Alveolar microstrain and the dark side of the lung.

abstract：:Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furthermore, it may simu...

journal_title：Critical care (London, England)

authors： Levi M,van der Poll T

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

journal_title：Critical care (London, England)

authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Currently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection. METHODS:The numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The ...

journal_title：Critical care (London, England)

authors： Wu W,Shi Y,Gao H,Liang W,Sheng J,Li L

更新日期：2014-03-24 00:00:00

abstract：INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...

journal_title：Critical care (London, England)

authors： Garrubba M,Turner T,Grieveson C

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Making a differential diagnosis between bacterial meningitis and aseptic meningitis is a critical clinical problem. The utility of a cerebrospinal fluid (CSF) lactate assay for this purpose has been debated and is not yet routinely clinically performed. To adequately evaluate this assay, a systematic revie...

journal_title：Critical care (London, England)

authors： Huy NT,Thao NT,Diep DT,Kikuchi M,Zamora J,Hirayama K

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Blood transfusion in the perioperative period has frequently been associated with an excess of nosocomial infections. Whilst transfused whole blood induces specific host immune alteration that may predispose to nosocomial infections, the immunomodulating properties associated with leukodepleted blood remai...

journal_title：Critical care (London, England)

authors： Fragkou PC,Torrance HD,Pearse RM,Ackland GL,Prowle JR,Owen HC,Hinds CJ,O'Dwyer MJ

更新日期：2014-10-01 00:00:00

abstract：:In the publication of this article [1], there are 4 collaborating authors missing from the 'MARS consortium'. This has now been included in this correction article. ...

journal_title：Critical care (London, England)

authors： Klein Klouwenberg PMC,Spitoni C,van der Poll T,Bonten MJ,Cremer OL,MARS consortium.

更新日期：2020-02-06 00:00:00

abstract：INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...

journal_title：Critical care (London, England)

authors： Mu DL,Wang DX,Li LH,Shan GJ,Li J,Yu QJ,Shi CX

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. METHODS:This retrospective observational study in a general ICU of a university hospital included a total of 153 patients with sepsis, severe seps...

journal_title：Critical care (London, England)

authors： Nakamura M,Oda S,Sadahiro T,Watanabe E,Abe R,Nakada TA,Morita Y,Hirasawa H

更新日期：2012-12-12 00:00:00

abstract：BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...

journal_title：Critical care (London, England)

authors： Wu CP,Xu YJ,Wang TG,Ku SC,Chan DC,Lee JJ,Wei YC,Hsiao TY,Chen CC

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided inconsistent results on whether intensive care unit (ICU) discharge at night and on weekends is associated with an increased risk of mortality. This systematic review and meta-analysis aimed to determine whether ICU discharge time was associated with hospital mortality. ...

journal_title：Critical care (London, England)

authors： Yang S,Wang Z,Liu Z,Wang J,Ma L

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can pre...

journal_title：Critical care (London, England)

authors： Wang HC,Lin WC,Lin YJ,Rau CS,Lee TH,Chang WN,Tsai NW,Cheng BC,Kung CT,Lu CH

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Post-cardiac arrest (CA) patients are at risk of secondary ischemic damage in the case of suboptimal brain oxygenation during an ICU stay. We hypothesized that elevated central venous pressures (CVP) would impair cerebral perfusion and oxygenation (venous cerebral congestion). The aim of the present study wa...

journal_title：Critical care (London, England)

authors： Ameloot K,Genbrugge C,Meex I,Eertmans W,Jans F,De Deyne C,Dens J,Mullens W,Ferdinande B,Dupont M

更新日期：2016-05-15 00:00:00

abstract：INTRODUCTION:We compared the effects of mechanical ventilation with a lower tidal volume (V(T)) strategy versus those of greater V(T) in patients with or without acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) on the use of opioids and sedatives. METHODS:This is a secondary analysis of a previously ...

journal_title：Critical care (London, England)

authors： Wolthuis EK,Veelo DP,Choi G,Determann RM,Korevaar JC,Spronk PE,Kuiper MA,Schultz MJ

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...

journal_title：Critical care (London, England)

authors： Volakli E,Spies C,Michalopoulos A,Groeneveld AB,Sakr Y,Vincent JL

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Diaphragm dysfunction develops frequently in ventilated intensive care unit (ICU) patients. Both disuse atrophy (ventilator over-assist) and high respiratory muscle effort (ventilator under-assist) seem to be involved. A strong rationale exists to monitor diaphragm effort and titrate support to maintain resp...

journal_title：Critical care (London, England)

authors： Jansen D,Jonkman AH,Roesthuis L,Gadgil S,van der Hoeven JG,Scheffer GJ,Girbes A,Doorduin J,Sinderby CS,Heunks LMA

更新日期：2018-09-27 00:00:00

abstract：INTRODUCTION:To investigate whether respiratory variation of inferior vena cava diameter (cIVC) predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure (ACF). METHODS:Forty patients with ACF and spontaneous breathing were included. Response to fluid challenge was defined as a 15...

journal_title：Critical care (London, England)

authors： Muller L,Bobbia X,Toumi M,Louart G,Molinari N,Ragonnet B,Quintard H,Leone M,Zoric L,Lefrant JY,AzuRea group.

更新日期：2012-10-08 00:00:00

abstract：INTRODUCTION:Passive leg raising (PLR) is a simple reversible maneuver that mimics rapid fluid loading and increases cardiac preload. The effects of this endogenous volume expansion on stroke volume enable the testing of fluid responsiveness with accuracy in spontaneously breathing patients. However, this maneuver requ...

journal_title：Critical care (London, England)

authors： Biais M,Vidil L,Sarrabay P,Cottenceau V,Revel P,Sztark F

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of seps...

journal_title：Critical care (London, England)

authors： Paunel-Görgülü A,Flohé S,Scholz M,Windolf J,Lögters T

更新日期：2011-01-01 00:00:00

abstract：:Vasopressin (antidiuretic hormone) is emerging as a potentially major advance in the treatment of septic shock. Terlipressin (tricyl-lysine-vasopressin) is the synthetic, long-acting analogue of vasopressin, and has comparable pharmacodynamic but different pharmacokinetic properties. Vasopressin mediates vasoconstrict...

journal_title：Critical care (London, England)

authors： Delmas A,Leone M,Rousseau S,Albanèse J,Martin C

更新日期：2005-04-01 00:00:00

abstract：:Progress in management of critically ill neurological patients has led to improved survival rates. However, severe residual neurological impairment, such as persistent coma, occurs in some survivors. This raises concerns about whether it is ethically appropriate to apply aggressive care routinely, which is also associ...

journal_title：Critical care (London, England)

authors： Weiss N,Galanaud D,Carpentier A,Naccache L,Puybasset L

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Dynamic predictors of fluid responsiveness, namely systolic pressure variation, pulse pressure variation, stroke volume variation and pleth variability index have been shown to be useful to identify in advance patients who will respond to a fluid load by a significant increase in stroke volume and cardiac ...

journal_title：Critical care (London, England)

authors： Benes J,Giglio M,Brienza N,Michard F

更新日期：2014-10-28 00:00:00

abstract：:The encouraging results of recent clinical trials on therapy of severe sepsis and septic shock are paralleled by ongoing studies on the epidemiology of sepsis and infection in intensive care unit patients all over the world. The development of network-based systems for assessing morbidity and mortality in intensive ca...

journal_title：Critical care (London, England)

authors： Gerlach H,Keh D

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients; its level is related to the severity of infection. We evaluated the value of PCT as a marker of bacterial infection for emergency department patients. METHODS:This prospective observational study consecutively enrol...

journal_title：Critical care (London, England)

authors： Chan YL,Tseng CP,Tsay PK,Chang SS,Chiu TF,Chen JC

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Although less invasive than pulmonary artery catheters (PACs), arterial pulse pressure analysis techniques for estimating cardiac output (CO) have not been simultaneously compared to PAC bolus thermodilution CO (COtd) or continuous CO (CCO) devices. METHODS:We compared the accuracy, bias and trending abil...

journal_title：Critical care (London, England)

authors： Hadian M,Kim HK,Severyn DA,Pinsky MR

更新日期：2010-01-01 00:00:00

abstract：:Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple anti-inflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis. ...

journal_title：Critical care (London, England)

authors： Kirschenbaum L,Astiz M

更新日期：2005-06-01 00:00:00

abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

journal_title：Critical care (London, England)

authors： Stanworth SJ,Hunt BJ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize the management of brain deceased donors before recovery of organs. However the single administration...

journal_title：Critical care (London, England)

authors： Pinsard M,Ragot S,Mertes PM,Bleichner JP,Zitouni S,Cook F,Pierrot M,Dube L,Menguy E,Lefèvre LM,Escaravage L,Dequin PF,Vignon P,Pichon N

更新日期：2014-07-23 00:00:00

abstract：:Many prior studies have shown that, in critically ill patients, acute kidney injury (AKI) commonly occurs in association with sepsis and its presence portends an increased likelihood of poor outcomes. In contrast, few studies have focused specifically on the influence of AKI on the long-term risk of developing sepsis....

journal_title：Critical care (London, England)

authors： Clark E,Bagshaw SM

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity. METHODS:Prospective observational study in critically ill patients. Diaphragm electr...

journal_title：Critical care (London, England)

authors： Sklar MC,Madotto F,Jonkman A,Rauseo M,Soliman I,Damiani LF,Telias I,Dubo S,Chen L,Rittayamai N,Chen GQ,Goligher EC,Dres M,Coudroy R,Pham T,Artigas RM,Friedrich JO,Sinderby C,Heunks L,Brochard L

更新日期：2021-01-11 00:00:00