Abstract:
BACKGROUND:Brucella is a facultative, intracellular pathogen that causes severe disease in animals and humans. Immunity against Brucella involves both humoral and cellular responses. To investigate the characteristics of immune response in acute brucellosis in Sprague-Dawley (SD) rats, IgG and its subclass specific immunoglobulins' (IgG1 and IgG2a) response in sera against B. abortus biotype 1 infection were studied. METHODOLOGY:Thirty-six rats were inoculated intraperitoneally with 0.1 ml apyrogenic saline containing 1x10(10) colony forming unit (CFU) of B. abortus biotype 1 Korean bovine isolate. Four rats were used as uninfected controls. The sera were collected from infected rats at 3, 7, 14, 21, 28, 35, 42, 49, and 56 days post infection (DPI) and screened for Brucella specific antibody response by the rose bengal plate test (RBPT). IgG and its subclass specific immunoglobulins' (IgG1 and IgG2a) response in the sera were measured by a lipopolysaccharide (LPS) based indirect enzyme-linked immunosorbent assay (IELISA). RESULTS:Brucella specific IgG, IgG1 and IgG2a responses in the sera of infected rats were detected from 3 DPI by IELISA. IgG and IgG1 concentrations in sera reached the peak level at 35 DPI, and then the concentrations gradually declined to the end of the experiment. IgG2a concentrations in the sera remained almost constant from 7 DPI until the end of this study. CONCLUSION:In acute brucellosis, IgG2a response (indicative of a Th1 response) was found to be significantly dominant over IgG1 response (indicative of Th2 response) (P < 0.001).
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Khatun MM,Islam MA,Baek BK,Lee SIdoi
10.3855/jidc.248subject
Has Abstractpub_date
2009-06-01 00:00:00pages
392-7issue
5eissn
2036-6590issn
1972-2680journal_volume
3pub_type
杂志文章abstract:INTRODUCTION:Miscarriage is one of the most common adverse pregnancy outcomes. The aim of this study was to investigate the relationship between miscarriage in humans and infections caused by zoonotic bacteria and genital pathogens. METHODOLOGY:Cervicovaginal swabs and placenta samples from 132 women with miscarriage ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9829
更新日期:2019-05-31 00:00:00
abstract:INTRODUCTION:The impact of mutations in the reverse transcriptase region of HBV on serum HBsAg titer and its correlation with HBV DNA is largely unknown. METHODOLOGY:A total of 644 patients, with a history of lamivudine or adefovir dipivoxil resistance who underwent genotypic resistance tests, were enrolled in this st...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11447
更新日期:2019-11-30 00:00:00
abstract:INTRODUCTION:Acinetobacter baumannii is a Gram-negative nosocomial pathogen that has the capacity to develop resistance to all classes of antimicrobial compounds. However, very little is known regarding its susceptibility to biocides (antiseptics and disinfectants) and capacity to form biofilms, particularly for Malays...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11455
更新日期:2019-07-31 00:00:00
abstract:BACKGROUND:Pseudomonas aeruginosa and Acinetobacter baumannii have been reported to cause outbreaks of ventilator-associated pneumonia (VAP) in several studies. The high prevalence of these pathogens prompted us to study the different strains of these pathogens prevailing in our intensive care units (ICUs) and determin...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.800
更新日期:2010-06-03 00:00:00
abstract::We present the case of a 42-year-old male patient who applied to the emergency department of our hospital with clinical nephritis, orchitis, acute renal failure without endocarditis, and a low-grade fever. Brucella agglutinin titers were 1:160, Rose Bengal test was positive and Brucella melitensis was isolated from ur...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1442
更新日期:2011-12-13 00:00:00
abstract:INTRODUCTION:Invasive fungal infection (IFI) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. A previous history of IFI is not an absolute contraindication for allo-HSCT, particularly in the era of secondary antifungal prophylaxis (SAP). Prompt di...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9961
更新日期:2018-09-30 00:00:00
abstract:BACKGROUND:The diagnosis of extra-pulmonary tuberculosis (EPTB) by conventional methods such as culture and microscopy has low sensitivity and requires an invasive procedure. A simple rapid serological test would be of great value. METHODS:Six antigens (ESAT-6, Ag85A, TB10.4, Rv3881c, lipoarabinomannan (LAM) and Ara6-...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.116
更新日期:2010-03-08 00:00:00
abstract:INTRODUCTION:Staphylococcal colonization is a risk factor for healthcare-associated infections, which are frequent in Neonatal Intensive Care Units (NICU). This study analyzed microbiology, epidemiology and clinical aspects of Staphylococcus spp. colonizing neonates. METHODOLOGY:Nasal or periumbilical swabs were evalu...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11241
更新日期:2019-09-30 00:00:00
abstract:INTRODUCTION:Imported parasitosis, which do not require an invertebrate vector, are extremely dangerous and can lead to the occurrence of disease in currently parasite free areas. In the present study we report a case of multi-parasitic infection in a young immigrant from Ghana to Italy caused by filaria, Schistosoma s...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.13151
更新日期:2020-11-30 00:00:00
abstract:INTRODUCTION:Extended-Spectrum Beta-Lactamases (ESBL) are a common mechanism of bacterial resistance in Enterobacteriaceae. The purpose of this study is to characterize the ESBL genes produced by community-acquired uropathogenic Escherichia coli strains in the Nouna District, in the West-African country, Burkina Faso. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11737
更新日期:2020-11-30 00:00:00
abstract:INTRODUCTION:When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms of bacterial pericarditi...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6027
更新日期:2015-07-30 00:00:00
abstract:INTRODUCTION:Argentina has been a preferential target for Bolivian immigrants for decades. The relatively recent migratory flux includes Germany, France, the United States, Australia, Japan, and some Latin American countries. The aim of this cross-sectional study was to describe the prevalence of Chagas disease in preg...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7118
更新日期:2016-09-30 00:00:00
abstract:INTRODUCTION:Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. METHODOLOGY:in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris-red thyme geraniol w...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10988
更新日期:2018-11-30 00:00:00
abstract:INTRODUCTION:When a surgical operation is to be conducted through a hair bearing part of the body, hair removal is often performed. This study aimed to evaluate the relationship of two methods of preoperative hair removal to postoperative wound infection in a developing country where razor shaving is very popular. MET...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,随机对照试验
doi:10.3855/jidc.1527
更新日期:2011-10-13 00:00:00
abstract:INTRODUCTION:Due to intercontinental traffic, population migration trends, natural disasters, and climate change, imported malaria remains important to consider in a febrile returning traveler. This study aims to raise awareness about malaria and help European clinicians maintain a working knowledge of this disease by ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.6799
更新日期:2016-08-02 00:00:00
abstract:INTRODUCTION:Septicemia is considered as an important cause of life-threating infections. The study was aimed at determining the incidence of septicemia considering different age groups and gender among suspected patients admitted to a tertiary care hospital in Iraq. METHODOLOGY:A total of 168 blood samples were colle...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.13089
更新日期:2020-12-31 00:00:00
abstract::Zika virus (ZIKV) infection is spreading rapidly within the Americas after originating from an outbreak in Brazil. We describe the current ZIKV infection epidemic in Brazil and the neurological symptoms arising. First cases of an acute exanthematic disease were reported in Brazil's Northeast region at the end of 2014....
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8217
更新日期:2016-02-28 00:00:00
abstract:INTRODUCTION:Diagnosis of bloodstream infections using bacteriological cultures suffers from low sensitivity and reporting delay. Advanced molecular techniques introduced in many laboratories provide rapid results and may show improvements in patient outcomes. This study aimed to evaluate the usefulness of a molecular ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4867
更新日期:2014-10-15 00:00:00
abstract:INTRODUCTION:Screening blood donors for blood-borne pathogens is very critical for the recipient's safety. Similar to hepatitis B and C infections, hepatitis G infection is transmitted through contaminated blood and causes acute and chronic hepatitis. Previous reports have shown that the prevalence of hepatitis G virus...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3796
更新日期:2014-01-15 00:00:00
abstract:INTRODUCTION:Cholera still remains a significant cause of morbidity and mortality in developing countries, although comprehensive surveillance data to inform policy and strategies are scarce. METHODOLOGY:A desk review of the national cholera database and zonal and districts reports was conducted. Interviews were condu...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3506
更新日期:2014-06-11 00:00:00
abstract:BACKGROUND:The treatment of methicillin-resistant staphylococcal infections has been a growing problem both in and out of hospitals for the past 30 years. Therefore, there is a need for other antibiotics as an alternative to glycopeptides in the treatment of methicillin-resistant staphylococcal infections. This study i...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3867
更新日期:2013-11-15 00:00:00
abstract:INTRODUCTION:Sepsis is a major cause of childhood death worldwide. In developing countries, epidemiological data about sepsis is scarce. This study describes and compares the frequency of etiological agents and initial sites of infection in children with or without sepsis, identifying risk factors and assessing outcome...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9257
更新日期:2017-09-05 00:00:00
abstract:INTRODUCTION:Sources of pathogenic Rickettsia in wildlife are largely unknown in Brazil. In this work, potential tick vectors and seroreactivity of small mammals against four spotted-fever group Rickettsia (R. rickettsii, R. parkeri, R. amblyommii and R. rhipicephali) and Rickettsia bellii from peri-urban areas of Uber...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7084
更新日期:2016-03-31 00:00:00
abstract:INTRODUCTION:Rickettsia sibirica mongolitimonae was recently reported as a common rickettsiosis in France. Current serological evidence suggests the presence of scrub typhus and spotted fever group rickettsiosis in Sri Lanka. We detected a human case of R. sibirica mongolitimonae in Sri Lanka. METHODOLOGY:A skin biops...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.8743
更新日期:2017-09-05 00:00:00
abstract:INTRODUCTION:Hepatitis B infection is a serious global public health problem. The aim of the study was to assess the seroprevalance of hepatitis B surface antigen (HBsAg), as well as the risk factors associated with hepatitis B virus (HBV) infection among pregnant women attending antenatal care clinics of the Universit...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10018
更新日期:2018-10-31 00:00:00
abstract:INTRODUCTION:This study sought to identify the association of antibiotic prescribing and the risk of antibiotic-associated diarrhoea (AAD) in Korle Bu Teaching Hospital (KBTH) in Ghana. METHODOLOGY:Patients from the Male Urology Ward and Treatment Room of the Surgical Department of KBTH were followed up over three mon...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.11259
更新日期:2020-08-31 00:00:00
abstract::The incidence of invasive salmonellosis has increased among children and HIV-infected adults in Malawi. This has been associated with the emergence of drug resistance in the non-typhoidal Salmonella serovars Enteritidis and Typhimurium. In contrast, S. Typhi isolates have remained fully sensitive to commonly used anti...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章,评审
doi:10.3855/jidc.158
更新日期:2008-12-01 00:00:00
abstract::Chikungunya virus is an emerging arboviral disease that has been spreading rapidly across south Asia in recent years. Until recently, no chikungunya cases have been reported in Nepal. For the first time, we report three cases of chikungunya virus infection in Nepal. ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3701
更新日期:2014-06-11 00:00:00
abstract:INTRODUCTION:Antimicrobial resistance (AR) is a multifaceted problem of global significance. In addition to developing new drugs and using antimicrobial guidelines, it is essential that health professionals understand all aspects of the problem and the most effective ways to handle it. This study evaluated pharmacists'...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.4853
更新日期:2015-03-15 00:00:00
abstract::A clinical case of infection caused by Fasciolopsis buski in a 24 weeks pregnant woman from Vietnam affected by systemic lupus erythematosus (SLE) is reported here. On 22 February 2012 the patient was admitted to Hue Hospital in Hue, Vietnam, with a diagnosis of general illness and suspected acute anaemia. Laboratory ...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.7017
更新日期:2015-07-04 00:00:00