Abstract:
:Purpose: To determine the association between frailty and postoperative complications in elderly Chinese patients and to determine whether addition of frailty assessment improves the predictive ability of the American Society of Anesthesiologists (ASA) score, Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), and Estimation of Physiologic Ability and Surgical Stress (E-PASS) score. Patients and methods: A prospective cohort study was conducted in a tertiary hospital. Elderly patients undergoing major thoracic or abdominal surgery were included. Frailty phenotype and ASA, POSSUM, and E-PASS scores were assessed. Demographic, preoperative, and surgical variables were extracted from medical records. Primary outcome measure was in-hospital Clavien-Dindo ≥ grade II complications. Multiple logistic regression was used to examine the association between frailty and complications. Receiver operating characteristic curves were used to explore the predictive ability of frailty. Results: Prevalence of frailty was 26.12%. Significant differences were observed between the frail and non-frail groups with respect to age, Activities of Daily Living, Charlson Comorbidity Index, respiratory function, presence of malignancy, serum albumin, prealbumin, and hemoglobin levels (P<0.05). ASA, POSSUM, and E-PASS scores were higher in the frail group. After adjusting for all covariates, frailty was significantly associated with postoperative complications in hospital [odds ratio: 16.59, 95% CI: 4.56-60.40, P<0.001]. The area under the curve (AUC) for frailty was 0.762 (95% CI: 0.703-0.814). The AUC for ASA, POSSUM, and E-PASS for prediction of complications was 0.751 (95% CI: 0.692-0.804), 0.762 (95% CI: 0.704-0.814), and 0.824 (95% CI: 0.771-0.870), respectively. Addition of frailty assessment increased the AUC to 0.858 (95% CI: 0.808-0.899), 0.842 (95% CI: 0.790-0.885), and 0.854 (95% CI: 0.803-0.896), respectively. Conclusion: Frailty is an effective predictor of postoperative complications in elderly Chinese patients undergoing major thoracic and abdominal surgery. Frailty assessment can improve the predictive ability of current surgical risk assessment tools. Frailty phenotype should be considered perioperatively. Frailty assessment could also expand the scope for nurses to evaluate patients for safety management.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Han B,Li Q,Chen Xdoi
10.2147/CIA.S201062subject
Has Abstractpub_date
2019-05-22 00:00:00pages
947-957eissn
1176-9092issn
1178-1998pii
201062journal_volume
14pub_type
杂志文章abstract:PURPOSE:Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S135364
更新日期:2017-05-26 00:00:00
abstract::Avoiding medications in which the risks outweigh the benefits in the elderly patient is a challenge for physicians, and different criteria to identify inappropriate prescription (IP) exist to aid prescribers. Definition of IP indicators in the Italian geriatric population affected by cardiovascular disease and chronic...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S137403
更新日期:2017-10-19 00:00:00
abstract:Purpose:Ineffective interdisciplinary communication is linked to many adverse consequences of hospitalization. This study evaluated the effect of SIBR, a model of care that encourages interdisciplinary communication and patient and family participations, on in-hospital deaths and new nursing home (NH) placements. Mate...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S171508
更新日期:2018-11-08 00:00:00
abstract:BACKGROUND:Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63596
更新日期:2014-07-22 00:00:00
abstract::Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data support...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S4482
更新日期:2010-12-03 00:00:00
abstract::Sensorimotor functions decrease in old age. The well-documented loss of tactile acuity in elderly is accompanied by deterioration ofhaptic performance and fine manipulative movements. Physical training and exercise can maintain sensorimotor fitness into high age. However, regular schedules of training require discipli...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s3174
更新日期:2008-01-01 00:00:00
abstract:Introduction:Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S170111
更新日期:2018-08-03 00:00:00
abstract:BACKGROUND:Gerontological research aims at understanding factors that are crucial for mediating "successful aging". This term denotes the absence of significant disease and disabilities, maintenance of high levels of physical and cognitive function, and preservation of social and productive activities. Preservation of ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S15433
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:With longer life expectancies, the prevalence of arrhythmias is increasing; thus, there is a need for new methods to screen the older outpatient population. This population-based study describes the prevalence of arrhythmias in 200 outpatients aged ≥66 years. We also investigated the feasibility of wireless lon...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110532
更新日期:2016-08-10 00:00:00
abstract:BACKGROUND:Visual impairment is more prevalent in the elderly and depression is common in this population. Although many studies have investigated depression or quality of life (QOL) in older adults with visual impairment, few have looked at the association between these two concepts for this population. The aim of thi...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S27717
更新日期:2013-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals presen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134605
更新日期:2017-05-15 00:00:00
abstract:Purpose:The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in pat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S195451
更新日期:2019-02-27 00:00:00
abstract:BACKGROUND:One of the key clinical features of Alzheimer's disease (AD) is impairment in daily functioning. Patients with mild cognitive impairment (MCI) also commonly have mild problems performing complex tasks. Information and communication technology (ICT), particularly techniques involving imaging and video process...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S36297
更新日期:2012-01-01 00:00:00
abstract::Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebe...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
abstract::Approximately 50% of hospitalized elders have cognitive impairment (CI) that increases their vulnerability to hospital-acquired complications. Matching geriatric evaluation and recommendations to the true pace of hospital care may improve the care of elders in general, in particular those with CI. Integrating informat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to assess the elongation of the styloid process on digital panoramic radiographs and to evaluate the prevalence of the elongation according to age, sex and types. PATIENTS AND METHODS:Digital panoramic radiographs of 198 geriatric edentulous patients were analyzed. The radio...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S129818
更新日期:2017-03-30 00:00:00
abstract:BACKGROUND:The aim of this study was to examine the trend in increasing life expectancy in relation to heart attack and cardiac catheterization. METHODS:A retrospective study of very elderly patients over 90 years of age (study group) and between 70 and 79 years of age (control group) with myocardial infarction and ac...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S29045
更新日期:2012-01-01 00:00:00
abstract:Background:Being elderly and retired are related phenomena that overlap in a time symmetry. The present study aimed to assess the effect of an empowering self-management model on the self-efficacy and sense of coherence (SOC) in retired elderly with chronic diseases. Methods:A randomized controlled trial that included...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S183276
更新日期:2018-11-01 00:00:00
abstract:Objective:The aim of this study was to compare the perceived oral health of elderly persons and the clinical reality of their oral status. Background:Persons aged over 60 have considerable need for oral health care; a need that increases over time. However, this population appears to be unaware of their state of oral ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S204533
更新日期:2019-06-28 00:00:00
abstract:PURPOSE:Patients leaving the hospital are at increased risk of functional decline and hospital readmission. The Employee and Community Health service at Mayo Clinic in Rochester developed a care transition program (CTP) to provide home-based care services for medically complex patients. The study objective was to deter...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S44390
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The main purpose of this study was to investigate whether carotid artery stenting (CAS) plus medicine in patients with severe carotid artery stenosis provide a better long-term blood pressure (BP) control compared to other medical treatments alone. The other aim was to explore the correlation between post-CA...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S122352
更新日期:2017-01-06 00:00:00
abstract::Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and physical frailty phenotype in older persons, is increasingly considered the main geriatric condition predisposing to dementia. Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promo...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S139163
更新日期:2018-08-29 00:00:00
abstract:Background:Cognitive function has been suggested to be correlated with mortality, while studies regarding the association among the very elderly population with chronic kidney disease (CKD) are extremely limited. Aim:To explore the association between cognitive function and mortality among the very elderly Chinese pop...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S173696
更新日期:2018-10-18 00:00:00
abstract::Nutrition is an important element of health in the older population and affects the aging process. The prevalence of malnutrition is increasing in this population and is associated with a decline in: functional status, impaired muscle function, decreased bone mass, immune dysfunction, anemia, reduced cognitive functio...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s9664
更新日期:2010-08-09 00:00:00
abstract:Background:When considering the "joint as an organ", the tissues in a joint act as complementary components of an organ, and the "set point" is the cellular activity for homeostasis of the joint tissues. Even in the absence of injury, joint tissues have adaptive responses to processes, like aging and menopause, which r...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S151453
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To investigate the long-term effects of three antiarthritics, namely dexamethasone, celecoxib, and methotrexate on the histology and metabolism of intact bone tissue in rats. METHODS:Thirty-two 12-week-old healthy female Sprague Dawley rats were randomly allocated into four groups: 1) control (saline, daily)...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85225
更新日期:2015-08-05 00:00:00
abstract::Frailty is a common and important geriatric syndrome characterized by age-associated declines in physiologic reserve and function across multiorgan systems, leading to increased vulnerability for adverse health outcomes. Two major frailty models have been described in the literature. The frailty phenotype defines frai...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S45300
更新日期:2014-03-19 00:00:00
abstract:Aim:To contribute to the knowledge about the mechanisms involved in aortic stiffness due to ageing. Materials and Methods:Aortic rings from young (1.5±0.5 months, 0.8±0.2 kg), adult (6±0.5 months, 2.7±0.5 kg) and old (28±8 months, 3.2±0.8 kg) male New Zealand rabbits were used to evaluate: 1) intima-media thickness by...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S236173
更新日期:2020-04-20 00:00:00
abstract:Purpose:Sleep disorders, such as insomnia with objective short sleep duration, are associated with increased risk of hypertension. The objective of the study was to evaluate the effects of insomnia and daytime sleepiness on the quality of life (QOL) among elderly hypertensive patients. Patients and methods:This cross-...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S188499
更新日期:2019-01-15 00:00:00
abstract:Objective:The objective involved the analysis of the efficiency of the Program of Movement Recreation of Elderly People (PMREP) exercise program expressed in terms of the stabilography measures and coactivation of muscles in women in the age group of 60-70 years. The assumption that was assumed stems from theoretical i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S167782
更新日期:2018-09-12 00:00:00