Abstract:
:Prostaglandin (PG) efflux into ureteral (UE) and venous effluents (VE) of rabbit isolated perfused kidneys was determined by superfusion bioassay and radioimmunoassay (RIA), in response to injections of arginine-vasopressin (AVP), the non-pressor vasopressin analogue 1-deamino-8-D-arginine vasopressin (dDAVP) and arachidonic acid (AA). dDAVP (10-1000 ng) failed to stimulate renal PG release, whereas AVP (10-100 ng) and AA (10-50 micrograms) caused a dose-dependent release of PG. AVP evoked PG release into both effluents with release into the VE greater than UE at high doses. In contrast, PG release by AA was almost exclusively into the VE. Indomethacin (2.8 X 10(-6) mol/l) abolished AVP- and AA-induced PG efflux in both effluents, and vasodepressor responses to AA. PGE2 was the predominant PG released in response to AVP in both effluents whereas AA released primarily 6-keto-PGF1 alpha. The contrasting sites and profile of released PG suggest that exogenous AA and AVP stimulate the release of PG from different regions/cell types within the kidney.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Miller MJ,Westlin WF,McNeill H,McGiff JCdoi
10.1111/j.1440-1681.1986.tb00942.xsubject
Has Abstractpub_date
1986-08-01 00:00:00pages
577-84issue
8eissn
0305-1870issn
1440-1681journal_volume
13pub_type
杂志文章abstract::1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 临床试验,更正并重新发布的文章,杂志文章,随机对照试验
doi:10.1111/j.1440-1681.1998.tb02199.x
更新日期:1998-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1983.tb00850.x
更新日期:1983-11-01 00:00:00
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doi:10.1046/j.1440-1681.2002.03748.x
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1440-1681.1983.tb00192.x
更新日期:1983-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1991.tb01451.x
更新日期:1991-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/1440-1681.13006
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1681.2000.03232.x
更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-07-01 00:00:00
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doi:10.1111/j.1440-1681.1995.tb02027.x
更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/1440-1681.12694
更新日期:2017-02-01 00:00:00
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doi:10.1111/j.1440-1681.1979.tb00046.x
更新日期:1979-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1989.tb01586.x
更新日期:1989-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/1440-1681.13091
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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更新日期:2006-09-01 00:00:00
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更新日期:2007-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1998.t01-19-.x
更新日期:1998-03-01 00:00:00
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1046/j.1440-1681.1999.03100.x
更新日期:1999-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 社论,评审
doi:10.1111/j.1440-1681.1991.tb01468.x
更新日期:1991-06-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00