Abstract:
:Most patients with myelodysplastic syndromes (MDS) are elderly (median age range 65 to 70 years); as a consequence, the incidence and prevalence of these diseases are rising as the population ages. Physicians are often uncertain about how to identify patients who may benefit from specific treatment strategies. The International Prognostic Scoring System is a widely used tool to assess the risk of transformation to leukemia and to guide treatment decisions, but it fails to take into account many aspects of treating elderly patients, including comorbid illnesses, secondary causes of MDS, prior therapy for MDS, and other age-related health, functional, cognitive, and social problems that affect the outcome and managing of myelodysplastic symptoms. Patients with low-risk disease traditionally have been given only best supportive care, but evidence is increasing that treatment with novel non-conventional drugs such as lenalidomide or methyltransferase inhibitors may influence the natural history of the disease and should be used in conjunction with supportive-care measures. Supportive care of these patients could also be improved in order to enhance their quality of life and functional performance. Elderly patients commonly have multiple medical problems and use medications to deal with these. In addition, they are more likely to have more than one health care provider. These factors all increase the risk of drug interactions and the consequent treatment of toxicities. Manifestations of common toxicities or illnesses may be more subtle in the elderly, owing to age-associated functional deficits in multiple organ systems. Particularly important to the elderly MDS patient is the age-related decline in normal bone marrow function, including the diminished capacity of response to stressors such as infection or myelosuppressive treatments. Through the integration of geriatric and oncological strategies, a personalized approach toward this unique population may be applied. As with many diseases in the elderly, reliance on family members or friends to maintain the prescribed treatments, including travel to and from appointments, may place additional stressors on the patient and his/her support network. Careful evaluation and knowledge of functional status, ability to tolerate treatments, effect of disease progression, and general overall health conditions can provide the best opportunity to support these patients. Immediate assessment of daily living activities may detect deficiencies or deficits that often require early interventions.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Ria R,Moschetta M,Reale A,Mangialardi G,Castrovilli A,Vacca A,Dammacco Fdoi
10.2147/cia.s5203subject
Has Abstractpub_date
2009-01-01 00:00:00pages
413-23eissn
1176-9092issn
1178-1998journal_volume
4pub_type
杂志文章,评审abstract::Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-ana...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析,评审
doi:10.2147/CIA.S146213
更新日期:2017-09-22 00:00:00
abstract:Background:Aging is a spontaneous and inevitable phenomenon of biology, which can lead to the gradual deterioration of tissues and organs. One of the age-related deterioration processes is immunosenescence, which leads to changes in the function of immune systems, including immune cells and associated cytokines. A prop...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S237601
更新日期:2020-01-29 00:00:00
abstract:Objective:The objective involved the analysis of the efficiency of the Program of Movement Recreation of Elderly People (PMREP) exercise program expressed in terms of the stabilography measures and coactivation of muscles in women in the age group of 60-70 years. The assumption that was assumed stems from theoretical i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S167782
更新日期:2018-09-12 00:00:00
abstract:Objective:Urticaria is a mast cell-related disease caused severe itching and the lifetime prevalence of urticaria is about 20% in general population. Our purpose is to evaluate risk of urticaria in geriatric stroke patients received influenza vaccination (IV). Methods:In a cohort of 192,728 patients with newly diagnos...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S228324
更新日期:2019-11-26 00:00:00
abstract:BACKGROUND:The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. METHODS:The motor functions and ultrasound images of 19 elderly (73 ± 3.2 years) and 19 young (22 ± 1.5 years) individuals were...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S67820
更新日期:2014-09-05 00:00:00
abstract:Introduction:Paternalism, assuming control of aged care, is a widespread orientation in older adults care. Paternalistic attitudes and practices are commonly understood as a threat to the freedom and autonomy of a person, making patients more dependent. Therefore, the reduction of these attitudes and behaviors is a pri...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S213644
更新日期:2019-08-26 00:00:00
abstract:Purpose:The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly. Patients and methods:Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S192050
更新日期:2019-02-15 00:00:00
abstract::The use of atypical antipsychotic drugs in the elderly has become wider and wider in recent years; in fact, these agents have novel receptor binding profiles, good efficacy with regard to negative symptoms, and reduced extrapyramidal symptoms. However, in recent years, the use of both conventional and atypical antipsy...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S63942
更新日期:2014-08-16 00:00:00
abstract::Frailty is a common and important geriatric syndrome characterized by age-associated declines in physiologic reserve and function across multiorgan systems, leading to increased vulnerability for adverse health outcomes. Two major frailty models have been described in the literature. The frailty phenotype defines frai...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S45300
更新日期:2014-03-19 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S70372
更新日期:2015-01-23 00:00:00
abstract:OBJECTIVE:To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population. METHODS:This was a prospective cohort study of patients 65 years and older without hemato-logic disorders who received thromboelastography (TEG) examination at the Chi...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S49478
更新日期:2013-01-01 00:00:00
abstract:Purpose:This study evaluates the effect of introducing active gait training (AGT) to patients who are severely disabled with nasogastric tube feeding or gastrostoma on the recovery of oral feeding. Patients and Methods:We conducted a historical cohort study at a single rehabilitation center in Japan between January 20...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S270277
更新日期:2020-10-13 00:00:00
abstract::Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S44797
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S55972
更新日期:2014-02-14 00:00:00
abstract:Background and Aim:Caregivers in the home environment have an important role in timely detecting and responding to abuse. The aim of this review was to provide insight into both the existing tools for the assessment of and interventions for elder abuse by formal and informal caregivers in the home environment, and to c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S261877
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:It is important to obtain knowledge about the prevalence of nutritional risk and associated factors among older home-dwelling people in order to be able to meet nutritional challenges in this group in the future and to plan appropriate interventions. The aim of this survey was to investigate the prevalence o...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S35986
更新日期:2012-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134205
更新日期:2017-07-04 00:00:00
abstract:BACKGROUND:Demand for nursing and social services may vary depending on the socio-demographic variables, health status, receipt of formal and informal care provided, and place of residence. OBJECTIVES:To conduct a comparative analysis of the expectations of older people from urban, rural, and institutional environment...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S72534
更新日期:2015-02-02 00:00:00
abstract:Objective:The aim of this study was to evaluate the effects of dental status and chewing efficiency on the oral-health-related quality of life (OHRQoL) of nursing-home residents. Materials and Methods:The study was conducted in nine nursing homes. All eligible participants were included, and general and medical data, ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S273671
更新日期:2020-11-11 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S242038
更新日期:2020-03-26 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S122352
更新日期:2017-01-06 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1101
更新日期:2008-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S89401
更新日期:2015-08-24 00:00:00
abstract:Background:Being elderly and retired are related phenomena that overlap in a time symmetry. The present study aimed to assess the effect of an empowering self-management model on the self-efficacy and sense of coherence (SOC) in retired elderly with chronic diseases. Methods:A randomized controlled trial that included...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S183276
更新日期:2018-11-01 00:00:00
abstract::Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating informat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:Purpose:Producing tongue pressure (TP) by pushing the tongue against the palate consists of lifting the tongue muscles and elevating the floor of the mouth via suprahyoid muscle contraction. Though studies have shown that tongue-pressure resistance training (TPRT) increases tongue function, none have focused on suprahy...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S194808
更新日期:2019-03-22 00:00:00
abstract:PURPOSE:Patients leaving the hospital are at increased risk of functional decline and hospital readmission. The Employee and Community Health service at Mayo Clinic in Rochester developed a care transition program (CTP) to provide home-based care services for medically complex patients. The study objective was to deter...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S44390
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article on p. 1237 in vol. 13, PMID: 30034227.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S182535
更新日期:2018-09-05 00:00:00
abstract::The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass inde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2017-06-28 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2017-05-15 00:00:00