Abstract:
INTRODUCTION:The widespread use of tigecycline raises the question of increasing infection rates of Pseudomonas aeruginosa (PA) in ICUs which are not affected by this antibiotic. OBJECTIVE:The aim of this study was to determine if treatment with tigecycline is a risk factor for PA infection in ICU patients. METHODOLOGY:A retrospective and observational study was conducted at Erciyes University Hospital, Turkey, between 2008 and 2010. The Erciyes University Hospital is a 1300-bed tertiary care facility. The patients included in this study were hospitalized in four adult ICUs. Patients with PA infections (case group) were compared with patients with nosocomial infection other than PA (control group). RESULTS:A total of 1,167 patients with any nosocomial infections were included in the study. Two hundred and seventy eight (23.8%) of the patients had PA infection during their ICU stay. Fifty nine patients (21.2%) in the case group received tigecycline before developing PA infections, which were found to be significantly more frequent than in the controls (p < 0.01). Multivariate analysis showed that risk factors for PA infection were previous tigecycline use (4 times), external ventricular shunt (4.2 times), thoracic drainage catheter (2.5 times) and tracheostomy (1.6 times). CONCLUSION:Our results contribute to the need for new studies to determine the safety of tigecycline use, especially for the treatment of critically ill patients. Since tigecycline seems to be an alternative for the treatment of multidrug resistant (MDR) microorganisms, rational use of this antibiotic in ICU patients is essential.
journal_name
J Infect Dev Ctriesjournal_title
Journal of infection in developing countriesauthors
Ulu-Kilic A,Alp E,Altun D,Cevahir F,Kalın G,Demiraslan Hdoi
10.3855/jidc.4700subject
Has Abstractpub_date
2015-03-15 00:00:00pages
309-12issue
3eissn
2036-6590issn
1972-2680journal_volume
9pub_type
杂志文章abstract:INTRODUCTION:The sputum smear or the culture are the definitive diagnosis of pulmonary tuberculosis. Only a fraction of clinical patients are culture-confirmed. METHODOLOGY:A total of 24 clinical cases (40 ± 14 years old) with positive smear and negative co-morbidity were studied. Cases were selected from 600 patients...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.10583
更新日期:2019-01-31 00:00:00
abstract:INTRODUCTION:Schistosomiasis is one of the Neglected Tropical Diseases in Ethiopia. Since 2015, yearly school-based mass drug administration (MDA) using praziquantel has become the major control strategy. This study aimed to assess trends of Schistosoma mansoni infection in a high-endemic area in Northwest Ethiopia. M...
journal_title:Journal of infection in developing countries
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doi:10.3855/jidc.11727
更新日期:2020-06-29 00:00:00
abstract::The case of a Hickman catheter-related bacteremia caused by Gordonia sputi in a patient with breast cancer is presented. Blood cultures grew a Gram-positive rod, susceptible to several antimicrobials, subsequently identified by 16S rRNA gene sequencing as Gordonia sputi. The infection resolved after successful treatme...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1770
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abstract:INTRODUCTION:Septicemia is considered as an important cause of life-threating infections. The study was aimed at determining the incidence of septicemia considering different age groups and gender among suspected patients admitted to a tertiary care hospital in Iraq. METHODOLOGY:A total of 168 blood samples were colle...
journal_title:Journal of infection in developing countries
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更新日期:2020-12-31 00:00:00
abstract:INTRODUCTION:This study aims at defining through a retrospective evaluation, the clinical parameters affecting the clinical course and consequently the management of patients presenting with cervicofacial abscesses. METHODOLOGY:A total of 394 patients diagnosed with abscess at the University of Sassari Otorhinolaryngo...
journal_title:Journal of infection in developing countries
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abstract:INTRODUCTION:Due to the shortcomings in the 1997-World Health Organisation (WHO) dengue case classification (DCC), a revised classification was proposed in 2009. This study was aimed to assess the clinical usefulness of the two classifications during a large dengue epidemic. METHODOLOGY:Clinical data of dengue patient...
journal_title:Journal of infection in developing countries
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abstract:INTRODUCTION:Human papillomavirus (HPV) infection is typically critical in the oncogenesis of cervical cancer. However, available HPV detection kits differ in their ability and sensitivity to detect various types of HPV, and this variability has led to inconsistencies in the reporting of the geographic prevalence of HP...
journal_title:Journal of infection in developing countries
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abstract:INTRODUCTION:Sexually transmitted infections (STI) are a major public health, social, and economic problem leading to morbidity, mortality, and stigma. This study was conducted to determine the prevalence of STIs, investigate behavioral risk factors and the relationship between the STIs/HIV and demographic factors. ME...
journal_title:Journal of infection in developing countries
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更新日期:2015-04-15 00:00:00
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Screening blood donors for blood-borne pathogens is very critical for the recipient's safety. Similar to hepatitis B and C infections, hepatitis G infection is transmitted through contaminated blood and causes acute and chronic hepatitis. Previous reports have shown that the prevalence of hepatitis G virus...
journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.3796
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abstract::Zika virus (ZIKV) infection is spreading rapidly within the Americas after originating from an outbreak in Brazil. We describe the current ZIKV infection epidemic in Brazil and the neurological symptoms arising. First cases of an acute exanthematic disease were reported in Brazil's Northeast region at the end of 2014....
journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.1525
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-09-12 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
doi:10.3855/jidc.9961
更新日期:2018-09-30 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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更新日期:2011-03-02 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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更新日期:2012-05-14 00:00:00
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journal_title:Journal of infection in developing countries
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更新日期:2019-08-31 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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更新日期:2009-12-15 00:00:00
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journal_title:Journal of infection in developing countries
pub_type: 杂志文章
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更新日期:2016-05-31 00:00:00