Micropuncture comparison of nephron function during acute and chronic ADH excess in the rat.


:1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or 10-12 days ('chronic') of continuous treatment with arginine vasopressin, 50 mU/h. A third group of animals receiving no exogenous ADH acted as controls. 2. Chronic ADH treatment led to more profound concentration of the urine and antidiuresis than acute treatment, due to enhanced extraction of water in the renal medulla. 3. Fractional sodium excretion during this protocol was increased after 'acute' but not 'chronic' ADH treatment. The acute natriuretic response was brought about principally along the length of the proximal tubule, probably due to volume expansion and increased arterial blood pressure. 4. Fractional excretion of potassium was also increased by 'acute' ADH, but this response was due to stimulation of potassium secretion in the late distal tubule. 5. It is concluded that acute and chronic exposure to ADH have different effects on nephron function, as a result of both direct and indirect actions.


Field MJ,Seow F,Lawrence JR




Has Abstract


1989-02-01 00:00:00












  • Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker.

    abstract::1. Emotional stress is one of the aetiologies of cardiac accidents, but the precise mechanisms remain to be elucidated. In the present study we used the immobilization stress model in rats to investigate electrocardiographic (ECG) changes. 2. A rapid elevation of the ST segment at the II, III, aVF and precordial leads...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ueyama T,Yoshida K,Senba E

    更新日期:2000-05-01 00:00:00

  • Microcomputer statistics packages for biomedical scientists.

    abstract::1. There are hundreds of commercially available microcomputer statistics packages, ranging from the very cheap and elementary to the very expensive and complex, and from the very general to the very specialized. This review covers only those that appear to be popular with biomedical investigators who deal with fairly ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ludbrook J

    更新日期:1995-12-01 00:00:00

  • The many essential interfaces of clinical pharmacology.

    abstract::1. Clinical pharmacology requires numerous skills and most activities involve interactions with other specialities, both clinical and experimental. 2. A range of experts has had a major influence on the nature and design of my research, which is illustrated by the evolution of my knowledge of adverse drug reactions an...

    journal_title:Clinical and experimental pharmacology & physiology



    authors: Shenfield GM

    更新日期:2001-11-01 00:00:00

  • NAMPT -3186C/T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus.

    abstract::1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sheng FF,Dai XP,Qu J,Lei GH,Lu HB,Wu J,Xu XJ,Pei Q,Dong M,Liu YZ,Zhou HH,Liu ZQ

    更新日期:2011-08-01 00:00:00

  • Effects of phytoncides on blood pressure under restraint stress in SHRSP.

    abstract::1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kawakami K,Kawamoto M,Nomura M,Otani H,Nabika T,Gonda T

    更新日期:2004-12-01 00:00:00

  • Dual nitric oxide mechanisms of cholestasis-induced bradycardia in the rat.

    abstract::1. Cholestatic liver disease is associated with nitric oxide (NO) overproduction and bradycardia. Nitric oxide has a dual effect on sinoatrial node and its effects depend on its concentration. Nitric oxide can increase heart rate by activating hyperpolarization-activated pacemaker current (If) but, at high concentrati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Mani AR,Nahavandi A,Moosavi M,Safarinejad R,Dehpour AR

    更新日期:2002-10-01 00:00:00

  • Amelioration of cardiac function in chronic myocardial infarcted rats following administration of vector pcDNA3.1AM.

    abstract::1. The present study was designed to examine the cardiovascular effects of intravenously administered pcDNA3.1AM, a recombinant non-virus vector carrying a rat adrenomedullin (AM) gene translation fragment, in rats with chronic cardiac dysfunction induced by ligation of the left descending coronary artery. 2. Haemodyn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang XF,Shao Y,Chen SW,Tian DZ,Huang GY,Huang Y,Yao T,Lu LM

    更新日期:2007-09-01 00:00:00

  • Ion channels, long QT syndrome and arrhythmogenesis in ageing.

    abstract::Ageing is associated with increased prevalences of both atrial and ventricular arrhythmias, reflecting disruption of the normal sequence of ion channel activation and inactivation generating the propagated cardiac action potential. Experimental models with specific ion channel genetic modifications have helped clarify...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Jeevaratnam K,Chadda KR,Salvage SC,Valli H,Ahmad S,Grace AA,Huang CL

    更新日期:2017-12-01 00:00:00

  • Continuous fluoxetine administration prevents recurrence of pulmonary arterial hypertension and prolongs survival in rats.

    abstract::1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhu SP,Mao ZF,Huang J,Wang JY

    更新日期:2009-08-01 00:00:00

  • Efferent mechanisms responsible for the bradycardia produced by lesions coinciding with the A1 group of central catecholamine neurons in the conscious rabbit.

    abstract::The effector mechanisms responsible for the bradycardia evoked by bilateral lesions of the brainstem coinciding with the A1 catecholamine cells were analyzed in four groups of rabbits. Sham or lesion operations were carried out in animals with intact cardiac effectors, with cardiac sympathetic block induced by propran...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Denoroy L,West MJ,Chalmers J

    更新日期:1984-03-01 00:00:00

  • Regional brain activation in humans during respiratory and blood pressure challenges.

    abstract::1. The aim of the present study was to determine the brain sites mediating aspects of respiratory and cardiovascular control in adult humans using non-invasive functional magnetic resonance (fMRI) procedures, thereby avoiding the spatial and temporal sampling limitations associated with classic neural assessment techn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Harper RM,Gozal D,Bandler R,Spriggs D,Lee J,Alger J

    更新日期:1998-06-01 00:00:00

  • Role of brain prostanoids in glucagon-like peptide-1-induced central activation of sympatho-adrenomedullary outflow in rats.

    abstract::1. The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. 2. Glucagon-like peptide-1 and other compounds were administered intracerebroventricularly (i.c.v....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

    更新日期:2008-08-01 00:00:00

  • Lipidomics reveals the dynamics of lipid profile altered by omega-3 polyunsaturated fatty acid supplementation in healthy people.

    abstract::Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

    更新日期:2020-07-01 00:00:00

  • A novel model of constrictive pericarditis associated with myocardial fibrosis in rats.

    abstract::An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

    更新日期:2020-12-21 00:00:00

  • Capsazepine partially inhibits neurally mediated gastric mucus secretion following activation of protease-activated receptor 2.

    abstract::1. Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection. 2. We studied the possible cross-talk between PAR2 and vanilloid receptor 1 (VR1). The VR1 antagonist capsazepine partially inhibited the PAR2-mediated increase in gastri...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kawabata A,Kinoshita M,Kuroda R,Kakehi K

    更新日期:2002-04-01 00:00:00

  • Erlotinib activates mitochondrial death pathways related to the production of reactive oxygen species in the human non-small cell lung cancer cell line A549.

    abstract::1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

    更新日期:2009-05-01 00:00:00

  • Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro.

    abstract::1. It has been suggested that Na+/K(+)-ATPase and Na(+)-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K(+)-ATPase activity using Rb+ uptake by 'minislices' (prisms) of the cerebral cortex. This preparation preserves the morphology of neurons, sy...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nanitsos EK,Acosta GB,Saihara Y,Stanton D,Liao LP,Shin JW,Rae C,Balcar VJ

    更新日期:2004-11-01 00:00:00

  • Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species.

    abstract::  NADPH oxidases (Nox) are reactive oxygen species (ROS)-generating enzymes that play important physiological roles in host defence and redox signalling. However, Nox activity is upregulated in the vascular wall during atherosclerosis and contributes to plaque formation by promoting oxidative stress and inflammation. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Rivera J,Walduck AK,Strugnell RA,Sobey CG,Drummond GR

    更新日期:2012-03-01 00:00:00

  • Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats.

    abstract::1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

    更新日期:2008-07-01 00:00:00

  • Alteration of fexofenadine disposition in the rat isolated perfused liver following injection of bacterial lipopolysaccharide.

    abstract::1. The aim of the present study was to examine the effect of bacterial lipopolysaccharide (LPS) on the disposition of an organic anion transporting polypeptide and P-glycoprotein substrate in the rat isolated perfused liver. 2. Male Sprague-Dawley rats were divided into four groups. Three of the groups received 1, 2.5...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tong Y,Zhang R,Ngo SN,Davey AK

    更新日期:2006-08-01 00:00:00

  • Renal prostaglandin efflux induced by vasopressin, dDAVP and arachidonic acid: contrasting profile and sites of release.

    abstract::Prostaglandin (PG) efflux into ureteral (UE) and venous effluents (VE) of rabbit isolated perfused kidneys was determined by superfusion bioassay and radioimmunoassay (RIA), in response to injections of arginine-vasopressin (AVP), the non-pressor vasopressin analogue 1-deamino-8-D-arginine vasopressin (dDAVP) and arac...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Miller MJ,Westlin WF,McNeill H,McGiff JC

    更新日期:1986-08-01 00:00:00

  • Molecular regulation of skeletal muscle mass.

    abstract::1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Russell AP

    更新日期:2010-03-01 00:00:00

  • Nitric oxide as a metabolic regulator during exercise: effects of training in health and disease.

    abstract::1. Accumulating animal and human data suggest that nitric oxide (NO) is important for both coronary and peripheral haemodynamic control and metabolic regulation during performance of exercise. 2. While still controversial, NO of endothelial origin is thought to potentiate exercise-induced hyperaemia, both in the perip...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Kingwell BA

    更新日期:2000-04-01 00:00:00

  • Autoradiographic analysis of (-)-[125I]-CYP binding in mouse kidney.

    abstract::The distribution and binding characteristics of the radioligand (-)-[125I]-cyanopindolol (CYP) have been examined in slide mounted mouse kidney sections, using the technique of in vitro labelling and autoradiography. (-)-[125I]-CYP binding to sections was of high affinity (KD = 55.8 pmol/l, s.e.m. = 8.1, n = 4) to a s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lew R,Summers RJ

    更新日期:1986-03-01 00:00:00

  • Oestrogen receptors and cardiovascular disease.

    abstract::1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Baysal K,Losordo DW

    更新日期:1996-06-01 00:00:00

  • The euglycaemic hyperinsulinaemic clamp: an evaluation of current methodology.

    abstract::1. The recognition of the role of insulin resistance in disease states and the recent development of new drugs that modify insulin-dependent metabolism has led to increased use of the euglycaemic hyperinsulinaemic clamp to measure in vivo insulin sensitivity, but several key aspects of the technique are poorly documen...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Morris AD,Ueda S,Petrie JR,Connell JM,Elliott HL,Donnelly R

    更新日期:1997-07-01 00:00:00

  • Progesterone antagonizes development but not maintenance of ACTH-induced hypertension in sheep.

    abstract::1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

    更新日期:1989-08-01 00:00:00

  • Dose-dependent effect of alcohol on insulin-like growth factor systems in male rats.

    abstract::1. Chronic alcohol treatment has been reported to be associated with liver and kidney damage. The insulin-like growth factor (IGF) is the major growth factor related to alcohol consumption. However, the effect of alcohol on the IGF system in the liver and kidney has not been fully elucidated. Thus, the present study w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Park SH,Heo JS,Kang CW

    更新日期:2004-01-01 00:00:00

  • Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase.

    abstract::1. Reactive oxygen species (ROS) are a diverse family of molecules that are produced throughout the vascular wall. Many ROS, such as the superoxide anion (*O2-) and hydrogen peroxide (H2O2), are now known to act as cellular signalling molecules within blood vessels. In particular, these molecules can exert powerful ef...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Paravicini TM,Sobey CG

    更新日期:2003-11-01 00:00:00

  • Control of intravascular volume during pregnancy.

    abstract::1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kaufman S

    更新日期:1995-02-01 00:00:00