Abstract:
:Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response resulting from the application of inappropriate mechanical forces to the lung parenchyma. The current paradigm attributes VILI to overstretching due to very high-volume ventilation (volutrauma) and cyclic changes in aeration due to very low-volume ventilation (atelectrauma); however, this model cannot explain some research findings. In the present review, we discuss the relevance of cyclic deformation of lung tissue as the main determinant of VILI. Parenchymal stability resulting from the interplay of respiratory parameters such as tidal volume, positive end-expiratory pressure or respiratory rate can explain the results of different clinical trials and experimental studies that do not fit with the classic volutrauma/atelectrauma model. Focusing on tissue deformation could lead to new bedside monitoring and ventilatory strategies.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Albaiceta GM,Blanch Ldoi
10.1186/cc10052subject
Has Abstractpub_date
2011-04-07 00:00:00pages
304issue
2eissn
1364-8535issn
1466-609Xpii
cc10052journal_volume
15pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:BACKGROUND:Clinical team composition for prehospital paediatric intubation may affect success and complication rates. We performed a systematic review and meta-analysis to determine the success and complication rates by type of clinical team. METHODS:We searched MEDLINE, EMBASE, and CINAHL for interventional and obser...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析
doi:10.1186/s13054-020-02865-y
更新日期:2020-04-15 00:00:00
abstract:INTRODUCTION:In critically ill patients, delirium is a serious and frequent disorder that is associated with a prolonged intensive care and hospital stay and an increased morbidity and mortality. Without the use of a delirium screening instrument, delirium is often missed by ICU nurses and physicians. The effects of im...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7991
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Accurate prediction of delirium in the intensive care unit (ICU) may facilitate efficient use of early preventive strategies and stratification of ICU patients by delirium risk in clinical research, but the optimal delirium prediction model to use is unclear. We compared the predictive performance and user c...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1186/s13054-018-2037-6
更新日期:2018-05-05 00:00:00
abstract:INTRODUCTION:Inter-hospital transport of critically ill patients is increasing. When performed by specialized retrieval teams there are less adverse events compared to transport by ambulance. These transports are performed with technical equipment also used in an Intensive Care Unit (ICU). As a consequence technical pr...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11191
更新日期:2012-02-12 00:00:00
abstract:BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03296-5
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Optimal glycaemic targets in traumatic brain injury (TBI) remain unclear. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing intensive with conventional glycaemic control in TBI requiring admission to an intensive care unit (ICU). METHODS:We systematically se...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s13054-017-1883-y
更新日期:2018-01-19 00:00:00
abstract:INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3777
更新日期:2005-08-01 00:00:00
abstract:INTRODUCTION:Extracorporeal lung assist, an extreme resource in patients with acute respiratory failure (ARF), is expanding its indications since knowledge about ventilator-induced lung injury has increased and protective ventilation has become the standard in ARF. METHODS:A prospective study on seven adult sheep was ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5082
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Little is known about the development of acute lung injury outside the intensive care unit. We set out to document the following: the association between predefined clinical conditions and the development of acute lung injury by using the American-European consensus definition; the frequency of lung injury d...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6113
更新日期:2007-01-01 00:00:00
abstract::The US Institute of Medicine's focus on patient safety has motivated hospital administrators to facilitate a culture of safety. As a result, subcommittees of the pharmacy and therapeutics committee have emerged in many hospitals to focus on adverse events and patient safety. Antimicrobial harms have gained the attenti...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6819
更新日期:2008-01-01 00:00:00
abstract::BACKGROUND: The present study was undertaken to examine the feasibility of venous oxygen measurements in the inferior vena cava (IVC) via a catheter through the umbilical vein. This may serve as a proxy for mixed venous oxygenation and the complications of right atrial cannulation can be avoided at the same time. It h...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc126
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:The aim of the study was to evaluate the ability of different static and dynamic measurements of preload to predict fluid responsiveness in patients with spontaneous respiratory movements. METHODS:The subjects were 21 critically ill patients with spontaneous breathing movements receiving mechanical ventil...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4970
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Elevated serum levels of S100beta, an astrocyte-derived protein, correlate with unfavourable neurological outcomes following cardiac surgery, neurotrauma, and resuscitation. This study evaluated whether pre-/postoperative serum S100beta levels correlate with unfavourable clinical and radiological findings ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5058
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The pathophysiology of acute kidney injury (AKI) in sepsis is ill defined. We investigated parameters associated with low glomerular filtration, and their predictive value to discriminate transient from intrinsic septic AKI. METHODS:In 107 sepsis patients, AKI was defined by the Risk, Injury, Failure, Los...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13057
更新日期:2013-10-13 00:00:00
abstract:INTRODUCTION:Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a stimulation of heat shock protein (HSP)70. We infused either alanine-glutamine or saline during endotoxin challenge ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc7696
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Curricular content is often based on the personal opinions of a small number of individuals. Although convenient, such curricula may not meet the needs of the target learner, the program or the institution. Using an objective method to ensure content validity of a curriculum can alleviate this issue. METH...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7087
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc1043
更新日期:2001-10-01 00:00:00
abstract::The definition of what constitutes a 'normal' adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define 'adrenal insufficiency'. These criteria have been based on the baseline cortisol level or the increment in cortisol following corticotropi...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc5105
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Fever is associated with a poor outcome in severely brain-injured patients, and its control is one of the therapies used in this condition. But, fever suppression may promote infection, and severely brain-injured patients are frequently exposed to infectious diseases, particularly ventilator-associated pne...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0689-4
更新日期:2014-12-15 00:00:00
abstract:INTRODUCTION:New technology using partial carbon dioxide rebreathing has been developed to measure cardiac output. Because rebreathing increases respiratory effort, we investigated whether a newly developed system with 35 s rebreathing causes a lesser increase in respiratory effort under partial ventilatory support tha...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3801
更新日期:2005-10-05 00:00:00
abstract::Determine the effectiveness of decontamination, and perform thorough dry or wet decontamination, depending on the circumstances. Always remain cognizant of the fact that, even after decontamination has been completed, contamination may not have been completely eliminated. Perform periodic monitoring to determine wheth...
journal_title:Critical care (London, England)
pub_type: 历史文章,杂志文章,评审
doi:10.1186/cc3062
更新日期:2005-08-01 00:00:00
abstract::The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11370
更新日期:2012-07-11 00:00:00
abstract:BACKGROUND:This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. METHODS:Haemorrhagic shock was induced in five healthy, anaesthetized sheep by ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2056-3
更新日期:2018-05-29 00:00:00
abstract:INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1120-5
更新日期:2015-11-18 00:00:00
abstract:INTRODUCTION:Pre-existing atrial fibrillation (AF) may worsen prognosis in patients admitted to the intensive care unit (ICU). METHODS:In a cohort study (2005-2011) including all patients with first-time ICU admissions in Denmark (n=57,110), we compared patients with and without pre-existing AF and estimated absolute ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1007-5
更新日期:2015-08-19 00:00:00
abstract::Heart rate variability in the frequency domain can now be obtained at the bedside in the ICU. Promising data suggest that it may help to characterize a patient response to a spontaneous breathing trial. Refinement of the analysis could even help to predict the outcome of extubation or at least help to detect early pat...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13807
更新日期:2014-03-31 00:00:00
abstract::This review documents important progress made in 2013 in the field of critical care respirology, in particular with regard to acute respiratory failure and acute respiratory distress syndrome. Twenty-five original articles published in the respirology and critical care sections of Critical Care are discussed in the fo...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-014-0577-y
更新日期:2014-10-15 00:00:00
abstract:BACKGROUND:Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic shock patients. METHODS:In this retrospective cohort study in a provincial tertiary care hospita...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1499-7
更新日期:2016-10-06 00:00:00
abstract::The multicenter study conducted by Lorente and coworkers published in the previous issue of Critical Care demonstrates that matrix metalloproteinase (MMP)-9 and MMP-10 and their inhibitor tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are promising novel biomarkers to predict severity and outcome of sepsis. I...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8156
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Passive leg raising (PLR) is a simple reversible maneuver that mimics rapid fluid loading and increases cardiac preload. The effects of this endogenous volume expansion on stroke volume enable the testing of fluid responsiveness with accuracy in spontaneously breathing patients. However, this maneuver requ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8195
更新日期:2009-01-01 00:00:00