Strategies of treating cancer by cytokine regulation of chromosome end remodelling.

abstract：:Diabetes is a major risk factor for cardiovascular disease, affecting both endothelial and smooth muscle cells. Store-operated Ca2+ channels (SOCCs) have been implicated in many diabetic complications. Vascular dysfunction is common in patients with diabetes, but the role of SOCCs in diabetic vasculopathy is still unc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Schach C,Wester M,Leibl F,Redel A,Gruber M,Maier LS,Endemann D,Wagner S

更新日期：2020-07-01 00:00:00

abstract：:1. Resistance changes of the afferent and efferent arterioles determine blood flow and filtration rate in the kidney. The tone of both vessels results from the influence of nerves and humoral and paracrine factors, through a balance of constrictor and dilator systems. Angiotensin (Ang) II and nitric oxide (NO) are imp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Patzak A,Lai E,Persson PB,Persson AE

更新日期：2005-05-01 00:00:00

abstract：:1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood...

journal_title：Clinical and experimental pharmacology & physiology

authors： Navakatikyan MA,Leonard BL,Evans RG,Malpas SC

更新日期：2000-08-01 00:00:00

abstract：:1. The effects of dietary sodium on blood pressure and levels of sodium, other electrolytes and noradrenaline (NA) in the cerebrospinal fluid (CSF) and blood of 15 patients with essential hypertension were studied. The CSF and blood sampling was carried out after 7 days of a high salt intake (16-18 g/day) and after 7 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawano Y,Yoshida K,Kawamura M,Yoshimi H,Ashida T,Abe H,Imanishi M,Kimura G,Kojima S,Kuramochi M

更新日期：1992-04-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:1. The concentration of methylguanidine and guanidinosuccinic acid has been measured in normal human plasma and discrepancies between various published methods for measuring methylguanidine have been resolved. Previous methods have been modified to allow these guanidines, together with guanidinoacetic acid and creatin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lazdins I,Dawborn JK

更新日期：1978-01-01 00:00:00

abstract：:Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Walweel K,Oo YW,Laver DR

更新日期：2017-01-01 00:00:00

abstract：:1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan GJ

更新日期：1980-05-01 00:00:00

abstract：:1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after Bordetella pertussis vaccination. In a long-t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Terpstra GK,Raaijmakers JA,Kreukniet J

更新日期：1979-03-01 00:00:00

abstract：:Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of differe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alkreathy HM,Alkhatib MH,Al Musaddi SA,Balamash KSA,Osman NN,Ahmad A

更新日期：2019-05-01 00:00:00

abstract：:1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

更新日期：2004-04-01 00:00:00

abstract：:Radiation-induced lung injury (RILI) is a serious complication in thoracic tumour radiotherapy. It often occurs in clinical chest radiotherapy and acute whole-body irradiation (WBI) caused by nuclear accidents or nuclear weapon attack. Some radioprotective agents have been reported to exert protective effects when giv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kun C,Tao L,Leiyuan H,Yunhao F,Ning W,Zhe L,Yuanyuan C,Xiao L,Hongran Q,Jianming C,Fu G,Yanyong Y

更新日期：2019-12-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:1. The aim of this study was to evaluate the role of endothelium in mediating the response to acetylcholine in the thoracic aorta and coronary vessels of rats exposed to cigarette smoking. Total serum cholesterol was measured at the beginning and end of the experiment. 2. The relaxation response to acetylcholine was s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jorge PA,Ozaki MR,Almeida EA

更新日期：1995-06-01 00:00:00

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00

abstract：:1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

更新日期：1997-09-01 00:00:00

abstract：:1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Willems L,Headrick JP

更新日期：2005-03-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. However, the functional expression of the components of this pathway in human disease has not been full...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dzimiri N,Basco C,Moorji A,Afrane B,Al-Halees Z

更新日期：2002-03-01 00:00:00

abstract：:1. Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krieger MH,Moreira ED,Oliveira EM,Oliveira VL,Krieger EM,Krieger JE

更新日期：2006-05-01 00:00:00

abstract：:1. The acute effects of captopril on blood pressure, renin, angiotensin, bradykinin and catecholamines were examined in patients with essential (n = 10, Group 1), accelerated (n = 6, Group 2) and renal hypertension (n = 14, Group 3). 2. Blood pressure showed little change in Group 1, fell significantly in Group 2, wit...

journal_title：Clinical and experimental pharmacology & physiology

authors： McGrath BP,Matthews PG,Johnston CI

更新日期：1980-09-01 00:00:00

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00

abstract：:1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomiyasu BA,Chen CJ,Marshall JM

更新日期：1988-09-01 00:00:00

abstract：:1. The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic index and shows considerable interindividual differences in its pharmacokinetics. Interindividual differences in the activity and expression of the metabolising enzymes...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu YF,Qiu W,Liu ZQ,Zhu LJ,Liu ZQ,Tu JH,Wang D,Li Z,He J,Zhong GP,Zhou G,Zhou HH

更新日期：2006-11-01 00:00:00

abstract：:1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

更新日期：1996-06-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00

abstract：:Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

更新日期：2017-07-01 00:00:00

abstract：:1. Nitric oxide (NO) synthase inhibitors and Paf antagonists abrogate hypotension in septic shock. The latter may act by blocking intracellular transduction mechanisms in vascular smooth muscle cells and inflammatory cells. We examined the effect of Paf antagonists on expression of inducible NO synthase. 2. A murine m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Arthur JF,Shahin S,Dusting GJ

更新日期：1995-06-01 00:00:00

abstract：:1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pickering TG,Schwartz JE,James GD

更新日期：1995-03-01 00:00:00