Rilmenidine acts as a partial agonist at prejunctional alpha 2-adrenoceptors in guinea-pig atria.

abstract：:1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

更新日期：1994-05-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:1. The endogenous production of and/or the bioavailability of nitric oxide (NO) is decreased in pulmonary hypertensive diseases. L-arginine (L-arg) is the substrate for NO synthase (NOS). L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui H,Chen B,Chicoine LG,Nelin LD

更新日期：2011-12-01 00:00:00

abstract：:1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nord EP

更新日期：1996-04-01 00:00:00

abstract：:1. Amino acid neurotransmitters are critical for controlling the activity of most central neurons, including sympathetic preganglionic neurons (SPN), the spinal cord neurons involved in controlling blood pressure and other autonomic functions. 2. In studies reviewed here, SPN were identified either by retrograde traci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Llewellyn-Smith IJ

更新日期：2002-05-01 00:00:00

abstract：:1. The object of this study was to determine whether meat protein per se is responsible for the higher blood pressures (BP) in omnivores compared with vegetarians. 2. Assessments were made by a double blind randomized control trial in 64 normotensive volunteers recruited from Royal Perth Hospital staff. 3. All volunte...

journal_title：Clinical and experimental pharmacology & physiology

authors： Prescott SL,Jenner DA,Beilin LJ,Margetts BM,Vandongen R

更新日期：1987-03-01 00:00:00

abstract：:1. Nitric oxide (NO) is an important mediator of contractile function in the heart. However, isolated papillary muscle preparations appear to lack NO responsiveness in certain animal species. Although cat, guinea-pig and ferret models have been NO responsive, there have been mixed results in the rat papillary muscle. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Worthley MI,Horowitz JD,Zeitz CJ

更新日期：2005-07-01 00:00:00

abstract：:1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lüllmann H,Peters T

更新日期：1977-01-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine-containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control inf...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macdonald G,Assef R,Watkins S,Burrell J

更新日期：1987-03-01 00:00:00

abstract：:Nowadays, tramadol hydrochloride is frequently used as a pain reliever, and for the treatment of premature ejaculation. Decreased semen quality was noted in chronic tramadol users. The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats. A total of 40 albino adult ma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ahmed MA,Kurkar A

更新日期：2014-04-01 00:00:00

abstract：:1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abdulla EM,Calaminici M,Campbell IC

更新日期：1995-05-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. Oxygen (O2) transfer from the blood to tissues is a function of the red blood cell (RBC) O2 saturation (SO2), the plasma O2 content being negligible. Under conditions of increased tissue O2 demand, the SO2 of arterial blood does not change appreciably (97%); however, the SO2 of mixed venous blood, equal to that of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Buchwald H,O'Dea TJ,Menchaca HJ,Michalek VN,Rohde TD

更新日期：2000-12-01 00:00:00

abstract：:1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

journal_title：Clinical and experimental pharmacology & physiology

authors： Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

更新日期：1994-12-01 00:00:00

abstract：:1. Altered calcium regulation has been observed in experimental and human hypertension. In this study erythrocyte (RBC) intracellular calcium concentration ([Ca2+]i) was compared in conscious spontaneously hypertensive rats (SHR) and their normotensive controls (WKY) at rest and after injection of the dihydropyridine ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris MJ,David-Dufilho M,Devynck MA

更新日期：1988-04-01 00:00:00

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:1. L-Type Ca2+ channels play important roles in cardiac excitation and conduction. The present study used the whole-cell patch-clamp technique to investigate properties of Ca2+ channels in guinea-pig isolated ventricular myocytes. The effects of internal application of the proteolytic enzymes trypsin and carboxypeptid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dooley PC,Hancox JC,Chapman RA

更新日期：1999-02-01 00:00:00

abstract：:1. Acute myocardial infarction (AMI) is strongly associated with atherosclerosis, and is responsible for significant morbidity and mortality worldwide. The pathogenic mechanisms that underlie atherosclerosis and AMI are undefined at present. The calcium-sensing receptor (CaSR) is a member of the superfamily of G-prote...

journal_title：Clinical and experimental pharmacology & physiology

authors： Guo J,Li HZ,Zhang WH,Wang LC,Wang LN,Zhang L,Li GW,Li HX,Yang BF,Wu L,Wang R,Xu CQ

更新日期：2010-03-01 00:00:00

abstract：:1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sendeski MM

更新日期：2011-05-01 00:00:00

abstract：:1. Cardiovascular events and outcome in septic shock may be predicted by monitoring the fall in intramural pH (pHi), as an index of splanchnic perfusion and mucosal ischaemia. In the present study, a small animal model for monitoring the changes of gastric pHi or intramucosal [H+] following challenge with the endotoxi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lamarque D,Whittle BJ

更新日期：2001-03-01 00:00:00

abstract：:1. The purpose of the present study was to investigate whether there was a cooperative interaction between substance P (SP) and glutamate (GLU) administered subcutaneously on Adelta and C primary afferent fibre activity in dorsal hairy skin of the rat in vivo. The single unit activities of Adelta and C afferent fibres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Q,Zhao Y,Guo Y,Cao DY,Tian YL,Yao FR,Wang HS

更新日期：2006-12-01 00:00:00

abstract：:Alcohol-induced hypertension is well recognized with clear evidence for a direct pressor effect of chronic alcohol consumption provided by a number of intervention studies in humans. In experimental animals, the effect of alcohol on blood pressure is less consistent; however, in Sprague-Dawley rats, alcohol feeding co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cowpland C,Su GM,Murray M,Puddey IB,Croft KD

更新日期：2006-03-01 00:00:00

abstract：:1. Total fluid and saline intakes were greater in spontaneously hypertensive rats (SHR) than in normotensive rats (NTR). 2. Total fluid and saline intake were significantly elevated in prehypertensive SHR, 5 weeks old, compared with age-matched NTR, and the intakes fell with age in both strains but remained considerab...

journal_title：Clinical and experimental pharmacology & physiology

authors： May CN,Parsons BJ

更新日期：1983-01-01 00:00:00

abstract：:1. Nitric oxide (NO), or peroxynitrite, is known to inhibit haemoproteins, including cytochrome P450 mono-oxygenases. The present study explores the functional correlates of the inhibition by NO of renal epoxygenase on the vascular responses to arachidonic acid (AA) in the perfused kidney. 2. Control kidneys produce m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oyekan A

更新日期：2002-11-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:1. Stroke is the second most common cause of death and a major cause of disability worldwide. Despite increasing knowledge of the cellular and molecular mechanisms that occur in stroke, there are still large gaps in our understanding that are impeding therapeutic progress. In addition, there are no drugs yet that can ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sun XL,Hu G

更新日期：2010-02-01 00:00:00

abstract：:1. The present study investigates the contribution of the sympathetic and vagal parasympathetic systems to the tachycardic response of long-lasting (40 min) conditioned fear responses to context. 2. The conditioned fear response evoked by re-exposure to a footshock chamber was tested 10 min after intravenous injection...

journal_title：Clinical and experimental pharmacology & physiology

authors： Carrive P

更新日期：2006-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. We foun...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fu X,Shen Y,Wang W,Li X

更新日期：2018-01-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00