Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sectional study from northeast China.

Abstract:

:Background and objective: Oxidative stress has been demonstrated to be a mechanism that leads to bone mass reduction, and according to many studies, serum uric acid (UA) is a strong endogenous antioxidant that can protect bone mineral density (BMD). To date, there have been no large-scale, cross-sectional studies based on the population in northeast China to assess the relationship between serum UA and BMD. Therefore, we examined the association between serum UA and BMD among a Chinese population older than 60 years old in northeast China. Methods: This research was a cross-sectional study of 3465 Chinese individuals over 60 years old in nine communities from the city of Shenyang, which is the capital of northeast China's Liaoning Province. Participants were stratified into three groups by serum UA or BMD levels, and then Pearson's correlation analysis and multiple regression analysis were used to study the relationship between serum UA and BMD. Results: We found that participants with higher serum UA levels had significantly greater BMD and T-values compared to those of participants with lower serum UA levels. After adjusting for confounding factors, Pearson's correlation analysis and multiple regression analysis showed that higher serum UA levels remained associated with higher BMD levels (P<0.05). In different models, the prevalence of osteoporosis (OP) among participants with higher serum UA levels was reduced by 23% to 26% (P<0.05) compared to that in individuals with lower serum UA levels. In addition, serum UA levels were negatively correlated with estimated glomerular filtration rate (eGFR) and positively correlated with 25-hydroxy vitamin D3 [25-(OH)D3] (P<0.05). Conclusion: We concluded that higher serum UA levels are associated with greater BMD, and serum UA might have a protective effect on bone metabolism due to its antioxidant properties.

journal_name

Clin Interv Aging

authors

Chen F,Wang Y,Guo Y,Wang J,Yang A,Lv Q,Liu Y,Ma G,Liu Y,Wang D

doi

10.2147/CIA.S186500

subject

Has Abstract

pub_date

2019-06-12 00:00:00

pages

1065-1073

eissn

1176-9092

issn

1178-1998

pii

186500

journal_volume

14

pub_type

杂志文章
  • Capability for self-care of patients with heart failure.

    abstract:Background:A thorough analysis of the capability for self-care in patients with heart failure (HF) reduces the frequency of hospitalizations that are caused by decompensation. The aim of the study was to assess the effect of the method of therapy for HF, the degree of the acceptance of illness, and the occurrence of fr...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S178393

    authors: Mlynarska A,Golba KS,Mlynarski R

    更新日期:2018-10-08 00:00:00

  • A scoping review of crisis teams managing dementia in older people.

    abstract:BACKGROUND:Research on crisis teams for older adults with dementia is limited. This scoping review aimed to 1) conduct a systematic literature review reporting on the effectiveness of crisis interventions for older people with dementia and 2) conduct a scoping survey with dementia crisis teams mapping services across E...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S142341

    authors: Streater A,Coleston-Shields DM,Yates J,Stanyon M,Orrell M

    更新日期:2017-10-03 00:00:00

  • Role of zoledronic acid in the prevention and treatment of osteoporosis.

    abstract::Taken once a year, intravenous zoledronic acid (Zol) (Reclast® or Aclasta®) is a third-generation nitrogen-containing bisphosphonate that is effective compared with placebo in reducing the risk of fractures in patients with postmenopausal osteoporosis and recent low-trauma hip fracture. In glucocorticoid-induced osteo...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S7282

    authors: Räkel A,Boucher A,Ste-Marie LG

    更新日期:2011-01-01 00:00:00

  • Mindfulness training for psychological stress in family caregivers of persons with dementia: a systematic review and meta-analysis of randomized controlled trials.

    abstract::Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-ana...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,meta分析,评审

    doi:10.2147/CIA.S146213

    authors: Liu Z,Chen QL,Sun YY

    更新日期:2017-09-22 00:00:00

  • Can short-term residential care for stroke rehabilitation help to reduce the institutionalization of stroke survivors?

    abstract:BACKGROUND:Stroke survivors may not be receiving optimal rehabilitation as a result of a shortage of hospital resources, and many of them are institutionalized. A rehabilitation program provided in a short-term residential care setting may help to fill the service gap. OBJECTIVES:The primary objectives of this study w...

    journal_title:Clinical interventions in aging

    pub_type: 临床试验,杂志文章

    doi:10.2147/CIA.S56532

    authors: Chau PH,Tang MW,Yeung F,Chan TW,Cheng JO,Woo J

    更新日期:2014-02-12 00:00:00

  • Hypernatremia in the geriatric population.

    abstract::Hypernatremia in the geriatric population is a common disorder associated with significant morbidity and mortality. Older people are predisposed to developing hypernatremia because of age-related physiologic changes such as decreased thirst drive, impaired urinary concentrating ability, and reduced total body water. M...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S65214

    authors: Shah MK,Workeneh B,Taffet GE

    更新日期:2014-11-19 00:00:00

  • Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese.

    abstract:BACKGROUND:No conventional creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation performed consistently outstandingly in elderly Chinese in our previous studies. This research aimed to further evaluate the performance of some recently proposed estimation equations based on creatinine and ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S68801

    authors: Ye X,Wei L,Pei X,Zhu B,Wu J,Zhao W

    更新日期:2014-09-11 00:00:00

  • Association between body composition and stair negotiation ability among individuals >55 years of age: a cross-sectional study.

    abstract:BACKGROUND:Loss of muscle strength exerts a considerable impact on the quality of life and mortality of older adults. The present household survey study measured body composition and muscle strength with the aim of analyzing the roles of low lean mass, low muscle strength and obesity in stair negotiation ability and th...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S126779

    authors: Dip RM,Cabrera MA,Prato SF

    更新日期:2017-08-18 00:00:00

  • Understanding experiences of patients and family caregivers in the Mayo Clinic Care Transitions program: a qualitative study.

    abstract:Background:Care transitions programs are increasingly used to improve care and reduce re-admission of patients after hospitalization. To learn from the experience of patients who have participated in the Mayo Clinic Care Transitions (MCCT) program and to understand the patient experience, we sought perspectives of pati...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S183893

    authors: Takahashi PY,Finnie DM,Quigg SM,Borkenhagen LS,Kumbamu A,Kimeu AK,Griffin JM

    更新日期:2018-12-19 00:00:00

  • Tongue-pressure resistance training improves tongue and suprahyoid muscle functions simultaneously.

    abstract:Purpose:Producing tongue pressure (TP) by pushing the tongue against the palate consists of lifting the tongue muscles and elevating the floor of the mouth via suprahyoid muscle contraction. Though studies have shown that tongue-pressure resistance training (TPRT) increases tongue function, none have focused on suprahy...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S194808

    authors: Namiki C,Hara K,Tohara H,Kobayashi K,Chantaramanee A,Nakagawa K,Saitou T,Yamaguchi K,Yoshimi K,Nakane A,Minakuchi S

    更新日期:2019-03-22 00:00:00

  • Prevalence of functional dependence in Chinese centenarians and its relationship with serum vitamin D status.

    abstract:Background:Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D s...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S182318

    authors: Yao Y,Fu S,Shi Q,Zhang H,Zhu Q,Zhang F,Luan F,Zhao Y,He Y

    更新日期:2018-10-17 00:00:00

  • Older women with dementia can perform fast alternating forearm movements and performance is correlated with tests of lower extremity function.

    abstract:BACKGROUND:The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia. METHODS:Fast alternating movements was studied in 26 female patients (mean age 81.7 ± 5.9 years) ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S37733

    authors: Bramell-Risberg E,Jarnlo GB,Elmståhl S

    更新日期:2013-01-01 00:00:00

  • The effects of a multicomponent dyadic intervention on the mood, behavior, and physical health of people with dementia: a randomized controlled trial.

    abstract:PURPOSE:The effects of a multicomponent dyadic intervention on the mood, behavior, and physical health of people with dementia living in the community were evaluated in a randomized controlled trial. This multicomponent dyadic intervention is a translated and adapted version of an intervention that has been shown to be...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S95789

    authors: Prick AE,de Lange J,Scherder E,Twisk J,Pot AM

    更新日期:2016-03-31 00:00:00

  • Alendronate improves QOL of postmenopausal women with osteoporosis.

    abstract:PURPOSE:Postmenopausal osteoporosis causes bone fracture as well as pain, physical, psychological and socially adverse effects, which affects a patient's quality of life (QOL). The effect of alendronate on QOL was investigated compared with that of alfacalcidol in post-menopausal osteoporotic women. PATIENTS AND METHO...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/cia.s9696

    authors: Kawate H,Ohnaka K,Adachi M,Kono S,Ikematsu H,Matsuo H,Higuchi K,Takayama T,Takayanagi R

    更新日期:2010-04-26 00:00:00

  • Beneficial effects of prolonged blood pressure control after carotid artery stenting.

    abstract:OBJECTIVES:The main purpose of this study was to investigate whether carotid artery stenting (CAS) plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP) control compared to other medical treatments alone. The other aim was to explore the correlation between post-CA...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S122352

    authors: Chang A,Hung HF,Hsieh FI,Chen WH,Yeh HL,Yeh JH,Chiu HC,Lien LM

    更新日期:2017-01-06 00:00:00

  • Short-term changes of blood pressure and aortic stiffness in older patients after transcatheter aortic valve implantation.

    abstract:Background:Both aortic valve stenosis and aortic stiffness are moderators of arterio ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of transcatheter aortic valve implantation (TAVI) on aortic functional properties are limited. We performed a study to inv...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S211328

    authors: Goudzwaard JA,Disegna E,de Ronde-Tillmans MJ,Lenzen MJ,de Jaegere PP,Mattace-Raso FU

    更新日期:2019-08-02 00:00:00

  • Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial.

    abstract:PURPOSE:To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using a randomized, blank-controlled, parallel-group design. PATIENTS AND METHODS:Two hundred and five volunteers aged ≥45 years were randomly divide...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S141518

    authors: Pu F,Guo Y,Li M,Zhu H,Wang S,Shen X,He M,Huang C,He F

    更新日期:2017-08-08 00:00:00

  • A comparison between metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty as surgical treatments for hallux rigidus: a retrospective study with short- to midterm follow-up.

    abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S110865

    authors: Mermerkaya MU,Adli H

    更新日期:2016-12-13 00:00:00

  • Oral health in the elderly patient and its impact on general well-being: a nonsystematic review.

    abstract::Data on the oral health of the elderly depict a worrying situation, with an elevated prevalence of caries and moderate periodontal disease, frequent edentulism, and numerous cases of dry mouth and oral cancer. There is wide evidence that periodontitis is a risk factor for certain systemic diseases, and impaired oral h...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S54630

    authors: Gil-Montoya JA,de Mello AL,Barrios R,Gonzalez-Moles MA,Bravo M

    更新日期:2015-02-11 00:00:00

  • Age-related changes in muscle strength and spinal kyphosis angles in an elderly Japanese population.

    abstract::Lumbar kyphosis and the decreased mobility of the lumbar spine increase the risk of falls and impair both the quality of life and the ability to perform activities of daily living. However, in the elderly Japanese population, little is known about the age-related changes and sex-related differences in muscle strength,...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S113352

    authors: Kasukawa Y,Miyakoshi N,Hongo M,Ishikawa Y,Kudo D,Suzuki M,Mizutani T,Kimura R,Ono Y,Shimada Y

    更新日期:2017-02-20 00:00:00

  • A gero-informatics tool to enhance the care of hospitalized older adults with cognitive impairment.

    abstract::Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating informat...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:

    authors: Boustani M,Munger S,Beck R,Campbell N,Weiner M

    更新日期:2007-01-01 00:00:00

  • Impact of Different Geriatric Conditions on Choice of Therapy and In-Hospital Outcomes in Elderly Patients with Acute Coronary Syndrome.

    abstract:Introduction:The clinical benefit of invasive therapy in elderly patients with acute coronary syndrome (ACS) remains unclear. Furthermore, the decision-making process to treat this growing patient group is also debatable. The purpose of this study was to assess the association between elderly ACS patients, the treatmen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S249017

    authors: Rittger H,Stadelmaier C,Kieschnick T,Büber D,Rank K,Vitali-Serdoz L,Bastian D,Waliszewski M

    更新日期:2020-05-25 00:00:00

  • Life-Space Mobility in the Elderly: Current Perspectives.

    abstract::Life-space mobility (LSM) is a concept for assessing patterns of functional mobility over time. LSM is gaining traction in the research of geriatric population health. Several instruments have been developed to measure LSM, such as the University of Alabama at Birmingham Life-Space Assessment (LSA) or the Nursing Home...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S196944

    authors: Johnson J,Rodriguez MA,Al Snih S

    更新日期:2020-09-15 00:00:00

  • Polypharmacy: misleading, but manageable.

    abstract::The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effe...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/cia.s2468

    authors: Bushardt RL,Massey EB,Simpson TW,Ariail JC,Simpson KN

    更新日期:2008-01-01 00:00:00

  • A medical costs study of older patients with acute myocardial infarction and metabolic syndrome in hospital.

    abstract:BACKGROUND:Older patients with acute myocardial infarction (AMI) usually have a poor prognosis, but whether this poor prognosis leads to high hospital costs remains unclear. This study investigated the clinical outcomes of and costs incurred by older patients with AMI and metabolic syndrome (MS) in hospital. METHODS A...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S70372

    authors: Fan GQ,Fu KL,Jin CW,Wang XZ,Han L,Wang H,Zhong M,Zhang Y,Zhang W,Wang ZH

    更新日期:2015-01-23 00:00:00

  • Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss.

    abstract::Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is k...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S10153

    authors: Trouvin AP,Goëb V

    更新日期:2010-11-19 00:00:00

  • The merits and problems of Neuropsychiatric Inventory as an assessment tool in people with dementia and other neurological disorders.

    abstract:OBJECTIVE:The Neuropsychiatric Inventory (NPI) is one of the most commonly used assessment scales for assessing symptoms in people with dementia and other neurological disorders. This paper analyzes its conceptual framework, measurement mode, psychometric properties, and merits and problems. METHOD:All articles discus...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S63504

    authors: Lai CK

    更新日期:2014-07-08 00:00:00

  • Kidney function and cognitive decline in an oldest-old Chinese population.

    abstract:BACKGROUND:Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old. SUBJECTS AND METHODS:This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The me...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S134205

    authors: Bai K,Pan Y,Lu F,Zhao Y,Wang J,Zhang L

    更新日期:2017-07-04 00:00:00

  • Behavioral cues to expand a pain model of the cognitively impaired elderly in long-term care.

    abstract:BACKGROUND:The purpose of this study was to determine the relationship between hypothesized pain behaviors in the elderly and a measurement model of pain derived from the Minimum Data Set-Resident Assessment Instrument (MDS-RAI) 2.0 items. METHODS:This work included a longitudinal cohort recruited from Medicare-certif...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S29656

    authors: Burfield AH,Wan TT,Sole ML,Cooper JW

    更新日期:2012-01-01 00:00:00

  • Attenuated Renal and Hepatic Cells Apoptosis Following Swimming Exercise Supplemented with Garlic Extract in Old Rats.

    abstract:Background/Objective:One of the problems associated with aging is the development of apoptosis in different tissues. There is evidence that physical activity and herbal remedies can be useful. This study aimed to determine the effect of swimming training (SW) alone or combined with garlic extract on renal and hepatic c...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S250321

    authors: Farzanegi P,Abbaszadeh H,Farokhi F,Rahmati-Ahmadabad S,Hosseini SA,Ahmad A,Mazandarani MR,Rezaei I,Shokrie M,Vizvari E,Alinejad H,Azarbayjani MA

    更新日期:2020-08-18 00:00:00