Complications of regional citrate anticoagulation: accumulation or overload?

abstract：BACKGROUND:Mottling around the knee, reflecting a reduced skin blood flow, is predictive of mortality in patients with septic shock. However, the causative pathophysiology of mottling remains unknown. We hypothesized that the cutaneous hypoperfusion observed in the mottled area is related to regional endothelial dysfun...

journal_title：Critical care (London, England)

authors： Bourcier S,Joffre J,Dubée V,Preda G,Baudel JL,Bigé N,Leblanc G,Levy BI,Guidet B,Maury E,Ait-Oufella H

更新日期：2017-06-23 00:00:00

abstract：INTRODUCTION:Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and delirium guidelines are incorporated into order sets at hospital...

journal_title：Critical care (London, England)

authors： Dale CR,Hayden SJ,Treggiari MM,Curtis JR,Seymour CW,Yanez ND 3rd,Fan VS

更新日期：2012-06-18 00:00:00

abstract：:Hypertension is an extremely common clinical problem, affecting approximately 50 million people in the USA and approximately 1 billion individuals worldwide. Approximately 1% of these patients will develop acute elevations in blood pressure at some point in their lifetime. A number of terms have been applied to severe...

journal_title：Critical care (London, England)

authors： Varon J,Marik PE

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...

journal_title：Critical care (London, England)

authors： Favre E,Bernini A,Morelli P,Pasquier J,Miroz JP,Abed-Maillard S,Ben-Hamouda N,Oddo M

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Inflammation plays an important role in the initiation and progression of acute kidney injury (AKI). However, evidence regarding the prognostic effect of the platelet-to-lymphocyte ratio (PLR), a novel systemic inflammation marker, among patients with AKI is scarce. In this study, we investigated the value o...

journal_title：Critical care (London, England)

authors： Zheng CF,Liu WY,Zeng FF,Zheng MH,Shi HY,Zhou Y,Pan JY

更新日期：2017-09-08 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is a technique for providing life support, in case the natural lungs are failing and are not able to maintain a sufficient oxygenation of the body's organ systems. ECMO technique was an adaptation of conventional cardiopulmonary bypass techniques and introduced into treatment...

journal_title：Critical care (London, England)

authors： Lewandowski K

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of seps...

journal_title：Critical care (London, England)

authors： Paunel-Görgülü A,Flohé S,Scholz M,Windolf J,Lögters T

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...

journal_title：Critical care (London, England)

authors： Schultz MJ,Haas LE

更新日期：2011-01-01 00:00:00

abstract：:The use of corticosteroids in septic shock remains controversial. It has been demonstrated that high doses of steroids (30 mg/kg methylprednisolone) for short periods of time are not beneficial. More recent studies using smaller doses (200-300 mg/day hydrocortisone) for longer periods of time have shown beneficial eff...

journal_title：Critical care (London, England)

authors： Goodman S,Sprung CL,International Sepsis Forum.

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Resuscitation with saline is a standard initial response to hypotension or shock of almost any cause. Saline resuscitation is thought to generate an increase in cardiac output through a preload-dependent (increased end-diastolic volume) augmentation of stroke volume. We sought to confirm this to be the mec...

journal_title：Critical care (London, England)

authors： Kumar A,Anel R,Bunnell E,Zanotti S,Habet K,Haery C,Marshall S,Cheang M,Neumann A,Ali A,Kavinsky C,Parrillo JE

更新日期：2004-06-01 00:00:00

abstract：:Sepsis is characterized by a dysregulated immune response to infection leading to life-threatening organ dysfunction. Sepsis-induced liver injury is recognized as a powerful independent predictor of mortality in the intensive care unit. During systemic infections, the liver regulates immune defenses via bacterial clea...

journal_title：Critical care (London, England)

authors： Sun J,Zhang J,Wang X,Ji F,Ronco C,Tian J,Yin Y

更新日期：2020-10-19 00:00:00

abstract：INTRODUCTION:New technology using partial carbon dioxide rebreathing has been developed to measure cardiac output. Because rebreathing increases respiratory effort, we investigated whether a newly developed system with 35 s rebreathing causes a lesser increase in respiratory effort under partial ventilatory support tha...

journal_title：Critical care (London, England)

authors： Tachibana K,Imanaka H,Takeuchi M,Nishida T,Takauchi Y,Nishimura M

更新日期：2005-10-05 00:00:00

abstract：:Care of the critically ill patient is becoming increasingly complex. Protocols, which standardize care of patients with similar diseases, represent a potential solution to managing multiple simultaneous problems in critically ill patients. In this article, we examine the advantages and disadvantages to care protocoliz...

journal_title：Critical care (London, England)

authors： Chang SY,Sevransky J,Martin GS

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Severe acute pancreatitis (SAP) requiring admission to a critical care unit is associated with high mortality and long lengths of stay. We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database. METHODS:We conducted a secondary analysi...

journal_title：Critical care (London, England)

authors： Harrison DA,D'Amico G,Singer M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Postoperative atrial fibrillation (POAF) is commonplace after cardiothoracic surgery. A rate control strategy using short-acting beta blockers is recommended as a first-line therapy in patients without hemodynamic instability. Microcirculatory effects of POAF and esmolol have not yet been investigated. We hy...

journal_title：Critical care (London, England)

authors： Fornier W,Jacquet-Lagrèze M,Collenot T,Teixeira P,Portran P,Schweizer R,Ovize M,Fellahi JL

更新日期：2017-12-12 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. METHODS:The PubMed and EMBASE databases were searched using the search terms 'artificial respiration', 'instrumentation', 'device', 'devices', 'm...

journal_title：Critical care (London, England)

authors： Duyndam A,Ista E,Houmes RJ,van Driel B,Reiss I,Tibboel D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Intensive care medicine is a relatively young discipline that has rapidly grown into a full-fledged medical subspecialty. Intensivists are responsible for managing an ever-increasing number of patients with complex, life-threatening diseases. Several factors may influence their performance, including age, tr...

journal_title：Critical care (London, England)

authors： Castro R,Nin N,Ríos F,Alegría L,Estenssoro E,Murias G,Friedman G,Jibaja M,Ospina-Tascon G,Hurtado J,Marín MDC,Machado FR,Cavalcanti AB,Dubin A,Azevedo L,Cecconi M,Bakker J,Hernandez G,Latin-American Intensive Care Net

更新日期：2018-02-21 00:00:00

abstract：:Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns, the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load, the immune response becomes disproportionate and patients may develop an overshooting systemic inflammat...

journal_title：Critical care (London, England)

authors： Flierl MA,Stahel PF,Touban BM,Beauchamp KM,Morgan SJ,Smith WR,Ipaktchi KR

更新日期：2009-01-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) has a substantial mortality rate and annually affects more than 140,000 people in the USA alone. Standard management includes lung protective ventilation but this impairs carbon dioxide clearance and may lead to right heart dysfunction or increased intracranial pressure. Extr...

journal_title：Critical care (London, England)

authors： Cove ME,MacLaren G,Federspiel WJ,Kellum JA

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...

journal_title：Critical care (London, England)

authors： Hagel S,Scherag A,Schuierer L,Hoffmann R,Luyt CE,Pletz MW,Kesselmeier M,Weis S

更新日期：2020-09-29 00:00:00

abstract：INTRODUCTION:Stimulation of beta2-adrenergic receptors (beta2-ARs) inhibits tumor necrosis factor-alpha (TNF-alpha) release in monocytes. In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. The aims of this study were to analyze the molecular mechanisms ...

journal_title：Critical care (London, England)

authors： Link A,Selejan S,Maack C,Lenz M,Böhm M

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...

journal_title：Critical care (London, England)

authors： Sussmane JB,de Soto M,Torbati D

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic sh...

journal_title：Critical care (London, England)

authors： Contou D,Roux D,Jochmans S,Coudroy R,Guérot E,Grimaldi D,Ricome S,Maury E,Plantefève G,Mayaux J,Mekontso Dessap A,Brun-Buisson C,de Prost N

更新日期：2016-11-06 00:00:00

abstract：:Great variability exists in data collection and coding of variables in studies on traumatic brain injury (TBI). This confounds comparison of results and analysis of data across studies. The difficulties in performing a meta-analysis of individual patient data were recently illustrated in the IMPACT project (Internatio...

journal_title：Critical care (London, England)

authors： Maas AI

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possible to monitor sublingual microcirculatory perfusion over time. The goal of this review is to provide...

journal_title：Critical care (London, England)

authors： den Os MM,van den Brom CE,van Leeuwen ALI,Dekker NAM

更新日期：2020-05-13 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Bacterial infection represents a serious risk in neonates and critically ill paediatric patients. Current clinical practice is characterized by frequent antibiotic treatment despite low incidence of true infection. However, some patients escape early diagnosis and progress to septic shock. Many new markers...

journal_title：Critical care (London, England)

authors： Horisberger T,Harbarth S,Nadal D,Baenziger O,Fischer JE

更新日期：2004-12-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2019 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available...

journal_title：Critical care (London, England)

authors： Milford EM,Reade MC

更新日期：2019-03-09 00:00:00

abstract：INTRODUCTION:Although early use of broad-spectrum antimicrobials in critically ill patients may increase antimicrobial adequacy, uncontrolled use of these agents may select for more-resistant organisms. This study investigated the effects of early use of broad-spectrum antimicrobials in critically ill patients with hos...

journal_title：Critical care (London, England)

authors： Kim JW,Chung J,Choi SH,Jang HJ,Hong SB,Lim CM,Koh Y

更新日期：2012-02-15 00:00:00

abstract：INTRODUCTION:Prognosis in patients suffering out-of-hospital cardiac arrest is poor. Higher survival rates have been observed only in patients with ventricular fibrillation who were fortunate enough to have basic and advanced life support initiated soon after cardiac arrest. An ability to predict cardiac arrest outcome...

journal_title：Critical care (London, England)

authors： Kolar M,Krizmaric M,Klemen P,Grmec S

更新日期：2008-01-01 00:00:00