Abstract:
PURPOSE:Postmenopausal osteoporosis causes bone fracture as well as pain, physical, psychological and socially adverse effects, which affects a patient's quality of life (QOL). The effect of alendronate on QOL was investigated compared with that of alfacalcidol in post-menopausal osteoporotic women. PATIENTS AND METHODS:A total of 44 postmenopausal osteoporotic women (mean age 69.8 years) with back or joint pain, although capable of walking, were randomly assigned to two groups; group A (n=25) received 5 mg/day of alendronate, and group B (n=19) received 0.5 microg/day of alfacalcidol, for the first 4 months. For the following 2 months, the group A received 0.5 microg/day of alfacalcidol and the group B received 5 mg/day of alendronate in a crossover design. The patient's QOL was evaluated by score of Japanese Osteoporosis Quality of Life Questionnaire (JOQOL), and pain intensity using a visual analog scale (VAS). Bone metabolism was measured by bone mineral density (BMD) and a biomarker for bone resorption, urinary crosslinked N-terminal telopeptide of type I collagen (NTX). RESULTS:With 4-month treatment, alendronate, but not alfacalcidol, improved pain-related QOL, reduced joint pain by VAS, and increased bone mineral density. Both treatments significantly reduced bone resorption, the inhibition was significantly higher with alendronate (-56.5%) compared with alfacalcidol (-18.1%). After crossover, the patients in group A received alfacalcidol and had a reduced total and daily living activity-related QOL scores, and increased upper back pain by VAS. The group B received alendronate had significantly reduced bone resorption after the 2 months. CONCLUSION:Alendronate improves the QOL of Japanese postmenopausal women with osteoporosis by reducing pain intensity as well as increasing bone mineral density.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Kawate H,Ohnaka K,Adachi M,Kono S,Ikematsu H,Matsuo H,Higuchi K,Takayama T,Takayanagi Rdoi
10.2147/cia.s9696subject
Has Abstractpub_date
2010-04-26 00:00:00pages
123-31eissn
1176-9092issn
1178-1998journal_volume
5pub_type
杂志文章,随机对照试验abstract::Taken once a year, intravenous zoledronic acid (Zol) (Reclast® or Aclasta®) is a third-generation nitrogen-containing bisphosphonate that is effective compared with placebo in reducing the risk of fractures in patients with postmenopausal osteoporosis and recent low-trauma hip fracture. In glucocorticoid-induced osteo...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S7282
更新日期:2011-01-01 00:00:00
abstract::The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effe...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s2468
更新日期:2008-01-01 00:00:00
abstract:Background:Ergonomic hazards are the most important cause of knee osteoarthritis (OA) in aged para rubber farmers. Ergonomic management comprising improvement of working conditions and muscle-strengthening exercise has been well documented in terms of workers' health benefit. However, those interventions were not adequ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S144288
更新日期:2018-01-17 00:00:00
abstract:OBJECTIVE:Routine measurement of the carotid intima-media thickness is not recommended in recent clinical practice guidelines for risk assessment of the first atherosclerotic cardiovascular disease (ASCVD) event (the definition of which includes acute coronary syndromes, a history of myocardial infarction, stable or un...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85216
更新日期:2015-07-07 00:00:00
abstract::Background: Current surgical risk assessment tools fall short of appreciating geriatric risk factors including cognitive deficits, depressive, and frailty symptoms that may worsen outcomes post-transcatheter aortic valve implantation (TAVI). This study hypothesized that a screening tool, SMARTIE, would improve detecti...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S201615
更新日期:2019-05-08 00:00:00
abstract:OBJECTIVE:We studied the effect of sustained virologic response (SVR) after treatment with pegylated-interferon (PEG-IFN) plus ribavirin on the development of liver cirrhosis in elderly patients with chronic hepatitis C (CHC). PATIENTS AND METHODS:This retrospective study enrolled 145 elderly CHC patients (aged ≥65 ye...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S97242
更新日期:2016-03-17 00:00:00
abstract::The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57294
更新日期:2014-04-15 00:00:00
abstract:OBJECTIVE:The objectives of this study were to assess the elongation of the styloid process on digital panoramic radiographs and to evaluate the prevalence of the elongation according to age, sex and types. PATIENTS AND METHODS:Digital panoramic radiographs of 198 geriatric edentulous patients were analyzed. The radio...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S129818
更新日期:2017-03-30 00:00:00
abstract:Purpose:This study evaluates the effect of introducing active gait training (AGT) to patients who are severely disabled with nasogastric tube feeding or gastrostoma on the recovery of oral feeding. Patients and Methods:We conducted a historical cohort study at a single rehabilitation center in Japan between January 20...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S270277
更新日期:2020-10-13 00:00:00
abstract::Bazedoxifene, a novel selective estrogen receptor modulator, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. Two large Phase III clinical trials showed that bazedoxifene, as well as raloxifene, increased bone mineral density, decreas...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S15711
更新日期:2011-01-01 00:00:00
abstract::[This corrects the article on p. 1903 in vol. 12, PMID: 29184396.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S167276
更新日期:2018-03-13 00:00:00
abstract::Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder with no clear prevalence factors and is a significant danger to the elderly. The intracranial glymphatic system is the internal environment that maintains brain survival and metabolism, and thus fluid exchange changes in the glymphatic sys...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S290709
更新日期:2021-01-15 00:00:00
abstract:Study design:Multivariate analysis of retrospective registry data. Objective:To report the perioperative complication in a large cohort of surgery for elderly degenerative lumbar scoliosis (DLS) patients and to analyze the risk factors. Summary of background data:The perioperative complication rate and risk factors f...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S218204
更新日期:2019-12-16 00:00:00
abstract::Older adults age 65 and over account for a disproportional number of hospital stays and discharges compared to other age groups. The objective of this paper is to describe placement and characteristics of older patients discharged from an acute care for the elderly (ACE) unit. The study sample consists of 1,351 men an...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (F...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S60838
更新日期:2014-04-10 00:00:00
abstract:Background:Myocardial infarction (MI) is a common cause of death worldwide. It is characterized by coronary artery occlusion that causes ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Materials and Methods:To explore potential targets for treatment of MI, we reorganized and analyz...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S281290
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Use of intensive anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications during percutaneous coronary intervention via the transfemoral route. Recently, the transradial access has been intensively employed as an alternative means ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S50939
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Previous studies have identified hyperlipidemia as a potential risk factor for dementia and Alzheimer's disease. However, studies on cholesterol measured in late-life and cognitive function have been inconsistent. Few studies have explored nonlinear relationships or considered interactions with other bioma...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S64766
更新日期:2014-10-23 00:00:00
abstract:Background:Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large elastic arteries and is a predominant risk factor for cardiovascular disease, the leading cause of morbidity and mortality in modern societies. Although exercise reduc...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S220283
更新日期:2019-09-02 00:00:00
abstract:Background:Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D s...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S182318
更新日期:2018-10-17 00:00:00
abstract::Osteoporosis and fragility fractures are relevant health issues because of their impact in terms of morbidity, mortality, and socioeconomic burden. Despite this alarming scenario, both underdiagnosis and undertreatment are common features of osteoporotic patients, particularly those who have already sustained a fragil...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S242038
更新日期:2020-03-26 00:00:00
abstract::The purpose of this study was to determine the test-retest reliability of the International Physical Activity Questionnaire (IPAQ) for older adults in Serbia. Six hundred and sixty older adults (352 men, 53%; 308 women, 47%; mean age 67.65±5.76 years) participated in the study. To examine test-retest reliability, the ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57379
更新日期:2014-04-07 00:00:00
abstract:Background:Being elderly and retired are related phenomena that overlap in a time symmetry. The present study aimed to assess the effect of an empowering self-management model on the self-efficacy and sense of coherence (SOC) in retired elderly with chronic diseases. Methods:A randomized controlled trial that included...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S183276
更新日期:2018-11-01 00:00:00
abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S151427
更新日期:2018-05-24 00:00:00
abstract:PURPOSE:With longer life expectancies, the prevalence of arrhythmias is increasing; thus, there is a need for new methods to screen the older outpatient population. This population-based study describes the prevalence of arrhythmias in 200 outpatients aged ≥66 years. We also investigated the feasibility of wireless lon...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110532
更新日期:2016-08-10 00:00:00
abstract:Purpose:The aim of the study was to evaluate the impact of inertial training on upper and lower extremity strength in the elderly. The study also assessed the influence of inertial training on their independence, balance, and speed and quality of gait. Methods:Twenty physically inactive older residents of a nursing ho...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
abstract:BACKGROUND:Endovascular option has been proposed for a very limited and selected number of Stanford type A aortic dissection (TAAD) patients. We have performed a computed tomography (CT)-based TAAD study to explore appropriate endograft configurations for the ascending aortic pathology. METHODS:TAAD patients treated w...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S104961
更新日期:2016-07-14 00:00:00
abstract:BACKGROUND:Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. PURPOSE:To determine the relationship between multiple vascular risk exposures, as counted on an index in cases...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S28143
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Despite advances in operative repair, ruptured abdominal aortic aneurysm (rAAA) remains associated with high mortality and morbidity rates, especially in elderly patients. The purpose of this study was to evaluate the outcomes of emergency endovascular aneurysm repair (eEVAR), conventional open repair (OPEN)...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S64718
更新日期:2014-10-13 00:00:00
abstract::Background and objective: Oxidative stress has been demonstrated to be a mechanism that leads to bone mass reduction, and according to many studies, serum uric acid (UA) is a strong endogenous antioxidant that can protect bone mineral density (BMD). To date, there have been no large-scale, cross-sectional studies base...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S186500
更新日期:2019-06-12 00:00:00