Polypharmacy: misleading, but manageable.

Abstract:

:The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effects, drug/drug interactions, drug/disease interactions, and inappropriate dosing. The purpose of this study is to identify a consensus definition for polypharmacy and evaluate its prevalence among elderly outpatients. The authors also sought to identify or develop a clinical tool which would assist healthcare practitioners guard against inappropriate drug therapy in elderly patients. The most commonly cited definition was a medication not matching a diagnosis. Inappropriate was part of definitions used frequently. Some definitions placed a numeric value on concurrent medications. Two common definitions (ie, 6 or more medications or a potentially inappropriate medication) were used to evaluate polypharmacy in elderly South Carolinians (n = 1027). Data analysis demonstrates that a significant percentage of this population is prescribed six or more concomitant drugs and/or uses a potentially inappropriate medication. The findings are 29.4% are prescribed 6 or more concurrent drugs, 15.7% are prescribed one or more potentially inappropriate drugs, and 9.3% meet both definitions of polypharmacy used in this study. The authors recommend use of less ambiguous terminology such as hyperpharmacotherapy or multiple medication use. A structured approach to identify and manage inappropriate polypharmacy is suggested and a clinical tool is provided.

journal_name

Clin Interv Aging

authors

Bushardt RL,Massey EB,Simpson TW,Ariail JC,Simpson KN

doi

10.2147/cia.s2468

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

383-9

issue

2

eissn

1176-9092

issn

1178-1998

journal_volume

3

pub_type

杂志文章
  • Current and emerging treatment options for the elderly patient with chronic kidney disease.

    abstract::The objective of this article is to review the current and emerging treatments of CKD prior to dialysis in the elderly. Worldwide, there are increasing numbers of people who are aged over 65 years. In parallel, there are increasing numbers of elderly patients presenting with chronic kidney disease (CKD), particularly ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S39763

    authors: Fassett RG

    更新日期:2014-01-15 00:00:00

  • Mindfulness training for psychological stress in family caregivers of persons with dementia: a systematic review and meta-analysis of randomized controlled trials.

    abstract::Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-ana...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,meta分析,评审

    doi:10.2147/CIA.S146213

    authors: Liu Z,Chen QL,Sun YY

    更新日期:2017-09-22 00:00:00

  • Detection of activities of daily living impairment in Alzheimer's disease and mild cognitive impairment using information and communication technology.

    abstract:BACKGROUND:One of the key clinical features of Alzheimer's disease (AD) is impairment in daily functioning. Patients with mild cognitive impairment (MCI) also commonly have mild problems performing complex tasks. Information and communication technology (ICT), particularly techniques involving imaging and video process...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S36297

    authors: Sacco G,Joumier V,Darmon N,Dechamps A,Derreumaux A,Lee JH,Piano J,Bordone N,Konig A,Teboul B,David R,Guerin O,Bremond F,Robert P

    更新日期:2012-01-01 00:00:00

  • Trunk Skeletal Muscle Mass and Phase Angle Measured by Bioelectrical Impedance Analysis are Associated with the Chance of Femoral Neck Fracture in Very Elderly People.

    abstract:Background:The study aimed to investigate the potential association of trunk skeletal muscle mass (tSM) and phase angle measured by bioelectrical impedance analysis (BIA) with the chance of femoral neck fractures in very elderly people. Patients and Methods:This case-control study enrolled 78 femoral neck fracture pat...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S250629

    authors: Chen J,Lu K,Chen H,Hu N,Chen J,Liang X,Qin J,Huang W

    更新日期:2020-06-12 00:00:00

  • Gene-expression changes in knee-joint tissues with aging and menopause: implications for the joint as an organ.

    abstract:Background:When considering the "joint as an organ", the tissues in a joint act as complementary components of an organ, and the "set point" is the cellular activity for homeostasis of the joint tissues. Even in the absence of injury, joint tissues have adaptive responses to processes, like aging and menopause, which r...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S151453

    authors: Rollick NC,Lemmex DB,Ono Y,Reno CR,Hart DA,Lo IK,Thornton GM

    更新日期:2018-03-01 00:00:00

  • Management of hyperlipidemia with statins in the older patient.

    abstract::Numerous randomized, double-blind, placebo-controlled studies and observational studies have demonstrated that statins decrease mortality and major cardiovascular events in older high-risk persons with hypercholesterolemia. The Heart Protection Study found that statins decreased mortality and major cardiovascular even...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/ciia.2006.1.4.433

    authors: Aronow WS

    更新日期:2006-01-01 00:00:00

  • Integrating participatory ergonomic management in non-weight-bearing exercise and progressive resistance exercise on self-care and functional ability in aged farmers with knee osteoarthritis: a clustered randomized controlled trial.

    abstract:Background:Ergonomic hazards are the most important cause of knee osteoarthritis (OA) in aged para rubber farmers. Ergonomic management comprising improvement of working conditions and muscle-strengthening exercise has been well documented in terms of workers' health benefit. However, those interventions were not adequ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S144288

    authors: Isaramalai SA,Hounsri K,Kongkamol C,Wattanapisitkul P,Tangadulrat N,Kaewmanee T,Yuenyongviwat V

    更新日期:2018-01-17 00:00:00

  • Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss.

    abstract::Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is k...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S10153

    authors: Trouvin AP,Goëb V

    更新日期:2010-11-19 00:00:00

  • Reduction of body fat and improved lipid profile associated with daily consumption of a Puer tea extract in a hyperlipidemic population: a randomized placebo-controlled trial.

    abstract:OBJECTIVE:The goal for this study was to evaluate the effects of daily consumption of Puer tea extract (PTE) on body weight, body-fat composition, and lipid profile in a non-Asian population in the absence of dietary restrictions. MATERIALS AND METHODS:A randomized, double-blind, placebo-controlled study design was us...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S94881

    authors: Jensen GS,Beaman JL,He Y,Guo Z,Sun H

    更新日期:2016-03-24 00:00:00

  • Prevalence and pattern of the elongated styloid process among geriatric patients in Saudi Arabia.

    abstract:OBJECTIVE:The objectives of this study were to assess the elongation of the styloid process on digital panoramic radiographs and to evaluate the prevalence of the elongation according to age, sex and types. PATIENTS AND METHODS:Digital panoramic radiographs of 198 geriatric edentulous patients were analyzed. The radio...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S129818

    authors: AlZarea BK

    更新日期:2017-03-30 00:00:00

  • Short-Term Effects of a Deterioration of General Health on the Oral Health of Nursing-Home Residents.

    abstract:Purpose:The purpose of this study was to identify how changes to general health might affect the oral health of nursing-home residents over a six-month period. Materials and Methods:The study was conducted in nine nursing homes in Germany. Sociodemographic and general data were collected at baseline and after six mont...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S234938

    authors: Klotz AL,Zajac M,Ehret J,Kilian S,Rammelsberg P,Zenthöfer A

    更新日期:2020-01-09 00:00:00

  • Optimal treatment of actinic keratoses.

    abstract::The most compelling reason and primary goal of treating actinic keratoses is to prevent malignant transformation into invasive squamous cell carcinoma, and although there are well established guidelines outlining treatment modalities and regimens for squamous cell carcinoma, the more commonly encountered precancerous ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S31930

    authors: Uhlenhake EE

    更新日期:2013-01-01 00:00:00

  • Frailty and postoperative complications in older Chinese adults undergoing major thoracic and abdominal surgery.

    abstract::Purpose: To determine the association between frailty and postoperative complications in elderly Chinese patients and to determine whether addition of frailty assessment improves the predictive ability of the American Society of Anesthesiologists (ASA) score, Physiological and Operative Severity Score for the Enumerat...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S201062

    authors: Han B,Li Q,Chen X

    更新日期:2019-05-22 00:00:00

  • Social participation and perceived depression among elderly population in South Africa.

    abstract::There is a growing consensus regarding the influence of various psychosocial factors such as degree of social participation on health and disease outcomes, quality of life, and general well-being. Older individuals with diminished motor and physical functionality suffer a heightened risk of social exclusion and loneli...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S137993

    authors: Hao G,Bishwajit G,Tang S,Nie C,Ji L,Huang R

    更新日期:2017-06-23 00:00:00

  • Physical performance in recently aged adults after 6 weeks traditional Thai dance: a randomized controlled trial.

    abstract:BACKGROUND:Exercise has been shown to be effective in cardiovascular endurance in the elderly. We studied the effect of Thai dancing on physical performance of Thai elderly. METHODS:This was an open-labeled, randomized intervention study. The Thai dancing group exercised for 40 minutes three times a week for 6 weeks. ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S41076

    authors: Janyacharoen T,Laophosri M,Kanpittaya J,Auvichayapat P,Sawanyawisuth K

    更新日期:2013-01-01 00:00:00

  • A training intervention to reduce paternalistic care and promote autonomy: a preliminary study.

    abstract:Introduction:Paternalism, assuming control of aged care, is a widespread orientation in older adults care. Paternalistic attitudes and practices are commonly understood as a threat to the freedom and autonomy of a person, making patients more dependent. Therefore, the reduction of these attitudes and behaviors is a pri...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S213644

    authors: Sánchez-Izquierdo M,Santacreu M,Olmos R,Fernández-Ballesteros R

    更新日期:2019-08-26 00:00:00

  • Changing from bevacizumab to ranibizumab in age-related macular degeneration. Is it safe?

    abstract:OBJECTIVE:To report our experiences in changing from intravitreal bevacizumab to ranibizumab in age-related macular degeneration (AMD). DESIGN:Retrospective case series. PARTICIPANTS AND METHODS:We retrospectively reviewed the records of 34 patients (36 eyes) who were treated with monthly injections of intravitreal b...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/cia.s8367

    authors: Karagiannis DA,Ladas ID,Parikakis E,Georgalas I,Kotsolis A,Amariotakis G,Soumplis V,Mitropoulos P

    更新日期:2009-01-01 00:00:00

  • Update on bazedoxifene: a novel selective estrogen receptor modulator.

    abstract::In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients' unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues t...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:

    authors: Biskobing DM

    更新日期:2007-01-01 00:00:00

  • Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-KCa2.3 signaling complex.

    abstract:Background:Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large elastic arteries and is a predominant risk factor for cardiovascular disease, the leading cause of morbidity and mortality in modern societies. Although exercise reduc...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S220283

    authors: Huang J,Zhang H,Tan X,Hu M,Shen B

    更新日期:2019-09-02 00:00:00

  • Clinical and economic aspects of the use of nebivolol in the treatment of elderly patients with heart failure.

    abstract::Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data support...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S4482

    authors: Del Sindaco D,Tinti MD,Monzo L,Pulignano G

    更新日期:2010-12-03 00:00:00

  • Activities of daily living as an additional predictor of complications and outcomes in elderly patients with acute myocardial infarction.

    abstract:BACKGROUND:Age is an important determinant of outcome in acute myocardial infarction (AMI). However, in clinical settings, there is an occasional mismatch between chronological age and physical age. We evaluated whether activities of daily living (ADL), which reflect physical age, also predict complications and prognos...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S107136

    authors: Nakajima H,Yoshioka J,Totsuka N,Miyazawa I,Usui T,Urasawa N,Kobayashi T,Mochidome T

    更新日期:2016-08-24 00:00:00

  • Population-based health promotion perspective for older driver safety: conceptual framework to intervention plan.

    abstract::The topic of motor vehicle crashes among the elderly is dynamic and multi-faceted requiring a comprehensive and synergistic approach to intervention planning. This approach must be based on the values of a given population as well as health statistics and asserted through community, organizational and policy strategie...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:

    authors: Classen S,Lopez ED,Winter S,Awadzi KD,Ferree N,Garvan CW

    更新日期:2007-01-01 00:00:00

  • Efficacy and safety of stenting for elderly patients with severe and symptomatic carotid artery stenosis: a critical meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To investigate both short-term and long-term therapeutic efficacy and safety of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for elderly patients with severe and symptomatic carotid artery stenosis. METHODS:PubMed, EMBASE, Cochrane Library, Clinical Trials Register Centers, and Googl...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,meta分析

    doi:10.2147/CIA.S91721

    authors: Ouyang YA,Jiang Y,Yu M,Zhang Y,Huang H

    更新日期:2015-10-28 00:00:00

  • Age-related changes in muscle strength and spinal kyphosis angles in an elderly Japanese population.

    abstract::Lumbar kyphosis and the decreased mobility of the lumbar spine increase the risk of falls and impair both the quality of life and the ability to perform activities of daily living. However, in the elderly Japanese population, little is known about the age-related changes and sex-related differences in muscle strength,...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S113352

    authors: Kasukawa Y,Miyakoshi N,Hongo M,Ishikawa Y,Kudo D,Suzuki M,Mizutani T,Kimura R,Ono Y,Shimada Y

    更新日期:2017-02-20 00:00:00

  • Comprehensive geriatric intervention program with and without weekly class-style exercise: research protocol of a cluster randomized controlled trial in Kyoto-Kameoka Study.

    abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S151427

    authors: Watanabe Y,Yamada Y,Yokoyama K,Yoshida T,Yoshinaka Y,Yoshimoto M,Tanaka Y,Itoi A,Yamagata E,Ebine N,Ishikawa-Takata K,Kimura M

    更新日期:2018-05-24 00:00:00

  • Structured interdisciplinary bedside rounds, in-hospital deaths, and new nursing home placements among older inpatients.

    abstract:Purpose:Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements. Mate...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S171508

    authors: Basic D,Huynh E,Gonzales R,Shanley C

    更新日期:2018-11-08 00:00:00

  • Impact on facial rejuvenation with dermatological preparations.

    abstract::The treatment options for facial rejuvenation using dermatological, nonsurgical techniques have dramatically increased in the past 10 years. This follows the introduction of botulinum toxin and a variety of dermal fillers. The public interest in noninvasive treatments has changed the market beyond recognition with mor...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/cia.s3524

    authors: Bowler PJ

    更新日期:2009-01-01 00:00:00

  • Percutaneous kyphoplasty combined with zoledronic acid infusion in the treatment of osteoporotic thoracolumbar fractures in the elderly.

    abstract:Objective:We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OVCFs]). Materials and methods:We retrospectively analyzed 95 elde...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S146871

    authors: Shi C,Zhang M,Cheng AY,Huang ZF

    更新日期:2018-05-04 00:00:00

  • Older women with dementia can perform fast alternating forearm movements and performance is correlated with tests of lower extremity function.

    abstract:BACKGROUND:The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia. METHODS:Fast alternating movements was studied in 26 female patients (mean age 81.7 ± 5.9 years) ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S37733

    authors: Bramell-Risberg E,Jarnlo GB,Elmståhl S

    更新日期:2013-01-01 00:00:00

  • A comparison between metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty as surgical treatments for hallux rigidus: a retrospective study with short- to midterm follow-up.

    abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S110865

    authors: Mermerkaya MU,Adli H

    更新日期:2016-12-13 00:00:00