Abstract:
:Fracture of the hip is frequently a catastrophic event in the elderly, often resulting in death within a year and of the survivors, few regain pre-fracture quality of life. Although less appreciated, fractures of the spine result in significant morbidity and are also associated with increased mortality compared with individuals without a fracture. In recent years there has been an explosion in the development of new drugs for the treatment of osteoporosis. Recombinant human parathyroid hormone (1-34) (20 microg/day) is a recent addition to this armamentarium with a novel mechanism of action, which was approved by the US FDA for the treatment of postmenopausal osteoporosis and male osteoporosis secondary to hypogonadism in November 2002. It is the first osteoporosis treatment that leads to the formation of new bone with architecture similar to normal bone. Intense efforts have been made to understand the effect of teriparatide on antiresorptive therapy and vice versa. Although these relationships are not completely understood, the results of recent studies allow clinicians to begin to optimize therapeutic gains in bone mineral density and improve anti-fracture efficacy.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Bodenner D,Redman C,Riggs Adoi
10.2147/cia.s241subject
Has Abstractpub_date
2007-01-01 00:00:00pages
499-507issue
4eissn
1176-9092issn
1178-1998journal_volume
2pub_type
杂志文章,评审abstract:OBJECTIVES:The main purpose of this study was to investigate whether carotid artery stenting (CAS) plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP) control compared to other medical treatments alone. The other aim was to explore the correlation between post-CA...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S122352
更新日期:2017-01-06 00:00:00
abstract:Purpose:Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements. Mate...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S171508
更新日期:2018-11-08 00:00:00
abstract:Objective:We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer's disease (AD). Methods:A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
doi:10.2147/CIA.S210062
更新日期:2019-07-12 00:00:00
abstract:PURPOSE:The purpose of this study is to compare the efficacy and safety of one-site and two-site combined phacotrabeculectomy with foldable posterior chamber intraocular lens implantation. METHODS:Thirty-four patients (41 eyes) with glaucoma and cataract were randomly assigned to undergo either a one-site (22 eyes) or...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S89401
更新日期:2015-08-24 00:00:00
abstract:OBJECTIVE:To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population. METHODS:This was a prospective cohort study of patients 65 years and older without hemato-logic disorders who received thromboelastography (TEG) examination at the Chi...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S49478
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110865
更新日期:2016-12-13 00:00:00
abstract::The topic of motor vehicle crashes among the elderly is dynamic and multi-faceted requiring a comprehensive and synergistic approach to intervention planning. This approach must be based on the values of a given population as well as health statistics and asserted through community, organizational and policy strategie...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:Background:Neuromuscular electrical stimulation with muscle contraction, administered through the skin of the neck, improves a patient's swallowing ability. However, the beneficial effects of transcutaneous electrical sensory stimulation (TESS), without muscle contraction, are controversial. We investigated the effect ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S140746
更新日期:2017-11-07 00:00:00
abstract:Background:Cognitive function has been suggested to be correlated with mortality, while studies regarding the association among the very elderly population with chronic kidney disease (CKD) are extremely limited. Aim:To explore the association between cognitive function and mortality among the very elderly Chinese pop...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S173696
更新日期:2018-10-18 00:00:00
abstract::Hypernatremia in the geriatric population is a common disorder associated with significant morbidity and mortality. Older people are predisposed to developing hypernatremia because of age-related physiologic changes such as decreased thirst drive, impaired urinary concentrating ability, and reduced total body water. M...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S65214
更新日期:2014-11-19 00:00:00
abstract:BACKGROUND:The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. METHODS:We analyzed serum samples collected from 2...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57714
更新日期:2014-03-17 00:00:00
abstract:PURPOSE:To study the feasibility of first, reaching functionally declined, but still independent older persons at risk of falls through their general practitioner (GP) and second, to reduce their physiological and psychological fall risk factors with a complex exercise intervention. We investigated the effects of a 16-...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S46218
更新日期:2013-01-01 00:00:00
abstract::Life-space mobility (LSM) is a concept for assessing patterns of functional mobility over time. LSM is gaining traction in the research of geriatric population health. Several instruments have been developed to measure LSM, such as the University of Alabama at Birmingham Life-Space Assessment (LSA) or the Nursing Home...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S196944
更新日期:2020-09-15 00:00:00
abstract::Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebe...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
abstract:OBJECTIVE:The goal for this study was to evaluate the effects of daily consumption of Puer tea extract (PTE) on body weight, body-fat composition, and lipid profile in a non-Asian population in the absence of dietary restrictions. MATERIALS AND METHODS:A randomized, double-blind, placebo-controlled study design was us...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S94881
更新日期:2016-03-24 00:00:00
abstract:Background:Tinnitus and dizziness are frequent in old age and often seen as concomitant symptoms in patients with dementia. In earlier clinical trials, Ginkgo biloba extract EGb 761® was found to alleviate tinnitus and dizziness in elderly patients. Consequently, a meta-analysis was conducted to evaluate the effects of...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析,评审
doi:10.2147/CIA.S157877
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:Satisfaction with treatment is considered a relevant factor for assessing results in clinical practice. However, when assessing satisfaction in dependent patients, the opinion of their caregivers becomes crucial, since implicit in satisfaction is the degree of caregiver involvement, of adherence to treatment...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S83086
更新日期:2015-06-17 00:00:00
abstract:PURPOSE:This validation study aims to examine Cornell Scale for Depression in Dementia (CSDD) items in terms of the agreement found between residents and caregivers, and also to compare alternative models of the Thai version of the CSDD. PATIENTS AND METHODS:A cross-sectional study was conducted of 84 elderly resident...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S45201
更新日期:2013-01-01 00:00:00
abstract::Taken once a year, intravenous zoledronic acid (Zol) (Reclast® or Aclasta®) is a third-generation nitrogen-containing bisphosphonate that is effective compared with placebo in reducing the risk of fractures in patients with postmenopausal osteoporosis and recent low-trauma hip fracture. In glucocorticoid-induced osteo...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S7282
更新日期:2011-01-01 00:00:00
abstract:Introduction:Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S170111
更新日期:2018-08-03 00:00:00
abstract:PURPOSE:Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S135364
更新日期:2017-05-26 00:00:00
abstract:BACKGROUND:Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. PURPOSE:To determine the relationship between multiple vascular risk exposures, as counted on an index in cases...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S28143
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to analyze and compare the movement kinematics of sit-to-stand (STS) and back-to-sit (BTS) transfers between frail aged adults and young subjects, as well as to determine the relationship between kinematic changes and functional capacities. METHODS:We analyzed the Timed Up and Go...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S74755
更新日期:2015-02-26 00:00:00
abstract:PURPOSE:Postmenopausal osteoporosis causes bone fracture as well as pain, physical, psychological and socially adverse effects, which affects a patient's quality of life (QOL). The effect of alendronate on QOL was investigated compared with that of alfacalcidol in post-menopausal osteoporotic women. PATIENTS AND METHO...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/cia.s9696
更新日期:2010-04-26 00:00:00
abstract:BACKGROUND:Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old. SUBJECTS AND METHODS:This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The me...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134205
更新日期:2017-07-04 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S55972
更新日期:2014-02-14 00:00:00
abstract:BACKGROUND:Use of intensive anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications during percutaneous coronary intervention via the transfemoral route. Recently, the transradial access has been intensively employed as an alternative means ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S50939
更新日期:2013-01-01 00:00:00
abstract:Aim:To contribute to the knowledge about the mechanisms involved in aortic stiffness due to ageing. Materials and Methods:Aortic rings from young (1.5±0.5 months, 0.8±0.2 kg), adult (6±0.5 months, 2.7±0.5 kg) and old (28±8 months, 3.2±0.8 kg) male New Zealand rabbits were used to evaluate: 1) intima-media thickness by...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S236173
更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63596
更新日期:2014-07-22 00:00:00
abstract:Purpose:We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods:Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S200269
更新日期:2019-06-28 00:00:00