Diversity within pericytes.

abstract：:1. To assess the effect of dietary phytosterol on stroke and the lifespan of salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), we investigated the effects of the addition of phytosterol to soybean oil (phytosterol content: 0.3%) on stroke onset, lifespan following onset of stroke and overall lifespan c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ogawa H,Yamamoto K,Kamisako T,Meguro T

更新日期：2003-12-01 00:00:00

abstract：:1. Infections and related sepsis are two of the most prevalent issues in the care of critically ill patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate dosing, is important to improve the clinical outcome for these patients. 2. β-Lactams are the most common antibiotic class u...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sinnollareddy MG,Roberts MS,Lipman J,Roberts JA

更新日期：2012-06-01 00:00:00

abstract：:1. In rat isolated tail arteries and atria in which transmitter stores are labelled with (3H)-noradrenaline, isoprenaline in low concentrations facilitates the stimulation-induced efflux of tritium. 2. This effect is dependent on the frequency and duration of electrical stimulation, being observed only at low frequenc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Medgett IC,McCulloch MW,Rand MJ,Story DF

更新日期：1980-09-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a major disease that threatens human health. Neurotransmitters and the amygdala are found to be critical in the development and maintenance of PTSD. We aim to investigate the role of glycyrrhizin in treating PTSD. Contextual fear extinction and elevated plus maze test w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lai S,Shi L,Jiang Z,Lin Z

更新日期：2020-01-01 00:00:00

abstract：:1. Obstruction of the upper airway could be an initiating factor in the Sudden Infant Death Syndrome (SIDS). Responses to upper airway obstruction include augmentation of respiratory efforts, active dilation of the upper airway and electrocortical arousal. Vulnerable individuals may fail to mount these responses effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Harding R,Jakubowska AE,McCrabb GJ

更新日期：1995-08-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:Diabetes is a major risk factor for cardiovascular disease, affecting both endothelial and smooth muscle cells. Store-operated Ca2+ channels (SOCCs) have been implicated in many diabetic complications. Vascular dysfunction is common in patients with diabetes, but the role of SOCCs in diabetic vasculopathy is still unc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Schach C,Wester M,Leibl F,Redel A,Gruber M,Maier LS,Endemann D,Wagner S

更新日期：2020-07-01 00:00:00

abstract：:1. The effect of endothelin on phosphatidylinositol turnover in rat atria was investigated by measuring the generation of inositol phosphates following [3H]-inositol labelling. 2. In the presence of 10 mmol/L LiCl, endothelin caused dose-dependent increases in the accumulation of inositol mono, bis and trisphosphates ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kuraja IJ,Woodcock EA

更新日期：1990-04-01 00:00:00

abstract：:Bone is a remarkable living tissue that provides a framework for animal body support and motion. However, under excessive loads and deformations, bone is prone is to damage through fracture. Furthermore, once the bone is weakened by osteoporosis, bone fracture can occur even after only minimal trauma. Various techniqu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang L,Richardson M,Mendis P

更新日期：2012-08-01 00:00:00

abstract：:Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pringle KG,Zakar T,Lumbers ER

更新日期：2017-05-01 00:00:00

abstract：:1. It has been proposed that hypertension alters the respiratory and cardiovascular responses to chemoreceptor stimulation. However, in studies of human hypertension or in genetic animal models of hypertension it has been difficult to unequivocally attribute the changes to hypertension per se, rather than to a genetic...

journal_title：Clinical and experimental pharmacology & physiology

authors： Groom AS,Malpas SC

更新日期：1997-03-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:Short-term salt loading and salt restriction in a group of normal pregnant women produced no changes in lying, sitting or standing blood pressures or heart rates. Home blood pressures showed no trend to change over the periods of altered salt intake. Although plasma volume and plasma renin activity changed with altere...

journal_title：Clinical and experimental pharmacology & physiology

authors： McEniery PJ,Hunyor SN,Cooper KA,Gallery ED,Gyory AZ,Boyce ES

更新日期：1985-05-01 00:00:00

abstract：:1. The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic index and shows considerable interindividual differences in its pharmacokinetics. Interindividual differences in the activity and expression of the metabolising enzymes...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu YF,Qiu W,Liu ZQ,Zhu LJ,Liu ZQ,Tu JH,Wang D,Li Z,He J,Zhong GP,Zhou G,Zhou HH

更新日期：2006-11-01 00:00:00

abstract：:Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

更新日期：2012-02-01 00:00:00

abstract：:To test a possible role of endogenous opioids in the blood pressure (BP) and heart rate (HR) responses to the converting enzyme inhibitor captopril in man, nine normal subjects were given captopril (50 mg) or placebo with and without the opioid antagonist naloxone (0.2 mg/kg i.v.). Treatments were given in random orde...

journal_title：Clinical and experimental pharmacology & physiology

authors： Millar JA,Sturani A,Rubin PC,Lawrie C,Reid JL

更新日期：1983-05-01 00:00:00

abstract：:1. Oxidative stress (OS) is a biological entity indicated as being responsible for several pathologies, including diabetes. Diabetes can also be associated with human cirrhosis. Portal hypertension (PH), a major syndrome in cirrhosis, produces hyperdynamic splanchnic circulation and hyperaemia. The present study was d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Evelson P,Llesuy S,Filinger E,Rodriguez RR,Lemberg A,Scorticati C,Susemihl M,Villareal I,Polo JM,Peredo H,Perazzo JC

更新日期：2004-03-01 00:00:00

abstract：:1. The neuronal release of acetylcholine (ACh) and its autoregulation by neuromodulators, substance P (SP) and methionine enkephalin (MEK), have been studied using superfused rodent cerebral slices. Nicotine exerts significant effects on autoregulation of ACh release, which may have toxicological implications. 2. Posi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sastry BV

更新日期：1995-04-01 00:00:00

abstract：:1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after Bordetella pertussis vaccination. In a long-t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Terpstra GK,Raaijmakers JA,Kreukniet J

更新日期：1979-03-01 00:00:00

abstract：:1. The use of the isolated lung strip and single open tracheal ring for studying Schultz Dale anaphylactic contractions in both the peripheral and central airways is described. 2. This method is particularly relevant to studies of anaphylaxis because many preparations may be obtained from a single sensitized animal. 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lulich KM,Papadimitriou JM,Paterson JW

更新日期：1979-11-01 00:00:00

abstract：:The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

更新日期：2020-08-01 00:00:00

abstract：:1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid. 2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the ac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wai SS,Coupar IM

更新日期：1976-03-01 00:00:00

abstract：:1. There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity. 2. The hope of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nandam LS,Jhaveri D,Bartlett P

更新日期：2007-05-01 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodge G,Makarious MM,Charlesworth JA,Duggan KA

更新日期：1997-06-01 00:00:00

abstract：:1. The functional innervation of autonomic target tissues occurs early during development, at a time when both the nerves and post-synaptic target tissues are still differentiating. 2. Physiological responses appear soon after the arrival of the first fibres when uptake and release mechanisms within the nerves are alr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hill CE,Phillips JK,Sandow SL

更新日期：1999-08-01 00:00:00

abstract：:1. Studies of evolutionary temperature adaptation of muscle and locomotor performance in fish are reviewed with a focus on the Antarctic fauna living at subzero temperatures. 2. Only limited data are available to compare the sustained and burst swimming kinematics and performance of Antarctic, temperate and tropical s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Franklin CE

更新日期：1998-09-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

更新日期：1995-02-01 00:00:00

abstract：:1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Expe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hsu BG,Yang FL,Lee RP,Peng TC,Chen HI

更新日期：2005-01-01 00:00:00