Year in review 2013: Critical Care--sepsis.


:This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises articles on four main topics: sepsis pathogenesis, diagnostic and prognostic biomarkers, potential new therapies, and epidemiologic and outcome studies.


Crit Care


de Montmollin E,Annane D




Has Abstract


2014-10-15 00:00:00














  • Predicting on-going hemorrhage and transfusion requirement after severe trauma: a validation of six scoring systems and algorithms on the TraumaRegister DGU.

    abstract:INTRODUCTION:The early aggressive management of the acute coagulopathy of trauma may improve survival in the trauma population. However, the timely identification of lethal exsanguination remains challenging. This study validated six scoring systems and algorithms to stratify patients for the risk of massive transfusio...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Brockamp T,Nienaber U,Mutschler M,Wafaisade A,Peiniger S,Lefering R,Bouillon B,Maegele M,TraumaRegister DGU.

    更新日期:2012-07-20 00:00:00

  • Investigation of microcirculation in patients with venoarterial extracorporeal membrane oxygenation life support.

    abstract:BACKGROUND:Microcirculatory dysfunction develops in both septic and cardiogenic shock patients, and it is associated with poor prognosis in patients with septic shock. Information on the association between microcirculatory dysfunction and prognosis in cardiogenic shock patients with venoarterial extracorporeal membran...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Yeh YC,Lee CT,Wang CH,Tu YK,Lai CH,Wang YC,Chao A,Huang CH,Cheng YJ,Chen YS,NTUH Center of Microcirculation Medical Research (NCMMR).

    更新日期:2018-08-19 00:00:00

  • Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

    abstract:INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Bhatraju P,Hsu C,Mukherjee P,Glavan BJ,Burt A,Mikacenic C,Himmelfarb J,Wurfel M

    更新日期:2015-10-19 00:00:00

  • Evidence-based review of the use of the pulmonary artery catheter: impact data and complications.

    abstract::The pulmonary artery catheter (PAC) was introduced in 1971 for the assessment of heart function at the bedside. Since then it has generated much enthusiasm and controversy regarding the benefits and potential harms caused by this invasive form of hemodynamic monitoring. This review discusses all clinical studies condu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Hadian M,Pinsky MR

    更新日期:2006-01-01 00:00:00

  • Serial increase of IL-12 response and human leukocyte antigen-DR expression in severe sepsis survivors.

    abstract:INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

    更新日期:2011-01-01 00:00:00

  • Impact of timing of renal replacement therapy initiation on outcome of septic acute kidney injury.

    abstract:INTRODUCTION:Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simpl...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chou YH,Huang TM,Wu VC,Wang CY,Shiao CC,Lai CF,Tsai HB,Chao CT,Young GH,Wang WJ,Kao TW,Lin SL,Han YY,Chou A,Lin TH,Yang YW,Chen YM,Tsai PR,Lin YF,Huang JW,Chiang WC,Chou NK,Ko WJ,Wu KD,Tsai TJ,NSARF Stud

    更新日期:2011-01-01 00:00:00

  • Prognostic indicators in patients presenting with acute cardiogenic pulmonary edema treated with CPAP: it's not the acid that matters, it's back to basics.

    abstract::Several prognostic markers have been identified for patients admitted with acute cardiogenic pulmonary edema. Most of the markers are based on clinical risk scores. Unlike hypercapnic respiratory failure, acidosis is not an adverse predictor in these patients. Hemodynamic variables that assess pathophysiological mecha...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章,评审


    authors: Schlosshan D,Elliott M

    更新日期:2010-01-01 00:00:00

  • Case report: a ball valve blood clot in the airways - life-saving whole tube suction.

    abstract::Respiratory tract obstruction due to a blood clot may result in life threatening ventilatory impairment. Ball valve blood clot obstructions of the airways are rare. A ball valve blood clot acts as a one-way valve, allowing (near) normal air entry into the airways, but (completely) blocking expiration. In a near fatal ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Dongelmans DA,Jonkers RE,Schultz MJ

    更新日期:2004-10-01 00:00:00

  • Influence of temperature on thromboelastometry and platelet aggregation in cardiac arrest patients undergoing targeted temperature management.

    abstract:BACKGROUND:Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to examine whether temperature influences the whole blood coagulation tests. METHODS:We included 40 patie...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Jeppesen AN,Kirkegaard H,Ilkjær S,Hvas AM

    更新日期:2016-04-30 00:00:00

  • Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial.

    abstract:INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Žuran I,Poredos P,Skale R,Voga G,Gabrscek L,Pareznik R

    更新日期:2009-01-01 00:00:00

  • Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database.

    abstract:PURPOSE:Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) database was searched to identify septic patients ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chen H,Zhu Z,Zhao C,Guo Y,Chen D,Wei Y,Jin J

    更新日期:2020-07-14 00:00:00

  • Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database.

    abstract:BACKGROUND:Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARD...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Boyle AJ,Madotto F,Laffey JG,Bellani G,Pham T,Pesenti A,Thompson BT,O'Kane CM,Deane AM,McAuley DF,LUNG SAFE Investigators.,ESICM Trials Group.

    更新日期:2018-10-27 00:00:00

  • Hyperbilirubinaemia after major thoracic surgery: comparison between open-heart surgery and oesophagectomy.

    abstract:BACKGROUND:Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Hosotsubo KK,Nishimura M,Nishimura S

    更新日期:2000-01-01 00:00:00

  • An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury.

    abstract:INTRODUCTION:In patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS), recent randomised controlled trials (RCTs) showed a consistent trend of mortality reduction with prone ventilation. We updated a meta-analysis on this topic. METHODS:RCTs that compared ventilation of adult patients...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,meta分析


    authors: Abroug F,Ouanes-Besbes L,Dachraoui F,Ouanes I,Brochard L

    更新日期:2011-01-01 00:00:00

  • 'One patient amongst many': a qualitative analysis of intensive care unit patients' experiences of transferring to the general ward.

    abstract:INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Field K,Prinjha S,Rowan K

    更新日期:2008-01-01 00:00:00

  • Delirium prediction in the intensive care unit: comparison of two delirium prediction models.

    abstract:BACKGROUND:Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to use is unclear. We compared the predictive performance and user c...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Wassenaar A,Schoonhoven L,Devlin JW,van Haren FMP,Slooter AJC,Jorens PG,van der Jagt M,Simons KS,Egerod I,Burry LD,Beishuizen A,Matos J,Donders ART,Pickkers P,van den Boogaard M

    更新日期:2018-05-05 00:00:00

  • Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study.

    abstract:INTRODUCTION:Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell antibodies. We evaluated the validity of these markers in patients scheduled for hemopoietic stem ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Brodska H,Drabek T,Malickova K,Kazda A,Vitek A,Zima T,Markova M

    更新日期:2009-01-01 00:00:00

  • Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study.

    abstract:INTRODUCTION:Glial fibrillary acidic protein (GFAP) may serve as a serum marker of traumatic brain injury (TBI) that can be used to monitor biochemical changes in patients and gauge the response to treatment. However, the temporal profile of serum GFAP in the acute period of brain injury and the associated utility for ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lei J,Gao G,Feng J,Jin Y,Wang C,Mao Q,Jiang J

    更新日期:2015-10-12 00:00:00

  • Do we need new trials of procalcitonin-guided antibiotic therapy?

    abstract::Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect of a procalcitonin (PCT)-guided antibiotic treatment on outcomes in acute lower respiratory trac...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lisboa T,Salluh J,Povoa P

    更新日期:2018-01-27 00:00:00

  • High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study.

    abstract:INTRODUCTION:The pathophysiology of postoperative delirium remains poorly understood. The purpose of this study was to examine the relationship between serum cortisol level and occurrence of early postoperative delirium in patients undergoing coronary artery bypass graft (CABG) surgery. METHODS:A total of 243 patients...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mu DL,Wang DX,Li LH,Shan GJ,Li J,Yu QJ,Shi CX

    更新日期:2010-01-01 00:00:00

  • Bench-to-bedside review: Cytopathic hypoxia.

    abstract::The rate of oxygen consumption by certain tissues is impaired when mice or rats are injected with lipopolysaccharide. A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Fink MP

    更新日期:2002-12-01 00:00:00

  • The race against the "septic shark".

    abstract::Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the curren...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Westphal M,Kampmeier T

    更新日期:2015-01-01 00:00:00

  • Bench-to-bedside review: carbon dioxide.

    abstract::Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO2 represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common - and generally underappreciated - component of many disease states, including early asthma, high-altitude pulmo...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Curley G,Laffey JG,Kavanagh BP

    更新日期:2010-01-01 00:00:00

  • Central venous oxygenation: when physiology explains apparent discrepancies.

    abstract::Central venous oxygen saturation (ScvO2) >70% or mixed venous oxygen saturation (SvO2) >65% is recommended for both septic and non-septic patients. Although it is the task of experts to suggest clear and simple guidelines, there is a risk of reducing critical care to these simple recommendations. This article reviews ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Squara P

    更新日期:2014-11-10 00:00:00

  • Infections of respiratory or abdominal origin in ICU patients: what are the differences?

    abstract:INTRODUCTION:There are few data related to the effects of different sources of infection on outcome. We used the Sepsis Occurrence in Acutely ill Patients (SOAP) database to investigate differences in the impact of respiratory tract and abdominal sites of infection on organ failure and survival. METHODS:The SOAP study...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Volakli E,Spies C,Michalopoulos A,Groeneveld AB,Sakr Y,Vincent JL

    更新日期:2010-01-01 00:00:00

  • Pro/con clinical debate: steroids are a key component in the treatment of SARS. Pro: Yes, steroids are a key component of the treatment regimen for SARS.

    abstract::SARS (severe acute respiratory syndrome) proved an enormous physical and emotional challenge to frontline health care workers throughout the world in late 2002 through to mid 2003. A large percentage of patients (many being health care workers themselves) became critically ill. Unfortunately, clinicians caring for the...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Gomersall CD

    更新日期:2004-04-01 00:00:00

  • Influence of different electrode belt positions on electrical impedance tomography imaging of regional ventilation: a prospective observational study.

    abstract:BACKGROUND:Electrical impedance tomography (EIT) is a non-invasive bedside tool which allows an individualized ventilator strategy by monitoring tidal ventilation and lung aeration. EIT can be performed at different cranio-caudal thoracic levels, but data are missing about the optimal belt position. The main goal of th...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Karsten J,Stueber T,Voigt N,Teschner E,Heinze H

    更新日期:2016-01-08 00:00:00

  • Shock subtypes by left ventricular ejection fraction following out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

    更新日期:2018-06-15 00:00:00

  • A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion.

    abstract:INTRODUCTION:Although activation of A3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine agonists activate mitogen-activated protein kinases, and these kinases have been implicated in ischemia/reperfusion injur...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Matot I,Weiniger CF,Zeira E,Galun E,Joshi BV,Jacobson KA

    更新日期:2006-01-01 00:00:00

  • Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.

    abstract:BACKGROUND:The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. METHODS:In this work, an antibiotic cocktail was used to ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Li M,Li C,Wu X,Chen T,Ren L,Xu B,Cao J

    更新日期:2020-05-27 00:00:00