Abstract:
BACKGROUND:Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old. SUBJECTS AND METHODS:This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The median follow-up time was 3.3 years, and 247 (87.0%) participants provided valid data at their last visit. Kidney function was evaluated by measuring the estimated glomerular filtration rate (eGFR) at baseline, and cognitive function was evaluated using the Mini-Mental State Examination (MMSE) at both baseline and annual visits. A reliable decrease in the MMSE score over the follow-up period was observed based on a Reliable Change Index of 1.645 (equivalent to a 90% confidence interval [CI]), which was used to define cognitive decline. Poisson regression models were built to analyze the association between baseline kidney function and cognitive decline. RESULTS:A total of 18 (7.3%) cases of incident cognitive decline were observed during the follow-up period. After adjusting for potential confounders, the relative risk of developing cognitive decline was 4.03 (95% CI 1.09-13.81) among participants with an eGFR of 30-59 mL/min/1.73 m2 compared to participants with an eGFR of ≥60 mL/min/1.73 m2. CONCLUSION:Early-stage chronic kidney disease was correlated with cognitive decline in an oldest-old Chinese population.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Bai K,Pan Y,Lu F,Zhao Y,Wang J,Zhang Ldoi
10.2147/CIA.S134205subject
Has Abstractpub_date
2017-07-04 00:00:00pages
1049-1054eissn
1176-9092issn
1178-1998pii
cia-12-1049journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Stroke survivors may not be receiving optimal rehabilitation as a result of a shortage of hospital resources, and many of them are institutionalized. A rehabilitation program provided in a short-term residential care setting may help to fill the service gap. OBJECTIVES:The primary objectives of this study w...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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abstract::Most patients with myelodysplastic syndromes (MDS) are elderly (median age range 65 to 70 years); as a consequence, the incidence and prevalence of these diseases are rising as the population ages. Physicians are often uncertain about how to identify patients who may benefit from specific treatment strategies. The Int...
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pub_type: 杂志文章,评审
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S32356
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical interventions in aging
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pub_type: 杂志文章,随机对照试验
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S211328
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S107136
更新日期:2016-08-24 00:00:00
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journal_title:Clinical interventions in aging
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pub_type: 杂志文章
doi:10.2147/CIA.S10615
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S53441
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
doi:10.2147/CIA.S91721
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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