Abstract:
:In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients' unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues to search for more effective and tolerable osteoporosis agents. Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment. A new drug application (NDA) for postmenopausal osteoporosis prevention was recently submitted to the FDA. Preclinical and clinical studies with bazedoxifene demonstrate more tissue selectivity than other SERMs. In particular, bazedoxifene has minimal if any agonist activity in the uterus and is able to antagonize effects of estrogen on the uterus. Animal studies and early clinical studies suggest effects in the bone similar to other SERMs with prevention of postmenopausal bone loss. Until more data on efficacy and safety are published, however, its role in osteoporosis is unknown.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Biskobing DMsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
299-303issue
3eissn
1176-9092issn
1178-1998journal_volume
2pub_type
杂志文章,评审abstract:Background:Myocardial infarction (MI) is a common cause of death worldwide. It is characterized by coronary artery occlusion that causes ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Materials and Methods:To explore potential targets for treatment of MI, we reorganized and analyz...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S281290
更新日期:2020-12-01 00:00:00
abstract::[This corrects the article on p. 737 in vol. 13, PMID: 29731615.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S172968
更新日期:2018-09-10 00:00:00
abstract:Purpose:Producing tongue pressure (TP) by pushing the tongue against the palate consists of lifting the tongue muscles and elevating the floor of the mouth via suprahyoid muscle contraction. Though studies have shown that tongue-pressure resistance training (TPRT) increases tongue function, none have focused on suprahy...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S194808
更新日期:2019-03-22 00:00:00
abstract:BACKGROUND:Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. PURPOSE:To determine the relationship between multiple vascular risk exposures, as counted on an index in cases...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S28143
更新日期:2012-01-01 00:00:00
abstract:Purpose:The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly. Patients and methods:Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S192050
更新日期:2019-02-15 00:00:00
abstract::Background: Current surgical risk assessment tools fall short of appreciating geriatric risk factors including cognitive deficits, depressive, and frailty symptoms that may worsen outcomes post-transcatheter aortic valve implantation (TAVI). This study hypothesized that a screening tool, SMARTIE, would improve detecti...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S201615
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Aortic valve stenosis is common in the elderly, with a prevalence of nearly 3% in patients aged 75 years or older. Despite the fact that sleep-related breathing disorders (SRBD) are thought to be associated with cardiac disease, little is known about their prevalence in this patient cohort. The purpose of th...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S87189
更新日期:2015-09-07 00:00:00
abstract:BACKGROUND:Life style and physical activity play a pivotal role in prevention and treatment of osteoporosis. The mechanism for better bone metabolism and improvement of physical disorders is not clear yet. Trace minerals such as Ca, Mn, Cu, and Zn are essential precursors for most vital biological process, especially t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S100566
更新日期:2016-02-29 00:00:00
abstract::Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-ana...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析,评审
doi:10.2147/CIA.S146213
更新日期:2017-09-22 00:00:00
abstract:OBJECTIVE:The purpose of this work was to analyze and compare the movement kinematics of sit-to-stand (STS) and back-to-sit (BTS) transfers between frail aged adults and young subjects, as well as to determine the relationship between kinematic changes and functional capacities. METHODS:We analyzed the Timed Up and Go...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S74755
更新日期:2015-02-26 00:00:00
abstract::Lumbar kyphosis and the decreased mobility of the lumbar spine increase the risk of falls and impair both the quality of life and the ability to perform activities of daily living. However, in the elderly Japanese population, little is known about the age-related changes and sex-related differences in muscle strength,...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S113352
更新日期:2017-02-20 00:00:00
abstract:Background:Transcutaneous electrical nerve stimulation (TENS) is a noninvasive modality which may be used to reduce acute postoperative pain. Intense perioperative pain within the first few days after hip fracture surgery is common and is related to negative consequences such as restricted and delayed ambulation. Obje...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S203658
更新日期:2019-10-29 00:00:00
abstract:Purpose:The incidence of proximal humeral fractures is high in the elderly, and the superior management of these fractures remains a controversy. The study aims to compare clinical outcomes of intramedullary nails, locking plates and conservative treatment for the management of displaced proximal humeral fractures in t...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章
doi:10.2147/CIA.S144084
更新日期:2017-11-29 00:00:00
abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S151427
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is closely linked to cardiovascular risk factors. METHODS:Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63337
更新日期:2014-07-16 00:00:00
abstract::Osteoarthritis is the most common arthritis in the world. It affects millions of people with age being the greatest risk factor for developing the disease. The burden of disease will worsen with the aging of the world's population. The disease causes pain and functional disability. The direct costs of osteoarthritis i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1632
更新日期:2007-01-01 00:00:00
abstract:Purpose:The aim of the study was to evaluate the impact of inertial training on upper and lower extremity strength in the elderly. The study also assessed the influence of inertial training on their independence, balance, and speed and quality of gait. Methods:Twenty physically inactive older residents of a nursing ho...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
abstract:BACKGROUND:The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. METHODS:The motor functions and ultrasound images of 19 elderly (73 ± 3.2 years) and 19 young (22 ± 1.5 years) individuals were...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S67820
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:Gerontological research aims at understanding factors that are crucial for mediating "successful aging". This term denotes the absence of significant disease and disabilities, maintenance of high levels of physical and cognitive function, and preservation of social and productive activities. Preservation of ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S15433
更新日期:2011-01-01 00:00:00
abstract:Purpose:This study aimed to investigate the effect of religious intervention on depressive symptoms and quality of life (QOL) among Indonesian elderly in nursing homes (NHs). Patients and methods:This was a quasi-experimental study with repeated measures. Sixty elderly residents at three NHs in three districts in Yogy...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S162946
更新日期:2018-03-23 00:00:00
abstract:BACKGROUND:Rheumatic diseases, irrespective of etiology and clinical course, influence different areas of a patient's life. Adapting to disability and limitations caused by an illness is very difficult for many patients. The main goal of a therapeutic procedure should be improvement of health-related quality of life (Q...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S116185
更新日期:2016-11-28 00:00:00
abstract::Fluctuating Parkinson's disease (PD) represents a clinical management challenge. The primary utility of levodopa in patients with PD is moderated by the "wearing off" phenomena seen with long-term use. COMT inhibitors slow down the rapid metabolism of levodopa, resulting in a more-sustained response to dopaminergic th...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/ciia.2006.1.4.317
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the effect of two sessions of resistance exercise with different volumes on post-exercise hypotension, forearm blood flow, and forearm vascular resistance in hypertensive elderly subjects. METHODS:The study was conducted with ten hypertensive elderly (65±3 years, 28...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S53441
更新日期:2014-12-12 00:00:00
abstract:OBJECTIVE:The best practice tariff (BPT) incentivizes hospitals in the England and Wales National Health Service to provide multiprofessional care to patients with hip fractures. The initial six targets included: 1) admission under consultant-led joint orthopedic-geriatric care, 2) multidisciplinary assessment protocol...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S65736
更新日期:2014-12-01 00:00:00
abstract::Dementia is one of the most important public health problems as a result of the rapid increase in the number of elderly persons worldwide. Improvement of prevention strategies and caring for people with dementia should be undertaken. We performed a door-to-door study to screen all subjects aged 50 years and older (n=4...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S48325
更新日期:2014-01-01 00:00:00
abstract:Aim:To contribute to the knowledge about the mechanisms involved in aortic stiffness due to ageing. Materials and Methods:Aortic rings from young (1.5±0.5 months, 0.8±0.2 kg), adult (6±0.5 months, 2.7±0.5 kg) and old (28±8 months, 3.2±0.8 kg) male New Zealand rabbits were used to evaluate: 1) intima-media thickness by...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S236173
更新日期:2020-04-20 00:00:00
abstract::The increasingly aged population worldwide means more people are living with chronic diseases, reduced autonomy, and taking various medications. Health professionals should take these into consideration when managing dermatological problems in elderly patients. Accordingly, current research is investigating the dermat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S96232
更新日期:2016-02-12 00:00:00
abstract::Sensorimotor functions decrease in old age. The well-documented loss of tactile acuity in elderly is accompanied by deterioration ofhaptic performance and fine manipulative movements. Physical training and exercise can maintain sensorimotor fitness into high age. However, regular schedules of training require discipli...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s3174
更新日期:2008-01-01 00:00:00
abstract::The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass inde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S120876
更新日期:2017-06-28 00:00:00
abstract::Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating informat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00