Abstract:
:Osteoarthritis is the most common arthritis in the world. It affects millions of people with age being the greatest risk factor for developing the disease. The burden of disease will worsen with the aging of the world's population. The disease causes pain and functional disability. The direct costs of osteoarthritis include hospital and physician visits, medications, and assistive services. The indirect costs include work absences and lost wages. Many studies have sought to find a therapy to relieve pain and reduce disability. Glucosamine hydrochloride (HCl) is one of these therapies. There are limited studies of glucosamine HCl in humans. Although some subjects do report statistically significant improvement in pain and function from products combining glucosamine HCl and other agents, glucosamine HCl by itself appears to offer little benefit to those suffering from osteoarthritis.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Fox BA,Stephens MMdoi
10.2147/cia.s1632subject
Has Abstractpub_date
2007-01-01 00:00:00pages
599-604issue
4eissn
1176-9092issn
1178-1998journal_volume
2pub_type
杂志文章,评审abstract:OBJECTIVE:Routine measurement of the carotid intima-media thickness is not recommended in recent clinical practice guidelines for risk assessment of the first atherosclerotic cardiovascular disease (ASCVD) event (the definition of which includes acute coronary syndromes, a history of myocardial infarction, stable or un...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85216
更新日期:2015-07-07 00:00:00
abstract:BACKGROUND:Life style and physical activity play a pivotal role in prevention and treatment of osteoporosis. The mechanism for better bone metabolism and improvement of physical disorders is not clear yet. Trace minerals such as Ca, Mn, Cu, and Zn are essential precursors for most vital biological process, especially t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S100566
更新日期:2016-02-29 00:00:00
abstract:PURPOSE:Postmenopausal osteoporosis causes bone fracture as well as pain, physical, psychological and socially adverse effects, which affects a patient's quality of life (QOL). The effect of alendronate on QOL was investigated compared with that of alfacalcidol in post-menopausal osteoporotic women. PATIENTS AND METHO...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/cia.s9696
更新日期:2010-04-26 00:00:00
abstract::[This corrects the article on p. 1903 in vol. 12, PMID: 29184396.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S167276
更新日期:2018-03-13 00:00:00
abstract:OBJECTIVE:The main purpose of the investigation reported here was to analyze the effect of resistance training (RT) performed at different weekly frequencies on flexibility in older women. PARTICIPANTS AND METHODS:Fifty-three older women (≥60 years old) were randomly assigned to perform RT either two (n=28; group "G2x...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S77433
更新日期:2015-03-05 00:00:00
abstract:Background:A thorough analysis of the capability for self-care in patients with heart failure (HF) reduces the frequency of hospitalizations that are caused by decompensation. The aim of the study was to assess the effect of the method of therapy for HF, the degree of the acceptance of illness, and the occurrence of fr...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S178393
更新日期:2018-10-08 00:00:00
abstract:OBJECTIVE:The best practice tariff (BPT) incentivizes hospitals in the England and Wales National Health Service to provide multiprofessional care to patients with hip fractures. The initial six targets included: 1) admission under consultant-led joint orthopedic-geriatric care, 2) multidisciplinary assessment protocol...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S65736
更新日期:2014-12-01 00:00:00
abstract::Osteoporosis and fragility fractures are relevant health issues because of their impact in terms of morbidity, mortality, and socioeconomic burden. Despite this alarming scenario, both underdiagnosis and undertreatment are common features of osteoporotic patients, particularly those who have already sustained a fragil...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S242038
更新日期:2020-03-26 00:00:00
abstract:PURPOSE:Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S135364
更新日期:2017-05-26 00:00:00
abstract::There is a growing consensus regarding the influence of various psychosocial factors such as degree of social participation on health and disease outcomes, quality of life, and general well-being. Older individuals with diminished motor and physical functionality suffer a heightened risk of social exclusion and loneli...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S137993
更新日期:2017-06-23 00:00:00
abstract::Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally,...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S36367
更新日期:2013-01-01 00:00:00
abstract:Objective:We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer's disease (AD). Methods:A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
doi:10.2147/CIA.S210062
更新日期:2019-07-12 00:00:00
abstract::Purpose: To determine the association between frailty and postoperative complications in elderly Chinese patients and to determine whether addition of frailty assessment improves the predictive ability of the American Society of Anesthesiologists (ASA) score, Physiological and Operative Severity Score for the Enumerat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S201062
更新日期:2019-05-22 00:00:00
abstract:Purpose:The purpose of this study was to identify how changes to general health might affect the oral health of nursing-home residents over a six-month period. Materials and Methods:The study was conducted in nine nursing homes in Germany. Sociodemographic and general data were collected at baseline and after six mont...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S234938
更新日期:2020-01-09 00:00:00
abstract::Type 2 diabetes mellitus affects 5.9% of the world adult population, with older people and some ethnic groups disproportionately affected. Treatment of older people with diabetes differs in many ways from that in younger adults since the majority have type 2 disease and are at particular risk of macrovascular rather t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3142
更新日期:2009-01-01 00:00:00
abstract:Purpose:DNA methylation is thought to play a role in exercise-induced gene expression. We aimed to examine changes in muscular strength and body composition in elderly patients with end-stage knee osteoarthritis before and after artificial knee arthroplasty and exercise therapy. We aimed to confirm the relationship bet...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S213154
更新日期:2019-08-07 00:00:00
abstract:Purpose:We evaluated the relationship between pretreatment IL-6 and hsCRP levels, symptom severity and functional outcome of patients with acute ischemic stroke (AIS) treated with IV-thrombolysis. Patients and Methods:IL-6 and hsCRP samples were obtained from 83 consecutively treated Caucasian patients with AIS prior ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S258381
更新日期:2020-08-06 00:00:00
abstract:BACKGROUND:Age is an important determinant of outcome in acute myocardial infarction (AMI). However, in clinical settings, there is an occasional mismatch between chronological age and physical age. We evaluated whether activities of daily living (ADL), which reflect physical age, also predict complications and prognos...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S107136
更新日期:2016-08-24 00:00:00
abstract:OBJECTIVE:To report our experiences in changing from intravitreal bevacizumab to ranibizumab in age-related macular degeneration (AMD). DESIGN:Retrospective case series. PARTICIPANTS AND METHODS:We retrospectively reviewed the records of 34 patients (36 eyes) who were treated with monthly injections of intravitreal b...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s8367
更新日期:2009-01-01 00:00:00
abstract::The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass inde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S120876
更新日期:2017-06-28 00:00:00
abstract:PURPOSE:In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (F...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S60838
更新日期:2014-04-10 00:00:00
abstract::The purpose of this study was to determine the test-retest reliability of the International Physical Activity Questionnaire (IPAQ) for older adults in Serbia. Six hundred and sixty older adults (352 men, 53%; 308 women, 47%; mean age 67.65±5.76 years) participated in the study. To examine test-retest reliability, the ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57379
更新日期:2014-04-07 00:00:00
abstract::The evaluation of pain and the subsequent issue of pain control is a clinical challenge that all healthcare providers face. Pain in the elderly population is especially difficult given the myriad of physiological, pharmacological, and psychological aspects of caring for the geriatric patient. Opiates are the mainstay ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1847
更新日期:2008-01-01 00:00:00
abstract::Background and objective: Oxidative stress has been demonstrated to be a mechanism that leads to bone mass reduction, and according to many studies, serum uric acid (UA) is a strong endogenous antioxidant that can protect bone mineral density (BMD). To date, there have been no large-scale, cross-sectional studies base...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S186500
更新日期:2019-06-12 00:00:00
abstract:Purpose:Define the effectiveness of teriparatide (TPTD) treatment on reducing the incidence of new vertebral compression fractures (NVCFs) and back pain and improving quality of life after percutaneous kyphoplasty (PKP). Methods:Two years of clinical follow-up data from primary osteoporotic women who had experienced i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S224663
更新日期:2019-10-01 00:00:00
abstract:Background:Being elderly and retired are related phenomena that overlap in a time symmetry. The present study aimed to assess the effect of an empowering self-management model on the self-efficacy and sense of coherence (SOC) in retired elderly with chronic diseases. Methods:A randomized controlled trial that included...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S183276
更新日期:2018-11-01 00:00:00
abstract:Purpose:We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods:Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S200269
更新日期:2019-06-28 00:00:00
abstract::Atrial fibrillation (AF) is associated with an increased incidence and severity of strokes. The burden of AF-related stroke is expected to increase in parallel with the aging of the population. Oral anticoagulation with warfarin has been the pharmacologic standard for stroke risk reduction in patients with AF. When us...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S37818
更新日期:2013-01-01 00:00:00
abstract::Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder with no clear prevalence factors and is a significant danger to the elderly. The intracranial glymphatic system is the internal environment that maintains brain survival and metabolism, and thus fluid exchange changes in the glymphatic sys...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S290709
更新日期:2021-01-15 00:00:00
abstract::Frailty is a common and important geriatric syndrome characterized by age-associated declines in physiologic reserve and function across multiorgan systems, leading to increased vulnerability for adverse health outcomes. Two major frailty models have been described in the literature. The frailty phenotype defines frai...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S45300
更新日期:2014-03-19 00:00:00