Abstract:
:Bazedoxifene, a novel selective estrogen receptor modulator, has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. Two large Phase III clinical trials showed that bazedoxifene, as well as raloxifene, increased bone mineral density, decreased levels of bone turnover markers, and significantly reduced the risk of new vertebral fractures in postmenopausal women compared with placebo. Although the incidence of nonvertebral fractures with bazedoxifene or raloxifene did not differ significantly from that with placebo, a post hoc analysis of a subgroup of women at higher fracture risk revealed that bazedoxifene significantly reduced the nonvertebral fracture risk relative to placebo and raloxifene. Bazedoxifene also improved the lipid profile by reducing the serum concentrations of total cholesterol and low-density lipoprotein cholesterol, with an increase in the serum level of high-density lipoprotein cholesterol. The incidences of vasodilatation (hot flushes), leg cramps, and venous thromboembolic events were significantly higher with bazedoxifene and raloxifene compared with placebo. There was no evidence of endometrial and breast stimulation with bazedoxifene. Taking advantage of the favorable effects of bazedoxifene on the breast and endometrium, the pairing of bazedoxifene with conjugated estrogens is under investigation for the treatment of menopausal symptoms and prevention of postmenopausal osteoporosis. A Phase III trial showed that combination therapy of bazedoxifene and conjugated estrogens significantly increased bone mineral density and decreased bone turnover markers, with relief of hot flushes and improvement of vaginal atrophy. This article reviews the clinical efficacy and safety of bazedoxifene in the treatment of postmenopausal osteoporosis.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Kawate H,Takayanagi Rdoi
10.2147/CIA.S15711subject
Has Abstractpub_date
2011-01-01 00:00:00pages
151-60eissn
1176-9092issn
1178-1998pii
cia-6-151journal_volume
6pub_type
杂志文章,评审abstract:Background:Postoperative functional training for fracture or osteoarthritis is mainly focused on functional self-exercise, which aims to recover the function of the lower limbs. Purpose:To compare the function and life quality recovery in patients with fracture or arthritis treated with novel muscle training device (N...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S277118
更新日期:2020-11-18 00:00:00
abstract::Fracture of the hip is frequently a catastrophic event in the elderly, often resulting in death within a year and of the survivors, few regain pre-fracture quality of life. Although less appreciated, fractures of the spine result in significant morbidity and are also associated with increased mortality compared with i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s241
更新日期:2007-01-01 00:00:00
abstract:Background:A thorough analysis of the capability for self-care in patients with heart failure (HF) reduces the frequency of hospitalizations that are caused by decompensation. The aim of the study was to assess the effect of the method of therapy for HF, the degree of the acceptance of illness, and the occurrence of fr...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S178393
更新日期:2018-10-08 00:00:00
abstract:Background:Myocardial infarction (MI) is a common cause of death worldwide. It is characterized by coronary artery occlusion that causes ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Materials and Methods:To explore potential targets for treatment of MI, we reorganized and analyz...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S281290
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S55972
更新日期:2014-02-14 00:00:00
abstract::Promoting health and prolonging independence in the home is a priority for older adults, caregivers, clinicians, and society at large. Rapidly developing robotics technology provides a platform for interventions, with the fields of physically and socially assistive robots expanding in recent years. However, less atten...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S253236
更新日期:2020-07-13 00:00:00
abstract::Vitamin E has been proposed as a potential clinical intervention for Alzheimer's disease (AD) given the plausibility of its various biological functions in influencing the neurodegenerative processes associated with the condition. The tocopherol and tocotrienol isoforms of vitamin E have multiple properties including ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S186760
更新日期:2019-07-18 00:00:00
abstract::Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating informat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Type 2 diabetes mellitus affects 5.9% of the world adult population, with older people and some ethnic groups disproportionately affected. Treatment of older people with diabetes differs in many ways from that in younger adults since the majority have type 2 disease and are at particular risk of macrovascular rather t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3142
更新日期:2009-01-01 00:00:00
abstract:Objective:We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OVCFs]). Materials and methods:We retrospectively analyzed 95 elde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S146871
更新日期:2018-05-04 00:00:00
abstract:Introduction:Paternalism, assuming control of aged care, is a widespread orientation in older adults care. Paternalistic attitudes and practices are commonly understood as a threat to the freedom and autonomy of a person, making patients more dependent. Therefore, the reduction of these attitudes and behaviors is a pri...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S213644
更新日期:2019-08-26 00:00:00
abstract:Background:Cognitive function has been suggested to be correlated with mortality, while studies regarding the association among the very elderly population with chronic kidney disease (CKD) are extremely limited. Aim:To explore the association between cognitive function and mortality among the very elderly Chinese pop...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S173696
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. METHODS:The motor functions and ultrasound images of 19 elderly (73 ± 3.2 years) and 19 young (22 ± 1.5 years) individuals were...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S67820
更新日期:2014-09-05 00:00:00
abstract:OBJECTIVE:To describe challenges in disseminating the Health Enhancement Program (HEP), a community-based disability prevention program for community dwelling elders, and to examine program effectiveness in geographically dispersed sites. METHODS:Within-group, pre-test-post-test comparisons of disability risk factors,...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/ciia.2006.1.3.267
更新日期:2006-01-01 00:00:00
abstract:Study design:Multivariate analysis of retrospective registry data. Objective:To report the perioperative complication in a large cohort of surgery for elderly degenerative lumbar scoliosis (DLS) patients and to analyze the risk factors. Summary of background data:The perioperative complication rate and risk factors f...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S218204
更新日期:2019-12-16 00:00:00
abstract::Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S44797
更新日期:2013-01-01 00:00:00
abstract:Background:The study aimed to investigate the potential association of trunk skeletal muscle mass (tSM) and phase angle measured by bioelectrical impedance analysis (BIA) with the chance of femoral neck fractures in very elderly people. Patients and Methods:This case-control study enrolled 78 femoral neck fracture pat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S250629
更新日期:2020-06-12 00:00:00
abstract:Purpose:The post-stroke elderly was increased caused by increasing stroke and advanced medical. However, ankle-foot orthoses (AFOs) can be uncomfortable for hemiplegic patients; therefore, the usability is not good. In this study, we analyzed ankle and knee joint angles in post-stroke elderly patients to assess the fun...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S222087
更新日期:2019-12-05 00:00:00
abstract:Background:Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large elastic arteries and is a predominant risk factor for cardiovascular disease, the leading cause of morbidity and mortality in modern societies. Although exercise reduc...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S220283
更新日期:2019-09-02 00:00:00
abstract::Overactive bladder (OAB) is a difficult condition to live with and is very costly to the community. OAB affects 16% of the adult population and rises with increasing age. We describe the necessary steps in evaluation and behavioral therapy prior to initiating medical therapy. There are several medications that have be...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3414
更新日期:2008-01-01 00:00:00
abstract:Purpose:This study evaluates the effect of introducing active gait training (AGT) to patients who are severely disabled with nasogastric tube feeding or gastrostoma on the recovery of oral feeding. Patients and Methods:We conducted a historical cohort study at a single rehabilitation center in Japan between January 20...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S270277
更新日期:2020-10-13 00:00:00
abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S151427
更新日期:2018-05-24 00:00:00
abstract::The introduction of organized cervical cancer (CC) screening programs has drastically reduced the prevalence of CC. However the incidence is still too high, especially among elderly women. All guidelines strongly recommend a regular Papanicolaou (Pap) testing for young and middle-aged patients. On the other hand, many...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57294
更新日期:2014-04-15 00:00:00
abstract::The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effe...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s2468
更新日期:2008-01-01 00:00:00
abstract:Background:Multiple cranial dural arteriovenous fistulas (dAVFs) are considered to be an uncommon vascular condition. dAVFs usually manifest with vague symptoms, which are related to the site of occurrence of the lesion and present with complex angio-architectural features, which in turn can render treatment procedures...
journal_title:Clinical interventions in aging
pub_type:
doi:10.2147/CIA.S277762
更新日期:2020-12-08 00:00:00
abstract:Purpose:Femoral neck fracture usually occurs in the geriatric population. Postoperative pneumonia (POP) is known to be devastated, and it is the most frequent complication among patients receiving surgical treatment for femoral neck fractures. However, whether patients who have hypoalbuminaemia are susceptible to the d...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S231736
更新日期:2019-11-13 00:00:00
abstract:Objective:The aim of this study was to compare the perceived oral health of elderly persons and the clinical reality of their oral status. Background:Persons aged over 60 have considerable need for oral health care; a need that increases over time. However, this population appears to be unaware of their state of oral ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S204533
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the trend in increasing life expectancy in relation to heart attack and cardiac catheterization. METHODS:A retrospective study of very elderly patients over 90 years of age (study group) and between 70 and 79 years of age (control group) with myocardial infarction and ac...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S29045
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To study the feasibility of first, reaching functionally declined, but still independent older persons at risk of falls through their general practitioner (GP) and second, to reduce their physiological and psychological fall risk factors with a complex exercise intervention. We investigated the effects of a 16-...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S46218
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63596
更新日期:2014-07-22 00:00:00