Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation.

abstract：INTRODUCTION:Stimulation of beta2-adrenergic receptors (beta2-ARs) inhibits tumor necrosis factor-alpha (TNF-alpha) release in monocytes. In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. The aims of this study were to analyze the molecular mechanisms ...

journal_title：Critical care (London, England)

authors： Link A,Selejan S,Maack C,Lenz M,Böhm M

更新日期：2008-01-01 00:00:00

abstract：:Despite continuous advances in technologic and pharmacologic management, the mortality rate from septic shock remains high. Care of patients with sepsis includes measures to support the circulatory system and treat the underlying infection. There is a substantial body of knowledge indicating that fluid resuscitation, ...

journal_title：Critical care (London, England)

authors： Waxman AB,Ward N,Thompson T,Lilly CM,Lisbon A,Hill N,Nasraway SA,Heard S,Corwin H,Levy M

更新日期：2005-08-20 00:00:00

abstract：INTRODUCTION:The present study was conducted to assess the value of serum concentration of lipopolysaccharide-binding protein (LBP) in patients with systemic inflammatory response syndrome (SIRS), sepsis and septic shock with respect to its ability to differentiate between infectious and noninfectious etiologies in SIR...

journal_title：Critical care (London, England)

authors： Prucha M,Herold I,Zazula R,Dubska L,Dostal M,Hildebrand T,Hyanek J

更新日期：2003-12-01 00:00:00

abstract：INTRODUCTION:Lymphocyte apoptosis has been suggested to play a central role in sepsis pathophysiology, and studies in animal models demonstrated that blocking this pathway improves outcome. However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the differe...

journal_title：Critical care (London, England)

authors： Turrel-Davin F,Guignant C,Lepape A,Mougin B,Monneret G,Venet F

更新日期：2010-01-01 00:00:00

abstract：:Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...

journal_title：Critical care (London, England)

authors： Rudd KE,Kissoon N,Limmathurotsakul D,Bory S,Mutahunga B,Seymour CW,Angus DC,West TE

更新日期：2018-09-23 00:00:00

abstract：INTRODUCTION:The purpose of this study was to investigate whether common variants across the nuclear factor erythroid 2-like 2 (NFE2L2) gene contribute to the development of the acute respiratory distress syndrome (ARDS) in patients with severe sepsis. NFE2L2 is involved in the response to oxidative stress, and it has ...

journal_title：Critical care (London, England)

authors： Acosta-Herrera M,Pino-Yanes M,Blanco J,Ballesteros JC,Ambrós A,Corrales A,Gandía F,Subirá C,Domínguez D,Baluja A,Añón JM,Adalia R,Pérez-Méndez L,Flores C,Villar J,GRECIA and GEN-SEP networks.

更新日期：2015-06-16 00:00:00

abstract：INTRODUCTION:Norepinephrine, regularly used to increase systemic arterial blood pressure and thus improve cerebral perfusion following severe traumatic brain injury (TBI), may activate platelets. This, in turn, could promote microthrombosis formation and induce additional brain damage. METHODS:The objective of this st...

journal_title：Critical care (London, England)

authors： Tschuor C,Asmis LM,Lenzlinger PM,Tanner M,Härter L,Keel M,Stocker R,Stover JF

更新日期：2008-01-01 00:00:00

abstract：:ICU delirium is associated with poor patient outcome. Risk factor stratification is essential to the understanding, prevention and treatment of this disorder. Alcohol consumption, smoking and prior cognitive impairment appear strongly correlated with delirium risk. Several potentially modifiable associations deserve p...

journal_title：Critical care (London, England)

authors： Skrobik Y

更新日期：2009-01-01 00:00:00

abstract：:Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy ...

journal_title：Critical care (London, England)

authors： Marini JJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Early survival following severe injury has been improved with refined resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among this fragile group of patients leading to prolonged hospital stay and late mortality. MODS after trauma is widely attributed to dysregulated inflammation ...

journal_title：Critical care (London, England)

authors： Manson J,Cole E,De'Ath HD,Vulliamy P,Meier U,Pennington D,Brohi K

更新日期：2016-06-07 00:00:00

abstract：:Stress hyperglycaemia is a common event in acute critical illness. There is increasing evidence that maintaining normoglycaemia and treatment with insulin (or with glucose-insulin-potassium [GIK]), even in non-diabetic persons, is helpful in limiting organ damage after myocardial infarction, stroke, traumatic brain in...

journal_title：Critical care (London, England)

authors： Johan Groeneveld AB,Beishuizen A,Visser FC

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet t...

journal_title：Critical care (London, England)

authors： Tuinman PR,Vlaar AP,Cornet AD,Hofstra JJ,Levi M,Meijers JC,Beishuizen A,Schultz MJ,Groeneveld AJ,Juffermans NP

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is ad...

journal_title：Critical care (London, England)

authors： Grahl JJ,Stollings JL,Rakhit S,Person AK,Wang L,Thompson JL,Pandharipande PP,Ely EW,Patel MB

更新日期：2018-12-12 00:00:00

abstract：:The decision to withdraw or withhold life supporting treatment in moribund patients is difficult under any circumstances. When the patient becomes incompetent to clarify their wishes regarding continued maintenance in long-term facilities, surrogates sometimes cannot agree, further clouding the issue. We examine a cas...

journal_title：Critical care (London, England)

authors： Buckley T,Crippen D,DeWitt AL,Fisher M,Liolios A,Scheetz CL,Whetstine LM

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) receptor 1 (CX3CR1) was identified as the most differentially expressed gene between survivors and non-survivors in two independent cohorts of septic shock patients and was proposed as a marker of sepsis-induced immunosuppression. Whether such a biomarker is associated with mortality...

journal_title：Critical care (London, England)

authors： Friggeri A,Cazalis MA,Pachot A,Cour M,Argaud L,Allaouchiche B,Floccard B,Schmitt Z,Martin O,Rimmelé T,Fontaine-Kesteloot O,Page M,Piriou V,Bohé J,Monneret G,Morisset S,Textoris J,Vallin H,Blein S,Maucort-Boulch D,

更新日期：2016-06-30 00:00:00

abstract：:The recognition of colonization pressure as an important risk factor for acquisition of antibiotic-resistant bacteria in the ICU, including Acinetobacter species, has major consequences for our understanding of risk factor analyses. Moreover, the importance of colonization pressure underpins the role of cross-transmis...

journal_title：Critical care (London, England)

authors： Bonten MJ

更新日期：2012-07-31 00:00:00

abstract：INTRODUCTION:The FloTrac/Vigileo (Edwards Lifesciences, Irvine, CA, USA) allows pulse pressure-derived cardiac output measurement without external calibration. Software modifications were performed in order to eliminate initially observed deficits. The aim of this study was to assess changes in cardiac output determine...

journal_title：Critical care (London, England)

authors： Senn A,Button D,Zollinger A,Hofer CK

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:N-acetylcysteine (NAC) has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore, the mo...

journal_title：Critical care (London, England)

authors： Hein OV,Ohring R,Schilling A,Oellerich M,Armstrong VW,Kox WJ,Spies C

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resis...

journal_title：Critical care (London, England)

authors： Nielsen ST,Janum S,Krogh-Madsen R,Solomon TP,Møller K

更新日期：2015-11-16 00:00:00

abstract：INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...

journal_title：Critical care (London, England)

authors： Field K,Prinjha S,Rowan K

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing, dynamic parameters like pulse pressure variation (PPV) and systolic pressure variation (SPV) are usually small. We hypothesized that during ...

journal_title：Critical care (London, England)

authors： Dahl MK,Vistisen ST,Koefoed-Nielsen J,Larsson A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated with low glomerular filtration, and their predictive value to discriminate transient from intrinsic septic AKI. METHODS:In 107 sepsis patients, AKI was defined by the Risk, Injury, Failure, Los...

journal_title：Critical care (London, England)

authors： Vanmassenhove J,Glorieux G,Hoste E,Dhondt A,Vanholder R,Van Biesen W

更新日期：2013-10-13 00:00:00

abstract：INTRODUCTION:Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown. METHODS:We used the Get With The Guidelines®-Res...

journal_title：Critical care (London, England)

authors： Peng TJ,Andersen LW,Saindon BZ,Giberson TA,Kim WY,Berg K,Novack V,Donnino MW,American Heart Association’s Get With The Guidelines®-Resuscitation Investigators.

更新日期：2015-04-10 00:00:00

abstract：:Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...

journal_title：Critical care (London, England)

authors： Sullivan EH,Gibson LE,Berra L,Chang MG,Bittner EA

更新日期：2020-06-05 00:00:00

abstract：INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...

journal_title：Critical care (London, England)

authors： Mu DL,Wang DX,Li LH,Shan GJ,Li J,Yu QJ,Shi CX

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:In patients with severe sepsis and septic shock as cause of Intensive Care Unit (ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy initiated before ICU admission. METHODS:We conducted a prospective observational study enrolling patients admitted to the ICU with severe se...

journal_title：Critical care (London, England)

authors： Garnacho-Montero J,Gutiérrez-Pizarraya A,Escoresca-Ortega A,Fernández-Delgado E,López-Sánchez JM

更新日期：2015-08-27 00:00:00

abstract：:Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechanisms of injury, yet uncertainty over the topographical distribution of these mechanisms continues to fuel cont...

journal_title：Critical care (London, England)

authors： Oeckler RA,Hubmayr RD

更新日期：2007-01-01 00:00:00

abstract：:Assessment of vasomotor tone is essential in defining appropriate resuscitation strategies for the hypotensive patient. Although changes in mean arterial pressure to cardiac output define arterial resistance, resistance is only one component of vasomotor tone. Compliance is the other component. The reciprocal of compl...

journal_title：Critical care (London, England)

authors： Pinsky MR

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Sepsis, severe sepsis and septic shock are common conditions with high mortality. Their early diagnosis in the Emergency Department (ED) is one of the keys to improving survival. Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other sce...

journal_title：Critical care (London, England)

authors： Ulla M,Pizzolato E,Lucchiari M,Loiacono M,Soardo F,Forno D,Morello F,Lupia E,Moiraghi C,Mengozzi G,Battista S

更新日期：2013-07-30 00:00:00

abstract：:Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibiti...

journal_title：Critical care (London, England)

authors： Abraham E

更新日期：2013-06-11 00:00:00