Abstract:
INTRODUCTION:The study was conducted to validate in vivo the Adequacy Calculator, a Microsoft Excel-based program, designed to assess the prescription and delivery of renal replacement therapy in the critical care setting. METHODS:The design was a prospective cohort study, set in two intensive care units of teaching hospitals. The participants were 30 consecutive critically ill patients with acute renal failure treated with 106 continuous renal replacement therapies (CRRT). Urea clearance computation was performed with the Adequacy Calculator (KCALC). Simultaneous blood and effluent urea samples were collected to measure the effectively delivered urea clearance (KDEL) at the beginning of each treatment and, during 73 treatments, between the 18th and 24th treatment hour. The correlation between 179 computed and 179 measured clearances was assessed. Fractional clearances for urea were calculated as spKt/V (where sp represents single pool, K is clearance, t is time, and V is urea volume of distribution) obtained from software prescription and compared with the delivered spKt/V obtained from empirical data. RESULTS:We found that the value of clearance predicted by the calculator was strongly correlated with the value obtained from computation on blood and dialysate determination (r = 0.97) during the first 24 treatment hours, regardless of the renal replacement modality used. The delivered spKt/V (1.25) was less than prescribed (1.4) from the Adequacy Calculator by 10.7%, owing to therapy downtime. CONCLUSION:The Adequacy Calculator is a simple tool for prescribing CRRT and for predicting the delivered dose. The calculator might be a helpful tool for standardizing therapy and for comparing disparate treatments, making it possible to perform large multi-centre studies on CRRT.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Ricci Z,Salvatori G,Bonello M,Pisitkun T,Bolgan I,D'Amico G,Dan M,Piccinni P,Ronco Cdoi
10.1186/cc3517keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
R266-73issue
3eissn
1364-8535issn
1466-609Xpii
cc3517journal_volume
9pub_type
杂志文章,多中心研究相关文献
CRITICAL CARE文献大全abstract:INTRODUCTION:Fever is frequently observed in critically ill patients. An independent association of fever with increased mortality has been observed in non-neurological critically ill patients with mixed febrile etiology. The association of fever and antipyretics with mortality, however, may be different between infect...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/cc11211
更新日期:2012-02-28 00:00:00
abstract:INTRODUCTION:To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). METHODS:Medline, EMBASE and other databases were searched for English-language articles with the major objective of ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7160
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13162
更新日期:2013-12-16 00:00:00
abstract::Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is also started as a bridge-to-transplantation/ventricular assist device in the case of unrecoverable cardiac or ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2541-3
更新日期:2019-07-30 00:00:00
abstract::Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response resulting from the application of inappropriate mechanical forces to the lung parenchyma. The current paradigm attributes VILI to overstretching due to very high-volume ventilation (volutrauma) and cyclic changes in aeration due ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc10052
更新日期:2011-04-07 00:00:00
abstract:INTRODUCTION:Veno-venous extracorporeal membrane oxygenation (vvECMO) can be a life-saving therapy in patients with severe acute lung failure refractory to conventional therapy. Nevertheless, vvECMO is a procedure associated with high costs and resource utilization. The aim of this study was to assess published models ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13824
更新日期:2014-04-09 00:00:00
abstract:INTRODUCTION:Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in antibiotic stewardship programs. We compared a local ecology based algorithm (LEBA) to a surveillan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13990
更新日期:2014-07-15 00:00:00
abstract:INTRODUCTION:In intensive care unit patients we assessed, using bispectral index (BIS) monitoring, whether the addition of magnesium sulphate infusion could decrease the sufentanil infusion required to maintain sedation. PATIENTS AND METHODS:A total of 30 adult patients who were expected to require mechanical ventilat...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1186/cc2365
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10100
更新日期:2011-01-01 00:00:00
abstract::A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing,and...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13787
更新日期:2014-03-24 00:00:00
abstract:BACKGROUND:Post-cardiac arrest (CA) patients are at risk of secondary ischemic damage in the case of suboptimal brain oxygenation during an ICU stay. We hypothesized that elevated central venous pressures (CVP) would impair cerebral perfusion and oxygenation (venous cerebral congestion). The aim of the present study wa...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1297-2
更新日期:2016-05-15 00:00:00
abstract::Care of the critically ill patient is becoming increasingly complex. Protocols, which standardize care of patients with similar diseases, represent a potential solution to managing multiple simultaneous problems in critically ill patients. In this article, we examine the advantages and disadvantages to care protocoliz...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc10578
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). METHODS:We performed a retrospective single-center cohort study of patients treat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1225-5
更新日期:2016-02-19 00:00:00
abstract::Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8026
更新日期:2009-01-01 00:00:00
abstract::This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-014-0578-x
更新日期:2014-10-15 00:00:00
abstract:INTRODUCTION:Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for final pathogen identification and antimicrobial susceptibility testing. We organized a prospective observational multicenter study in three study site...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9234
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained. METHOD:We conducted a prospective, controlled before-and-after examination of the effect of a MET system on the long-term incidence of ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3906
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resis...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1118-z
更新日期:2015-11-16 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and functional status. METHODS:This is a cohort study of all adult ICU trauma patients admitted to a unive...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6111
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, it plays pivotal roles in the pathogenesis of sepsis in several ways. Our previous study showed that rs1800625 (-429T/C) revealed a strong clinical relevance with sepsis morbidity rate and...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0727-2
更新日期:2015-01-09 00:00:00
abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2426-5
更新日期:2019-05-06 00:00:00
abstract::Outcomes studies of infections with resistant bacteria often do not account appropriately for intermediate variables--events in the causal pathway between the exposure and the outcome--when controlling for confounders. We discuss how failure to distinguish between confounders and intermediate variables can bias the an...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc5019
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pati...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10444
更新日期:2011-01-01 00:00:00
abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3007
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury. METHODS:Twenty-one sheep (37 ± 2 ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc9342
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Despite quick implementation of reperfusion therapies, a few patients with high-risk, acute, massive, pulmonary embolism (PE) remain highly hemodynamically unstable. Others have absolute contraindication to receive reperfusion therapies. Venoarterial-extracorporeal membrane oxygenation (VA-ECMO) might lower ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1655-8
更新日期:2017-03-28 00:00:00
abstract::Regional citrate anticoagulation (RCA) is now recommended over systemic heparin for continuous renal replacement therapy in patients without contraindications. Its use is likely to increase throughout the world. However, in the absence of citrate blood level monitoring, the diagnosis of citrate accumulation, the most ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1880-1
更新日期:2017-11-19 00:00:00
abstract:INTRODUCTION:The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of the general population and examine the impact of pre-existing disease and factors related to ICU ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc8967
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Epidemiologic assessment of critically ill people in Intensive Care Units (ICUs) is needed to ensure the health care system can meet current and future needs. However, few such studies have been published. METHODS:Population-based analysis of all adult ICU care in the Canadian province of Manitoba, 1999 t...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc13026
更新日期:2013-09-30 00:00:00
abstract::The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3917
更新日期:2006-02-01 00:00:00