Different durations of cognitive stimulation therapy for Alzheimer's disease: a systematic review and meta-analysis.

Abstract:

Objective:We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer's disease (AD). Methods:A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool. Results:Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST. Conclusion:Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

journal_name

Clin Interv Aging

authors

Chen J,Duan Y,Li H,Lu L,Liu J,Tang C

doi

10.2147/CIA.S210062

subject

Has Abstract

pub_date

2019-07-12 00:00:00

pages

1243-1254

eissn

1176-9092

issn

1178-1998

pii

210062

journal_volume

14

pub_type

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