Sample size requirements for clinical trials of isolated systolic hypertension.

abstract：:1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mellors LJ,Kotsanas G,Wendt IR

更新日期：1999-11-01 00:00:00

abstract：:1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

更新日期：2009-05-01 00:00:00

abstract：:1. In order to find an anaesthesia with minimum perturbation to the metabolism of chylomicrons, the effects of seven different anaesthetic agents on clearance from plasma of chylomicron-like emulsions were compared. 2. Avertin, urethane, fentanyl, and a ketamine/xylazine mixture all slowed the removal from plasma of e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mortimer BC,Umeda Y,Elsegood CL,Redgrave TG

更新日期：1993-01-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park SH,Heo JS,Kang CW

更新日期：2004-01-01 00:00:00

abstract：:1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivory LP

更新日期：1996-10-01 00:00:00

abstract：:1. Insulin-like growth factor (IGF)-I has acute effects on cardiovascular function, including a well-characterized vasodilator response in isolated arteries. In addition to increasing the release of nitric oxide, IGF-I also has effects on a variety of other signalling pathways that affect vascular tone, in particular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cao N,Lau S,Nguyen TT,White PJ

更新日期：2006-12-01 00:00:00

abstract：:1. Hepatocyte growth factor (HGF) has the therapeutic potential to improve renal fibrosis and proteinuria in rodents with chronic kidney disease. In contrast, long-term administration of human HGF to normal rats reportedly elicits proteinuria. Thus, the role of HGF during proteinuria remains contentious. The aim of th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mizuno S,Ikebuchi F,Fukuta K,Kato T,Matsumoto K,Adachi K,Abe T,Nakamura T

更新日期：2011-03-01 00:00:00

abstract：:Rutaecarpine is a major alkaloid isolated from Evodia rutaecarpa. Here, we investigated the effects of rutaecarpine on osteoclast differentiation induced by macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κ-B ligand (RANKL) in bone marrow-derived macrophages (BMMs). Treatment with...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fukuma Y,Sakai E,Komaki S,Nishishita K,Okamoto K,Tsukuba T

更新日期：2018-08-01 00:00:00

abstract：:1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

更新日期：1999-05-01 00:00:00

abstract：:1. The effect of cicletanine, a novel antihypertensive agent with natriuretic activity, on blood pressure and progression of renal failure of 5/6 nephrectomized spontaneously hypertensive rats with salt loading was examined. 2. All nephrectomized rats were randomly assigned to one of four groups and their diet was cha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nakamoto H,Suzuki H,Ohishi A,Katsumata H,Sakaguchi H,Saruta T

更新日期：1999-03-01 00:00:00

abstract：:1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

journal_title：Clinical and experimental pharmacology & physiology

authors： Field MJ,Seow F,Lawrence JR

更新日期：1989-02-01 00:00:00

abstract：:1. Amino acid neurotransmitters are critical for controlling the activity of most central neurons, including sympathetic preganglionic neurons (SPN), the spinal cord neurons involved in controlling blood pressure and other autonomic functions. 2. In studies reviewed here, SPN were identified either by retrograde traci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Llewellyn-Smith IJ

更新日期：2002-05-01 00:00:00

abstract：:Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen Y,Fu Y,An Y,Cao J,Wang J,Zhang J

更新日期：2018-04-01 00:00:00

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

更新日期：2010-01-01 00:00:00

abstract：:1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Babu PV,Sabitha KE,Shyamaladevi CS

更新日期：2006-04-01 00:00:00

abstract：:Prostaglandin (PG) efflux into ureteral (UE) and venous effluents (VE) of rabbit isolated perfused kidneys was determined by superfusion bioassay and radioimmunoassay (RIA), in response to injections of arginine-vasopressin (AVP), the non-pressor vasopressin analogue 1-deamino-8-D-arginine vasopressin (dDAVP) and arac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miller MJ,Westlin WF,McNeill H,McGiff JC

更新日期：1986-08-01 00:00:00

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:1. The efficacy of coumarin (1,2-benzopyrone) was examined for the regulation of hyperthyroidism in female rats. 2. Coumarin was administered (10 mg/kg per day for 15 days) to l-thyroxine (L-T(4))-induced hyperthyroid as well as to euthyroid rats and changes in serum concentrations of thyroid hormones and in associate...

journal_title：Clinical and experimental pharmacology & physiology

authors： Panda S,Kar A

更新日期：2007-11-01 00:00:00

abstract：:1. The present study was carried out to determine whether rilmenidine, a recently introduced antihypertensive agent which acts on alpha 2-adrenoceptors, has partial agonist activity on prejunctional alpha 2-adrenoceptors in guinea-pig atria. 2. Isolated preparations of guinea-pig atria were incubated with [3H]-noradre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Rand MJ

更新日期：1988-10-01 00:00:00

abstract：:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1994-10-01 00:00:00

abstract：:1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang JH,Li PQ,Fu QY,Li QX,Cai WW

更新日期：2007-05-01 00:00:00

abstract：:1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,O'Shea RA

更新日期：1977-11-01 00:00:00

abstract：:1. The haemodynamic and metabolic effects of oral intake of approximately 30 mg/kg per day N-nitro-L-arginine (NOLA) were examined in sham and adrenocorticotrophin (ACTH, 0.5 mg/kg per day) treated conscious Sprague-Dawley rats (n = 33). 2. NOLA administration produced an increase in systolic blood pressure of 24 +/- ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li M,Dusting GJ,Whitworth JA

更新日期：1992-10-01 00:00:00

abstract：:1. Electrolytic lesions were made in various brain regions of the rat, and the effects of these lesions on nociceptive threshold and the antinociceptive actions of morphine were tested using a shock titration technique. 2. Lesions in the medial thalamus, the periaqueductal grey area, or the caudate nucleus, had no eff...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yeung JC,Yaksh TL,Rudy TA

更新日期：1975-05-01 00:00:00

abstract：:1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

更新日期：1998-02-01 00:00:00

abstract：:Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whitworth JA,Connell JM,Lever AF,Fraser R

更新日期：1986-04-01 00:00:00

abstract：:1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yoshimura J,Fukami K,Koike K,Nagano M,Matsumoto T,Iwatani R,Kusumoto T,Hazama T,Ueda S,Adachi H,Hirai Y,Takasu K,Ohshima K,Yamagishi S,Okuda S

更新日期：2010-09-01 00:00:00

abstract：:1. Pericytes are cells of microvessels (arterioles, capillaries and venules) that wrap around endothelial cells. They are most abundant on venules and are common on capillaries. 2. The pericyte population is highly variable between different tissues and organs, probably in a manner reflecting postarteriolar hydrostati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sims DE

更新日期：2000-10-01 00:00:00