Inhibition of NO synthesis has an additive effect on hypertension induced by ACTH in conscious rats.

abstract：:1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

更新日期：2001-10-01 00:00:00

abstract：:1. To assess the effect of dietary phytosterol on stroke and the lifespan of salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), we investigated the effects of the addition of phytosterol to soybean oil (phytosterol content: 0.3%) on stroke onset, lifespan following onset of stroke and overall lifespan c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ogawa H,Yamamoto K,Kamisako T,Meguro T

更新日期：2003-12-01 00:00:00

abstract：:1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo r...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston H

更新日期：1992-05-01 00:00:00

abstract：:1. Nitric oxide (NO), or peroxynitrite, is known to inhibit haemoproteins, including cytochrome P450 mono-oxygenases. The present study explores the functional correlates of the inhibition by NO of renal epoxygenase on the vascular responses to arachidonic acid (AA) in the perfused kidney. 2. Control kidneys produce m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oyekan A

更新日期：2002-11-01 00:00:00

abstract：:1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ratan RR,Baraban JM

更新日期：1995-04-01 00:00:00

abstract：:1. The effects of ethacrynic acid were studied on relaxations elicited by nitric oxide (NO), the NO-donors sodium nitroprusside (SNP) and glyceryl trinitrate (GTN), nitrergic nerve stimulation and the NO-independent agent papaverine in isolated preparations of rat anococcygeus muscles. 2. Ethacrynic acid (100 mumol/L)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Brosch SF,Rand MJ

更新日期：1994-04-01 00:00:00

abstract：:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang X,Jia Z,Shi H,Pan C

更新日期：2018-10-01 00:00:00

abstract：:1. The present review describes the actions of sensory neuropeptides on the contractility of the rat and guinea-pig prostate gland and discusses the differences in sensitivity of the smooth muscle of the prostates taken from these species to these neuropeptides. 2. Nerve fibres immunoreactive for the tachykinins subst...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,Lau WA,Buljubasich S,Pennefather JN

更新日期：2000-11-01 00:00:00

abstract：:1. We tested the effects of intravenous infusions of angiotensin II (AngII; 300 ng/kg per min) and the vasopressin V1 receptor agonist [Phe2,Ile3,Orn8]-vasopressin (30 ng/kg per min) on regional kidney perfusion in an extracorporeal circuit model in anaesthetized rabbits in which renal artery pressure (RAP) can be set...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evans RG,Correia AG,Weekes SR,Madden AC

更新日期：2000-12-01 00:00:00

abstract：:1. The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction. 2. Japanese white rabbits underwent 30 min of coronary occlusion, followed by 48 h of reperfusion. Cilostazol (1 and 5 mg/kg) or vehicle was given intr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bai Y,Muqier,Murakami H,Iwasa M,Sumi S,Yamada Y,Ushikoshi H,Aoyama T,Nishigaki K,Takemura G,Uno B,Minatoguchi S

更新日期：2011-10-01 00:00:00

abstract：:1. The present review focuses on some of the processes producing rhythms in sympathetic nerves influencing cardiovascular functions and considers their potential relevance to nervous integration. 2. Two mechanisms are considered that may account for rhythmic sympathetic discharges. First, neuronal elements of peripher...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gilbey MP

更新日期：2007-04-01 00:00:00

abstract：:1. There has been interest in the suggestion that enzyme-inducing drugs, such as anticonvulsants, may produce beneficial changes in lipoprotein levels, in particular a rise in the ratio of high density lipoprotein cholesterol to total cholesterol. 2. This controlled study observed the effects of diets of charcoal or o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Heller RF,Henry DA,Brent PJ

更新日期：1989-10-01 00:00:00

abstract：:The efficacy of streptokinase as an intracoronary thrombolytic agent is well-recognized. The effect of streptokinase, distinct from its thrombolytic action, on ischaemic myocardium distal to an area of coronary artery occlusion when reperfusion occurs has not been well-defined. In order to do this, myocardial creatine...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mickelson JK,Carlson CJ,Margaretten W,Rapaport E

更新日期：1986-09-01 00:00:00

abstract：:1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

更新日期：2003-07-01 00:00:00

abstract：:1. The aim of the present study was to assess the bioequivalence of two cefadroxil products, namely Ultracef (a reference product) in the form of a 500 mg capsule (produced by Bristol-Myers Squibb Laboratories, Princeton, NJ, USA) and Roxil (a test product) in the form of a 500 mg capsule (produced by Tabuk Pharmaceut...

journal_title：Clinical and experimental pharmacology & physiology

authors： Otoom S,Hasan M,Najib N

更新日期：2004-07-01 00:00:00

abstract：:The activity of dopamine-beta-hydroxylase (D beta H) in the serum was measured in patients with quadriplegia and in healthy subjects. We assume that the plasma D beta H levels reflect sympathetic tone. Quadriplegics had significantly lower D beta H levels at rest. After head-up tilting a significant decrease in D beta...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ohry A,Rabinowitz R,Korczyn AD

更新日期：1980-07-01 00:00:00

abstract：:C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

更新日期：2020-06-01 00:00:00

abstract：:Studies in rats have shown that neomycin administration attenuates certain types of adrenocortical steroid dependent hypertension, including ACTH hypertension. The effects of oral neomycin on ACTH induced hypertension were examined in conscious sheep. Neomycin has no effect on the blood pressure or metabolic responses...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tresham J,Coghlan JP,Denton DA,Scoggins BA,Whitworth JA

更新日期：1984-11-01 00:00:00

abstract：:1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with vario...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mamo JC,Yu KC,Elsegood CL,Smith D,Vine D,Gennat HC,Voevodin M,Proctor SD

更新日期：1997-03-01 00:00:00

abstract：:1. The effect of bromocriptine (a prolactin suppressant drug) on the serum levels of calcium was studied in the male rat. The drug was administered subcutaneously at a dosage of 100 microgram per 100 g body weight three times per day. 2. Chronic treatment with bromocriptine had no significant effect on the serum calci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan CM,Tan GJ

更新日期：1978-09-01 00:00:00

abstract：:Ulcerative colitis is a major form of inflammatory bowel disease and increases the risk of the development of colorectal carcinoma. The anti-inflammatory and immunomodulatory properties of mesenchymal stem cells (MSC) make them promising tools for treating immune-mediated and inflammatory diseases. However, the lack o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lin Y,Lin L,Wang Q,Jin Y,Zhang Y,Cao Y,Zheng C

更新日期：2015-01-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa T

更新日期：1986-01-01 00:00:00

abstract：:1. To determine whether total interruption of the local cardiac renin-angiotensin system by angiotensin II (AngII) receptor antagonist limits myocardial ischaemia, intracoronary (i.c.) or intravenous (i.v.) infusion of AngII receptor antagonists was compared in ischaemic dogs. 2. Dogs subjected to 90 min coronary arte...

journal_title：Clinical and experimental pharmacology & physiology

authors： So T,Nakashima Y,Imamura M,Arakawa K

更新日期：1998-07-01 00:00:00

abstract：:1. Sulfur dioxide (SO(2) ) has recently been found to have various biological effects on the cardiovascular system. The present study was designed to explore the effects of SO(2) derivatives on the L-type calcium current (I (Ca, L) ) in isolated rat ventricular cardiomyocytes. 2. A Langendorf system was used to dissoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang RY,Du JB,Sun Y,Chen S,Tsai HJ,Yuan L,Li L,Tang CS,Jin HF

更新日期：2011-07-01 00:00:00

abstract：:1. Oxygen (O2) transfer from the blood to tissues is a function of the red blood cell (RBC) O2 saturation (SO2), the plasma O2 content being negligible. Under conditions of increased tissue O2 demand, the SO2 of arterial blood does not change appreciably (97%); however, the SO2 of mixed venous blood, equal to that of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Buchwald H,O'Dea TJ,Menchaca HJ,Michalek VN,Rohde TD

更新日期：2000-12-01 00:00:00

abstract：:1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sendeski MM

更新日期：2011-05-01 00:00:00

abstract：:1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP-sensitive K+ (KATP) channel opening property in its cardioprotective action. 2. In open-chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion followed by 30 min of reperfu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwamoto T,Miura T,Urabe K,Itoya M,Shimamoto K,Iimura O

更新日期：1993-09-01 00:00:00

abstract：:1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wu S,Li Q,Du M,Li SY,Ren J

更新日期：2007-01-01 00:00:00

abstract：:1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hishinuma S,Matsumoto Y,Sato R,Saito M

更新日期：2007-01-01 00:00:00