Influence of Ageing on Vascular Reactivity and Receptor Expression in Rabbit Aorta: A Complement to Elastocalcinosis and Smooth Muscle Mechanisms.

Abstract:

Aim:To contribute to the knowledge about the mechanisms involved in aortic stiffness due to ageing. Materials and Methods:Aortic rings from young (1.5±0.5 months, 0.8±0.2 kg), adult (6±0.5 months, 2.7±0.5 kg) and old (28±8 months, 3.2±0.8 kg) male New Zealand rabbits were used to evaluate: 1) intima-media thickness by optical microscopy; 2) vascular reactivity (VR) in terms of sensitivity (pD2) and efficacy (Emax) to KCl; phenylephrine (PE); U-46619, a thromboxane A2 receptor agonist, TXA2; carbachol (CCh), isoproterenol and sodium nitroprusside (SNP), using organ bath experiments; and 3) the expression of receptors α1, β2 and thromboxane-prostanoids (TP), by immunofluorescence. Results:Ageing 1) did not change the thickness of tunica; 2) significantly reduced the pD2 to KCl, increased the pD2 to PE and reduced both the pD2 and Emax to TXA2, CCh and isoproterenol, and reduced the pD2 to SNP; and 3) significantly increased the expression of α1 and β2 receptors in the intima and adventitia, and the expression of TP only in the adventitia. Conclusion:Our results suggest that ageing makes the aorta more reactive to α1 adrenergic contraction, and it could be a compensation for lower responsiveness to prostanoids. The aged aorta is less reactive to endothelium-dependent and non-dependent relaxation, and the vessel seems to try to compensate for that stiffness increasing β2 receptors, although probably less functional. These results complement the proposed mechanisms of elastocalcinosis and smooth muscle rigidity, expanding the vision that should guide the treatment of aortic stiffness due to aging.

journal_name

Clin Interv Aging

authors

Cupitra NI,Calderón JC,Narvaez-Sanchez R

doi

10.2147/CIA.S236173

subject

Has Abstract

pub_date

2020-04-20 00:00:00

pages

537-545

eissn

1176-9092

issn

1178-1998

pii

236173

journal_volume

15

pub_type

杂志文章
  • A comparison between metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty as surgical treatments for hallux rigidus: a retrospective study with short- to midterm follow-up.

    abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S110865

    authors: Mermerkaya MU,Adli H

    更新日期:2016-12-13 00:00:00

  • Nutritional screening of older home-dwelling Norwegians: a comparison between two instruments.

    abstract:BACKGROUND:It is important to obtain knowledge about the prevalence of nutritional risk and associated factors among older home-dwelling people in order to be able to meet nutritional challenges in this group in the future and to plan appropriate interventions. The aim of this survey was to investigate the prevalence o...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S35986

    authors: Söderhamn U,Dale B,Sundsli K,Söderhamn O

    更新日期:2012-01-01 00:00:00

  • The relationship between cholesterol and cognitive function is homocysteine-dependent.

    abstract:INTRODUCTION:Previous studies have identified hyperlipidemia as a potential risk factor for dementia and Alzheimer's disease. However, studies on cholesterol measured in late-life and cognitive function have been inconsistent. Few studies have explored nonlinear relationships or considered interactions with other bioma...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S64766

    authors: Cheng Y,Jin Y,Unverzagt FW,Su L,Yang L,Ma F,Hake AM,Kettler C,Chen C,Liu J,Bian J,Li P,Murrell JR,Hendrie HC,Gao S

    更新日期:2014-10-23 00:00:00

  • Correlation between bone mineral density and serum trace elements in response to supervised aerobic training in older adults.

    abstract:BACKGROUND:Life style and physical activity play a pivotal role in prevention and treatment of osteoporosis. The mechanism for better bone metabolism and improvement of physical disorders is not clear yet. Trace minerals such as Ca, Mn, Cu, and Zn are essential precursors for most vital biological process, especially t...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S100566

    authors: Alghadir AH,Gabr SA,Al-Eisa ES,Alghadir MH

    更新日期:2016-02-29 00:00:00

  • Trunk Skeletal Muscle Mass and Phase Angle Measured by Bioelectrical Impedance Analysis are Associated with the Chance of Femoral Neck Fracture in Very Elderly People.

    abstract:Background:The study aimed to investigate the potential association of trunk skeletal muscle mass (tSM) and phase angle measured by bioelectrical impedance analysis (BIA) with the chance of femoral neck fractures in very elderly people. Patients and Methods:This case-control study enrolled 78 femoral neck fracture pat...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S250629

    authors: Chen J,Lu K,Chen H,Hu N,Chen J,Liang X,Qin J,Huang W

    更新日期:2020-06-12 00:00:00

  • Severe aortic valve stenosis in the elderly: high prevalence of sleep-related breathing disorders.

    abstract:BACKGROUND:Aortic valve stenosis is common in the elderly, with a prevalence of nearly 3% in patients aged 75 years or older. Despite the fact that sleep-related breathing disorders (SRBD) are thought to be associated with cardiac disease, little is known about their prevalence in this patient cohort. The purpose of th...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S87189

    authors: Keymel S,Hellhammer K,Zeus T,Merx M,Kelm M,Steiner S

    更新日期:2015-09-07 00:00:00

  • Predicting hemorrhage and obstruction in the elderly population using thromboelastographic indices.

    abstract:OBJECTIVE:To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population. METHODS:This was a prospective cohort study of patients 65 years and older without hemato-logic disorders who received thromboelastography (TEG) examination at the Chi...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S49478

    authors: Zheng Q,Fu S,Chen D,Li X,Li Y,Li Y,Yu J,Gong M,Bai J

    更新日期:2013-01-01 00:00:00

  • Association between body composition and stair negotiation ability among individuals >55 years of age: a cross-sectional study.

    abstract:BACKGROUND:Loss of muscle strength exerts a considerable impact on the quality of life and mortality of older adults. The present household survey study measured body composition and muscle strength with the aim of analyzing the roles of low lean mass, low muscle strength and obesity in stair negotiation ability and th...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S126779

    authors: Dip RM,Cabrera MA,Prato SF

    更新日期:2017-08-18 00:00:00

  • The mean platelet volume on admission predicts unfavorable stroke outcomes in patients treated with IV thrombolysis.

    abstract:Purpose:The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in pat...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S195451

    authors: Staszewski J,Pogoda A,Data K,Walczak K,Nowocień M,Frankowska E,Stępień A

    更新日期:2019-02-27 00:00:00

  • Impact of Different Geriatric Conditions on Choice of Therapy and In-Hospital Outcomes in Elderly Patients with Acute Coronary Syndrome.

    abstract:Introduction:The clinical benefit of invasive therapy in elderly patients with acute coronary syndrome (ACS) remains unclear. Furthermore, the decision-making process to treat this growing patient group is also debatable. The purpose of this study was to assess the association between elderly ACS patients, the treatmen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S249017

    authors: Rittger H,Stadelmaier C,Kieschnick T,Büber D,Rank K,Vitali-Serdoz L,Bastian D,Waliszewski M

    更新日期:2020-05-25 00:00:00

  • Efficacy and safety of bazedoxifene for postmenopausal osteoporosis.

    abstract::Bazedoxifene, a novel selective estrogen receptor modulator, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. Two large Phase III clinical trials showed that bazedoxifene, as well as raloxifene, increased bone mineral density, decreas...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S15711

    authors: Kawate H,Takayanagi R

    更新日期:2011-01-01 00:00:00

  • Pharmacological Therapy of Osteoporosis: What's New?

    abstract::Osteoporosis and fragility fractures are relevant health issues because of their impact in terms of morbidity, mortality, and socioeconomic burden. Despite this alarming scenario, both underdiagnosis and undertreatment are common features of osteoporotic patients, particularly those who have already sustained a fragil...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S242038

    authors: Iolascon G,Moretti A,Toro G,Gimigliano F,Liguori S,Paoletta M

    更新日期:2020-03-26 00:00:00

  • A review of tazarotene in the treatment of photodamaged skin.

    abstract::Chronic sun exposure leads to photodamage, which is characterized clinically by fine and coarse wrinkles, dyspigmentation, telangiectasia, laxity, roughness and a sallow appearance. Many treatments claim to reduce the signs of photodamage, however evidence from randomized controlled trials (RCT) to support these claim...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/cia.s1101

    authors: Ogden S,Samuel M,Griffiths CE

    更新日期:2008-01-01 00:00:00

  • Erratum: Effectiveness of the "Elderly Activity Performance Intervention" on elderly patients' discharge from a short-stay unit at the emergency department: a quasi-experimental trial [Corrigendum].

    abstract::[This corrects the article on p. 737 in vol. 13, PMID: 29731615.]. ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,已发布勘误

    doi:10.2147/CIA.S172968

    authors:

    更新日期:2018-09-10 00:00:00

  • Clinical investigation of transradial access for emergent percutaneous coronary intervention in patients with acute myocardial infarction.

    abstract:BACKGROUND:Use of intensive anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications during percutaneous coronary intervention via the transfemoral route. Recently, the transradial access has been intensively employed as an alternative means ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S50939

    authors: Qin X,Xiong W,Wang L,Guan E,Lu C

    更新日期:2013-01-01 00:00:00

  • Effect of vascular burden as measured by vascular indexes upon vascular dementia: a matched case-control study.

    abstract:BACKGROUND:Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. PURPOSE:To determine the relationship between multiple vascular risk exposures, as counted on an index in cases...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S28143

    authors: Takahashi PY,Caldwell CR,Targonski PV

    更新日期:2012-01-01 00:00:00

  • Short-Term Effects of a Deterioration of General Health on the Oral Health of Nursing-Home Residents.

    abstract:Purpose:The purpose of this study was to identify how changes to general health might affect the oral health of nursing-home residents over a six-month period. Materials and Methods:The study was conducted in nine nursing homes in Germany. Sociodemographic and general data were collected at baseline and after six mont...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S234938

    authors: Klotz AL,Zajac M,Ehret J,Kilian S,Rammelsberg P,Zenthöfer A

    更新日期:2020-01-09 00:00:00

  • Preoperative Serum Albumin Level As A Predictor Of Postoperative Pneumonia After Femoral Neck Fracture Surgery In A Geriatric Population.

    abstract:Purpose:Femoral neck fracture usually occurs in the geriatric population. Postoperative pneumonia (POP) is known to be devastated, and it is the most frequent complication among patients receiving surgical treatment for femoral neck fractures. However, whether patients who have hypoalbuminaemia are susceptible to the d...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S231736

    authors: Wang Y,Li X,Ji Y,Tian H,Liang X,Li N,Wang J

    更新日期:2019-11-13 00:00:00

  • Clinical and economic aspects of the use of nebivolol in the treatment of elderly patients with heart failure.

    abstract::Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data support...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S4482

    authors: Del Sindaco D,Tinti MD,Monzo L,Pulignano G

    更新日期:2010-12-03 00:00:00

  • Association Between Body Composition and Frailty in Elder Inpatients.

    abstract:Purpose:The study aimed to investigate the association between body composition and frailty in elder inpatients. Patients and Methods:This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and Ma...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S243211

    authors: Xu L,Zhang J,Shen S,Hong X,Zeng X,Yang Y,Liu Z,Chen L,Chen X

    更新日期:2020-03-04 00:00:00

  • Discrepancies in Cornell Scale for Depression in Dementia (CSDD) items between residents and caregivers, and the CSDD's factor structure.

    abstract:PURPOSE:This validation study aims to examine Cornell Scale for Depression in Dementia (CSDD) items in terms of the agreement found between residents and caregivers, and also to compare alternative models of the Thai version of the CSDD. PATIENTS AND METHODS:A cross-sectional study was conducted of 84 elderly resident...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S45201

    authors: Wongpakaran N,Wongpakaran T,van Reekum R

    更新日期:2013-01-01 00:00:00

  • Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis.

    abstract:Introduction:Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S170111

    authors: Mederle OA,Balas M,Ioanoviciu SD,Gurban CV,Tudor A,Borza C

    更新日期:2018-08-03 00:00:00

  • Perioperative Complications And Risk Factors In Degenerative Lumbar Scoliosis Surgery For Patients Older Than 70 Years Of Age.

    abstract:Study design:Multivariate analysis of retrospective registry data. Objective:To report the perioperative complication in a large cohort of surgery for elderly degenerative lumbar scoliosis (DLS) patients and to analyze the risk factors. Summary of background data:The perioperative complication rate and risk factors f...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S218204

    authors: Ding JZ,Kong C,Sun XY,Lu SB

    更新日期:2019-12-16 00:00:00

  • Cognitive function and 3-year mortality in the very elderly Chinese population with chronic kidney disease.

    abstract:Background:Cognitive function has been suggested to be correlated with mortality, while studies regarding the association among the very elderly population with chronic kidney disease (CKD) are extremely limited. Aim:To explore the association between cognitive function and mortality among the very elderly Chinese pop...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S173696

    authors: Bai K,Pan Y,Lu F,Zhao Y,Wang F,Zhang L

    更新日期:2018-10-18 00:00:00

  • Comparative analysis of the expected demands for nursing care services among older people from urban, rural, and institutional environments.

    abstract:BACKGROUND:Demand for nursing and social services may vary depending on the socio-demographic variables, health status, receipt of formal and informal care provided, and place of residence. OBJECTIVES:To conduct a comparative analysis of the expectations of older people from urban, rural, and institutional environment...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S72534

    authors: Borowiak E,Kostka J,Kostka T

    更新日期:2015-02-02 00:00:00

  • Update on bazedoxifene: a novel selective estrogen receptor modulator.

    abstract::In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients' unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues t...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:

    authors: Biskobing DM

    更新日期:2007-01-01 00:00:00

  • Treatment of Alzheimer's disease across the spectrum of severity.

    abstract::Alzheimer's disease (AD) is the most common cause of dementia affecting nearly 18 million people around the world and 4.5 million in the US. It is a progressive neurodegenerative condition that is estimated to dramatically increase in prevalence as the elderly population continues to grow. As the cognitive and neurops...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/ciia.2006.1.2.131

    authors: Shah S,Reichman WE

    更新日期:2006-01-01 00:00:00

  • Risk Of Urticaria In Geriatric Stroke Patients Who Received Influenza Vaccination: A Retrospective Cohort Study.

    abstract:Objective:Urticaria is a mast cell-related disease caused severe itching and the lifetime prevalence of urticaria is about 20% in general population. Our purpose is to evaluate risk of urticaria in geriatric stroke patients received influenza vaccination (IV). Methods:In a cohort of 192,728 patients with newly diagnos...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S228324

    authors: Lam F,Shih CC,Chen TL,Lin CS,Huang HJ,Yeh CC,Huang YC,Chiou HY,Liao CC

    更新日期:2019-11-26 00:00:00

  • Frequency analysis of ultrasonic echo intensities of the skeletal muscle in elderly and young individuals.

    abstract:BACKGROUND:The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. METHODS:The motor functions and ultrasound images of 19 elderly (73 ± 3.2 years) and 19 young (22 ± 1.5 years) individuals were...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S67820

    authors: Nishihara K,Kawai H,Hayashi H,Naruse H,Kimura A,Gomi T,Hoshi F

    更新日期:2014-09-05 00:00:00

  • Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese.

    abstract:BACKGROUND:No conventional creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation performed consistently outstandingly in elderly Chinese in our previous studies. This research aimed to further evaluate the performance of some recently proposed estimation equations based on creatinine and ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S68801

    authors: Ye X,Wei L,Pei X,Zhu B,Wu J,Zhao W

    更新日期:2014-09-11 00:00:00