helminthes, protozoans and Campylobacter spp. in Guatemalan children is a reflection of differences in the risk factors related to pathogen transmission. METHODOLOGY:Two hundred and eighty-nine fecal samples were collected from children of the Guatemalan highlands and...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.41
更新日期:2009-04-30 00:00:00
abstract:INTRODUCTION:Norovirus is not usually investigated in diarrheal patients in Bangladesh which may account for the many cases where no pathogens are identified. METHODOLOGY:Stool specimens collected from diarrheal patients from three hospitals in Bangladesh during 2011 were investigated for norovirus RNA using real-time...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.2944
更新日期:2013-11-15 00:00:00
abstract::Guangxi is a province of China endemic for enteric fever. Salmonella enterica serovar Paratyphi A has been found to be causing more and more enteric fever episodes in the last 10 years, evident not only from routine surveillance but also from prospective population-based surveillance. The prevalent pattern of paratyph...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.223
更新日期:2008-08-30 00:00:00
abstract:BACKGROUND:Brucella is a facultative, intracellular pathogen that causes severe disease in animals and humans. Immunity against Brucella involves both humoral and cellular responses. To investigate the characteristics of immune response in acute brucellosis in Sprague-Dawley (SD) rats, IgG and its subclass specific imm...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.248
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Giardiasis is a human health concern worldwide, especially among schoolchildren. Giardia duodenalis genotypes A and B are infective to humans, but their zoonotic potential remains controversial. In Mexico, the most prevalent genotype is A, but B was also detected in southeastern Mexico. In Sinaloa state, n...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8223
更新日期:2017-02-28 00:00:00
abstract::Ochrobactrum and Brucella are genetically related genera of the family Brucellaceae, sharing 98.8% rRNA similarity. Because of their phenotypic similarity, Ochrobactrum can be miscoded as Brucella by automated identification systems. The misidentification on blood cultures (BCs) of B. suis as O. anthropi by the VITEK ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7532
更新日期:2016-04-28 00:00:00
abstract:INTRODUCTION:Melioidosis can have multiple organ involvement which can then mimic other infections. The aim of this study was to determine if there are any factors significantly associated with melioidosis which can inform diagnostic evaluations before receiving the results of confirming laboratory testing. METHODOLOG...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10727
更新日期:2019-02-28 00:00:00
abstract:INTRODUCTION:In low- and middle-income countries such as India, private pharmacies play an important role in medical treatments, offering advice for common illnesses such as diarrhea and respiratory tract infections. There is a need to explore the details of the dispensing practices at the private pharmacies in low- an...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5694
更新日期:2015-05-18 00:00:00
abstract::We present the case of a 42-year-old male patient who applied to the emergency department of our hospital with clinical nephritis, orchitis, acute renal failure without endocarditis, and a low-grade fever. Brucella agglutinin titers were 1:160, Rose Bengal test was positive and Brucella melitensis was isolated from ur...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1442
更新日期:2011-12-13 00:00:00
abstract:INTRODUCTION:Ice can be contaminated by pathogenic bacteria. This study aimed to identify critical points in iced beverage production and distribution lines to examine the presence of pathogenic bacteria in a beverage and its processing environment, as well as when water and ice used as main ingredients. METHODOLOGY:T...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8934
更新日期:2017-06-30 00:00:00
abstract:INTRODUCTION:Sources of pathogenic Rickettsia in wildlife are largely unknown in Brazil. In this work, potential tick vectors and seroreactivity of small mammals against four spotted-fever group Rickettsia (R. rickettsii, R. parkeri, R. amblyommii and R. rhipicephali) and Rickettsia bellii from peri-urban areas of Uber...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7084
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:Many maternity hospitals in developing country settings deliver women who are of unknown HIV status. The main objectives of this study were to evaluate the acceptability of post-partum infant cord blood HIV testing and the subsequent uptake of interventions to prevent mother-to-child transmission of HIV. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract::Lebanon yearly witnesses a high flux of expatriates and workers from Dengue virus (DENV) endemic regions. Multiple cases of Dengue fever have been documented at the American University of Beirut Medical Center (AUBMC) in travellers to endemic regions. Given the presence of the Aedes aegypti mosquito in Lebanon, introd...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9954
更新日期:2018-04-30 00:00:00
abstract:INTRODUCTION:In Georgia as in most Eastern European countries, injecting drug use remains one of the leading transmission modes of HIV infection. This paper aims to identify HIV prevalence and risk determinants among people who inject drugs (PWID). METHODOLOGY:A cross -sectional, anonymous bio-behavioral survey of PWI...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9103
更新日期:2017-10-31 00:00:00
abstract:INTRODUCTION:Inappropriate use of antibiotics is recognised as a leading cause of antibiotic resistance. Little is known about antibiotic prescribing practices at public health facilities in low- and middle-income countries. We examined patterns of antibiotic prescribing in public health facilities in Nepal and explore...
journal_title:Journal of infection in developing countries
pub_type: 社论,多中心研究
doi:10.3855/jidc.11817
更新日期:2020-01-31 00:00:00
abstract:INTRODUCTION:Vaccine strategies represent an essential component for the future control of schistosomiasis. This work aimed to evaluate the role of detergents for potentiating the effect of Schistosoma mansoni tegumental antigens (TA) against challenge infection. METHODOLOGY:Two detergents; Triton X-100 (TX-100) and s...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1199
更新日期:2011-03-21 00:00:00
abstract:INTRODUCTION:El Salvador is regarded as a highly endemic country for Chagas disease, as evidenced by the relatively high estimated positive serology rate for Trypanosoma cruzi among blood donors. This study aimed to identify the factors contributing to this high rate by analyzing changes in T. cruzi seroprevalence. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4035
更新日期:2014-08-13 00:00:00
abstract:INTRODUCTION:This research aimed to determine the association of the combination of H. pylori infection and TP53 codon 72 polymorphism with non-cardia gastric cancer (GC) in Vietnam. METHODOLOGY:A total of 164 patients with non-cardia GC and 164 patients with peptic ulcer disease or functional dyspepsia in controls ma...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11488
更新日期:2019-11-30 00:00:00
abstract:INTRODUCTION:The current cohort study was conducted to determine the frequency and compare the mortality rate with associated characteristics among low birth weight and normal birth weight infants during the neonatal period at a tertiary healthcare facility, Karachi. METHODOLOGY:Close-ended structured questionnaires w...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3569
更新日期:2014-09-13 00:00:00
abstract:INTRODUCTION:Infections caused by multidrug-resistant bacteria are increasingly common and represent a serious problem for public health. Staphylococcus aureus is one of the major agents of infections, and methicillin-resistant S. aureus (MRSA) has spread worldwide. The aim of this study was to phenotypically and genot...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7887
更新日期:2016-12-30 00:00:00
abstract:INTRODUCTION:This study was initiated to investigate the risk factors of secondary infections in febrile neutropenic patients following chemotherapy, and to evaluate the clinical, microbiological, and mortality outcomes of these infections. METHODOLOGY:An evaluation was done on all patients with hematological malignan...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8530
更新日期:2017-07-31 00:00:00
abstract:INTRODUCTION:Sexually transmitted infections (STI) are a major public health, social, and economic problem leading to morbidity, mortality, and stigma. This study was conducted to determine the prevalence of STIs, investigate behavioral risk factors and the relationship between the STIs/HIV and demographic factors. ME...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5964
更新日期:2015-04-15 00:00:00
abstract:INTRODUCTION:Klebsiella pneumoniae is an opportunistic pathogen that causes a range of diseases. The appearance of extended-spectrum β-lactamase -and carbapenemase-producing strains, in addition to the biofilm-forming phenotype, is a major problem in the clinical environment. METHODOLOGY:A total of 33 clinical K. pneu...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9677
更新日期:2018-03-31 00:00:00
abstract:INTRODUCTION:Extended-Spectrum Beta-Lactamases (ESBL) are a common mechanism of bacterial resistance in Enterobacteriaceae. The purpose of this study is to characterize the ESBL genes produced by community-acquired uropathogenic Escherichia coli strains in the Nouna District, in the West-African country, Burkina Faso. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11737
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Infection with Herpes Simplex Virus Type-2 (HSV-2) is the primary cause of genital herpes and the most common cause of genital ulcer disease (GUD) worldwide. There is little information on the prevalence of HSV-2 in Nigeria. METHODOLOGY:Specimens were collected from 162 volunteers attending Jos University ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.567
更新日期:2010-10-04 00:00:00
abstract:BACKGROUND:The diagnosis of extra-pulmonary tuberculosis (EPTB) by conventional methods such as culture and microscopy has low sensitivity and requires an invasive procedure. A simple rapid serological test would be of great value. METHODS:Six antigens (ESAT-6, Ag85A, TB10.4, Rv3881c, lipoarabinomannan (LAM) and Ara6-...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.116
更新日期:2010-03-08 00:00:00
abstract:INTRODUCTION:Following the recommendation of the Global Leprosy Strategy, Ethiopia targeted to reduce the incidence of new leprosy cases, and the proportion with severe disability (grade 2) from 13.6% in 2016 to < 1% in 2020. This study assessed the clinical profile of new leprosy cases and the sequelae of previously t...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11706
更新日期:2020-06-29 00:00:00
abstract:INTRODUCTION:Typhoid fever is a common disease in Yunnan province; however, the resistant phenotype and epidemic characteristics of Salmonella in this area are still unclear. In this study, a 15-year surveillance of antimicrobial susceptibility of Salmonella is reported. METHODOLOGY:From January 1999 to December 2013,...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.5420
更新日期:2015-04-15 00:00:00
abstract:INTRODUCTION:The efficacy of non-adjuvanted seasonal influenza vaccine in young children is considered to be suboptimal. This study compared the safety and immunogenicity profiles of MF59-adjuvanted, trivalent, influenza vaccine (ATIV) and non-adjuvanted, trivalent, influenza vaccine (TIV) in Guatemalan children (N = 3...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3855/jidc.4594
更新日期:2014-09-12 00:00:00
abstract:INTRODUCTION:Human co-infection with Plasmodium falciparum and helminthes is ubiquitous throughout Africa. This study aimed to determine the co-infections of Plasmodium falciparum infection in HIV and intestinal parasitic infections, and their immunological distribution, in Benin City, Nigeria. METHODOLOGY:A total of ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1889
更新日期:2012-05-14 00:00:00