Cardiac baroreflexes and hypertension.

Abstract:

:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the baroreceptor-heart rate reflex has diminished sensitivity due mainly to reduced maximum capacity of the cardiac vagal component rather than a change to the sympathetic. 3. The development of this vagal deficit in spontaneously hypertensive rats (SHR) coincides with the onset of cardiac hypertrophy rather than vascular hypertrophy. A combination of chronic perindopril treatment regimens in young and older SHR showed that the vagal deficit was better correlated with the degree of cardiac hypertrophy than with other variables such as blood pressure, hypertension or indices of vascular hypertrophy. Similar results have been shown for renovascular hypertension in rats. 4. The bradycardia produced by electrical stimulation of the vagus in urethane anaesthetized young SHR was enhanced compared to Wistar-Kyoto rats (WKY) while responses observed in adult SHR and WKY were similar, suggesting that the vagal deficit in hypertensive rats is not due to a defect in the efferent arm of the baroreflex. 5. The association of the vagal deficit with cardiac hypertrophy, but not with the vagal efferent pathways, suggests an important role for cardiac afferents in hypertension in mediating the baroreflex deficit. 6. A diminished baroreflex and also a reduced heart rate variability is an independent risk factor for sudden death following myocardial infarction. Thus, antihypertensive therapy, which more effectively reduces cardiac hypertrophy, should have a desirable effect on baroreceptor reflexes and therefore in reducing blood pressure variability.

authors

Head GA

doi

10.1111/j.1440-1681.1994.tb02448.x

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

791-802

issue

10

eissn

0305-1870

issn

1440-1681

journal_volume

21

pub_type

杂志文章,评审
  • Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.

    abstract::1. Metformin is one of the most commonly used drugs for the treatment of Type 2 diabetes. Accumulating evidence suggests that metformin also has cardioprotective effects. In the present study, we investigated the cardioprotective effects of metformin and the mechanisms involved. 2. A rat model of chronic heart failure...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2010.05470.x

    authors: Wang XF,Zhang JY,Li L,Zhao XY,Tao HL,Zhang L

    更新日期:2011-02-01 00:00:00

  • Multiple inferences using confidence intervals.

    abstract::1. In a recent review article, the problem of making false-positive inferences as a result of making multiple comparisons between groups of experimental units or between experimental outcomes was addressed. 2. It was concluded that the most universally applicable solution was to use the Ryan-Holm step-down Bonferroni ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2000.03223.x

    authors: Ludbrook J

    更新日期:2000-03-01 00:00:00

  • Engineering imaging: using particle image velocimetry to see physiology in a new light.

    abstract::1. Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution. 2. Herein, we introduc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2008.05102.x

    authors: Fouras A,Dusting J,Sheridan J,Kawahashi M,Hirahara H,Hourigan K

    更新日期:2009-02-01 00:00:00

  • Paradoxical cardiovascular response to visceral afferent stimulation in the established spontaneously hypertensive rat.

    abstract::Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1985.tb00300.x

    authors: Koyama S,Manning JW

    更新日期:1985-01-01 00:00:00

  • Chaotic characteristics of renal nerve peak interval sequence in normotensive and hypertensive rats.

    abstract::1. The use of non-linear dynamic analysis for the measurement of control processes in low-dimensional signals, for example, blood pressure and heart rate variability, are well established and accepted. However, the application of these analytical techniques to a high-dimensional signal, such as renal sympathetic nerve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02340.x

    authors: Zhang T,Johns EJ

    更新日期:1998-11-01 00:00:00

  • Sympathoinhibitory action of nociceptin in the rat spinal cord.

    abstract::1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03635.x

    authors: Brailoiu GC,Lai CC,Chen CT,Hwang LL,Lin HH,Dun NJ

    更新日期:2002-03-01 00:00:00

  • Effects of pyruvate on intracellular Ca2+ regulation in cardiac myocytes from normal and diabetic rats.

    abstract::1. Pyruvate has been shown to enhance the contractile performance of cardiac muscle when provided as an alternative substrate to glucose. The aims of the present study were to determine whether the inotropic effects of pyruvate are due to increased mobilization of intracellular Ca2+ ([Ca2+]i) and to compare the effect...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.1999.03161.x

    authors: Mellors LJ,Kotsanas G,Wendt IR

    更新日期:1999-11-01 00:00:00

  • Autacoid interactions in the regulation of blood flow in the human placenta.

    abstract::1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02280.x

    authors: Gude NM,King RG,Brennecke SP

    更新日期:1998-09-01 00:00:00

  • Effects of local inhibition of the cardiac renin-angiotensin system with CV-11974 in a canine ischaemia-reperfusion model.

    abstract::1. To determine whether total interruption of the local cardiac renin-angiotensin system by angiotensin II (AngII) receptor antagonist limits myocardial ischaemia, intracoronary (i.c.) or intravenous (i.v.) infusion of AngII receptor antagonists was compared in ischaemic dogs. 2. Dogs subjected to 90 min coronary arte...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02243.x

    authors: So T,Nakashima Y,Imamura M,Arakawa K

    更新日期:1998-07-01 00:00:00

  • Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods.

    abstract::Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13402

    authors: Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

    更新日期:2020-09-05 00:00:00

  • Demonstration of hereditarily accelerated proliferation in astrocytes derived from spontaneously hypertensive rats.

    abstract::1. We examined the proliferative rates of cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR). Wistar-Kyoto rats (WKY) were used as a control for SHRSP and SHRSR. 2. In the presence of 10% fetal bovine serum (FBS), the doub...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1995.tb02073.x

    authors: Yamagata K,Nara Y,Tagami M,Yamori Y

    更新日期:1995-09-01 00:00:00

  • Cyp2c19 genotype and omeprazole hydroxylation phenotype in Chinese Li population.

    abstract::1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04583.x

    authors: Wang JH,Li PQ,Fu QY,Li QX,Cai WW

    更新日期:2007-05-01 00:00:00

  • Mechanisms underlying biochanin A-induced relaxation of the aorta differ between normotensive and hypertensive rats.

    abstract::1. The aim of the present study was to investigate the mechanism underlying biochanin A-induced relaxation of the aorta in spontaneously hypertensive rats (SHR). 2. The tension in isolated ring preparations of thoracic aortas from normotensive (Wistar-Kyoto (WKY) rats) and SHR at 5 and 10 weeks of age was measured iso...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04443.x

    authors: Wang HP,Gao Q,Mei RH,Zhao MH,Lu Y,Li XY,Bruce IC,Xia Q

    更新日期:2006-09-01 00:00:00

  • Effect of pregnancy in the rabbit on the pressor response to angiotensin and noradrenaline.

    abstract::The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1985.tb00911.x

    authors: Joels N,Humphreys PW

    更新日期:1985-11-01 00:00:00

  • Blood volume measurements in the neonatal lamb: validation of a method using [51Cr]-labelled red cells.

    abstract::1. The reproducibility of blood volume measurements, using [51Cr]-labelled red blood cells (RBC) was tested in three lambs, 79-89 days of age, and the accuracy was tested in eight lambs, 83 +/- 0.4 days of age, in which blood volume was measured simultaneously by [51Cr]-RBC and [125I]-gamma globulin plus haematocrit (...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02557.x

    authors: Moritz KM,Potocnik SJ,Tangalakis K,Wintour EM

    更新日期:1994-07-01 00:00:00

  • Antihyperglycaemic and anti-oxidant properties of Anoectochilus formosanus in diabetic rats.

    abstract::1. In the present study, we investigated aqueous extracts of Anoectochilus formosanus (AFE) for antihyperglycaemic and anti-oxidant effects in diabetic rats induced by streptozotocin (STZ). 2. Diabetic rats were randomly divided into groups and treated orally by gavage with vehicle (distilled water) or AFE (1 and 2 g/...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03717.x

    authors: Shih CC,Wu YW,Lin WC

    更新日期:2002-08-01 00:00:00

  • Postnatal outcomes in term and preterm lambs following fetal growth restriction.

    abstract::1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2001.03552.x

    authors: Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

    更新日期:2001-11-01 00:00:00

  • Dalteparin dose-dependently increases ROTEM(®) thrombelastography parameters only at supratherapeutic anti-factor Xa levels: an in vitro study.

    abstract::1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05593.x

    authors: Feuring M,Wehling M,Schultz A

    更新日期:2011-11-01 00:00:00

  • Ca2+-dependent differential development of carbachol-induced desensitization to receptor agonists and high K+ in guinea-pig taenia caeci.

    abstract::1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04530.x

    authors: Hishinuma S,Matsumoto Y,Sato R,Saito M

    更新日期:2007-01-01 00:00:00

  • Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia-inducible factors HIF1α and HIF2α.

    abstract::Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12693

    authors: Schöning JP,Monteiro M,Gu W

    更新日期:2017-02-01 00:00:00

  • Antihypertensive effects of DL-tetrahydropalmatine: an active principle isolated from Corydalis.

    abstract::1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1996.tb01769.x

    authors: Lin MT,Chueh FY,Hsieh MT,Chen CF

    更新日期:1996-08-01 00:00:00

  • Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension.

    abstract::According to Guyton's model, impaired renal sodium excretion plays a key role in the increased salt sensitivity of blood pressure (BP). Several factors contribute to impaired renal sodium excretion, including the sympathetic nervous system, the renin-angiotensin system and aldosterone. Accumulating evidence suggests t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.12177

    authors: Kawarazaki W,Fujita T

    更新日期:2013-12-01 00:00:00

  • Effect of acute administration of prazosin on blood pressure, heart rate and plasma renin level in the conscious normotensive rat.

    abstract::This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Furthermore the beta-adrenergic nervous system was also investigated to ascertain whether it was involved in this effect. Prazosin (0.1 or 1 mg/kg) was injected subcutaneously (s.c.) to conscio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1986.tb00936.x

    authors: Atkinson J,Luthi P,Sonnay M,Boillat N

    更新日期:1986-07-01 00:00:00

  • Pharmacodynamics of levodopa in Parkinson's disease.

    abstract::1. Levodopa markedly reduces parkinsonism during the first years of treatment. However, with continued therapy the response to levodopa becomes erratic and is complicated by involuntary movements. To improve the therapy of parkinsonism, the challenge is to understand why fluctuations in response develop and, once deve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1995.tb01946.x

    authors: Nutt JG

    更新日期:1995-11-01 00:00:00

  • Fixed dose of long-acting erythropoietic stimulating agents at higher frequency improves appetite, reduces inflammation and corrects anaemia in patients on haemodialysis.

    abstract::Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/1440-1681.12618

    authors: Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

    更新日期:2016-10-01 00:00:00

  • Uneven changes in circulating blood cell counts with adrenergic stimulation to the canine spleen.

    abstract::1. Responses of splenic diameter measured by sonomicrometry to alpha- and beta-adrenoceptor stimulants were estimated together with simultaneously measured systemic arterial and splenic venous concentrations of red blood cells (RBC), white blood cells (WBC) and platelets (PLT) in anaesthetized dogs. 2. Intravenous and...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03598.x

    authors: Ojiri Y,Noguchi K,Shiroma N,Matsuzaki T,Sakanashi M,Sakanashi M

    更新日期:2002-01-01 00:00:00

  • Pathophysiology of renal tissue damage by iodinated contrast media.

    abstract::1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05503.x

    authors: Sendeski MM

    更新日期:2011-05-01 00:00:00

  • Electrophysiological evidence for the interaction of substance P and glutamate on Adelta and C afferent fibre activity in rat hairy skin.

    abstract::1. The purpose of the present study was to investigate whether there was a cooperative interaction between substance P (SP) and glutamate (GLU) administered subcutaneously on Adelta and C primary afferent fibre activity in dorsal hairy skin of the rat in vivo. The single unit activities of Adelta and C afferent fibres...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04504.x

    authors: Zhang Q,Zhao Y,Guo Y,Cao DY,Tian YL,Yao FR,Wang HS

    更新日期:2006-12-01 00:00:00

  • Genetic factors regulate the rise in blood pressure in F2 generation crossed between stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.

    abstract::1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1991.tb01631.x

    authors: Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

    更新日期:1991-09-01 00:00:00

  • Gap junction and tissue invasion: a comparison of tumorigenesis and pregnancy.

    abstract::1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1996.tb01169.x

    authors: Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R

    更新日期:1996-12-01 00:00:00