Hypertension and maternal-fetal conflict during placental malaria.

abstract：:Nina Finley and co-authors discuss public involvement in planning and reporting medical research. ...

journal_title：PLoS medicine

authors： Finley N,Swartz TH,Cao K,Tucker JD

更新日期：2020-09-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1002781.]. ...

journal_title：PLoS medicine

authors： Penn-Nicholson A,Hraha T,Thompson EG,Sterling D,Mbandi SK,Wall KM,Fisher M,Suliman S,Shankar S,Hanekom WA,Janjic N,Hatherill M,Kaufmann SHE,Sutherland J,Walzl G,De Groote MA,Ochsner U,Zak DE,Scriba TJ,ACS and GC6–74

更新日期：2019-07-18 00:00:00

abstract：:Aaron Kesselheim and colleagues examine orphan-designated drugs approved between 2009 and 2015 in the United States. ...

journal_title：PLoS medicine

authors： Kesselheim AS,Treasure CL,Joffe S

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Socioeconomic adversity in early life has been hypothesized to "program" a vulnerable phenotype with exaggerated inflammatory responses, so increasing the risk of developing type 2 diabetes in adulthood. The aim of this study is to test this hypothesis by assessing the extent to which the association between...

journal_title：PLoS medicine

authors： Stringhini S,Batty GD,Bovet P,Shipley MJ,Marmot MG,Kumari M,Tabak AG,Kivimäki M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:As the number of HIV-infected women initiating lifelong antiretroviral therapy (ART) during pregnancy increases globally, concerns have emerged regarding low levels of retention in HIV services and suboptimal adherence to ART during the postpartum period. We examined the impact of integrating postpartum ART ...

journal_title：PLoS medicine

authors： Myer L,Phillips TK,Zerbe A,Brittain K,Lesosky M,Hsiao NY,Remien RH,Mellins CA,McIntyre JA,Abrams EJ

更新日期：2018-03-30 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.pmed.1003293.]. ...

journal_title：PLoS medicine

authors： PLOS Medicine Staff.

更新日期：2020-12-29 00:00:00

abstract：:In this month's editorial, PLOS Medicine's Chief Editor Larry Peiperl discusses the relevance of patient care to a journal editor's work. ...

journal_title：PLoS medicine

authors： Peiperl L,PLOS Medicine Editors.

更新日期：2017-09-26 00:00:00

abstract：:In this Perspective on the clinical trial by Rita Alloway and colleagues, Simon Ball explains the benefits to healthcare systems and individual patients of the bioequivalence established between generic and brand-name formulations of an immunosuppressive drug in transplant recipients. ...

journal_title：PLoS medicine

authors： Ball S

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Although it has long been appreciated that ovarian carcinoma subtypes (serous, clear cell, endometrioid, and mucinous) are associated with different natural histories, most ovarian carcinoma biomarker studies and current treatment protocols for women with this disease are not subtype specific. With the emerg...

journal_title：PLoS medicine

authors： Köbel M,Kalloger SE,Boyd N,McKinney S,Mehl E,Palmer C,Leung S,Bowen NJ,Ionescu DN,Rajput A,Prentice LM,Miller D,Santos J,Swenerton K,Gilks CB,Huntsman D

更新日期：2008-12-02 00:00:00

abstract：BACKGROUND:Evidence suggests that variations in fasting glucose and insulin amongst those without frank type 2 diabetes mellitus are important determinants of cardiovascular disease. However, the relative importance of variations in fasting insulin, glucose, and glycated haemoglobin as risk factors for cardiovascular d...

journal_title：PLoS medicine

authors： Lawlor DA,Fraser A,Ebrahim S,Smith GD

更新日期：2007-08-01 00:00:00

abstract：:Xonghong Xiao and colleagues analyze the challenge of antimicrobial resistance in China. A government strategy to promote rational use of antimicrobials in health care reduced antibiotic sales and percentage of prescriptions for antimicrobials for both hospitalized patients and outpatients, and offers insights to shap...

journal_title：PLoS medicine

authors： Xiao Y,Zhang J,Zheng B,Zhao L,Li S,Li L

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released revised guidelines in 2015 recommending that all people living with HIV, regardless of CD4 count, initiate antiretroviral therapy (ART) upon diagnosis. However, few studies have projected the global resources needed for rapid scale-up of ART. Under the Health Poli...

journal_title：PLoS medicine

authors： Dutta A,Barker C,Kallarakal A

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19. The objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index and mortality am...

journal_title：PLoS medicine

authors： Harrison SL,Fazio-Eynullayeva E,Lane DA,Underhill P,Lip GYH

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Diabetes is a well-known risk factor for tuberculosis (TB) and is increasingly prevalent in low- and middle-income countries, where the burden of TB is high. Glycemic control has the potential to modify the risk of TB. However, there are few studies on the association between glycemic control and TB risk, an...

journal_title：PLoS medicine

authors： Lee PH,Fu H,Lai TC,Chiang CY,Chan CC,Lin HH

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, necessitating screening. The reference diagnostic method for G6PD activ...

journal_title：PLoS medicine

authors： Pfeffer DA,Ley B,Howes RE,Adu P,Alam MS,Bansil P,Boum Y 2nd,Brito M,Charoenkwan P,Clements A,Cui L,Deng Z,Egesie OJ,Espino FE,von Fricken ME,Hamid MMA,He Y,Henriques G,Khan WA,Khim N,Kim S,Lacerda M,Lon C,Me

更新日期：2020-05-14 00:00:00

abstract：:As participant-led health research increases, Effy Vayena and and John Tasioulas examine what ethical questions are raised, and what types of standards need to be developed for appropriate ethical oversight for participant-led research projects. ...

journal_title：PLoS medicine

authors： Vayena E,Tasioulas J

更新日期：2013-01-01 00:00:00

abstract：:In a Perspective, Lynn Morris and Nonhlanhla Mkhize discuss the prospects for broadly neutralizing antibodies to be used in preventing HIV infection. ...

journal_title：PLoS medicine

authors： Morris L,Mkhize NN

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the develo...

journal_title：PLoS medicine

authors： Le Bihan A,de Kanter R,Angulo-Barturen I,Binkert C,Boss C,Brun R,Brunner R,Buchmann S,Burrows J,Dechering KJ,Delves M,Ewerling S,Ferrer S,Fischli C,Gamo-Benito FJ,Gnädig NF,Heidmann B,Jiménez-Díaz MB,Leroy D,Martíne

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) of houses provide effective malaria transmission control. There is conflicting evidence about whether it is more beneficial to provide both interventions in combination. A cluster randomised controlled trial was conducted to investigate wheth...

journal_title：PLoS medicine

authors： West PA,Protopopoff N,Wright A,Kivaju Z,Tigererwa R,Mosha FW,Kisinza W,Rowland M,Kleinschmidt I

更新日期：2014-04-15 00:00:00

abstract：BACKGROUND:Earlier puberty is widely linked with future obesity and cardiometabolic disease. We examined whether age at puberty onset likely influences adiposity and cardiometabolic traits independent of childhood adiposity. METHODS AND FINDINGS:One-sample Mendelian randomisation (MR) analyses were conducted on up to ...

journal_title：PLoS medicine

authors： Bell JA,Carslake D,Wade KH,Richmond RC,Langdon RJ,Vincent EE,Holmes MV,Timpson NJ,Davey Smith G

更新日期：2018-08-28 00:00:00

abstract：:Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers...

journal_title：PLoS medicine

authors： Liberati A,Altman DG,Tetzlaff J,Mulrow C,Gøtzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:Average profiles of salivary progesterone in women vary significantly at the inter- and intrapopulation level as a function of age and acute energetic conditions related to energy intake, energy expenditure, or a combination of both. In addition to acute stressors, baseline progesterone levels differ among p...

journal_title：PLoS medicine

authors： Núñez-de la Mora A,Chatterton RT,Choudhury OA,Napolitano DA,Bentley GR

更新日期：2007-05-01 00:00:00

abstract：:Tom Boyles reflects on differing approaches taken for treating patients with Ebola virus disease in low- and high-resource settings. ...

journal_title：PLoS medicine

authors： Boyles TH

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Spurred by the creation of potential modified risk tobacco products, the US Food and Drug Administration (FDA) commissioned the Institute of Medicine (IOM) to assess the science base for tobacco "harm reduction," leading to the 2001 IOM report Clearing the Smoke. The objective of this study was to determine ...

journal_title：PLoS medicine

authors： Tan CE,Kyriss T,Glantz SA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Counties are the smallest unit for which mortality data are routinely available, allowing consistent and comparable long-term analysis of trends in health disparities. Average life expectancy has steadily increased in the United States but there is limited information on long-term mortality trends in the US ...

journal_title：PLoS medicine

authors： Ezzati M,Friedman AB,Kulkarni SC,Murray CJ

更新日期：2008-04-22 00:00:00

abstract：BACKGROUND:Various risk factors have been associated with epithelial ovarian cancer risk in observational epidemiological studies. However, the causal nature of the risk factors reported, and thus their suitability as effective intervention targets, is unclear given the susceptibility of conventional observational desi...

journal_title：PLoS medicine

authors： Yarmolinsky J,Relton CL,Lophatananon A,Muir K,Menon U,Gentry-Maharaj A,Walther A,Zheng J,Fasching P,Zheng W,Yin Ling W,Park SK,Kim BG,Choi JY,Park B,Davey Smith G,Martin RM,Lewis SJ

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Experimental and observational research has suggested the potential for increased type 2 diabetes (T2D) risk among populations taking statins for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). However, few studies have directly compared statin-associated benefits and harms or exami...

journal_title：PLoS medicine

authors： Engeda JC,Lhachimi SK,Rosamond WD,Lund JL,Keyserling TC,Safford MM,Colantonio LD,Muntner P,Avery CL

更新日期：2020-08-26 00:00:00

abstract：:Drawing upon interviews with experts and a review of the literature, Gavin Yamey proposes a new framework for scaling up global health interventions. ...

journal_title：PLoS medicine

authors： Yamey G

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:It is unclear whether an upper gastrointestinal bleed is an isolated gastrointestinal event or an indicator of a deterioration in a patient's overall health status. Therefore, we investigated the excess causes of death in individuals after a non-variceal bleed compared with deaths in a matched sample of the ...

journal_title：PLoS medicine

authors： Crooks CJ,Card TR,West J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on to the conventional therapy compared with conventional therapy alone (diet, exercise, and/or drugs, exc...

journal_title：PLoS medicine

authors： Oyama J,Murohara T,Kitakaze M,Ishizu T,Sato Y,Kitagawa K,Kamiya H,Ajioka M,Ishihara M,Dai K,Nanasato M,Sata M,Maemura K,Tomiyama H,Higashi Y,Kaku K,Yamada H,Matsuhisa M,Yamashita K,Bando YK,Kashihara N,Ueda S,

更新日期：2016-06-28 00:00:00